| Item | Specification |
| Product Name | 8-Prenylnaringenin |
| Synonyms | 8-PN; Flavaprenin; Hopein; Sophoraflavanone B; 8-异戊烯基柚皮素 |
| CAS Number | 53846-50-7 |
| Molecular Formula | C₂₀H₂₀O₅ |
| Molecular Weight | 340.38 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity (HPLC) | ≥98.0% / ≥99.0% (customizable) |
| Loss on Drying | ≤ 1.0% |
| Residue on Ignition | ≤ 0.2% |
| Testing Method | HPLC / UV-Vis Spectroscopy / NMR |
| Production Method | Natural Plant Extraction & High-Purity Column Purification |
| Boiling Point | 597.6±50.0 °C (Predicted) |
| Solubility | Soluble in ethanol, methanol, DMSO and acetone; slightly soluble in hot water; insoluble in cold water |
| Natural Source | Naturally extracted from Humulus lupulus (hops) and sophora plants, a rare and high-activity prenylated flavonoid compound |
| Package | 1 kg/aluminum foil bag, 25 kg/fiber drum; custom packaging available |
| Storage | Store at 2–8°C in sealed, dark and dry conditions; avoid high temperature, strong light and oxidation |
| Shelf Life | 24 months under standard low-temperature sealed storage |
Product Description
Our 8-Prenylnaringenin powder (8-PN) is a high-purity natural prenylated flavonoid active ingredient, available in 98% and 99% HPLC grades. 8-Prenylnaringenin (CAS 53846-50-7), also known as 8-异戊烯基柚皮素, is a unique bioactive compound predominantly isolated from hop cones. It is scientifically recognized as one of the most potent natural phytoestrogens, exhibiting superior estrogen receptor-binding activity compared to common flavonoids and soy isoflavones. Combining powerful phytoestrogen regulation, bone protection, anti-oxidation, anti-inflammation and anti-tumor properties, 8-Prenylnaringenin is widely applied in menopausal health supplements, anti-aging skincare, functional nutritional formulas and biomedical research. As a professional bulk 8-Prenylnaringenin supplier, we provide high-purity, stable-batch and fully compliant products for global industrial and scientific research clients.
8-Prenylnaringenin belongs to the prenylflavonoid subclass of flavonoids. Its unique prenyl substitution structure greatly enhances molecular bioavailability and biological activity, enabling it to efficiently bind and activate both ERα and ERβ estrogen receptors in the human body. This core mechanism endows 8-PN with excellent menopausal symptom relief effects, effectively alleviating hot flashes, endocrine imbalance and discomforts caused by declining estrogen levels. In bone health regulation, it inhibits excessive bone resorption, preserves bone density, and reduces postmenopausal osteoporosis risk. In addition, 8-Prenylnaringenin delivers significant antioxidant capacity to eliminate cellular free radicals, relieve chronic low-grade inflammation, and inhibit the proliferation and migration of various tumor cells such as colon cancer cells. It also supports skeletal muscle repair and improves disuse muscle atrophy, owning multi-dimensional health care and research value.
Manufactured by Shaanxi BAISFU Bio-Engineering Co., Ltd., our premium 8-Prenylnaringenin powder adopts low-temperature selective extraction and high-precision preparative column chromatography purification technology. We select high-quality natural hop raw materials with stable active content, remove plant waxes, macromolecular impurities and invalid flavonoid components through multi-stage gradient purification, and completely retain the natural prenylflavonoid active structure. The whole production process strictly avoids harmful solvent residues and chemical synthetic additives, complying with food-grade, cosmetic-grade and research-grade safety standards. The mature and stable production process ensures consistent batch purity, stable solubility and reliable biological activity, fully meeting the rigorous requirements of high-end formula development and professional laboratory pharmacological experiments.
Every batch of 8-Prenylnaringenin powder undergoes strict multi-stage quality inspection, including HPLC purity detection, UV spectral characteristic verification and NMR structural identification to ensure accurate compound structure and stable high purity. The finished pale yellow crystalline powder features uniform color, low impurity content and excellent batch stability. All products comply with international natural additive safety regulations, cosmetic raw material standards and research-grade compound specifications, supporting safe and standardized application in health supplements, skincare products and biomedical research projects.
We maintain sufficient inventory and complete qualification documents for bulk 8-Prenylnaringenin supply. Whether you need natural hormone-regulating raw materials for menopausal health formulas, high-activity antioxidant anti-aging ingredients for skincare, or high-purity prenylflavonoid compounds for endocrine and anti-tumor pharmacological research, our 8-Prenylnaringenin powder is a cost-effective and reliable bulk raw material choice for global buyers.
Functions & Benefits
Potent Natural Phytoestrogen Regulation (Core Benefit)
8-Prenylnaringenin is the most active natural phytoestrogen discovered so far, with stronger estrogenic activity than ordinary soy isoflavones. It efficiently binds to human estrogen receptors ERα and ERβ, bidirectionally regulates endocrine levels, relieves menopausal hot flashes, insomnia, mood swings and endocrine disorders, and improves sub-health caused by estrogen decline in middle-aged and elderly women.
Bone Density Protection & Anti-Osteoporosis
8-PN significantly inhibits osteoclast activity and excessive bone resorption, effectively maintains bone mineral density, and reduces the risk of postmenopausal bone loss and osteoporosis. It provides natural and safe bone health protection, avoiding the side effects of synthetic hormone regulation, and is a core functional raw material for bone health and menopausal conditioning products.
High-Efficiency Antioxidant & Anti-Aging
As a high-activity prenylflavonoid, 8-Prenylnaringenin efficiently scavenges intracellular reactive oxygen free radicals, inhibits lipid peroxidation and oxidative DNA damage, reduces long-term oxidative stress aging, activates the body’s endogenous antioxidant defense system, and delays skin and systemic aging processes.
Broad-Spectrum Anti-Inflammatory Activity
It suppresses the activation of NF-κB inflammatory pathway and reduces the release of pro-inflammatory cytokines, relieving chronic low-grade inflammation in the body and skin. It improves inflammatory tissue damage, enhances body immune balance, and provides mild and efficient anti-inflammatory regulation for sub-health conditioning.
Anti-Tumor Proliferation & Cell Apoptosis Induction
Modern pharmacological studies verify that 8-Prenylnaringenin has significant anti-tumor activity. It inhibits the proliferation, migration and invasion of colon cancer and other tumor cells, blocks tumor cell cycle progression, and induces tumor cell apoptosis, with low toxicity to normal human cells, suitable for tumor mechanism research and auxiliary anti-tumor formula development.
Skeletal Muscle Repair & Metabolic Improvement
8-PN activates the Akt phosphorylation signaling pathway, promotes skeletal muscle protein synthesis, and effectively improves disuse muscle atrophy and muscle function decline. It assists in optimizing body metabolism and enhancing physical fitness, providing new directions for sports nutrition and sub-health recovery formulas.
Applications
Menopausal & Women’s Health Supplements
8-Prenylnaringenin is the core raw material for high-end menopausal conditioning health products. It is widely used in endocrine regulation formulas, menopausal symptom relief supplements, postmenopausal bone health products and female anti-aging nutritional formulations, providing natural phytoestrogen balance and body conditioning effects.
High-End Antioxidant Anti-Aging Skincare
Applied in antioxidant anti-aging essences, hormone-balancing skincare products and soothing repair formulas. It scavenges skin free radicals, resists oxidative aging, relieves inflammatory dullness, improves skin aging caused by endocrine changes, and maintains youthful skin condition.
Sports Nutrition & Metabolic Functional Products
Used in muscle repair nutrition powders, metabolic regulation supplements and physical recovery functional products. It promotes skeletal muscle repair, improves atrophy symptoms, optimizes body metabolism, and supports daily physical conditioning and sports recovery.
Biomedical & Scientific Research
Widely used in endocrine pharmacology research, menopausal syndrome mechanism research, bone metabolism experiments, tumor cell biology and flavonoid structure-activity relationship studies, serving as a standard high-purity research compound for university laboratories and medical research institutions.
Natural Functional Ingredient Development
Acts as a high-value natural prenylflavonoid intermediate for innovative functional product development, supporting the research and iteration of phytoestrogen regulators, bone-protective raw materials and anti-aging active ingredients.
FAQ
Q1: What is 8-Prenylnaringenin used for?
A: 8-Prenylnaringenin (8-PN) is a high-activity natural hop prenylflavonoid. It is mainly used for menopausal endocrine regulation, bone density protection, antioxidant anti-aging, body anti-inflammation, muscle repair, and biomedical endocrine and anti-tumor pharmacological research.
Q2: Is 8-Prenylnaringenin safe for health product and cosmetic use?
A: Yes, it is a pure natural plant-derived active ingredient extracted from hops, with mild properties, high safety and no obvious side effects. It complies with international natural additive and cosmetic safety standards, supporting long-term oral health product addition and topical skincare application.
Q3: What are the core advantages of 8-Prenylnaringenin?
A: 8-PN is known as the most potent natural phytoestrogen, with far higher endocrine regulation activity than ordinary soy isoflavones. It integrates menopausal conditioning, bone protection, anti-oxidation, anti-inflammation and anti-tumor multi-effects, featuring unique structural activity and comprehensive application value.
Q4: What is the correct storage method for 8-Prenylnaringenin powder?
A: The powder is sensitive to high temperature, oxidation and strong light. It needs to be tightly sealed and stored at 2–8°C in a dark and dry environment. Standard low-temperature sealed storage ensures a 24-month valid shelf life.
Q5: Can I get free 8-Prenylnaringenin samples?
A: Yes, we provide free 8-Prenylnaringenin powder samples for health product formula debugging, skincare product development and academic pharmacological research. Bulk orders support customized purity and packaging to meet diverse production and research needs.
