Mangostin CAS 6147-11-1 | Natural Xanthone from Mangosteen Pericarp
Product Introduction
α-Mangostin (also known as alpha-Mangostin or simply Mangostin) is the most abundant and biologically active xanthone isolated from the pericarp (fruit rind) of the mangosteen fruit (Garcinia mangostana L.), a tropical evergreen tree native to Southeast Asia. First isolated in the mid-19th century, α-Mangostin has emerged as one of the most extensively studied natural xanthones, with over 800 peer-reviewed publications documenting its remarkable multi-target pharmacological activities.
Physical Properties
| Property | Value |
| Appearance | Yellow to golden-yellow crystalline powder / fine powder |
| Odor | Characteristic, faint herbal |
| Melting Point | 180–182 °C |
| Boiling Point | 640.1 ± 55.0 °C (predicted) |
| Density | 1.265 ± 0.06 g/cm³ (predicted) |
| pKa | 7.22 ± 0.20 (predicted) |
| λmax (UV) | 346 nm (in methanol) |
| Particle Size | 100% through 80 mesh; customizable to 200 mesh |
| Crystallinity | Yellow crystalline solid |
| Stability | Stable as supplied solid (2 years); DMSO solution stable 1 month at -20°C |
Applications
| Application | Form | Recommended Purity | Typical Dosage (α-Mangostin) | Key Benefit |
| Anti-Inflammatory Capsules | Capsules / Softgels | ≥95% | 50–200 mg/day | Joint pain, arthritis relief |
| Antioxidant Complex | Capsules / Tablets | ≥90% | 50–100 mg/day | Cellular protection, anti-aging |
| Metabolic Health Formula | Capsules / Powders | ≥95% | 50–150 mg/day | Blood sugar, weight management |
| Immune Support | Capsules / Gummies | ≥50% | 25–100 mg/day | Immune modulation, STING activation |
| Brain Health Nootropic | Capsules / Softgels | ≥98% | 50–100 mg/day | Cognitive support, neuroprotection |
| Anti-MRSA Formula | Capsules | ≥98% | 100–200 mg/day | Antimicrobial support |
FAQ
Q1: What is α-Mangostin?
A: α-Mangostin (alpha-Mangostin, CAS 6147-11-1) is the primary bioactive xanthone compound found in the pericarp (rind) of the mangosteen fruit (Garcinia mangostana L.). It accounts for 70–80% of the total xanthone content and is responsible for most of mangosteen’s documented health benefits, including anti-inflammatory, antioxidant, anti-cancer, antimicrobial, and metabolic regulatory activities.
Q2: Is α-Mangostin natural or synthetic?
A: Our α-Mangostin is 100% natural, extracted from the pericarp of organically cultivated mangosteen fruits using supercritical CO₂ extraction and HPLC purification. We do not produce or supply synthetic α-Mangostin. Certificate of natural origin is available upon request.
Q3: What purity grades do you offer, and which should I choose?
A: We offer grades from 10% to ≥99% (HPLC). For dietary supplements, 50–90% is typical and cost-effective. For cosmetics and skincare, we recommend ≥95% for maximum activity and minimal inactive components. For pharmaceutical research and reference standards, ≥98% or ≥99% is appropriate. Our team can help you select based on your specific application and budget.
Q4: How do you solve the bioavailability problem of α-Mangostin?
A: This is the #1 challenge with α-Mangostin — its natural oral absorption is <1% due to poor water solubility. We offer three enhanced delivery options: (1) Self-Microemulsifying Drug Delivery System (SMEDDS) — forms nano-emulsion in GI fluid, increasing bioavailability 10–50×; (2) Phospholipid Complex — improves lipophilicity and absorption; (3) Cyclodextrin Inclusion Complex — improves water solubility and stability.
Q5: Is α-Mangostin safe for long-term use?
A: Mangosteen fruit and extracts have centuries of safe traditional use in Southeast Asia. At recommended supplemental levels (25–200 mg/day α-Mangostin), published studies report no serious adverse effects. As with any bioactive compound, we recommend consulting a healthcare professional before long-term supplementation, especially for pregnant/nursing women and those on prescription medications.
Q6: Does α-Mangostin have GRAS or FDA approval?
A: Mangosteen fruit extract is generally recognized as safe (GRAS) for use in foods and dietary supplements in the United States. Purified α-Mangostin (≥98%) as an isolated compound may require a New Dietary Ingredient (NDI) notification depending on the specific application and intended use. We provide full technical documentation to support regulatory submissions.
