Product Introduction
| Item | Specification |
| Product Name | Isoxanthohumol |
| Synonyms | 2′,4′,6′-Trihydroxy-4-methoxy-3-prenylchalcone; Isoxanthohumol; |
| CAS Number | 521-48-2 |
| Molecular Formula | C₂₁H₂₂O₅ |
| Molecular Weight | 354.40 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity (HPLC) | ≥98.0% / ≥99.0% (customizable) |
| Loss on Drying | ≤ 1.0% |
| Residue on Ignition | ≤ 0.2% |
| Testing Method | HPLC / UV-Vis Spectroscopy / NMR |
| Production Method | Natural Plant Extraction & High-Purity Column Purification |
| Melting Point | 168–170°C |
| Boiling Point | 592.4±50.0 °C (Predicted) |
| Solubility | Soluble in ethanol, methanol, DMSO and acetone; slightly soluble in hot water; insoluble in cold water |
| Natural Source | Naturally extracted from Humulus lupulus (hops), a unique prenylated flavonoid with high biological activity |
| Package | 1 kg/aluminum foil bag, 25 kg/fiber drum; custom packaging available |
| Storage | Store at -20°C in sealed, dark and dry conditions; avoid high temperature, strong light and oxidation |
| Shelf Life | 24 months under standard low-temperature sealed storage |
Product Description
Our Isoxanthohumol powder is a high-purity natural prenylated flavonoid active ingredient, available in 98% and 99% HPLC grades. Isoxanthohumol (CAS 521-48-2), commonly known as , is a unique high-activity bioactive compound specifically isolated from hops (Humulus lupulus). As a characteristic prenylated flavonoid, it possesses a special molecular structure that endows it with higher bioavailability and more comprehensive pharmacological activity than ordinary flavonoids. It integrates powerful antioxidant, broad-spectrum anti-inflammatory, mild phytoestrogen regulation, lipid metabolism improvement and anti-tumor proliferation effects, widely applied in anti-aging skincare, hormonal balance health supplements, lipid-regulating functional products and biomedical research. As a professional bulk Isoxanthohumol supplier, we provide high-purity, stable-batch and fully compliant products for global industrial and scientific research clients.
Isoxanthohumol belongs to the flavonoid subclass with a unique prenyl substitution structure, which significantly enhances its cell permeability and biological stability. Its core functional mechanism focuses on activating the Nrf2 antioxidant pathway and inhibiting the NF-κB inflammatory cascade, efficiently scavenging intracellular reactive oxygen free radicals, reducing oxidative stress damage, and blocking the release of multiple pro-inflammatory cytokines. Different from common flavonoids, Isoxanthohumol has mild and selective phytoestrogen activity, which can bidirectionally regulate human estrogen levels, improve hormonal imbalance symptoms, and assist in relieving sub-health problems caused by endocrine disorders. In terms of metabolic regulation, it effectively inhibits lipid peroxidation and abnormal fat accumulation, reduces blood lipid levels, and protects liver lipid metabolism function. In addition, modern pharmacological studies confirm that Isoxanthohumol can block tumor cell cycle progression, inhibit cell proliferation and migration, and induce tumor cell apoptosis, with high research value in anti-tumor auxiliary therapy.
Manufactured by Shaanxi BAISFU Bio-Engineering Co., Ltd., our premium Isoxanthohumol powder adopts low-temperature selective solvent extraction and multi-stage high-precision column chromatography purification technology. We select high-quality natural hop raw materials with stable active content, completely remove plant fibers, macromolecular impurities, residual wax and invalid components through gradient elution purification, and fully retain the complete active structure and biological activity of Isoxanthohumol. The entire production process strictly avoids harmful solvent residues and chemical synthetic additives, fully complying with cosmetic-grade, food-grade and research-grade safety standards. The mature and stable production process ensures consistent batch purity, uniform powder appearance and reliable activity stability, meeting the strict formula development and experimental requirements of global customers.
Every batch of Isoxanthohumol powder undergoes strict multi-dimensional quality inspection, including HPLC purity testing, UV spectral characteristic verification and NMR structural identification to ensure accurate molecular structure and stable high purity. The finished off-white crystalline powder features low impurity content, good solubility in organic solvents and excellent batch consistency. All products comply with international cosmetic additive regulations, natural functional ingredient safety standards and research-grade compound specifications, supporting safe and standardized application in skincare products, health supplements and biomedical research projects.
We maintain sufficient inventory and complete qualification documents for bulk Isoxanthohumol supply. Whether you need antioxidant anti-aging and soothing raw materials for skincare formulas, hormonal balance and lipid regulation ingredients for health products, or high-purity hop flavonoid compounds for oxidative stress, inflammation and tumor pharmacological research, our Isoxanthohumol powder is a cost-effective and reliable bulk raw material choice for global buyers.
Functions & Benefits
High-Efficiency Nrf2 Antioxidant & Anti-Aging (Core Benefit)
Isoxanthohumol is a high-activity natural hop flavonoid that specifically activates the Nrf2/HO-1 antioxidant signaling pathway. It efficiently scavenges DPPH, ABTS and intracellular reactive oxygen free radicals, inhibits cellular lipid peroxidation and oxidative DNA damage, enhances the body’s endogenous antioxidant defense capacity, reduces long-term oxidative stress aging, and comprehensively delays skin and systemic aging processes.
Broad-Spectrum Anti-Inflammatory & Soothing Relief
This natural prenylated flavonoid effectively inhibits the activation of NF-κB inflammatory pathway, significantly reducing the release of TNF-α, IL-6 and other pro-inflammatory factors. It relieves skin inflammatory redness, swelling and sensitivity, improves chronic low-grade inflammation in the body, stabilizes skin microecology, and delivers mild, non-irritating soothing effects suitable for long-term skincare and body conditioning.
Bidirectional Estrogen Regulation & Endocrine Conditioning
As a mild selective phytoestrogen, Isoxanthohumol can bidirectionally regulate human estrogen levels. It improves endocrine imbalance symptoms, relieves physical discomfort caused by hormonal fluctuations, assists in maintaining human reproductive system health, and is a safe and natural endocrine conditioning active ingredient.
Lipid Metabolism Regulation & Liver Protection
Modern nutritional studies verify that Isoxanthohumol can inhibit liver lipid peroxidation and excessive fat deposition, regulate blood lipid balance, improve metabolic disorders caused by high-fat diets, reduce lipid accumulation in the liver, and protect liver metabolic function, effectively improving hyperlipidemia and fatty liver tendency sub-health problems.
Anti-Tumor Proliferation & Cell Cycle Regulation
Isoxanthohumol significantly inhibits the proliferation, migration and invasion of various tumor cells, blocks abnormal tumor cell cycle progression, and induces tumor cell apoptosis. It has extremely low toxicity to normal human cells and is an important natural lead compound for anti-tumor pharmacological research and auxiliary functional development.
Skin Barrier Repair & Sensitive Skin Stabilization
Isoxanthohumol relieves skin oxidative damage and inflammatory irritation caused by UV radiation and environmental pollution, reduces skin redness, dullness and sensitivity, enhances skin barrier tolerance and self-repair ability, stabilizes fragile skin condition, and improves sensitive skin and aging skin problems.
Applications
Antioxidant Anti-Aging Skincare Products
Isoxanthohumol is widely used in high-end antioxidant anti-aging essences, soothing repair creams, sensitive skin care products and daily anti-oxidation skincare formulas. It scavenges skin free radicals, relieves inflammatory sensitivity, repairs damaged skin barriers, delays skin aging, and is a high-value natural active ingredient for clean beauty.
Endocrine & Metabolic Health Supplements
Applied in hormonal balance nutritional formulas, blood lipid regulation supplements and liver protection conditioning products. It bidirectionally regulates endocrine levels, optimizes lipid metabolism, protects liver health, and provides comprehensive sub-health conditioning for people with metabolic and endocrine disorders.
Functional Food & Nutritional Additives
As a natural high-activity flavonoid, Isoxanthohumol is used in functional health foods, nutritional fortified products and anti-aging dietary supplements. It enhances product antioxidant and health-care efficacy and improves product nutritional value.
Biomedical & Scientific Research
Widely used in Nrf2 antioxidant mechanism research, endocrine regulation pharmacology, lipid metabolism research, tumor cell biology and flavonoid structure-activity relationship studies, serving as a standard high-purity research compound for university laboratories and medical research institutions.
Natural Functional Ingredient Development
Acts as a high-value prenylated flavonoid intermediate for innovative functional product development, supporting the research and iteration of antioxidant, anti-inflammatory, endocrine-regulating and lipid-lowering natural raw materials.
FAQ
Q1: What is Isoxanthohumol powder used for?
A: Isoxanthohumol (Isoxanthohumol powder) is a high-activity natural prenylated flavonoid extracted from hops. It is mainly used for skincare antioxidant anti-aging and soothing repair, body endocrine balance regulation, blood lipid metabolism improvement, liver protection, and biomedical anti-inflammation and anti-tumor pharmacological research.
Q2: Is Isoxanthohumol safe for cosmetic and health product use?
A: Yes, Isoxanthohumol is a pure natural plant-derived active ingredient with mild properties, low irritation and high safety. It complies with international cosmetic raw material standards and natural functional food additive specifications, supporting long-term topical skincare application and oral health product addition.
Q3: What are the core advantages of Isoxanthohumol?
A: Isoxanthohumol is a unique hop-derived prenylated flavonoid with high bioavailability. It integrates anti-oxidation, anti-inflammation, endocrine regulation and lipid-lowering multi-effects, featuring stable molecular activity and comprehensive functions, which is more advantageous than ordinary single-function flavonoid ingredients.
Q4: How to store Isoxanthohumol powder correctly?
A: Isoxanthohumol powder is sensitive to high temperature, strong light and oxidation. It needs to be tightly sealed and stored at -20°C in a dark and dry environment. Standard low-temperature sealed storage ensures a 24-month valid shelf life.
Q5: Can I get free Isoxanthohumol samples?
A: Yes, we provide free Isoxanthohumol powder samples for skincare formula debugging, functional food development and academic pharmacological research. Bulk orders support customized purity and packaging to meet diverse production and research needs.
