A growing mound of scientific evidence has linked these chemicals to changes in children’s hormone systems, which can alter their normal development and increase their risk of childhood obesity, the new American Academy of Pediatrics (AAP) policy statement argues.

These chemicals affect the health of all humans, but can have a particularly strong effect in children, said lead author Dr. Leonardo Trasande, an environmental health researcher with New York University’s School of Medicine.

“Pound for pound, they eat more food, so they have higher levels of exposure compared to us adults,” Trasande explained. “Their organs are still developing in various ways, such that effects on that development can be permanent and lifelong.”

The chemical culprits

Some chemicals that affect food safety include:

Bisphenols like BPA, which are used in plastics and the lining of metal cans. They can act like estrogen in the body, affecting onset of puberty, decreasing fertility, increasing body fat and affecting the nervous and immune systems.
Phthalates, which are found in plastics and vinyl tubes used in industrial food production. These chemicals can affect male genital development, increase childhood obesity and contribute to heart disease.
Perfluoroalkyl chemicals (PFCs), used in grease-proof paper food packaging. They might reduce immunity, birth weight and fertility, and can affect the thyroid system.
Percholate, which is added to dry food packaging to control static electricity. It also is known to disrupt thyroid function and can affect early brain development.
Artificial food colors, which have been associated with worsened attention deficit hyperactivity disorder (ADHD) symptoms.
Nitrates and nitrites, which are used to preserve food and enhance color, particularly in cured and processed meats. These chemicals can interfere with thyroid hormone production, and have been linked with gastrointestinal and nervous system cancers.
“This is a critically important report about environmental risks that have received less attention than they deserve, whether by the pediatric community or regulators,” said Dr. Michael Grosso, chair of pediatrics and chief medical officer at Huntington Hospital in Huntington, N.Y.

“There is now a compelling body of evidence that the environmental chemicals that go into food processing and food containers may have significant effects on human health, including fertility, thyroid disease, certain cancers and much more,” Grosso said. “Of concern is that some of these remain in the body for years.”

Kristi King, senior dietitian with Texas Children’s Hospital in Houston, said she has “heightened concerns regarding those additives that are thyroid disrupters.”

“PFCs can alter thyroid function and metabolic changes. Perchlorate, nitrates and nitrites disrupt thyroid hormone production and inhibit iodine uptake in the body,” King explained.

“Iodine is extremely important in promoting growth and metabolism in children. Iodine is also essential for early brain and neurological development. Having an iodine deficiency could ultimately lead to poor growth and delayed [thinking] ability,” she said.

Tighter regulation needed

The policy statement calls on politicians and bureaucrats to tighten regulations related to food additives. These measures include a more rigorous and transparent “Generally Recognized as Safe” designation process, including new requirements for toxicity testing before use in the marketplace and retesting previously approved chemicals.

And Trasande argued that citizens can have an even greater impact in this area than elected officials.

“The general public can do a lot to drive the kinds of changes that are positive for children’s lives and human health,” Trasande said. “The ban on BPA from baby bottles and sippy cups was not driven by some scientific statement or some regulatory good feeling. It was driven by consumer outcry. The same could be said for phthalates in toys.”

What parents can do

The AAP policy statement said parents can limit their children’s exposure to these chemicals by:

Choosing fresh or frozen fruits and vegetables over canned.
Avoiding processed meats, particularly during pregnancy.
Not microwaving plastic containers of food, or placing plastics in the dishwasher.

Light drinking during pregnancy may affect babies’ brain development, according to a study that looked for signs of alcohol exposure in newborns’ faeces.

Although it’s well-established that heavy drinking during pregnancy is linked to intellectual disabilities and altered facial features in children, less is known about the effects of light drinking.

Studying this has been difficult, since mothers are often reluctant to admit any level of drinking during pregnancy due to the associated stigma, says Anna Eichler at the University Hospital Erlangen in Germany.

To get around this, Eichler and her colleagues looked for …

Yellow oleander has been used by Mexican folk healers to treat various illnesses for many centuries. A new study indicates that the fruit of this indigenous medicinal plant contains bioactive compounds that can treat different kinds of human cancers.

Known in scientific circles as either Thevetia peruviana or Cascabela peruviana, yellow oleander goes by the names of ayoyote or codo de fraile in Mexico, where it is used as a traditional herbal remedy for illnesses such as hemorrhoids, scabies, and ulcers.

It was also used to dissolve tumorous growths, a property that drew the attention of researchers from the Universidad Autónoma de Nuevo León (UANL) and the Universidad Nacional Autónoma de México (UNAM). The researchers were looking for natural cancer treatments that could prevent cancer cells from metastasizing from the original affected organ to a different organ.

All parts of the yellow oleander are toxic if ingested through the mouth. The toxicity comes from cardiac glycosides, which are present in large concentrations in the fruit.

Other parts of the plant were previously tested for cytotoxic activity on human gastric and pancreatic cancer lines. The Mexican researchers investigated the antiproliferative, apoptotic, and cytotoxic properties of a methanolic extract from its fruit on other human cancer cell lines. (Related: The evidence is clear: Hemp slows the progression of ovarian cancer.)

Fruit extract of yellow oleander may be able to treat human cancers
The fruits underwent processing to produce a methanolic extract. Different concentrations of the extract were applied to human breast, colorectal, lung, and prostate cancer cell lines.

Furthermore, the extract was also tested on cultured human skin fibroblast and Vero cells. These healthy human cells were included to determine if the extract was safe.

Clonogenic and wound-healing tests were performed on both tumorigenic and healthy cell lines. These tests measured the motility and proliferation of the cells after exposure to the extract.

A trypan blue exclusion test would reveal any morphological changes caused by the extract. The researchers also performed DNA fragmentation and acridine orange/ethidium bromide (AO/EB) double staining tests to measure the level of apoptosis or “cell suicide” in the treated cells.

Afterward, flash chromatographic techniques were used to separate the extract into its component fractions. The cytotoxic effects of these bioactive fractions were tested on colorectal cancer cells.

Fractions that showed cytotoxic activity against the cultured colorectal cancer cells were identified using mass spectrometry techniques.

Yellow oleander extract inhibits cancerous cells without harming healthy cells
The results of their experiment showed that yellow oleander fruit extract demonstrated cytotoxic activities on all four human cancer cell lines. It scored the highest against lung cancer cells.

Furthermore, the extract was able to reduce the cell motility and colony formation on all lines. It was able to prevent cancer cells from spreading to other organs where the latter can metastasize.

Treated cancer cell lines displayed smaller cell sizes, reduced bulging or “blebbing” in the plasma membrane of cells, and lower levels of cell detachment.

The yellow oleander extract also promoted apoptotic cell death in cancer cells, which further reduced the latter’s spread. DNA fragmentation and AO/EB double staining assays confirmed the self-destruction of cancer cells.

When subjected to flash chromatography, the extract produced six fractions. The fourth and fifth fractions showed the highest cytotoxicity on the prostate cancer cell line.

These fractions contained thevetiaflavone and six cardiac glycosides. Thevetiaflavone is a flavonoid while cardiac glycosides have been shown to inhibit other forms of cancers.

The researchers concluded that the fruit extract of yellow oleander could reduce the growth and spread of human breast and colorectal cancer while also inducing cell suicide in human prostate and lung cancer cells.

Product Description:

Product Name: Cooling agent ws-3

Chemical Name: N-Ethyl-2-(isopropyl)-5-methylcyclohexanecarboxamide

CAS No.: 39711-79-0

MF: C₁₃H₂₅NO

MW: 211.35

Appearance: White crystal powder

Odor:  Mild cooling, slight menthol odor (almost odorless)

Detection Method: HPLC

Purity: ≥99%

Melting Point: 87ºC-102ºC

Flash Point: >100℃

Specific Rotation: -49° ~ -54°

Water Solubility: Insoluble

FEMA No.: 3455

EINECS No.: 254-599-0

Shelf Life: 2 years

Package: 1kg per bag with double plastic inside and aluminium foil bag outside, or 25kg per fibre drum with double plastic bag inside, or according to customers’ requirement.

Storage: Store in cool and dry place. Keep away from strong light and heat.

Product Description:

Background:

WS 3 is an agonist of TRPM8 receptor with EC50 value of 3.7 μM [1].

Transient receptor potential cation channel subfamily M member 8 (TRPM8) is a Ca²⁺– and Na⁺-permeable ion channel and is activated by cooling agents and cold temperatures. TRPM8 belongs to TRP family and is expressed in sensory neurons.

WS 3 is an agonist of TRPM8 receptor and a cooling agent. In HEK293 cells expressed recombinant mouse TRPM8, WS 3 (30 μM) increased [Ca²⁺]i. WS 3 exhibited potency with EC50 value of 3.7 μM and induced 86% efficacy of the maximal response to icilin, the most potent agonist [1]. In HEK cells stably expressing either hTRPM8 or hTRPA1, WS 3 activated hTRPM8 and hTRPA1 with EC50 values of 2.2 and 120.6 μM, respectively. WS 3 was efficacious in eliciting cooling sensation [2].

References:
[1].  Behrendt HJ, Germann T, Gillen C, et al. Characterization of the mouse cold-menthol receptor TRPM8 and vanilloid receptor type-1 VR1 using a fluorometric imaging plate reader (FLIPR) assay. Br J Pharmacol, 2004, 141(4): 737-745.
[2].  Klein AH, Iodi Carstens M, McCluskey TS, et al. Novel menthol-derived cooling compounds activate primary and second-order trigeminal sensory neurons and modulate lingual thermosensitivity. Chem Senses, 2011, 36(7): 649-658.

Advantages:

Food Grade Cooling Agent ws-3 For Cigarette/Filter Tip/Tobacco/Oral Product

1. There is a high cooling effect without other unpleasant feelings such as bitterness, burning, stinging or tingling sensations and can bring more stimulative, fresh and aromatic sensory to

the entire mouth and throat.

2. Cooling agent ws-3 can solve the difficulty of developing new products with bad sensation.
3. When used with other flavors, it enhances the effects of the flavors. It also can be used with

other cooling agents.

4. Cooling agent ws-3 is water-solubility is no  more than 0.1%, it’s better than traditional cooling agents, so it can act on taste bud more wallop and has long cooling effect.

Functions:

1. Continuous and long lasting cooling and refreshing effect, having no hot, harsh and stinging sensation of Menthol and/or Peppermint.
2. Heat-Resistance: Heating under 200^oC will not reduce the cooling effect, suitable to use on baking and other high temperature heating process.
3. Its cooling intensity can maintain 15-30 minutes, enriching the refreshing of product and having no burning pain, stabbing and numbness, it’s cooler than traditional Menthol products.
4. Low dosage: 30-100 mg/kg dosage will give good cooling effect.
5. Excellent compatibility with other flavors, it can enhance the effect of the flavors. It also can be combined using with other cooling agents.

Applications:

1. Daily use products: toothpaste, oral products, Air Freshener, skin cream, shaving cream, shampoo, sunscreen, shower cream.
2. Food products: confectionery products, chocolate, dairy produce, beer, distilled spirit, beverage,

Chewing Gum.

3. Medicine: linctus, diminish inflammation ointment, dyspepsia, antipruritic, liniment, oral cavity

acesodyne, heatstroke pill.

4. Others: cigarette, filter tip and other tobacco, it also can be used for driving insects.

Usage:

1. Soluble in Ethanol/PG firstly, then adding water solution.
2. Or dissolved in flavors firstly, then added into your products.
3. Mixed with dementholized peppermint oil can increase the fragrance signally.

Product Description:

Broccoli is a member of the cabbage family, and is closely related to cauliflower. Its cultivation originated in Italy. Broccolo, its Italian name, means “cabbage sprout.” Because of its different components, broccoli provides a range of tastes and textures, from soft and flowery (the floret) to fibrous and crunchy (the stem and stalk). Broccoli contains glucosinolates, phytochemicals which break down to compounds called indoles and isothiocyanates (such as sulphoraphane). Broccoli also contains the carotenoid, lutein. Broccoli is an excellent source of the vitamins K, C, and A, as well as folate and fiber. Broccoli is a very good source of phosphorus, potassium, magnesium and the vitamins B6 and E.

Advantages:

1. 100% natural.
2. No synthetic pigments.
3. No chemical essences or flavors.
4. No preservative agents.
5. Good fluidity and dispersible in water.
6. Long preservative time than fresh fruit.
7. Easy for transportation due to powder form.
8. Made from the seasonal fruit, ensure the freshness and nutrition.
9. Microbiology control in line with national standards.
10. Heavy metal control fulfill National Norms and Codes.

Functions:

1. With the function of anti-cancer, and effectively improving capability of blood scavenging.
2. Having the great effect to prevent and regulate hypertension.
3. With the function of enhancing liver detoxification, improve immunity.
4. With the function of reducing blood sugar and cholesterol.

Applications:

1. As drugs raw materials of anti-cancer, it is mainly used in pharmaceutical field.
2. Applied in health product field, it can be used as raw material in health food, the purpose is to enhance immunity.
3. Applied in food fields, it is widely used as functional food additive.

Delivery Time: Within 3 working days after confirming your payment.

Shipping Details: DHL, TNT, FEDEX or EMS.

Payment: T/T, West Union, Paypal and Escrow service.

Product Name: Freeze Dried Carrot Powder

Latin Name:  Daucus carota L. var. sativa Hoffm.

Appearance: Orange fine powder

Oder: Characteristic

Process: Freeze dried

Active Ingredient: Beta carotene, vitamin

Specification: Vegetable powder

Used Part: Root

Particle Size: 100% pass 80 mesh

Test Method: HPLC

Model Number: 100% Nature

Shelf Life: Two years

Packaging Details: 1. 1-10kg/bag, double plastic bags inside, aluminum foil Bag outside.
2. 25kg/drum, double plastic bags inside.
3. According to your requirements.

Storage: Stored in a cool and dry well closed container and in ventilated area,

kept away from moisture and strong light or high temperature. 

Product Description:

The carrot is a root vegetable, usually orange in colour, though purple, red, white, and yellow varieties exist. It has a crisp texture when fresh. The most commonly eaten part of a carrot is a taproot, although the greens are sometimes eaten as well. It is a domesticated form of the wild carrot Daucus carota, native to Europe and southwestern Asia. The domestic carrot has been selectively bred for its greatly enlarged and more palatable, less woody-textured edible taproot.Most carrot cultivars are about 88% water, 7% sugar, 1% protein, 1% fibre, 1% ash, and 0.2% fat.

Advantages:

1. 100% natural.
2. No synthetic pigments.
3. No chemical essences or flavors.
4. No preservative agents.
5. Good fluidity and dispersible in water.
6. Long preservative time than fresh fruit.
7. Easy for transportation due to powder form.
8. Made from the seasonal fruit, ensure the freshness and nutrition.

1. Microbiology control in line with national standards.
2. Heavy metal control fulfill National Norms and Codes.

Functions:

1. Carrot powder can be used to enhance human immunity.
2. Carrot powder can be used to maintain the integrity of the skin mucous membrane layer, prevent skin dry and coarse.
3. Carrot powder can promote growth.
4. Carrot powder can be used as an antioxidant, may offer some protection against certain cancers and other diseases.

Applications:

1. Applied health product industry, carrot powder can be used as raw materials.
2. Applied in food and beverage industry ,carrot powder can be used as additives.

Delivery Time: within 3 -7 days after receiving payments.

Shipping Details: DHL, TNT, FEDEX or EMS.

Payment Terms: T/T, West Union, Paypal and Escrow service.

Company Information:

Xi’an Taima Biological Co., LTD. was founded in 2008, is a technological export-oriented private enterprise with the Rights of Self-Managed Import and Export, specializing in active ingredients modernized and industrialization research, development, production, and sales of natural medical botany.

Our factory covers an area of 6,000 square meters equipped with advanced equipment and the production process is in accordance with FDA.

FAQ:

Q1: Could you provide free sample for test?

A1: We can provide you free sample for test, and you only need to pay the delivery cost.

Q2: Which payment terms do you accept? 

A2: T/T, West Union, Paypal and Escrow service are available. But different payment terms against countries.

Q3: What’s about the MOQ ?

A3: It depends on different products. Usually our MOQ is 1kg.

Q4: What’s the delivery lead time?

A4: We will make delivery within 3-7 days after receiving payment.

Q5: What about the delivery port? 

A5: Main ports in China are available.

JOIN OUR WHOLESALE PROGRAM

• XIANTAIMA is proud to share you the business. We put the best price on our products to offer you more opportunities to earn money. Whether you are reseller or online worker (affiliate or drop shipper), we have reachable opportunities in store for you through our money making programs. All these opportunities are backed up with dependable customer service. We are always here to help you out with everything.
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• 100% ~ 300% Profit gain.

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Extract from Epimedium herb, with kidney yang, cough and asthma, dehumidification dehumidification, Qi heart and other effects.

【Chinese name】:YINYANGHUO
【English name】: Epimedium extract

【Active ingredients】: icariin
【detection method】: HPLC
【Product specifications】: 5% -98%, planting production is mainly based on low content.
【Properties】: This product is a yellow-brown powder.
【Introduction】: The raw materials used in the production of general enterprises are the whole plant of Sagittaria sagittatum, Epimedium sagittatum, or Epimedium sagittatum. The extract is brown powder.
【Main ingredients】: Herba Epimedii extract contains epimedium flavonoids, saponin, volatile oil, wax alcohol.
【Indications】: It has the effect of tonifying kidney, impotence, dehumidification, relieving cough, relieving asthma, and strengthening Qi.
【Save】 Save and keep it in a cool, dry place, protected from light, and away from heat.
【Shelf life】 two years

raw materials：

Epimedium is one of the oldest used herbs, first recorded in the “Shen Nong’s Herbal Classics”; Epimedium is one of the most widely used traditional Chinese medicines and has received extensive attention at home and abroad, in addition to its traditional use of kidney and aphrodisiac. Clinically, epimedium is also commonly used for the treatment of osteoporosis, menopausal syndrome, breast lumps, hypertension, coronary heart disease and other diseases. In addition, epimedium still has the effects of immune enhancement, anti-aging, anti-tumor, anti-AIDS, etc. There is thus a huge potential for research and development. However, epimedium is one of the most widely used medicinal herbs. There are five species listed in the Chinese Pharmacopoeia.
The main varieties used as medicinal raw materials are Sagitta Epimedium,Korean Epimedium,Wushan Epimedium.

pharmacology：

Has a long history of medicinal origins from various plants of the genus Epimedium. Li Shizhen said in his “Compendium of Materia Medica” that he had the effect of “promoting vitality, strengthening bones, making up waist and knees, and strengthening the heart.” Modern pharmacological experimental studies have shown that epimedium can increase blood flow to the heart and brain, promote hematopoietic function, immune function and bone metabolism, and have anti-aging and anti-tumor effects.

(1) Promoting reproductive system development: Epimedium has androgenic hormone-like effects to promote the development of epididymis and seminal vesicles in young mice. Testicular stromal cells in vitro can significantly promote testosterone secretion and cAMP production. Epimedium contains a variety of essential trace elements such as Zn, Mn, Fe and male reproductive function also has a very close relationship.

(2) Promoting Nucleic Acid Metabolism: Using in vitro cell culture and determination of 3H-TdR incorporation into cell DNA to study the effect of EPS on bone marrow cell proliferation and DNA synthesis rate in hydroxyurea-induced “yang-deficiency” mice. Mouse bone marrow cell proliferation and synthesis.

(3) protect cardiovascular and cerebrovascular
The effects of icariin on cerebral blood flow were measured with anesthetized rabbits and dogs using an electromagnetic flowmeter. The results showed that icariin could significantly and increase cerebral blood flow in rabbits and dogs, decrease cerebral vascular resistance, and slightly lower blood pressure. The effect of increasing cerebral blood flow may not be due to the effect on systemic hemodynamics, but is mainly the result of direct expansion of cerebral blood vessels. In addition, icariin can increase cerebral blood flow in experimental animals by dilating vascular smooth muscle, reduce cerebral vascular resistance, and protect against cerebral ischemic injury. The mechanism of vasodilation is related to the blocking effect of calcium channels. Epimedium total flavonoids can significantly increase cerebral blood flow, reduce cerebral vascular resistance, and selectively block ex vivo and whole animal myocardial β1 receptors, but have no blocking effect on tracheal β2 receptors and vascular smooth muscle α receptors. The above results provide a theoretical basis for the treatment of coronary heart disease and angina pectoris clinically.

(4) Inhibition of thrombosis and hematopoiesis
inhibit thrombosis in rabbits in vitro. The main factors that inhibit thrombosis may be related to the decrease of red blood cell aggregation and the decrease of whole blood viscosity. In vitro administration of total flavonoids of Epimedium can significantly inhibit platelet aggregation and prolong prothrombin time. Icariin promotes the production of CSF-like activity in mouse spleen lymphocytes. CSF is a type of glycoprotein that promotes the proliferation, differentiation, maturation and survival of human or animal bone marrow cells. It can promote hematopoiesis and stimulate the function of mature cells, and plays an important role in hematopoiesis. Icariin can also synergistically induce IL-2, 3, 6, while IL-3 can act on bone marrow pluripotent stem cells to promote the differentiation and proliferation of a variety of blood cells, and IL-6 cooperates with IL-3 to support the proliferation of pluripotent stem cells. It can thus promote the function of hematopoiesis.

(5) Anti-aging effects
The aging process is a complex and comprehensive process with many mechanisms. Epimedium preparations can affect aging mechanisms in different ways, such as affecting cell passage, prolonging the growth period, regulating the immune and secretory system, and improving body metabolism and organ functions. Epimedium has an anti-oxidant effect, and has a significant delaying effect on the age-related changes of hypothalamic neurotransmitters in natural aging animals.

(6) Enhance human immunity
Immune organs: Epimedium polysaccharides can shrink the thymus, promote thymus release of mature cells, and enhance cellular immune function.
Immune cells: Epimedium polysaccharide subcutaneous injection can increase the macrophage phagocytosis ability of mice and it is also effective when intragastrically administered. Icariin can also significantly activate macrophages, enhance phagocytosis of macrophages, and promote the production of IL-2 and TNF. can promote the proliferation of mouse T cells, but also has a role in the proliferation of B cells.
Immune factors: epimedium polysaccharides can increase IL-2 production in thymus and spleen cells of mice and induce IFN. It is likely that IFN-γ is mainly induced, and it may be considered as an effective, new in vivo interferon inducer.

(7) Prevention and treatment of osteoporosis
Epimedium inhibits the function of bone cells, especially the formation of calcified bone, there is a “bone” effect, a good control of osteoporosis.

(8) Anti-tumor effect
The icariin-induced apoptosis in tumor cells can affect the changes in the cell cycle distribution. The increased apoptosis rate is related to the reduction of S phase cells and the increase of cells in G0/G1 phase. And can reduce the apoptosis-related genes bcl-2 and c-myc gene mRNA and protein expression levels. Icariin synergistically induces IL-2, 3, 6 and enhances the activity of anti-cancer effector cells (NK, LNK). Epimedium flavonoids can significantly increase the macrophage phagocytosis, lymphocyte transformation and spleen to body ratio in tumor-bearing mice, significantly increase the rate of red blood cell C36 receptor rosettes and decrease the rate of red cell immune complex rosettes. It is suggested that total flavonoids of epimedium have a certain recovery effect on the low cellular immune function and red blood cell immune function of tumor-bearing mice, and to a certain extent can inhibit the growth of tumor cells. The use of total flavonoids of Epimedium as an adjunctive treatment for cancer patients may have a certain application prospect.