Sinomenine Hydrochloride – CAS 6080-33-7 | TCM Alkaloid API from Sinomenium acutum(Qing-teng)

Sinomenine Hydrochloride – CAS 6080-33-7

Sinomenine Hydrochloride – CAS 6080-33-7
1.Pharma API (ChP)
2.Reference Standard (≥98% HPLC)​
3.Upstream link​

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Sinomenine Hydrochloride – CAS 6080-33-7 TCM Alkaloid API from Sinomenium acutum(Qing-teng)

Sinomenine Hydrochloride – CAS 6080-33-7 | TCM Alkaloid API from Sinomenium acutum(Qing-teng)

Product Identification

ItemDetail
SynonymsSinomenine Hydrochloride; Sinomenine HCl; (ChP: “Yan Suan Qing Teng Jian”)
CAS RN (HCl)6080-33-7
CAS RN (free base)115-53-7
Molecular Formula (free base)C₁₉H₂₃NO₄
MW (free base)329.39
Alkaloid TypeMorphinan-type bisbenzylisoquinoline-related (menispermaceous)
Botanical SourceSinomenium acutum(Thunb.) Rehd. et Wils., Menispermaceae (“Qing-teng” 青藤)
HS Code (ref)2939 (vegetable alkaloids)
PharmacopoeiaChP (盐酸青藤碱 monograph); reference to TCM heritage
Related SKUsSinomenine CAS 115-53-7 (free base); “natural→salt API” cluster: Escin→Escin-Na 20977-05-3; Rutin→Troxerutin 7085-55-4

Description

Sinomenine is a morphinan-type alkaloid from Sinomenium acutum(青藤, “Qing-teng”), traditionally used in TCM for “wind-damp bi-syndrome” (joint pain, stiffness). The HCl salt (CAS 6080-33-7) is the commercial pharma form​ — water-soluble, ChP-monographed, deployed as injectable powder & oral tablets​ for rheumatoid arthritis (RA), osteoarthritis (OA), and adjunctive analgesia​ in the CN/SEA pharma channel.

Literature bioactivity clusters (buyer search hooks):

  • Anti-arthritic & Analgesic​ – suppresses TNF-α, IL-1β, IL-6, MMPs in RA models; microglia-modulating in some neuroinflammation assays (light link to Huperzine A neuro line)
  • Immunomodulatory​ – T/B-cell modulation at higher exposures, literature-level
  • Osteoclast/osteoblast balance​ – bone-remodeling signal (secondary to RA/OA use-case)

Four commercial buckets:

  • Pharma API – ChP RA/OA/Analgesic (main):​ ChP “盐酸青藤碱” injectable + tablet, CN hospital channel steady; SEA/EMA-route export inquiry growing. Search: “sinomenine hydrochloride API”, “盐酸青藤碱 manufacturer”, “sinomenine RA China pharma”.
  • Arthritis & Inflammation R&D:​ CRO/CDMO bulk 98%+ for RA/OA pipeline adjunct, analgesic comparator, microglia/neuro-inflammation tangential (stacks lightly with Huperzine A 102518-79-6 + Icaritin 118525-40-9​ in “neuro-inflam / brain-aging” R&D discussions).
  • TCM Export Brand:​ “Qing-teng / Sinomenium acutum” heritage positioning for CN-export TCM brands (usually as part of a “TCM-origin alkaloid API” cluster: berberine, tetrandrine, sinomenine).
  • Reference Standard / R&D:​ 98%+ HPLC for Sinomeniumextract QC, stability, formulation pilot.

Applications

Sinomenine Hydrochloride – CAS 6080-33-7 TCM Alkaloid API from Sinomenium acutum(Qing-teng)

Pharma API (ChP)​ – injectable powder, tablets; RA rheumatoid arthritis, OA osteoarthritis, adjunctive analgesia; CN hospital channel + SEA export

Arthritis & Inflammation R&D​ – CRO/CDMO bulk 98%+; RA/OA pipeline, analgesic comparator, cytokine (TNF-α/IL-1β/IL-6) modulation literature

TCM-Derived Alkaloid Cluster​ – “Qing-teng” heritage; often procured alongside Berberine, Tetrandrine, etc. for TCM-export API baskets

Reference Standard (≥98% HPLC)​ – Sinomeniumextract QC, sinomenine assay methodology

Upstream link​ – buyers often also check free base Sinomenine CAS 115-53-7 (R&D/standard); Taima cross-links

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