Product Introduction
| Item | Specification |
| Product Name | Liquiritigenin |
| Synonyms | 4′,7-Dihydroxyflavanone; (2S)-7-hydroxy-2-(4-hydroxyphenyl)chroman-4-one; Liquiritigenine; |
| CAS Number | 578-86-9 |
| Molecular Formula | C₁₅H₁₂O₄ |
| Molecular Weight | 256.25 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity (HPLC) | ≥98.0% / ≥99.0% (customizable) |
| Loss on Drying | ≤ 1.0% |
| Residue on Ignition | ≤ 0.2% |
| Testing Method | HPLC / UV-Vis Spectroscopy / NMR |
| Production Method | Natural Plant Extraction & High-Purity Column Purification |
| Melting Point | 206–208°C |
| Boiling Point | 529.5±50.0 °C (Predicted) |
| Solubility | Soluble in ethanol, methanol, DMSO and acetone; slightly soluble in hot water; insoluble in cold water |
| Natural Source | Naturally extracted from Glycyrrhiza uralensis (licorice root), a core bioactive flavanone compound in traditional licorice plants |
| Package | 1 kg/aluminum foil bag, 25 kg/fiber drum; custom packaging available |
| Storage | Store at -20°C in sealed, dark and dry conditions; avoid high temperature, strong light and oxidation |
| Shelf Life | 24 months under standard low-temperature sealed storage |
Product Description
Our Liquiritigenin powder is a high-purity natural licorice flavanone active ingredient, available in 98% and 99% HPLC grades. Liquiritigenin (CAS 578-86-9), commonly known as , is a signature bioactive monomer compound isolated from traditional licorice root. As a classic dihydroxy flavanone, it features a stable molecular structure, high biological safety and unique selective endocrine regulation activity, far superior to ordinary licorice extracts in purity and efficacy. It integrates powerful antioxidant, broad-spectrum anti-inflammatory, selective estrogen regulation, anti-allergy and hepatoprotective effects, widely applied in soothing skincare, hormone balance health supplements, liver protection products and biomedical pharmacological research. As a professional bulk Liquiritigenin supplier, we provide high-purity, stable-batch and fully compliant products for global industrial and scientific research clients.
Liquiritigenin belongs to the flavanone subclass of flavonoids, with a simple and stable 4′,7-dihydroxyflavanone structure that grants it excellent membrane permeability and bioactivity. Its core functional mechanism relies on activating the Nrf2 endogenous antioxidant pathway and inhibiting the NF-κB inflammatory cascade, efficiently scavenging intracellular reactive oxygen species, reducing oxidative stress damage and blocking multiple pro-inflammatory cytokine releases. The most distinctive advantage of Liquiritigenin is its high selective ERβ estrogen receptor agonist activity, enabling bidirectional and mild regulation of human endocrine levels without causing hormonal side effects, effectively improving sub-health caused by endocrine imbalance. Additionally, it exerts significant anti-allergic, anti-ulcer and choleretic effects, protects liver cell activity, optimizes liver metabolic detoxification, and inhibits xanthine oxidase activity to reduce oxidative damage in the body, with high clinical and formula application value.
Manufactured by Shaanxi BAISFU Bio-Engineering Co., Ltd., our premium Liquiritigenin powder adopts low-temperature water-alcohol selective extraction and multi-stage high-precision column chromatography purification technology. We select high-quality natural licorice root raw materials with stable active content, completely remove licorice polysaccharides, plant fibers, macromolecular impurities and invalid components through gradient elution purification, and fully retain the pure monomer structure and complete biological activity of Liquiritigenin. The entire production process strictly avoids harmful solvent residues and chemical synthetic additives, fully complying with cosmetic-grade, food-grade and research-grade safety standards. The mature and stable production process ensures consistent batch purity, uniform powder appearance and reliable activity stability, meeting the strict formula development and experimental requirements of global customers.
Every batch of Liquiritigenin powder undergoes strict multi-dimensional quality inspection, including HPLC purity testing, UV spectral characteristic verification and NMR structural identification to ensure accurate molecular structure and stable high purity. The finished off-white crystalline powder features low impurity content, good solubility in organic solvents and excellent batch consistency. All products comply with international cosmetic additive regulations, natural functional ingredient safety standards and research-grade compound specifications, supporting safe and standardized application in skincare products, health supplements and biomedical research projects.
We maintain sufficient inventory and complete qualification documents for bulk Liquiritigenin supply. Whether you need anti-inflammatory and anti-allergy soothing raw materials for skincare formulas, endocrine balance and liver protection ingredients for health products, or high-purity licorice flavanone compounds for oxidative stress, inflammation and endocrine pharmacological research, our Liquiritigenin powder is a cost-effective and reliable bulk raw material choice for global buyers.
Functions & Benefits
Nrf2 Antioxidant & Anti-Aging (Core Benefit)
Liquiritigenin is a high-efficiency natural antioxidant derived from licorice. It specifically activates the Nrf2/HO-1 antioxidant signaling pathway, efficiently scavenges DPPH, ABTS and intracellular reactive oxygen free radicals, inhibits lipid peroxidation and oxidative DNA damage, enhances endogenous antioxidant defense capacity, and delays skin and systemic aging caused by long-term oxidative stress.
Broad-Spectrum Anti-Inflammatory & Anti-Allergic
This natural flavanone effectively inhibits the activation of NF-κB inflammatory pathway, reduces the release of TNF-α, IL-6 and other pro-inflammatory factors, and relieves acute and chronic low-grade inflammation in the body. It also delivers significant anti-allergic activity, suppresses allergic skin reactions and redness swelling, stabilizes skin microecology, and is extremely mild with no irritation for sensitive skin care.
Selective ERβ Estrogen Regulation & Endocrine Balance
As a high-selectivity ERβ phytoestrogen agonist, Liquiritigenin bidirectionally regulates human estrogen levels, improves endocrine imbalance symptoms caused by hormonal fluctuations, relieves physical sub-health discomfort, and maintains reproductive and endocrine system stability. It features mild and targeted regulation without the side effects of excessive hormonal stimulation.
Hepatoprotective & Choleretic Effects
Modern pharmacological studies verify that Liquiritigenin protects liver parenchymal cells from oxidative and toxic damage, promotes bile secretion and excretion, optimizes liver detoxification and metabolic function, inhibits liver inflammatory infiltration, and effectively improves liver sub-health problems, serving as a natural mild liver-protective active ingredient.
Anti-Ulcer & Mucosa Protection
Liquiritigenin has significant anti-ulcer activity, which can protect gastrointestinal mucosa from inflammatory and oxidative damage, reduce mucosal erosion and ulceration risk, repair damaged mucosal barriers, and assist in maintaining digestive system health with mild and durable efficacy.
Skin Barrier Repair & Sensitive Skin Calming
Liquiritigenin relieves skin oxidative damage and inflammatory sensitivity caused by external stimuli such as UV radiation and environmental pollution, reduces skin redness, dullness and fragility, enhances skin barrier self-repair ability and tolerance, and maintains stable and healthy skin condition for sensitive skin.
Applications
Sensitive Skin Soothing & Anti-Aging Skincare
Liquiritigenin is widely used in high-end soothing repair essences, anti-redness skincare products, anti-allergy creams and antioxidant anti-aging formulas. It calms sensitive skin inflammation, scavenges skin free radicals, repairs damaged barriers, fades dullness, and is a classic high-value clean beauty active ingredient derived from natural licorice.
Endocrine Balance & Liver Protection Health Supplements
Applied in hormonal balance nutritional formulas, liver protection and detox supplements, and daily sub-health conditioning products. It regulates endocrine stability, optimizes liver metabolism, relieves chronic inflammation in the body, and provides mild and comprehensive health conditioning for sub-health groups.
Functional Food & Nutritional Additives
As a safe natural plant flavanone, Liquiritigenin is used in functional health foods, nutritional fortified products and daily dietary supplements. It enhances product antioxidant and health-care efficacy with high safety and wide applicability.
Biomedical & Scientific Research
Widely used in Nrf2 antioxidant mechanism research, endocrine pharmacology, liver protection research, anti-allergy pharmacodynamics and flavonoid structure-activity relationship studies, serving as a standard high-purity research compound for university laboratories and medical research institutions.
Natural Functional Ingredient Development
Acts as a high-value licorice flavanone intermediate for innovative functional product development, supporting the research and iteration of antioxidant, anti-inflammatory, endocrine-regulating and liver-protective natural raw materials.
FAQ
Q1: What is Liquiritigenin powder used for?
A: Liquiritigenin (Liquiritigenin powder) is a high-purity natural flavanone extracted from licorice root. It is mainly used for sensitive skin soothing, anti-allergy and anti-aging skincare, human endocrine balance regulation, liver protection and choleretic conditioning, as well as biomedical anti-inflammation and oxidative stress pharmacological research.
Q2: Is Liquiritigenin safe for cosmetic and health product use?
A: Yes, Liquiritigenin is a pure natural licorice-derived active ingredient with ultra-mild properties, zero irritation and high biocompatibility. It complies with international cosmetic raw material standards and natural functional food specifications, supporting long-term topical skincare and oral health product application.
Q3: What are the core advantages of Liquiritigenin?
A: Liquiritigenin is a pure licorice flavanone monomer with high purity and high bioavailability. It features unique selective ERβ endocrine regulation, combined with anti-oxidation, anti-inflammation, anti-allergy and liver protection multi-effects, with milder efficacy and higher safety than ordinary licorice extract ingredients.
Q4: How to store Liquiritigenin powder correctly?
A: Liquiritigenin powder is sensitive to high temperature, strong light and oxidation. It needs to be tightly sealed and stored at -20°C in a dark and dry environment. Standard low-temperature sealed storage ensures a 24-month valid shelf life.
Q5: Can I get free Liquiritigenin samples?
A: Yes, we provide free Liquiritigenin powder samples for skincare formula debugging, functional food development and academic pharmacological research. Bulk orders support customized purity and packaging to meet diverse production and research needs.
