caryophyllene

I. A Gift from Nature: A Star Ingredient from Plant Essential Oils

The natural essence of caryophyllene oxide lies in its wide presence in essential oils of medicinal and edible plants such as clove, black pepper, and rosemary, serving as a core component of plants’ own defense systems and flavor profiles. Compared with synthetic raw materials, this natural extract comes with an inherent “safety gene”, and its unique sensory characteristics make it a key to flavor innovation — based on a woody fragrance, intertwined with soft spicy notes and warm sweet undertones, with a fresh and lively top note, a rich and lingering middle note, and a sweet aftertaste, endowing products with a layered olfactory memory.

Notably, its excellent physical and chemical stability lays the foundation for multi-scenario applications: with a boiling point ranging from 279-301℃, the fragrance does not easily dissipate during high-temperature processing, and it is soluble in most organic solvents such as ethanol and ether, perfectly adapting to complex production processes including baking, steaming, and daily chemical formulation.

II. Multi-Dimensional Empowerment: Triggering a Natural Upgrade Wave Across Three Major Fields

As an all-round ingredient with both “external flavor” and “internal efficacy”, caryophyllene oxide is reshaping the raw material selection logic across multiple industries:

Food Industry: Acting as both a flavor optimizer and a safety guardian. When combined with black pepper and clove essential oils, it enhances the spicy depth of meat products; when synergized with rosemary, it delays lipid oxidation and extends the shelf life of baked goods; when paired with citrus flavors, it balances sweetness, helping beverages and candies achieve “clean label” upgrades. Its high-temperature stability adapts to various processing technologies while reducing the usage of chemical preservatives, accurately meeting consumer demand for natural and healthy products.

Daily Chemical Industry: Becoming a core carrier for fragrance upgrading and efficacy empowerment. Blended with sandalwood and cedarwood, it can extend the longevity of the middle and base notes of fragrances by 30%-50%; when combined with peppermint and eucalyptus, it prolongs the cooling sensation for 4-6 hours. Furthermore, relying on its natural antibacterial properties and transdermal absorption promotion effect, it helps the penetration of active ingredients in skin care products, balancing fragrance experience and skin care efficacy, and aligning with the natural transformation trend of high-end daily chemicals.

Pharmaceutical Industry: Continuous release of bioactive potential. Studies have confirmed that caryophyllene oxide exhibits significant inhibitory effects on pathogenic bacteria such as Klebsiella pneumoniae; when combined with acetaminophen, it enhances analgesic effects and reduces gastric mucosal damage. Its activities in antifungal, anti-inflammatory, and inducing tumor cell apoptosis have been verified through mechanisms such as PI3K/AKT/mTOR/S6K1 pathway regulation, providing new directions for new drug research and development and health product innovation.

III. Quality Assurance: Standardized Production Solves Industry Pain Points

The industrial application of natural ingredients relies on stable quality and comprehensive compliance. With years of experience in this field, Shaanxi Bestfor Bio-Engineering has achieved a purity of caryophyllene oxide ≥95% through green extraction processes and a full-process digital traceability system, with high-end batches exceeding 98.5%, completely solving the industry-wide problem of batch fluctuations in natural raw materials.

Product compliance covers mainstream global standards, not only meeting the National Food Safety Standard GB 2760 but also passing the evaluation of the International Fragrance Association (IFRA) and EU Cosmetics Regulation certification, being exported to more than 30 countries and regions worldwide. Relying on multiple certification systems such as GMP and ISO 9001, Bestfor provides partners with one-stop services from sample docking, formula optimization to bulk supply, enabling the efficient realization of natural ingredient value.

IV. Prospect Outlook: A New Value Track Amid the Natural Economy Wave

As predicted by the “2025-2031 China Caryophyllene Oxide Industry Research and Development Prospect Report”, the market scale will continue to expand, and caryophyllene oxide is ushering in unprecedented development opportunities. From the clean upgrade of food, the natural transformation of daily chemicals to the innovation of medical and health products, this natural essence is penetrating all links of the industry and unlocking more application scenarios.

A relevant person in charge of Shaanxi Bestfor Bio-Engineering stated: “The rise of caryophyllene oxide is the perfect combination of nature’s gift and ingenuity. In the future, we will continue to deepen the research and development and production of natural biological ingredients, and work hand in hand with partners from all industries to explore new blue oceans of value and share the dividends of the natural economy amid the green industry wave.”

Contact Information:

• Consultation Hotline: 029-81163280 (Weekdays 9:00-18:00)
• Business Cooperation: WeChat ID: 18502954664
• Company Address: Block A, Gaoke Shangdu, Zhangba Wulu, Xi’an City, Shaanxi Province, China

Hawthorn Basic Information
Botanical Name : Crataegus pinnatifida Bge. var. major N. E.
Medicinal Chinese Name : Hawthorn
Primitive: It is the mature fruit of the red crataegus pinnatifida Bge. var. major N. E. Br. or Shancha Crataegus pinnatifida Bge.
Use location : Fruit
Main origin : China
Place of production : Distributed in the northeast of China and Mongolia, Hebei, Shaanxi, Shandong, Jiangsu, Zhejiang, Henan and other places, mainly produced in Henan, Shandong, Hebei.
Harvesting and processing: After harvesting from September to October, the fruit is harvested, cut fresh or cut into two petals, dried or dried.
Medicinal Latin Name : Fructus Crataegi
Hawthorn medicinal properties
This product is spherical and has a diameter of 17.3~23.05mm. The surface is dark red, shiny, covered with grayish white spots; the top has a persistent flower bud, and the base has a stalk residue. Hawthorn tissue identification
The cross-section of the fruit is composed of a row of yellow-brown and thick-walled, and is composed of a class of square epidermal cells. It is 25~37.5μm long and 15~42μm wide. It is not ligated and is surrounded by the stratum corneum.
The epidermis is composed of hundreds of layers of polygonal or round-like soft cells. It is 50~145μm long and 42.5~110μm wide. It contains rich starch granules with a diameter of 4~8.75μm. The umbilical point is obvious or not obvious. A few clusters, diameter 16.25 ~ 31.25μm and yellow-brown matter, occasionally round, oval or polygonal stone cells, wood to micro-wood. The vascular bundle is located inside the mesocarp, and the xylem cells and the sieve cells are arranged side by side, micro-wood; the catheter is mainly spiral and net, with a diameter of 7.5~20μm. The endocarp is extremely thin and consists of several layers of polygonal or quasi-square soft cells.
Hawthorn HPLC fingerprint
Test liquid and sample preparation method
(1) Extraction method
The mountain medicinal material was powdered into a powder by a pulverizer, and 1.0 g of powder was weighed into a 50 mL centrifuge tube. After adding 8 mL of 70% EtOH aqueous solution, the ultrasonic wave (Branson 3200) was shaken for 15 minutes, and centrifuged with Hermle Z-400. The machine was centrifuged at 2,500 rpm for 10 min, and the supernatant was taken. The residue was further shaken with 8 mL of 70% EtOH for 15 minutes and repeated three times. The three supernatants were combined, placed in a 25 mL dosing bottle, and made up to 25 mL with 70% EtOH as a test solution.
Hawthorn chemical composition
The fruit contains epicatechin, quercetin, hyperoside, chlorogenic acid, citric acid and its monomethyl ester (citric acid symmetrical monomethyl) Ester), citric acid symmetrical dimethyl ester and citric acid trimethyl ester, sucrose, flavan polymers, ursolic acid. Hawthorn plant description
Deciduous trees, up to 6m. The branches are 1~2 cm long or have no thorns. Leaves alternate, petiole 2~6 cm long; leaves broadly ovate or triangular ovate, sparsely ovate-lanceolate, ca. 6–12 cm long, 5–8 cm wide, 5–9 pairs of pinnately lobes, apex gradually Tip, base broadly cuneate, shiny on top, pubescent along veins below, irregularly serrated at margin. Umbrella inflorescence, ca. 4~6 cm in diam.; tuberculate, 5-locate; corolla white, 1.5 cm in diam., petate 5, obovate or suborbicular; stamens ca. 20, anthers pink; Ovary lower position, 5 rooms, 5 styles. Pear fruit is nearly spherical, 2.5cm in diameter, deep red, with yellow-white small spots. The sepals fall off very late, leaving a round squat at the apex; small nucleus 3~5, an outward facing mask edge, smoothing inward. Flowering period from May to June, fruiting period from August to October.

Lycopene is a pigment and a member of the carotenoid family. Its antioxidant power is twice that of beta-carotene and 100 times that of vitamin E. Lycopene not only protects plants from UV rays, air pollution, etc., but also exerts antioxidant capacity in the human body, eliminates free radical damage to the human body, enhances immunity, delays aging, and inhibits cancer, thereby improving male fertility. It also has excellent effects in reducing the damage of cigarettes and alcohol. The human body cannot synthesize lycopene by itself and can only be taken from food. The study found that a tomato every day for 4 weeks can increase the body’s good cholesterol content by 15%, while reducing the bad cholesterol content, thereby protecting the cardiovascular.

(1) Improve immunity: It can enhance immunity and restore physical fitness.

(2) Anti-aging: Helps reduce UV damage to the skin, improve skin aging and age spots

(3) Inhibition of cancer cell growth: Women with higher levels of lycopene in serum have a lower risk of cervical cancer; and can inhibit the growth of breast cancer, gastric cancer, lung cancer and endothelial cancer cells.

(4) Protection of cardiovascular: It can inhibit the formation of arteriosclerosis and improve cardiovascular and cerebrovascular diseases such as hypertension, hyperlipemia and coronary heart disease. Because lycopene can prevent the oxidation of low-density lipoprotein in the blood, it can reduce the risk of atherosclerosis and coronary heart disease. Some scholars have concluded from the study of 10 European countries that eating tomato products containing at least 40 mg of lycopene per day can significantly reduce the risk of coronary heart disease.

(5) Men can help prevent and improve urinary system diseases such as benign prostatic hyperplasia and prostatitis, and help improve male sperm quality and reduce infertility risk.

(6) Prevention or improvement of cataract and age-related macular degeneration. Cataract and age-related macular degeneration are common eye diseases in the elderly.

Health tips:

● It is recommended to take 25-30 mg of lycopene per person per day, which is equivalent to a bottle of 250 ml tomato juice or 2 to 3 large tomatoes.

● Lycopene is fat-soluble and is more easily absorbed by the body when cooked with oil. Therefore, tomato processed products such as tomato juice, tomato sauce, etc. are more easily absorbed than fresh tomatoes.

Grape seed extract  is a natural antioxidant substance that can not be synthesized from grape seeds, which is a natural antioxidant substance that can not be synthesized in the human body. It has a strong anti-aging effect and enhances immunity. This product has been widely used in the healthcare products, medicine, and cosmetics industries. Introduction to basic information on grape seed extract
[Source]: Extract of seeds from the dried residue of grapefruit ripe fruit juice after sieving
The efficacy
1. Grape seed extract can effectively alleviate cell senescence; proanthocyanidin is a natural antioxidant substance, which has strong anti-oxidation and eliminates free radicals, and can effectively eliminate superoxide anion radicals and hydroxyl radicals.
2, grape seed extract can effectively protect eyesight; under normal circumstances, the eye receives light from dark to dark through the pigment reflection in the retina, this pigment is called “purplishin”, it is made up of protein and A vitamin consisting of. Like the function of vitamins, grape seed extract can improve the function of some vitamin A.
3. Grape seed extract is a natural sun cover that blocks UV rays from attacking the skin; the main component of grape seed extract, proanthocyanidin, repairs injured collagen and elastic fibers.
Other effects: protection of the cardiovascular system, anti-radiation, anti-mutation, anti-tumor, etc.

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Sucralose

Product Name: Sucralose

Chemical Name:

1,6-Dichloro-1,6-dideoxy-beta-D-fructofuranosyl 4-chloro-4-deoxy-alpha-D-galactose

CAS No.: 56038-13-2

MF: C₁₂H₁₉Cl₃O₈

MW: 397.64

Appearance: White powder

Detection Method: HPLC

Purity: ≥99%

Boiling point: 104-107°C

Specific Rotation: +84.0°- +87.5°

Solubility: Freely soluble in water, in methanol and in alcohol, slightly soluble in ethylacetate.

EINECS No.: 259-952-2

Shelf Life: 2 years

Package: 1kg per bag with double plastic inside and aluminium foil bag outside, or 25kg per fibre drum with double plastic bag inside, or according to customers’ requirement.

Storage: Store in cool and dry place. Keep away from strong light and heat.

Product Description:

Background:

Sucralose was discovered in 1976 by scientists from Tate & Lyle, working with researchers Leslie Hough and Shashikant Phadnis at Queen Elizabeth College (now part of King’s College London). While researching ways to use sucrose and its synthetic derivatives for industrial use, Phadnis was told to “test” a chlorinated sugar compound. Phadnis thought Hough asked him to “taste” it, so he did. He found the compound to be exceptionally sweet.

Tate & Lyle patented the substance in 1976; as of 2008, the only remaining patents concern specific manufacturing processes.

Sucralose was first approved for use in Canada in 1991. Subsequent approvals came in Australia in 1993, in New Zealand in 1996, in the United States in 1998, and in the European Union in 2004. By 2008, it had been approved in over 80 countries, including Mexico, Brazil, China, India, and Japan. In 2006, the US Food and Drug Administration amended the regulations for foods to include sucralose as a “non-nutritive sweetener” in food. In May 2008, Fusion Nutraceuticals launched a generic product to the market, using Tate & Lyle patents.

In April 2015 PepsiCo announced that it would be moving from aspartame to sucralose for most of its diet drinks in the US, due to sales of Diet Pepsi falling by more than 5% in the US. PepsiCo says its decision is a commercial one – responding to consumer preferences.

Functions:

1. High sweetness, 600, 650 times sweetness than cane sugar.
2. No Calorie, without leading to put weight.
3. Pure tastes like sugar and without unpleasant aftertaste.
4. Absolutely safe to human body and suitable for all kinds of people.
5. Without leading to tooth decay or dental plaque.
6. Good solubility and excellent stability.

Applications:

1. Beverage, Original juice, carbonated soft drink, fruit drink and tea drink.
2. Health foods, medicine and other low-sugar products used by patients with obesity, diabetes and cardiovascular disease.
3. Fermented foods, Milk, flavored milk and imitation milk products.
4. Canned fruits and preserves. Candies, Chewing gum, peppermint candy, hard candy, soft candy and throat-wetting candy.
5. Rapid filling beverage production lines.
6. Sweet food, Frozen dessert products Gel, pudding and jelly, sesame paste, breakfast cereal, and sugar for dining table.
7. Others, Salad dressing, seasoning, condiment, sweetener, extract of spice, meat products, mixture of soup and soup.

Usage:

Sucralose powder can be found in more than 4,500 food and beverage products. It is used because it is a no-calorie food sweetener, does not promote dental cavities, and is safe for consumption by diabetics. Sucralose is used as a replacement for, or in combination with, other artificial or natural Sweeteners such as Aspartame, acesulfame potassium or high-fructose corn syrup.

Delivery Time: within 3 -7 days after receiving payments

Shipping Details: DHL, TNT, FEDEX or EMS.

Payment Terms: T/T, West Union, Paypal and Escrow service.

Company Information:

Xi’an Taima Biological Co., LTD. was founded in 2008, is a technological export-oriented private enterprise with the Rights of Self-Managed Import and Export, specializing in active ingredients modernized and industrialization research, development, production, and sales of natural medical botany.

Our factory covers an area of 6,000 square meters equipped with advanced equipment and the production process is in accordance with FDA.

Caffeine is a way of life in modern western culture. The philosopher Terence McKenna once jokingly quipped that if caffeine were to disappear from the western diet the economy might collapse due to no one getting any work done! Here at Mountain Rose Herbs, we certainly enjoy our organic black and green teas, organic yerba mate, and even organic, fairly traded coffee. Some of us like to get creative with our caffeine intake, and guarana seed offers an excellent alternative.

What is Guarana?
Guarana is a member of the maple family, is native to the Amazon basin, and is especially common in Brazil. Guarana seeds have more caffeine per weight than any plant material on earth, almost three times as much as coffee beans! That’s why you’ll often find guarana extract in many of the energy drinks on the market. In addition to caffeine, guarana seed also contains theobromine and other xanthine alkaloids. Guarana provides a clean energy boost, sharpened mental clarity, and does not give you a “crash” similar to coffee.

Guarana is known as “national drink” in Brazil and has been regarded by the Indians of the Amazon basin for thousands of years as a source of youth, beauty, and longevity. Guarana is rich in xanthine derivatives (alkaloids, caffeine), amino acids, tannins, proteins, vitamins, minerals, etc. It was refreshing, nourishing yin and yang, controlling appetite, relieving abdominal pain, and recovering. Physical strength, energy supplement, and improved body function.
Caffeine is the main functional ingredient in guarana seeds, which has the effect of exciting the body and relieving fatigue, and this effect is more moderate. Guarana has an astringent effect and can be used to treat diarrhea.
The guarana seeds are baked and ground into a brown powder, then added with water, stirred into a paste, and then kneaded and shaped to form a guarana rod, which becomes dark red after drying. Guarana rods are crushed for beverage production.
Guarana is also used in sports foods to enhance athletes’ physical fitness and endurance.
Guarana extract main market application
Guarana extract has learned from the market research of planting nets that the use of guarana extract is used in functional beverages, sports drinks, energy bars, fruit drinks, jelly drinks, milk, dietary supplements, and pharmaceuticals.

(0.27 g, 1 mmol) was added to dichloromethane (5 ml) and stirred to dissolve. A 1 mol/L solution of BBr3 in dichloromethane (10 ml) was added dropwise, and the reaction was stirred at room temperature for 2 h, and the reaction was followed by TLC [developing solvent: acetone-hexane (1:2)]. The reaction mixture was poured into EtOAc (EtOAc m. Recrystallization from 50% ethanol gave white crystals (1) (0.20 g, 90%), mp 256 to 257.

[Pharmacological action]
(1) Anti-tumor effect
(2) treatment of cardiovascular disease
(3) Antioxidant and anti-free radical action
(4) Liver protection
(5) estrogen-like effects and affect bone metabolism
(6) Regulating immunity
(7) Anti-virus
(8) Anti-bacteria and fungi
(9) Anti-allergic reaction
(10) Radiation protection
(11) Prevention of acute infectious atypical pneumonia
[Use] Widely used in medicine, health care products, cosmetics and food additives