Product Introduction
| Item | Specification |
| Product Name | Melatonin |
| Synonyms | N-Acetyl-5-methoxytryptamine; Circadin |
| CAS Number | 73-31-4 |
| Molecular Formula | C₁₃H₁₆N₂O₂ |
| Molecular Weight | 232.28 g/mol |
| Appearance | White to off-white crystalline powder, odorless, stable crystal form under sealed low-temperature environment |
| Purity (HPLC) | ≥98.0% / ≥99.0% (Research Grade / Pharma Grade, customizable) |
| Loss on Drying | ≤ 0.2% |
| Residue on Ignition | ≤ 0.1% |
| Testing Method | HPLC / NMR / Mass Spectrometry / IR Spectrum / Receptor Activity Detection |
| Production Method | Indole Derivative Synthesis & Multi-Stage Purification & Low-Temperature Recrystallization |
| Melting Point | 116–118°C (lit.) |
| Boiling Point | 374.8°C at 760 mmHg |
| Density | 1.18 g/cm³ at 25°C |
| Flash Point | 180.5°C |
| Solubility | Soluble in DMSO, ethanol and methanol, slightly soluble in water, stable in neutral and weak acidic solutions, sensitive to strong light and high temperature |
| Core Feature | Downstream metabolite of Serotonin and Tryptophan, specific MT1/MT2 receptor agonist, circadian rhythm regulatory activity and natural antioxidant function |
| Package | 10mg/50mg/100mg sealed amber bottle, 1g/5g drum; vacuum moisture-proof packaging, custom specification available |
| Storage | Store in vacuum-sealed, low-temperature, dark and dry conditions; avoid strong light, high temperature and oxidation environments to prevent activity degradation |
| Shelf Life | 24 months under standard low-temperature sealed storage |
Product Description
Our Melatonin is a high-purity endogenous indoleamine neurohormone with stable molecular structure and complete biological activity, available in premium research grade and pharmaceutical grade. Melatonin (CAS 73-31-4), chemically named N-Acetyl-5-methoxytryptamine, is the final functional metabolite of the classic Tryptophan-Serotonin-Melatonin neurological metabolic pathway. Different from upstream Tryptophan for nutritional supply and Serotonin for neural signal transduction, Melatonin is professionally positioned in circadian rhythm regulation, sleep-wake cycle research, neuroprotection, antioxidant mechanism study and indole derivative drug development. As a professional bulk Melatonin supplier, we provide high-purity, low-oxidation, batch-stable Melatonin monomers for global neurological research institutions, pharmaceutical R&D laboratories and health product manufacturing enterprises.
Melatonin holds irreplaceable core value in chronobiology, neuropharmacology and biomedical research. Synthesized and secreted by the mammalian pineal gland, it specifically targets and activates MT1 and MT2 membrane receptors, effectively regulating biological clock rhythm, improving sleep quality and stabilizing neural emotional state. Beyond sleep regulation, Melatonin exhibits significant endogenous antioxidant and anti-inflammatory activities, protecting nerve cells from oxidative damage and delaying neuronal aging. It is widely used in experimental research on insomnia, circadian rhythm disorders, neurodegenerative diseases and immune regulation. In fine chemical synthesis, its stable methoxy and acetyl modified indole skeleton provides efficient modification sites, supporting the development of high-efficiency sleep-improving drugs, neuroprotective agents and indole-based targeted therapeutic molecules. Compared with ordinary low-purity Melatonin with oxidative impurities and unstable receptor activity, our purified product eliminates intermediate residues and isomer impurities, ensuring single-component purity and highly stable biological efficacy for accurate and repeatable experimental results.
Manufactured by Shaanxi BAISFU Bio-Engineering Co., Ltd., our premium Melatonin adopts advanced indole precision synthesis combined with low-temperature oxygen-free reaction and multi-stage gradient recrystallization purification process. The entire production process strictly controls reaction temperature, pH value and purification gradient, completely removing unreacted tryptamine intermediates, solvent residues and oxidative degradation products. By avoiding high-temperature induced molecular structure damage and activity attenuation, the production process fully retains the complete indole active skeleton and specific MT receptor agonistic activity of Melatonin. The finished product presents uniform white crystalline powder with stable crystal form, no caking, no yellowing and no discoloration, fully complying with high-standard biomedical research grade and pharmaceutical raw material grade quality requirements.
Every batch of Melatonin undergoes strict multi-dimensional quality inspection, including HPLC high-precision purity analysis, NMR structural verification, mass spectrometry molecular identification and biological receptor activity testing. It ensures zero invalid impurity interference, ultra-low trace residues and consistent batch biological activity, providing reliable raw material guarantee for circadian mechanism research, sleep disorder pharmacology experiments and indole derivative synthesis. The product features good solubility in polar organic solvents, stable biochemical activity in physiological buffer systems and excellent biocompatibility, fully meeting the strict raw material requirements of cell experiments, in vivo pharmacological tests and high-end pharmaceutical formulation development.
We maintain sufficient low-temperature inventory and complete qualification documents for bulk Melatonin supply. Whether you need standard rhythm-regulating neurotransmitter monomers for neurological research, core raw materials for sleep health products, or high-purity indole intermediates for custom drug synthesis, our premium Melatonin is a high-cost-performance and high-value biological fine chemical product choice for global buyers.
Functions & Benefits
Specific MT1/MT2 Receptor Agonist Activity (Core Benefit)
Melatonin is a highly specific agonist for MT1 and MT2 melatonin receptors. It can accurately activate circadian rhythm signal pathways, regulate the body’s biological clock, and effectively intervene in sleep-wake cycle disorders, serving as the core standard tool compound for chronobiology research.
Complete Tryptophan Metabolic Pathway Terminal Product
As the final functional product of the Tryptophan-Serotonin-Melatonin metabolic axis, Melatonin perfectly matches upstream indole metabolite research systems. It supports complete verification of neuro-nutrition metabolism and signal regulation mechanisms, forming a complete experimental research closed loop.
Powerful Endogenous Antioxidant & Neuroprotection
High-purity Melatonin has excellent free radical scavenging and antioxidant capacity, which can reduce neuronal oxidative stress damage, inhibit neuroinflammation and protect nervous system function. It is widely used in neurodegeneration and neuroprotective pharmacological research.
Low-Oxidation Purification & Ultra-Stable Activity
Our Melatonin adopts low-temperature oxygen-free purification technology to remove oxidative impurities and invalid degradation components. It solves the problem of easy oxidation and activity loss of conventional Melatonin products, maintaining long-term stable receptor activation and antioxidant activity.
Strict Batch Consistency & High Biocompatibility
Synthesized and recrystallized under constant low-temperature sterile conditions, Melatonin eliminates process quality fluctuations. The product has uniform crystal form, stable molecular structure and consistent biological efficacy, suitable for long-term neurological research and repeated pharmacological verification experiments.
Excellent Solubility & Formula Adaptability
Melatonin has good solubility in common polar organic solvents, easy to prepare into experimental stock solutions and pharmaceutical formulas. It maintains stable activity in physiological environments, perfectly adapting to cell culture, in vivo experiments and health product formulation processing.
Applications
Chronobiology & Sleep Disorder Research
Used as a standard high-purity rhythm-regulating hormone monomer for studying circadian clock mechanisms, sleep regulation pathways, insomnia pathogenesis and jet lag intervention effects. Widely applied in university neurobiology laboratories and sleep medical research institutions.
Tryptophan Metabolic Axis Mechanism Verification
Served as the terminal functional marker of the indole metabolic pathway, cooperating with upstream Tryptophan and Serotonin to complete the exploration of neuro-nutrition metabolism, emotional regulation and sleep rhythm correlation mechanisms.
Neuroprotection & Antioxidant Pharmacological Study
Applied in research on neuronal oxidative stress, neuroinflammation inhibition and neurodegenerative disease intervention. It provides stable active raw materials for antioxidant and neuroprotective drug efficacy evaluation.
MT Targeted Drug R&D & Indole Derivative Synthesis
Used as the core modified indole skeleton intermediate for the R&D of new sleep-improving drugs, circadian rhythm regulators and neuroprotective agents, supporting structural optimization and efficacy screening of MT receptor targeted molecules.
Health Product & Pharmaceutical Formula Development
Provided as high-purity raw materials for sleep conditioning health products and auxiliary pharmaceutical preparations, meeting strict pharmaceutical and food-grade safety standards for formula debugging and industrial production.
FAQ
Q1: What is Melatonin mainly used for?
A: Melatonin is a key endogenous circadian regulatory neurohormone. It is mainly used for sleep and circadian rhythm mechanism research, neuroprotective and antioxidant experiments, Tryptophan metabolic pathway verification, and MT receptor targeted drug development, with stable biological regulatory activity.
Q2: What is the metabolic connection between Melatonin, Serotonin and Tryptophan?
A: The three form a complete upstream-to-downstream indole metabolic axis: Tryptophan is metabolized into Serotonin, and Serotonin is further acetylated and methylated to generate Melatonin. This pathway dominates human neuro-nutrition metabolism, mood balance and sleep rhythm regulation, which is the core research system of indole biochemistry.
Q3: What are the core advantages of our Melatonin?
A: Our Melatonin adopts low-temperature oxygen-free synthesis and multi-stage recrystallization purification technology, featuring ultra-high single-component purity, zero oxidative impurity interference, stable MT receptor agonistic activity and consistent batch efficacy. It effectively avoids experimental errors caused by product oxidation and degradation, with outstanding stability and accuracy for scientific research.
Q4: How to store Melatonin correctly?
A: Melatonin is sensitive to strong light, high temperature and oxygen, prone to oxidative decomposition and activity attenuation. It must be stored in vacuum-sealed, low-temperature, cool and dark dry conditions. Standard low-temperature sealed storage ensures 24 months of stable shelf life and biological activity.
Q5: What is the appearance of high-purity Melatonin?
A: High-purity Melatonin is uniform white to off-white crystalline powder at room temperature, odorless, stable crystal state, no caking, no yellowing and no oxidative discoloration.
Q6: Can I get free Melatonin samples for testing?
A: Yes, we provide free Melatonin samples for sleep mechanism research, antioxidant verification and indole derivative synthesis tests. Bulk orders support customized purity and professional low-temperature vacuum packaging to meet high-standard scientific research and industrial production needs.
