Product Description:

Product Name: Cooling agent ws-3

Chemical Name: N-Ethyl-2-(isopropyl)-5-methylcyclohexanecarboxamide

CAS No.: 39711-79-0

MF: C₁₃H₂₅NO

MW: 211.35

Appearance: White crystal powder

Odor:  Mild cooling, slight menthol odor (almost odorless)

Detection Method: HPLC

Purity: ≥99%

Melting Point: 87ºC-102ºC

Flash Point: >100℃

Specific Rotation: -49° ~ -54°

Water Solubility: Insoluble

FEMA No.: 3455

EINECS No.: 254-599-0

Shelf Life: 2 years

Package: 1kg per bag with double plastic inside and aluminium foil bag outside, or 25kg per fibre drum with double plastic bag inside, or according to customers’ requirement.

Storage: Store in cool and dry place. Keep away from strong light and heat.

Product Description:

Background:

WS 3 is an agonist of TRPM8 receptor with EC50 value of 3.7 μM [1].

Transient receptor potential cation channel subfamily M member 8 (TRPM8) is a Ca²⁺– and Na⁺-permeable ion channel and is activated by cooling agents and cold temperatures. TRPM8 belongs to TRP family and is expressed in sensory neurons.

WS 3 is an agonist of TRPM8 receptor and a cooling agent. In HEK293 cells expressed recombinant mouse TRPM8, WS 3 (30 μM) increased [Ca²⁺]i. WS 3 exhibited potency with EC50 value of 3.7 μM and induced 86% efficacy of the maximal response to icilin, the most potent agonist [1]. In HEK cells stably expressing either hTRPM8 or hTRPA1, WS 3 activated hTRPM8 and hTRPA1 with EC50 values of 2.2 and 120.6 μM, respectively. WS 3 was efficacious in eliciting cooling sensation [2].

References:
[1].  Behrendt HJ, Germann T, Gillen C, et al. Characterization of the mouse cold-menthol receptor TRPM8 and vanilloid receptor type-1 VR1 using a fluorometric imaging plate reader (FLIPR) assay. Br J Pharmacol, 2004, 141(4): 737-745.
[2].  Klein AH, Iodi Carstens M, McCluskey TS, et al. Novel menthol-derived cooling compounds activate primary and second-order trigeminal sensory neurons and modulate lingual thermosensitivity. Chem Senses, 2011, 36(7): 649-658.

Advantages:

Food Grade Cooling Agent ws-3 For Cigarette/Filter Tip/Tobacco/Oral Product

1. There is a high cooling effect without other unpleasant feelings such as bitterness, burning, stinging or tingling sensations and can bring more stimulative, fresh and aromatic sensory to

the entire mouth and throat.

2. Cooling agent ws-3 can solve the difficulty of developing new products with bad sensation.
3. When used with other flavors, it enhances the effects of the flavors. It also can be used with

other cooling agents.

4. Cooling agent ws-3 is water-solubility is no  more than 0.1%, it’s better than traditional cooling agents, so it can act on taste bud more wallop and has long cooling effect.

Functions:

1. Continuous and long lasting cooling and refreshing effect, having no hot, harsh and stinging sensation of Menthol and/or Peppermint.
2. Heat-Resistance: Heating under 200^oC will not reduce the cooling effect, suitable to use on baking and other high temperature heating process.
3. Its cooling intensity can maintain 15-30 minutes, enriching the refreshing of product and having no burning pain, stabbing and numbness, it’s cooler than traditional Menthol products.
4. Low dosage: 30-100 mg/kg dosage will give good cooling effect.
5. Excellent compatibility with other flavors, it can enhance the effect of the flavors. It also can be combined using with other cooling agents.

Applications:

1. Daily use products: toothpaste, oral products, Air Freshener, skin cream, shaving cream, shampoo, sunscreen, shower cream.
2. Food products: confectionery products, chocolate, dairy produce, beer, distilled spirit, beverage,

Chewing Gum.

3. Medicine: linctus, diminish inflammation ointment, dyspepsia, antipruritic, liniment, oral cavity

acesodyne, heatstroke pill.

4. Others: cigarette, filter tip and other tobacco, it also can be used for driving insects.

Usage:

1. Soluble in Ethanol/PG firstly, then adding water solution.
2. Or dissolved in flavors firstly, then added into your products.
3. Mixed with dementholized peppermint oil can increase the fragrance signally.

Product Description:

Broccoli is a member of the cabbage family, and is closely related to cauliflower. Its cultivation originated in Italy. Broccolo, its Italian name, means “cabbage sprout.” Because of its different components, broccoli provides a range of tastes and textures, from soft and flowery (the floret) to fibrous and crunchy (the stem and stalk). Broccoli contains glucosinolates, phytochemicals which break down to compounds called indoles and isothiocyanates (such as sulphoraphane). Broccoli also contains the carotenoid, lutein. Broccoli is an excellent source of the vitamins K, C, and A, as well as folate and fiber. Broccoli is a very good source of phosphorus, potassium, magnesium and the vitamins B6 and E.

Advantages:

1. 100% natural.
2. No synthetic pigments.
3. No chemical essences or flavors.
4. No preservative agents.
5. Good fluidity and dispersible in water.
6. Long preservative time than fresh fruit.
7. Easy for transportation due to powder form.
8. Made from the seasonal fruit, ensure the freshness and nutrition.
9. Microbiology control in line with national standards.
10. Heavy metal control fulfill National Norms and Codes.

Functions:

1. With the function of anti-cancer, and effectively improving capability of blood scavenging.
2. Having the great effect to prevent and regulate hypertension.
3. With the function of enhancing liver detoxification, improve immunity.
4. With the function of reducing blood sugar and cholesterol.

Applications:

1. As drugs raw materials of anti-cancer, it is mainly used in pharmaceutical field.
2. Applied in health product field, it can be used as raw material in health food, the purpose is to enhance immunity.
3. Applied in food fields, it is widely used as functional food additive.

Delivery Time: Within 3 working days after confirming your payment.

Shipping Details: DHL, TNT, FEDEX or EMS.

Payment: T/T, West Union, Paypal and Escrow service.

Product Name: Freeze Dried Carrot Powder

Latin Name:  Daucus carota L. var. sativa Hoffm.

Appearance: Orange fine powder

Oder: Characteristic

Process: Freeze dried

Active Ingredient: Beta carotene, vitamin

Specification: Vegetable powder

Used Part: Root

Particle Size: 100% pass 80 mesh

Test Method: HPLC

Model Number: 100% Nature

Shelf Life: Two years

Packaging Details: 1. 1-10kg/bag, double plastic bags inside, aluminum foil Bag outside.
2. 25kg/drum, double plastic bags inside.
3. According to your requirements.

Storage: Stored in a cool and dry well closed container and in ventilated area,

kept away from moisture and strong light or high temperature. 

Product Description:

The carrot is a root vegetable, usually orange in colour, though purple, red, white, and yellow varieties exist. It has a crisp texture when fresh. The most commonly eaten part of a carrot is a taproot, although the greens are sometimes eaten as well. It is a domesticated form of the wild carrot Daucus carota, native to Europe and southwestern Asia. The domestic carrot has been selectively bred for its greatly enlarged and more palatable, less woody-textured edible taproot.Most carrot cultivars are about 88% water, 7% sugar, 1% protein, 1% fibre, 1% ash, and 0.2% fat.

Advantages:

1. 100% natural.
2. No synthetic pigments.
3. No chemical essences or flavors.
4. No preservative agents.
5. Good fluidity and dispersible in water.
6. Long preservative time than fresh fruit.
7. Easy for transportation due to powder form.
8. Made from the seasonal fruit, ensure the freshness and nutrition.

1. Microbiology control in line with national standards.
2. Heavy metal control fulfill National Norms and Codes.

Functions:

1. Carrot powder can be used to enhance human immunity.
2. Carrot powder can be used to maintain the integrity of the skin mucous membrane layer, prevent skin dry and coarse.
3. Carrot powder can promote growth.
4. Carrot powder can be used as an antioxidant, may offer some protection against certain cancers and other diseases.

Applications:

1. Applied health product industry, carrot powder can be used as raw materials.
2. Applied in food and beverage industry ,carrot powder can be used as additives.

Delivery Time: within 3 -7 days after receiving payments.

Shipping Details: DHL, TNT, FEDEX or EMS.

Payment Terms: T/T, West Union, Paypal and Escrow service.

Company Information:

Xi’an Taima Biological Co., LTD. was founded in 2008, is a technological export-oriented private enterprise with the Rights of Self-Managed Import and Export, specializing in active ingredients modernized and industrialization research, development, production, and sales of natural medical botany.

Our factory covers an area of 6,000 square meters equipped with advanced equipment and the production process is in accordance with FDA.

FAQ:

Q1: Could you provide free sample for test?

A1: We can provide you free sample for test, and you only need to pay the delivery cost.

Q2: Which payment terms do you accept? 

A2: T/T, West Union, Paypal and Escrow service are available. But different payment terms against countries.

Q3: What’s about the MOQ ?

A3: It depends on different products. Usually our MOQ is 1kg.

Q4: What’s the delivery lead time?

A4: We will make delivery within 3-7 days after receiving payment.

Q5: What about the delivery port? 

A5: Main ports in China are available.

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Extract from Epimedium herb, with kidney yang, cough and asthma, dehumidification dehumidification, Qi heart and other effects.

【Chinese name】:YINYANGHUO
【English name】: Epimedium extract

【Active ingredients】: icariin
【detection method】: HPLC
【Product specifications】: 5% -98%, planting production is mainly based on low content.
【Properties】: This product is a yellow-brown powder.
【Introduction】: The raw materials used in the production of general enterprises are the whole plant of Sagittaria sagittatum, Epimedium sagittatum, or Epimedium sagittatum. The extract is brown powder.
【Main ingredients】: Herba Epimedii extract contains epimedium flavonoids, saponin, volatile oil, wax alcohol.
【Indications】: It has the effect of tonifying kidney, impotence, dehumidification, relieving cough, relieving asthma, and strengthening Qi.
【Save】 Save and keep it in a cool, dry place, protected from light, and away from heat.
【Shelf life】 two years

raw materials：

Epimedium is one of the oldest used herbs, first recorded in the “Shen Nong’s Herbal Classics”; Epimedium is one of the most widely used traditional Chinese medicines and has received extensive attention at home and abroad, in addition to its traditional use of kidney and aphrodisiac. Clinically, epimedium is also commonly used for the treatment of osteoporosis, menopausal syndrome, breast lumps, hypertension, coronary heart disease and other diseases. In addition, epimedium still has the effects of immune enhancement, anti-aging, anti-tumor, anti-AIDS, etc. There is thus a huge potential for research and development. However, epimedium is one of the most widely used medicinal herbs. There are five species listed in the Chinese Pharmacopoeia.
The main varieties used as medicinal raw materials are Sagitta Epimedium,Korean Epimedium,Wushan Epimedium.

pharmacology：

Has a long history of medicinal origins from various plants of the genus Epimedium. Li Shizhen said in his “Compendium of Materia Medica” that he had the effect of “promoting vitality, strengthening bones, making up waist and knees, and strengthening the heart.” Modern pharmacological experimental studies have shown that epimedium can increase blood flow to the heart and brain, promote hematopoietic function, immune function and bone metabolism, and have anti-aging and anti-tumor effects.

(1) Promoting reproductive system development: Epimedium has androgenic hormone-like effects to promote the development of epididymis and seminal vesicles in young mice. Testicular stromal cells in vitro can significantly promote testosterone secretion and cAMP production. Epimedium contains a variety of essential trace elements such as Zn, Mn, Fe and male reproductive function also has a very close relationship.

(2) Promoting Nucleic Acid Metabolism: Using in vitro cell culture and determination of 3H-TdR incorporation into cell DNA to study the effect of EPS on bone marrow cell proliferation and DNA synthesis rate in hydroxyurea-induced “yang-deficiency” mice. Mouse bone marrow cell proliferation and synthesis.

(3) protect cardiovascular and cerebrovascular
The effects of icariin on cerebral blood flow were measured with anesthetized rabbits and dogs using an electromagnetic flowmeter. The results showed that icariin could significantly and increase cerebral blood flow in rabbits and dogs, decrease cerebral vascular resistance, and slightly lower blood pressure. The effect of increasing cerebral blood flow may not be due to the effect on systemic hemodynamics, but is mainly the result of direct expansion of cerebral blood vessels. In addition, icariin can increase cerebral blood flow in experimental animals by dilating vascular smooth muscle, reduce cerebral vascular resistance, and protect against cerebral ischemic injury. The mechanism of vasodilation is related to the blocking effect of calcium channels. Epimedium total flavonoids can significantly increase cerebral blood flow, reduce cerebral vascular resistance, and selectively block ex vivo and whole animal myocardial β1 receptors, but have no blocking effect on tracheal β2 receptors and vascular smooth muscle α receptors. The above results provide a theoretical basis for the treatment of coronary heart disease and angina pectoris clinically.

(4) Inhibition of thrombosis and hematopoiesis
inhibit thrombosis in rabbits in vitro. The main factors that inhibit thrombosis may be related to the decrease of red blood cell aggregation and the decrease of whole blood viscosity. In vitro administration of total flavonoids of Epimedium can significantly inhibit platelet aggregation and prolong prothrombin time. Icariin promotes the production of CSF-like activity in mouse spleen lymphocytes. CSF is a type of glycoprotein that promotes the proliferation, differentiation, maturation and survival of human or animal bone marrow cells. It can promote hematopoiesis and stimulate the function of mature cells, and plays an important role in hematopoiesis. Icariin can also synergistically induce IL-2, 3, 6, while IL-3 can act on bone marrow pluripotent stem cells to promote the differentiation and proliferation of a variety of blood cells, and IL-6 cooperates with IL-3 to support the proliferation of pluripotent stem cells. It can thus promote the function of hematopoiesis.

(5) Anti-aging effects
The aging process is a complex and comprehensive process with many mechanisms. Epimedium preparations can affect aging mechanisms in different ways, such as affecting cell passage, prolonging the growth period, regulating the immune and secretory system, and improving body metabolism and organ functions. Epimedium has an anti-oxidant effect, and has a significant delaying effect on the age-related changes of hypothalamic neurotransmitters in natural aging animals.

(6) Enhance human immunity
Immune organs: Epimedium polysaccharides can shrink the thymus, promote thymus release of mature cells, and enhance cellular immune function.
Immune cells: Epimedium polysaccharide subcutaneous injection can increase the macrophage phagocytosis ability of mice and it is also effective when intragastrically administered. Icariin can also significantly activate macrophages, enhance phagocytosis of macrophages, and promote the production of IL-2 and TNF. can promote the proliferation of mouse T cells, but also has a role in the proliferation of B cells.
Immune factors: epimedium polysaccharides can increase IL-2 production in thymus and spleen cells of mice and induce IFN. It is likely that IFN-γ is mainly induced, and it may be considered as an effective, new in vivo interferon inducer.

(7) Prevention and treatment of osteoporosis
Epimedium inhibits the function of bone cells, especially the formation of calcified bone, there is a “bone” effect, a good control of osteoporosis.

(8) Anti-tumor effect
The icariin-induced apoptosis in tumor cells can affect the changes in the cell cycle distribution. The increased apoptosis rate is related to the reduction of S phase cells and the increase of cells in G0/G1 phase. And can reduce the apoptosis-related genes bcl-2 and c-myc gene mRNA and protein expression levels. Icariin synergistically induces IL-2, 3, 6 and enhances the activity of anti-cancer effector cells (NK, LNK). Epimedium flavonoids can significantly increase the macrophage phagocytosis, lymphocyte transformation and spleen to body ratio in tumor-bearing mice, significantly increase the rate of red blood cell C36 receptor rosettes and decrease the rate of red cell immune complex rosettes. It is suggested that total flavonoids of epimedium have a certain recovery effect on the low cellular immune function and red blood cell immune function of tumor-bearing mice, and to a certain extent can inhibit the growth of tumor cells. The use of total flavonoids of Epimedium as an adjunctive treatment for cancer patients may have a certain application prospect.

Hedgehog ~ a magical Chinese herbal medicine, men use majestic, women drink it beauty

Hedgehog has long been used by urologists to improve male sexual dysfunction. Because this herb can effectively increase blood flow in the blood chamber of the penis sponge, it can achieve strong erection. According to a research report from the National University of Singapore, Hedgehog also has a rapid increase in the content of testosterone in the body and improves erectile function.

In recent years, sports health supplements based on extracts of black locust have been very popular in the European and American markets, and are favored by many sports athletes and bodybuilders. Hedgehog is a perennial vine, growing in China, India, Eastern Europe, Africa and other places. 5000 years ago, our ancestors discovered that acupuncture had aphrodisiac effect, used its medicine to treat impotence, and included a prescription for aphrodisiac. Hedgehog is also used as a hemostatic agent, urolithiasis, diuretics, inflammation, and arthritis. In recent years, studies have found that hedgehog can stimulate human pituitary luteinizing hormone secretion, thereby promoting the secretion of testosterone, improve blood testosterone levels, increase muscle strength, and promote physical recovery.

Hedgehog is not a stimulant. Its principle of drug action is different from synthetic steroid agonists such as androstenedione and dehydroepiandrosterone, precursors of anabolic hormones. Using synthetic steroid agonists can increase testosterone levels but inhibit self-testosterone secretion. Once the medicine is stopped, the testosterone in the body is insufficiently secreted, resulting in weak constitution, weakness, fatigue, and slow recovery. The increase in blood and testosterone caused by the use of hedgehogs is due to the increased secretion of self-testosterone, and there is no inhibition of self-testosterone synthesis. Moreover, taking a hedgehog medicine can help to stimulate and regulate the excitatory self-restraint secretion of testosterone back to normal. The Shaolin Institute of Firepower Tuina shows that: clinical studies have shown that Robinia pseudoacacia can increase the number of sperm and improve the vitality of sperm, enhance sexual desire and sexual ability, increase the frequency and hardness of erection, and accelerate the recovery of sexual ability after sexual life. Improve men’s reproductive ability. Hedgehog can also increase the concentration of estradiol in a woman’s body. At the same time, it has little effect on the secretion of testosterone, and promotes ovulation, thus improving women’s reproductive function.

Hedgehog has other drug effects: to improve and regulate menopausal syndrome; stabilize emotions; reduce hyperlipidemia and hypertension; improve immune function; increase the number of red blood cells and white blood cells; antibacterial and anti-inflammatory; relieve bone and joint pain; improve myocardial contractility Prevention and treatment of urinary tract stones; antioxidation; prevention of aging and so on.

The main active ingredients of Robinia pseudoacacia extract (from leaves, flowers, stems) include: phytosterols, saponins, flavonoids, alkaloids, resins, unsaturated fatty acids, biologically active proteins, nitrates, calcium, phosphorus, Iron and so on. Existing experimental and clinical studies have shown that the Robinia pseudoacacia extract does not have any adverse side effects on the body. The Robinia pseudoacacia extract is an ideal, safe, effective, non-hormonal natural exercise health supplement. Athletes and bodybuilders take 250-750mg of Robinia extract every day for 40-90 days.

The new research on the treatment of sexual dysfunction by Chinese medicine abroad: 蒺藜 contains a variety of alkaloids, and has antihypertensive and diuretic effects. Effective for prostate, penis, urethra and other diseases. Studies have shown that sputum stimulates libido by increasing blood testosterone concentrations. Has a rapid increase in testosterone levels in the body and improve erectile function!

Modern use:

1. Make tea. A lid with a mug, 70-mesh white powder (hedgehog powder), boiling water (be sure to use freshly boiled water). Stamp and simmer for 5 minutes, OK! You can drink!

2. Directly swallow, then drink saliva (preferably pure water or cool white).

3. Dosage: 3 times a day, 6 grams each time. (Each porcelain spoon is a flat spoon. You can use this to measure)

White beauty effects

White, give you baby-like skin! White peony contains a variety of alkaloids and terpenes, which have the effects of lowering blood pressure and lowering blood lipids. The peroxide-degrading enzymes contained therein have significant anti-aging effects.

Beauty effects: Jiufu can scratch scars on the face and leave skin soft and smooth.

Do you ever wonder what the freeze-dried fruits in some cereals are good for?

Although freeze-dried fruits are small and light-weight, studies show that the antioxidant phytochemicals found in the fruits’ fresh state are retained at levels almost as high after freeze-drying. Studies also show that the phytochemicals in freeze-dried fruits can reach our bloodstream.

Since the 1980s, one researcher has been studying how the phytochemicals in freeze-dried fruits, such as raspberries, strawberries and blueberries, might protect against cancers of the colon and esophagus. The American Institute for Cancer Research (AICR) has supported his work.

At AICR’s most recent annual research conference, this researcher, Gary Stoner, Ph.D., Professor and Chair of Environmental Health Sciences at Ohio State University, told the audience why he uses the whole freeze-dried berry instead of extracts. In addition to phytochemicals like ellagic acid, carotenoids and anthocyanins, the whole berry can contain significant amounts of vitamins C, E and folic acid. “Studies show that the substances in foods working together are more effective than any one in isolation,” he said.

A nutritional aerosol spray?
In his studies, freeze-dried berries are ground into a powder. After several experiments showed that the fruit powder prevented colon tumors, small-scale human trials were begun. Now, several larger human trials have been launched to study the effects of the berry powder on precursors to colon and esophageal cancers. Dr. Stoner is also trying to develop an aerosol spray from the berries for use in lung cancer experiments.

The amount of freeze-dried fruit that most people eat – the few pieces in a bowl of cereal poured from a box – is too little to count as a serving of fruit. To get a real nutritional impact from fruit in your cereal, you need to add more fresh, frozen, dried, or freeze-dried fruit. A serving of diced, cooked, or frozen fruit is one-half cup. A serving of dried fruit is one-quarter cup.

Cnidium Fruit (Cnidium monnieri)

Cnidium Fruit is part of an annual herb native to China. It has been used in traditional Chinese medicine for thousands of years, often for the relief of skin conditions like eczema. Modern science has shown this botantical to be effective as an anti-allergic¹, anti-inflammatory², and anti-microbial^3,4 agent. It has also been proven to reduce itching⁵.

References:

• Matsuda, H. et al., Anti-allergic effects of cnidii monnieri fructus (dried fruits of Cnidium monnieri) and its major component, osthol. Biol Pharm Bull. 2002, 25(6):809-12.
• LIAO et al. Osthole regulates inflammatory mediator expression through modulating NF-kB, mitogen-activated protein kinases, protein kinase C, and reactive oxygen species. J. Agric. Food Chem. 2010, 58: 10445–10451
• Figueroa, M. et al., Constituents, biological activities and quality control parameters of the crude extract and essential oil from Arracacia tolucensis var. multifida. J Ethnopharmacol. 2007, 113(1):125-31.
• Cai, J. et al., Studies on the quality of fructus Cnidii–comparison of antibacterial action. Zhongguo Zhong Yao Za Zhi. 1991, 16(8):451-3, 510.
•  Matsuda, H. et al., Antipruritic effect of Cnidii Monnieri Fructus (fruits of Cnidium monnieri CUSSON). Biol Pharm Bull. 2001, 24(9):1012-5.