Caryophyllene Oxide Solution by Xi’an Taima: Stable Woody-Spicy Aroma for Flavor, Fragrance & Personal Care

Xi’an Taima’s Caryophyllene Oxide Solution solves aroma instability with advanced aroma-locking tech—delivering softer, long-lasting woody-spicy notes for flavor, fragrance and personal care formulations.

Caryophyllene Oxide solution for flavor, fragrance and personal care applications has been newly developed by Xi’an Taima

Caryophyllene Oxide Solution Solves Industry Aroma Instability Challenge

Core Technology Behind Xi’an Taima’s Caryophyllene Oxide Solution

By adopting optimized purification and professional aroma-locking technology, Xi’an Taima greatly upgrades the performance of its Caryophyllene Oxide Solution. It effectively improves aroma stability and cuts down unpleasant harsh woody notes, delivering a cleaner, softer and well-balanced aroma profile that adapts to various formula systems.

Caryophyllene Oxide solution for flavor, fragrance and personal care applications has been newly developed by Xi’an Taima

Core Advantages of Caryophyllene Oxide Solution

• More stable woody-spicy aroma during processing and storage
• Softer odor profile with reduced harsh notes
• Better compatibility in flavor and fragrance formulations
• Suitable for food flavor, fragrance and personal care applications
• Helps manufacturers improve final product consistency

Application Scope of Caryophyllene Oxide Solution

Xi’an Taima’s Caryophyllene Oxide Solution is widely applicable to aroma formulations, functional fragrance systems, daily personal care products and multiple food flavor scenarios. Its stable woody-spicy aroma characteristic makes it a reliable high-quality raw material for enterprises to develop premium flavor, fragrance and personal care products.

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Caryophyllene Oxide;Natural Ingredient

Widely found in essential oils of natural plants such as clove, basil and black pepper, Caryophyllene Oxide is an oxidized derivative of β-Caryophyllene. It appears as white crystalline powder with a melting point of 62-63℃ and purity up to over 95%. Boasting excellent high-temperature stability, its fragrance hardly volatilizes at a boiling point of 279-301℃, making it perfectly adaptable to various processing scenarios. It features a unique fresh woody aroma blended with mild spicy and sweet notes, with fresh top note, mellow body note and long-lasting sweet aftertaste, serving as an indispensable flavor skeleton in natural perfumery.

Skin Penetration Enhancer

In the food industry, Caryophyllene Oxide acts not only as a high-quality spice ingredient but also an ideal natural preservative. Compliant with China’s GB 2760 standard for food additives, it can be used to prepare various food flavors and endow products with unique taste. Meanwhile, it delivers remarkable inhibitory effect on pathogenic bacteria such as Klebsiella pneumoniae, with an inhibition rate reaching 78.3% at a concentration of 0.8 mg/mL, effectively extending the shelf life of food. It has been widely applied in baked goods, beverages, condiments and more. An addition ratio of merely 0.05%-0.3% in biscuits, milk tea powder and other products can realize dual improvement of flavor and fresh-keeping performance.

Caryophyllene Oxide also gains great attention for its functional value in daily chemical and pharmaceutical sectors. As a novel transdermal absorption enhancer, it disrupts the ordered arrangement of corneal lipids and keratin, significantly improving the permeability of the skin barrier. Its penetration-promoting effect on polar macromolecules outperforms traditional terpenoid enhancers, with low irritation and high safety, making it a preferred ingredient for cosmetics and external pharmaceutical preparations. Pharmacological studies show that its combined use with paracetamol can boost analgesic effect by 32% and reduce the incidence of gastric mucosal damage. Its derivatives also have potential activities including anti-parasitic and cholinesterase inhibition, opening up new directions for pharmaceutical research and development.

With breakthroughs in green production technology, domestic enterprises have realized high-purity extraction and stable mass production of Caryophyllene Oxide. Adopting eco-friendly extraction processes for precise extraction from natural plant raw materials, the conversion rate and selectivity have reached advanced industry levels. This plant-derived ingredient is easily biodegradable with no environmental pollution, fully meeting the demand for sustainable development. It can replace part of chemical preservatives and insect repellents, catering to the consumption trend of natural ingredients.

Industry experts point out that the cross-field application of Caryophyllene Oxide is embracing a golden development period, and the global market scale is expected to exceed 500 million RMB by 2030. With core strengths of natural traceability, diversified functions and environmental friendliness, it will drive the food, daily chemical and pharmaceutical industries toward a healthier and more sustainable future, bringing superior product experience to consumers.

Xi’an Taima Biological Engineering Co., Ltd. proudly announces the launch of high-purity Caryophyllene Oxide, a natural terpene oxide widely found in essential oils such as clove and black pepper. This product offers a unique spicy, woody aroma with excellent stability and functional benefits.

Key Features

– Natural origin from plant essential oils
– Distinct spicy and woody aroma
– High thermal and formulation stability
– High purity suitable for food and cosmetic applications

Applications

– Food & Beverage: flavor enhancement for spicy and herbal drinks
– Cosmetics & Fragrance: perfume base notes and skincare formulations
– Functional Products: natural active ingredient for health-related uses

Quality Assurance

Produced under GMP standards with strict quality control. COA, FEMA, and IFRA documentation available upon request.

About Us

Xi’an Taima Biological Engineering Co., Ltd. specializes in food flavors and natural extracts, providing high-quality solutions to global customers.

Natural caryophyllene oxide reshapes the rules of multiple industries.

—— A Natural Compound with Bioactivity and Industrial Value Leads the Upgrade of Fragrance, Pharmaceutical, and Cosmetic Industries

(Special Report by [Correspondent’s Name]) Recently, with the implementation of multiple research achievements and the expansion of industrial applications of caryophyllene oxide (CAS No.: 1139-30-6), this bicyclic sesquiterpene compound derived from essential oils of clove, black pepper, and other plants has set off an innovation boom in the fragrance, pharmaceutical, skincare, and daily chemical industries due to its unique chemical properties and diverse bioactivities. From the research on giant pandas’ low-temperature adaptation mechanism to the technological breakthrough of transdermal absorption enhancers, its industrial value continues to be released, making it a key raw material for the green upgrading of related industries.

I. Natural Properties and Core Characteristics Lay the Industrial Foundation

Caryophyllene oxide has the molecular formula C15H24O, presenting as a white crystalline powder with a woody-spicy aroma and a melting point of 62-63°C. It complies with the EU Cosmetics Regulation (1223/2009), IFRA standards, and China’s GB2760 Food Additive List. As a low-toxic flammable solid (oral LD50 in rats > 5000 mg/kg), it requires storage at 2-8°C in a dark and moisture-proof environment, making it an ideal alternative to some chemically synthesized raw materials. Global industrial sales have maintained steady growth from 2021 to 2025, with rising demand for high-purity products (≥98%) and supply dominated by leading enterprises.

II. Breakthroughs in Bioactivity Research, Prominent Cross-Border Potential

• Temperature Perception Regulation: A 2024 study found that caryophyllene oxide can bind to the TRPM8 cold receptor on giant pandas’ skin, blocking Ca²⁺ channels to reduce low-temperature perception and increasing the cold tolerance threshold by 5-8°C. The frequency of giant pandas’ contact with areas sprayed with 0.3% concentration solution increased by 3.2 times compared to the control group, providing new ideas for the protection of animals in extreme environments.
• Antibacterial and Pharmacological Applications: At a concentration of ≥0.8 mg/mL, it inhibits Klebsiella pneumoniae by 78.3%, with its epoxidized structure damaging bacterial cell membrane permeability. When combined with acetaminophen, it enhances analgesic effect by 32% while reducing the risk of gastric mucosal injury, involving the regulation of the TRPV1 receptor pathway. In addition, its derivatives show significant inhibitory activity against parasites such as Leishmania donovani and Trypanosoma brucei, offering new directions for antiparasitic drug development.
• Transdermal Absorption Enhancement: A national patent published in late 2025 revealed that caryophyllene oxide is first applied to promote the transdermal absorption of macromolecular polar substances (e.g., polysaccharides, polypeptides). Its penetration-enhancing effect is superior to traditional terpenoid enhancers (1,8-cineole, β-caryophyllene), with significantly lower skin irritation than the chemically synthesized enhancer azone. This technology can increase the skin permeability of active ingredients such as ganoderma polysaccharides and hirudin by more than 30%, suitable for various external preparations and cosmetics with an addition concentration of only 0.5%-5%.
  

  Natural Active Caryophyllene Oxide: Breakthrough Applications in Multiple Fields and Future Value

III. Large-Scale Multifield Applications, Broad Market Prospects

• Fragrance, Food, and Daily Chemicals: As a compliant fragrance raw material (FEMA No. 4085), its woody-spicy note provides a unique flavor for perfumes, shampoos, aromatherapy products, and can be used in formulating citrus and herbal flavors for food and beverages, with long-lasting and stable aroma.
• Pharmaceuticals and Pesticides: Relying on antibacterial, anti-inflammatory, and analgesic activities, it serves as a core pharmaceutical intermediate for the development of external anti-inflammatory ointments and analgesic preparations. Its natural insect-repellent activity enables it to emerge in the green pesticide field, realizing residue-free protection.
• Skincare: Combining anti-inflammatory soothing and transdermal penetration-enhancing effects, it is suitable for various skin types and has been incorporated into anti-aging and repairing cosmetic formulas, receiving positive market feedback.
  

  From Plant Extract to Industrial Core: The Journey of Caryophyllene Oxide’s Cross-Industry Breakthroughs

IV. Industry Development Outlook

The global market size of caryophyllene oxide is expected to grow at an annual rate of over 8% from 2026 to 2032. Industry experts suggest optimizing extraction and synthesis processes to reduce costs and strengthening derivative research to expand application scenarios in anti-tumor, neuroprotection, and other fields. Currently, relevant enterprises have launched capacity expansion projects for high-purity caryophyllene oxide, and the global production capacity is expected to reach 500 tons/year by 2027 to meet the growing market demand.

The innovative application of caryophyllene oxide highlights the industrial potential of natural plant compounds and provides a new path for the green transformation of multiple industries. In the future, with the deepening of industry-university-research cooperation, this “natural multifunctional raw material” will continue to empower more segmented fields, bringing safer and more efficient product experiences to consumers.

Core Traits & Natural Advantages

Caryophyllene oxide, found in clove, black pepper, rosemary and cinnamon, has a molecular formula of C₁₅H₂₄O — appearing as white crystalline powder with stable physicochemical properties, low toxicity (oral LD₅₀ in rats >5000 mg/kg) and mild skin compatibility, meeting global safety standards. As a fragrance, it offers woody, spicy-sweet notes with long-lasting layering, ideal for blending with various scents. Biochemically, it exhibits strong antibacterial, anti-inflammatory and analgesic effects, with potential in antiparasitic and cholinesterase inhibition applications.

Multi-Industry Application Expansion

• Food Industry: Approved under China’s GB 2760 (FEMA 4085), it serves as a natural flavor enhancer for meat, condiments, beverages and confectionery, while acting as an antioxidant/antimicrobial to extend shelf life and reduce synthetic additives, aligning with clean-label trends.
• Daily Chemicals & Cosmetics: Compliant with IFRA and EU Regulation 1223/2009, it elevates fragrance quality in perfumes, toiletries and oral care products. Its transdermal penetration-enhancing and anti-inflammatory properties boost efficacy in skincare formulations.
• Pharmaceuticals: Preclinical studies highlight neuroprotective potential for Alzheimer’s and other neurodegenerative diseases, plus positive results in anti-anxiety and cognitive improvement research. Derivatives for antiparasitic and chronic inflammatory treatments are in preclinical stages.
• New Materials: Modified via click chemistry, it enhances biocompatibility of medical devices and biosensors. As a green solvent alternative, its penetration in synthetic rubber modifiers reached 21.8% in 2025.
• 

Industrial Upgrading & Technological Progress

Backed by China’s 14th Five-Year Bioeconomy Plan, domestic enterprises drive innovation: Zhejiang NHU achieves large-scale high-purity β-caryophyllene production, while Jiangsu Huachang Chemical optimizes catalytic processes to boost α-caryophyllene yield to 89.7%. Current industrial purity averages over 95% (high-end batches >98.5%), with improved full-chain quality control and supply chain support accelerating commercialization.

Experts predict future R&D will focus on high-purity separation, structural modification and novel delivery systems to enhance bioavailability. As global demand for natural ingredients surges, caryophyllene oxide will expand applications, sustaining market growth as a key driver of the natural active ingredients industry.

(Data as of March 2026; sourced from industry reports and academic research.)

caryophyllene

I. A Gift from Nature: A Star Ingredient from Plant Essential Oils

The natural essence of caryophyllene oxide lies in its wide presence in essential oils of medicinal and edible plants such as clove, black pepper, and rosemary, serving as a core component of plants’ own defense systems and flavor profiles. Compared with synthetic raw materials, this natural extract comes with an inherent “safety gene”, and its unique sensory characteristics make it a key to flavor innovation — based on a woody fragrance, intertwined with soft spicy notes and warm sweet undertones, with a fresh and lively top note, a rich and lingering middle note, and a sweet aftertaste, endowing products with a layered olfactory memory.

Notably, its excellent physical and chemical stability lays the foundation for multi-scenario applications: with a boiling point ranging from 279-301℃, the fragrance does not easily dissipate during high-temperature processing, and it is soluble in most organic solvents such as ethanol and ether, perfectly adapting to complex production processes including baking, steaming, and daily chemical formulation.

II. Multi-Dimensional Empowerment: Triggering a Natural Upgrade Wave Across Three Major Fields

As an all-round ingredient with both “external flavor” and “internal efficacy”, caryophyllene oxide is reshaping the raw material selection logic across multiple industries:

Food Industry: Acting as both a flavor optimizer and a safety guardian. When combined with black pepper and clove essential oils, it enhances the spicy depth of meat products; when synergized with rosemary, it delays lipid oxidation and extends the shelf life of baked goods; when paired with citrus flavors, it balances sweetness, helping beverages and candies achieve “clean label” upgrades. Its high-temperature stability adapts to various processing technologies while reducing the usage of chemical preservatives, accurately meeting consumer demand for natural and healthy products.

Daily Chemical Industry: Becoming a core carrier for fragrance upgrading and efficacy empowerment. Blended with sandalwood and cedarwood, it can extend the longevity of the middle and base notes of fragrances by 30%-50%; when combined with peppermint and eucalyptus, it prolongs the cooling sensation for 4-6 hours. Furthermore, relying on its natural antibacterial properties and transdermal absorption promotion effect, it helps the penetration of active ingredients in skin care products, balancing fragrance experience and skin care efficacy, and aligning with the natural transformation trend of high-end daily chemicals.

Pharmaceutical Industry: Continuous release of bioactive potential. Studies have confirmed that caryophyllene oxide exhibits significant inhibitory effects on pathogenic bacteria such as Klebsiella pneumoniae; when combined with acetaminophen, it enhances analgesic effects and reduces gastric mucosal damage. Its activities in antifungal, anti-inflammatory, and inducing tumor cell apoptosis have been verified through mechanisms such as PI3K/AKT/mTOR/S6K1 pathway regulation, providing new directions for new drug research and development and health product innovation.

III. Quality Assurance: Standardized Production Solves Industry Pain Points

The industrial application of natural ingredients relies on stable quality and comprehensive compliance. With years of experience in this field, Shaanxi Bestfor Bio-Engineering has achieved a purity of caryophyllene oxide ≥95% through green extraction processes and a full-process digital traceability system, with high-end batches exceeding 98.5%, completely solving the industry-wide problem of batch fluctuations in natural raw materials.

Product compliance covers mainstream global standards, not only meeting the National Food Safety Standard GB 2760 but also passing the evaluation of the International Fragrance Association (IFRA) and EU Cosmetics Regulation certification, being exported to more than 30 countries and regions worldwide. Relying on multiple certification systems such as GMP and ISO 9001, Bestfor provides partners with one-stop services from sample docking, formula optimization to bulk supply, enabling the efficient realization of natural ingredient value.

IV. Prospect Outlook: A New Value Track Amid the Natural Economy Wave

As predicted by the “2025-2031 China Caryophyllene Oxide Industry Research and Development Prospect Report”, the market scale will continue to expand, and caryophyllene oxide is ushering in unprecedented development opportunities. From the clean upgrade of food, the natural transformation of daily chemicals to the innovation of medical and health products, this natural essence is penetrating all links of the industry and unlocking more application scenarios.

A relevant person in charge of Shaanxi Bestfor Bio-Engineering stated: “The rise of caryophyllene oxide is the perfect combination of nature’s gift and ingenuity. In the future, we will continue to deepen the research and development and production of natural biological ingredients, and work hand in hand with partners from all industries to explore new blue oceans of value and share the dividends of the natural economy amid the green industry wave.”

Contact Information:

• Consultation Hotline: 029-81163280 (Weekdays 9:00-18:00)
• Business Cooperation: WeChat ID: 18502954664
• Company Address: Block A, Gaoke Shangdu, Zhangba Wulu, Xi’an City, Shaanxi Province, China

Recently, caryophyllene oxide (CAS: 1139-30-6), derived from natural plant extracts, has emerged as a popular natural functional ingredient in food, cosmetics, health technology, and other fields. Its large-scale application and new scientific research progress have injected strong momentum into the green upgrading of related industries.

Caryophyllene oxide is an oxidized derivative of β-caryophyllene, belonging to the class of natural sesquiterpene oxides. It is widely present in essential oils of plants such as clove, black pepper, rosemary, and salvia miltiorrhiza. With a white crystalline powder appearance, its molecular formula is C₁₅H₂₄O and molecular weight is 220.35. Characterized by a woody base note intertwined with soft spicy and warm sweet undertones, it boasts a rich, distinctive aroma. Meanwhile, it possesses multiple biological activities including antioxidant, antibacterial, anti-inflammatory, and discomfort-relieving properties, making it an “all-round” natural ingredient that combines sensory experience with functional value.

I. Food Sector: Dual Empowerment of Flavor and Preservation, Supporting Clean Label Upgrading

In the food industry, caryophyllene oxide is becoming the preferred natural raw material for flavoring and preservation. Its unique woody-spicy aroma can enhance the flavor depth of meat products and condiments, balance the sweetness of beverages and candies, and replace some synthetic fragrances, helping enterprises develop “clean label” products. Additionally, its excellent antioxidant and antibacterial activities can effectively delay oil oxidation, inhibit the growth of pathogenic bacteria, extend food shelf life, and reduce the usage of chemical preservatives. With outstanding high-temperature stability, it is suitable for various processing technologies such as baking, steaming, and frying, offering broad application scenarios. Currently, high-purity food-grade caryophyllene oxide has obtained FEMA 4085 certification, complying with global food additive safety standards.

II. Cosmetics and Beauty Sector: Natural Fragrance Blending + Penetration Enhancement, Creating High-End Efficacy Experiences

In the cosmetics field, caryophyllene oxide serves as a core carrier for fragrance upgrading and efficacy enhancement. As a natural fragrance raw material, it can perfectly blend with sandalwood, cedarwood, citrus, and other notes, improving the richness of the middle and base notes in fragrances and extending the scent retention time by 30%-50%. It is widely used in perfumes, aromatherapy products, and personal care items. More notably, recent research by Nanjing University of Chinese Medicine has confirmed that caryophyllene oxide can act as a natural transdermal absorption enhancer. It significantly disrupts the ordered arrangement of keratin, promoting the penetration of large-molecular polar substances through the skin—with effects comparable to azone, a commonly used chemical penetration enhancer, but with superior skin safety. It can be combined with skincare ingredients to enhance their permeability, aligning with the development trend of naturalness and efficacy in high-end cosmetics.

III. Health Technology Sector: Emerging Scientific Achievements, Expanding New Directions for Wellness

Scientific research breakthroughs in the health technology sector have further highlighted the value of caryophyllene oxide. Studies have shown that it exhibits significant anti-inflammatory and discomfort-relieving activities, and can act as a smooth muscle relaxant and calcium channel blocker, providing new ideas for cardiovascular care and other wellness scenarios. Furthermore, monomeric caryophyllene oxide extracted from the volatile oil of Stellera chamaejasme has been experimentally verified to exert obvious inhibitory effects on specific cells, inducing cell apoptosis and suppressing abnormal proliferation—with good safety at common dosages, providing a theoretical basis for the development of new wellness products. Meanwhile, its epoxidized structure can be used to construct antibacterial probes, demonstrating application potential in the field of biosensing.

IV. Industrial Development: High-Purity Mass Production, Promoting Global Application Implementation

Driven by growing market demand, domestic enterprises have achieved high-purity extraction and stable mass production of caryophyllene oxide. Companies such as Shaanxi Baisfu Biotechnology Co., Ltd. have leveraged mature technologies to increase product purity to over 98%, achieving industry-leading conversion rates and selectivity. The product has obtained multiple international compliance certifications, meeting the large-scale application needs of food, cosmetics, health technology, and other sectors. Currently, caryophyllene oxide has become a star product in the global natural raw material market, exported to Europe, America, Southeast Asia, and other regions.

Industry experts stated that under the consumption trend of “natural, safe, and efficient,” caryophyllene oxide, with its dual advantages of “natural origin + multi-functional properties,” will realize innovative applications in more fields in the future, becoming a key raw material driving the green transformation of related industries.