Product Introduction
| Item | Specification |
| Product Name | Indirubin |
| Synonyms | Indigo Red; Indigopurpurin; Couroupitine B; NSC 105327 |
| Latin Source Name | Indigofera tinctoria L. & Isatis indigotica Fort. |
| CAS Number | 479-41-4 |
| Molecular Formula | C₁₆H₁₀N₂O₂ |
| Molecular Weight | 262.26 g/mol |
| Specification | 98% (HPLC) |
| Appearance | Dark red crystalline fine powder, uniform texture, slight characteristic odor, no caking, no visible impurities or abnormal discoloration |
| Melting Point | 350-354°C |
| Loss on Drying | ≤ 0.5% |
| Residue on Ignition | ≤ 0.1% |
| Particle Size | 100% pass 80 mesh |
| Testing Method | HPLC / UV / Moisture Test / Ash Test / Microbiological Inspection |
| Production Method | High-quality Indigo Naturalis Selection → Cleaning & Drying → Crushing → Ethanol-Water Circulating Extraction → Macroporous Resin Purification → Recrystallization → Vacuum Drying → Fine Screening |
| Solubility | Slightly soluble in water, soluble in DMSO, methanol and ethanol, stable in neutral and weak acidic formula systems |
| Core Feature | 98% high-purity natural bis-indole alkaloid monomer, stable biological activity, powerful anti-tumor, anti-inflammatory and antioxidant properties, ultra-low impurities and high safety |
| Package | 10g/50g sealed sample bottle, 1kg/25kg vacuum aluminum foil drum; moisture-proof, light-proof and sealed packaging, customized specifications supported |
| Storage | Store in dry, cool and dark sealed environment; avoid high temperature, direct sunlight and humid air to prevent oxidation, discoloration and active ingredient loss |
| Shelf Life | 24 months under standard sealed storage conditions |
Product Description
Indirubin (CAS 479-41-4) is a high-value natural bis-indole alkaloid monomer compound isolated and purified from traditional medicinal Indigo Naturalis, derived from Indigofera tinctoria L. and Isatis indigotica Fort.. With a strict 98% HPLC purity standard, Indirubin retains stable and efficient natural biological activity, featuring outstanding anti-tumor, anti-inflammation, antioxidation, immune regulation and neuroprotective effects. It is a core functional raw material widely applied in anti-tumor pharmaceutical intermediates, immune health supplements, biomedical pharmacological research and high-end functional formula development.
Different from ordinary crude indigo naturalis extract containing multiple alkaloids, plant fibers and miscellaneous impurities, our Indirubin adopts low-temperature circulating solvent extraction and multi-stage macroporous resin purification technology, combined with repeated recrystallization refinement. The advanced production process thoroughly removes residual plant impurities, solvent residues and invalid hybrid components, ensuring single and stable active monomer composition. All production procedures comply with GMP purification standards, with full-index quality detection covering heavy metals, microorganisms and residual solvents, solving the problems of unstable efficacy, low purity and inaccurate dosage of crude extracts, fully meeting high-end formula R&D and industrial mass production standards.
Indirubin is globally renowned for its superior targeted anti-tumor activity. It serves as a potent kinase inhibitor, effectively inhibiting the activity of CDK and GSK-3β kinases, blocking tumor cell cycle proliferation, inducing tumor cell apoptosis, and suppressing tumor angiogenesis and metastasis. Its targeted anti-proliferative performance makes it a key research compound for anti-tumor new drug development and oncology pharmacological experiments.
As a natural high-efficiency anti-inflammatory and antioxidant ingredient, Indirubin can significantly inhibit the secretion of pro-inflammatory factors such as TNF-α and IL-6, reduce chronic systemic inflammation and tissue inflammatory damage. It efficiently scavenges excess free radicals in the body, inhibits cellular lipid peroxidation and oxidative stress, delays tissue and organ aging, and enhances the body’s natural antioxidant defense system.
Indirubin has unique immune regulation functions. It can balance the body’s immune response, regulate immune cell proliferation and differentiation, enhance systemic immune defense capability, and improve immune dysfunction caused by chronic inflammation and oxidative damage. It delivers gentle and targeted immune conditioning effects without causing immune overactivation, suitable for long-term immune balance maintenance research and application.
In neuroprotection research, high-purity Indirubin shows excellent neuroprotective activity. It can inhibit neuroinflammation, reduce neuronal oxidative damage, improve neural microcirculation, and has potential auxiliary regulatory effects on neurodegenerative problems, providing valuable raw materials for neurological disease mechanism research.
In pharmaceutical and scientific research fields, Indirubin serves as a key precursor compound for the development of new anti-tumor, anti-inflammatory and neuroprotective drugs. Its stable molecular structure, accurate high purity and clear pharmacological mechanism provide reliable raw material support for biomedical pharmacological research, new drug screening and compound formula innovation.
Our premium Indirubin product is uniform dark red crystalline fine powder with delicate texture, loose and non-caking, slight natural characteristic odor and no abnormal impurities. Each batch is strictly tested by professional HPLC equipment to guarantee 98% standard purity and consistent batch quality. It features stable chemical properties and excellent formula compatibility, suitable for pharmaceutical intermediate synthesis, research-grade experimental reagents and high-end functional health formula development.
Functions & Benefits
Targeted Anti-Tumor & Anti-Proliferative
Inhibits CDK and GSK-3β kinase activity, blocks tumor cell cycle progression, induces tumor cell apoptosis, suppresses angiogenesis and tumor metastasis for oncology research.
Powerful Anti-Inflammatory Activity
Suppresses pro-inflammatory factor expression, relieves chronic systemic inflammation and tissue inflammatory injury, and balances internal inflammatory microenvironment.
High-Efficiency Antioxidant Protection
Scavenges excess free radicals, inhibits cellular oxidative stress and lipid peroxidation, reduces oxidative damage, and delays tissue and organ aging.
Immune System Balance Regulation
Regulates immune cell activity, balances immune response, improves immune dysfunction caused by chronic inflammation, and maintains long-term immune homeostasis.
Neuroprotective Effects
Inhibits neuroinflammation, protects neurons from oxidative damage, improves neural microcirculation, and supports neurodegenerative disease research.
98% High-Purity Monomer & Stable Efficacy
Single bis-indole alkaloid monomer with ultra-low impurities, accurate active content and stable batch efficacy, avoiding unstable effects of mixed crude extracts.
High Safety & Clear Mechanism
Derived from natural indigo medicinal materials, physical purification processing, clear pharmacological mechanism, mild properties, high safety for scientific research and pharmaceutical application.
Applications
Anti-Tumor Pharmaceutical Intermediate
Core raw material for synthesis and R&D of new anti-tumor drugs, widely used in tumor cell proliferation inhibition and anti-metastasis drug research.
Biomedical Pharmacological Research
Standard 98% purity reagent for kinase inhibition experiments, anti-tumor mechanism research, anti-inflammatory and neuroprotective pharmacological studies.
Immune Balancing Functional Research
Applied in immune regulation formula research to improve chronic inflammation-induced immune disorders and maintain body immune balance.
Neuroprotection & Neurological Research
Used in neurodegenerative disease mechanism research and neuroprotective compound formula development.
High-End Scientific Research Reagents
Served as premium laboratory analytical reagent for organic chemistry, biochemistry and pharmaceutical screening experiments.
Compound Functional Formula Development
Compatible with various plant active monomers to develop compound anti-inflammatory, antioxidant and immune-regulating functional formulas.
FAQ
Q1: What is Indirubin used for?
A: Indirubin is a natural bis-indole alkaloid monomer extracted from Indigo Naturalis. It has excellent anti-tumor, anti-inflammatory, antioxidant and immune-balancing effects, widely used in pharmaceutical intermediate R&D, biomedical research and immune functional formula development.
Q2: What is the difference between Indirubin and indigo naturalis extract?
A: Ordinary indigo naturalis extract is a mixed powder containing multiple alkaloids and impurities with scattered and unstable efficacy; our Indirubin is a single 98% high-purity monomer, featuring accurate content, targeted efficacy, higher safety and stable experimental repeatability.
Q3: What are your Indirubin product advantages?
A: Our Indirubin adopts multi-stage resin purification and repeated recrystallization technology, with strict 98% HPLC purity, ultra-low residual impurities and solvents, uniform crystalline powder texture and stable batch difference, meeting pharmaceutical-grade and research-grade high standards.
Q4: How to store Indirubin correctly?
A: High-purity Indirubin is sensitive to light, heat and moisture. It must be sealed and stored in a cool, dry and dark environment to prevent oxidation discoloration, moisture absorption and attenuation of active pharmacological ingredients.
Q5: What does qualified 98% Indirubin powder look like?
A: Premium qualified Indirubin is uniform dark red crystalline fine powder, loose texture, no caking, no peculiar smell and no visible foreign impurities.
Q6: Can I get free Indirubin test samples?
A: Yes, we provide free 98% Indirubin test samples for formula R&D, pharmacological verification and scientific research trials. Bulk orders support customized packaging and professional technical guidance.
