XIANTAIMA Supplier
Extract from Epimedium herb, with kidney yang, cough and asthma, dehumidification dehumidification, Qi heart and other effects.
【Chinese name】:YINYANGHUO
【English name】: Epimedium extract
【Active ingredients】: icariin
【detection method】: HPLC
【Product specifications】: 5% -98%, planting production is mainly based on low content.
【Properties】: This product is a yellow-brown powder.
【Introduction】: The raw materials used in the production of general enterprises are the whole plant of Sagittaria sagittatum, Epimedium sagittatum, or Epimedium sagittatum. The extract is brown powder.
【Main ingredients】: Herba Epimedii extract contains epimedium flavonoids, saponin, volatile oil, wax alcohol.
【Indications】: It has the effect of tonifying kidney, impotence, dehumidification, relieving cough, relieving asthma, and strengthening Qi.
【Save】 Save and keep it in a cool, dry place, protected from light, and away from heat.
【Shelf life】 two years
raw materials：
Epimedium is one of the oldest used herbs, first recorded in the “Shen Nong’s Herbal Classics”; Epimedium is one of the most widely used traditional Chinese medicines and has received extensive attention at home and abroad, in addition to its traditional use of kidney and aphrodisiac. Clinically, epimedium is also commonly used for the treatment of osteoporosis, menopausal syndrome, breast lumps, hypertension, coronary heart disease and other diseases. In addition, epimedium still has the effects of immune enhancement, anti-aging, anti-tumor, anti-AIDS, etc. There is thus a huge potential for research and development. However, epimedium is one of the most widely used medicinal herbs. There are five species listed in the Chinese Pharmacopoeia.
The main varieties used as medicinal raw materials are Sagitta Epimedium,Korean Epimedium,Wushan Epimedium.
pharmacology：
Has a long history of medicinal origins from various plants of the genus Epimedium. Li Shizhen said in his “Compendium of Materia Medica” that he had the effect of “promoting vitality, strengthening bones, making up waist and knees, and strengthening the heart.” Modern pharmacological experimental studies have shown that epimedium can increase blood flow to the heart and brain, promote hematopoietic function, immune function and bone metabolism, and have anti-aging and anti-tumor effects.
(1) Promoting reproductive system development: Epimedium has androgenic hormone-like effects to promote the development of epididymis and seminal vesicles in young mice. Testicular stromal cells in vitro can significantly promote testosterone secretion and cAMP production. Epimedium contains a variety of essential trace elements such as Zn, Mn, Fe and male reproductive function also has a very close relationship.
(2) Promoting Nucleic Acid Metabolism: Using in vitro cell culture and determination of 3H-TdR incorporation into cell DNA to study the effect of EPS on bone marrow cell proliferation and DNA synthesis rate in hydroxyurea-induced “yang-deficiency” mice. Mouse bone marrow cell proliferation and synthesis.
(3) protect cardiovascular and cerebrovascular
The effects of icariin on cerebral blood flow were measured with anesthetized rabbits and dogs using an electromagnetic flowmeter. The results showed that icariin could significantly and increase cerebral blood flow in rabbits and dogs, decrease cerebral vascular resistance, and slightly lower blood pressure. The effect of increasing cerebral blood flow may not be due to the effect on systemic hemodynamics, but is mainly the result of direct expansion of cerebral blood vessels. In addition, icariin can increase cerebral blood flow in experimental animals by dilating vascular smooth muscle, reduce cerebral vascular resistance, and protect against cerebral ischemic injury. The mechanism of vasodilation is related to the blocking effect of calcium channels. Epimedium total flavonoids can significantly increase cerebral blood flow, reduce cerebral vascular resistance, and selectively block ex vivo and whole animal myocardial β1 receptors, but have no blocking effect on tracheal β2 receptors and vascular smooth muscle α receptors. The above results provide a theoretical basis for the treatment of coronary heart disease and angina pectoris clinically.
(4) Inhibition of thrombosis and hematopoiesis
inhibit thrombosis in rabbits in vitro. The main factors that inhibit thrombosis may be related to the decrease of red blood cell aggregation and the decrease of whole blood viscosity. In vitro administration of total flavonoids of Epimedium can significantly inhibit platelet aggregation and prolong prothrombin time. Icariin promotes the production of CSF-like activity in mouse spleen lymphocytes. CSF is a type of glycoprotein that promotes the proliferation, differentiation, maturation and survival of human or animal bone marrow cells. It can promote hematopoiesis and stimulate the function of mature cells, and plays an important role in hematopoiesis. Icariin can also synergistically induce IL-2, 3, 6, while IL-3 can act on bone marrow pluripotent stem cells to promote the differentiation and proliferation of a variety of blood cells, and IL-6 cooperates with IL-3 to support the proliferation of pluripotent stem cells. It can thus promote the function of hematopoiesis.
(5) Anti-aging effects
The aging process is a complex and comprehensive process with many mechanisms. Epimedium preparations can affect aging mechanisms in different ways, such as affecting cell passage, prolonging the growth period, regulating the immune and secretory system, and improving body metabolism and organ functions. Epimedium has an anti-oxidant effect, and has a significant delaying effect on the age-related changes of hypothalamic neurotransmitters in natural aging animals.
(6) Enhance human immunity
Immune organs: Epimedium polysaccharides can shrink the thymus, promote thymus release of mature cells, and enhance cellular immune function.
Immune cells: Epimedium polysaccharide subcutaneous injection can increase the macrophage phagocytosis ability of mice and it is also effective when intragastrically administered. Icariin can also significantly activate macrophages, enhance phagocytosis of macrophages, and promote the production of IL-2 and TNF. can promote the proliferation of mouse T cells, but also has a role in the proliferation of B cells.
Immune factors: epimedium polysaccharides can increase IL-2 production in thymus and spleen cells of mice and induce IFN. It is likely that IFN-γ is mainly induced, and it may be considered as an effective, new in vivo interferon inducer.
(7) Prevention and treatment of osteoporosis
Epimedium inhibits the function of bone cells, especially the formation of calcified bone, there is a “bone” effect, a good control of osteoporosis.
(8) Anti-tumor effect
The icariin-induced apoptosis in tumor cells can affect the changes in the cell cycle distribution. The increased apoptosis rate is related to the reduction of S phase cells and the increase of cells in G0/G1 phase. And can reduce the apoptosis-related genes bcl-2 and c-myc gene mRNA and protein expression levels. Icariin synergistically induces IL-2, 3, 6 and enhances the activity of anti-cancer effector cells (NK, LNK). Epimedium flavonoids can significantly increase the macrophage phagocytosis, lymphocyte transformation and spleen to body ratio in tumor-bearing mice, significantly increase the rate of red blood cell C36 receptor rosettes and decrease the rate of red cell immune complex rosettes. It is suggested that total flavonoids of epimedium have a certain recovery effect on the low cellular immune function and red blood cell immune function of tumor-bearing mice, and to a certain extent can inhibit the growth of tumor cells. The use of total flavonoids of Epimedium as an adjunctive treatment for cancer patients may have a certain application prospect.