Xanthohumol CAS 6754-58-1 Prenylated Chalcone from Humulus lupulus
Product Identification
| Item | Detail |
|---|---|
| Synonyms | Xanthohumol; 2′,4,4′-Trihydroxy-6′-methoxy-3′-prenylchalcone |
| CAS RN | 6754-58-1 |
| Molecular Formula | C₂₁H₂₂O₅ |
| MW | 354.40 |
| Botanical | Humulus lupulusL., Cannabaceae (hops, female inflorescence) |
| HS Code (ref) | 1302 / 2938 |
| Metabolite (in vivo) | 8-Prenylnaringenin (8-PN, CAS 53846-50-7) — if in SKU list, bundle |
| Sibling Stream | α-Acids (humulone) / β-Acids (lupulone) — brewing-grade, separate COA |
Description
Xanthohumol is the signature prenylated chalcone of hops — the plant everyone knows for beer, but Xn is the non-bitter polyphenol fraction (bitter = α/β-acids, Xn = polyphenol, <1% flower weight, needs dedicated EtOH extraction after/alongside CO₂ bittering). Literature clusters:
- Menopausal / women’s wellness (DTC EN #1): Hops traditional欧洲 use for “occasional hot-flush / women’s seasonal wellness” — real lit on 8-PN (Xn metabolite) for hot-flush VMS, but estrogenic / HRT-replacement claims are FDA/EMA red line (phytoestrogen category watched). DTC copy: “Humulus lupulus traditional use, women’s wellness supportive”— stack with black cohosh / red clover / Icariin? (Icariin = men’s, wrong direction — women’s stack = hops + red clover + chasteberry if in SKU). Search: “hops menopausal supplement”, “Xanthohumol hot flush”
- Metabolic / NAFLD R&D (B2B differentiated): Xn lit on SREBP-1c / ACC / fatty acid oxidation, NAFLD models, adipogenesis — prenyl-chalcone hits metabolic TFs, differentiated from Quercetin (senolytic NF-κB) and Parthenolide (NF-κB/STAT3). “Metabolic polyphenol” cluster emerging (resveratrol / pterostilbene / Xn). Search: “Xanthohumol NAFLD”, “hops metabolic R&D”
- Anticancer / Aromatase / STAT3: Xn = aromatase inhibition (MCF-7 lit, breast endocrine-adjacent R&D), STAT3/NF-κB (same sextet above), CYP1A1/1B1 modulation. R&D procurement: pure ≥98% for formulation pilot / SAR. DTC cannot claim “breast cancer / anti-estrogen” — structure-function / R&D only.
- Brewers’ / B2B Hops P.E.: Xn-std 1%–5% HPLC, often triple-peak COA: α-acids + β-acids + Xn (since same hop CO₂+EtOH cascade can give blended extract). Brewing buyers usually want α-acids% (bitter) — if they ask “hops extract Xn” they’re nutra, not brewing. Confirm on PO.
Applications
Menopausal / Women’s Wellness DTC – Hops P.E. Xn-std 1%–5%; DTC EN: “Humulus lupulus traditional, women’s wellness occasional hot-flush supportive”— avoid “HRT alternative / treat menopause / phytoestrogen therapy” (FDA/EMA phytoestrogen watch); stack with red clover / chasteberry (if in SKU) for “women’s botanical” cluster
Metabolic / NAFLD R&D – Xn ≥98% for SREBP-1c / ACC / adipogenesis models; “metabolic polyphenol” cluster (resveratrol/pterostilbene/Xn); inner-link to Quercetin (senolytic) + Parthenolide (NF-κB) sextet
Anticancer / Aromatase / STAT3 R&D – aromatase inhibition (breast-endocrine lit), STAT3/NF-κB; DTC no cancer/endocrine claims; R&D pure ≥98% unrestricted
Hops P.E. B2B (nutra grade) – Xn 1%–5% HPLC, triple-peak (α+β+Xn) optional; separate from brewing α-acids bulk (different COA/buyer) — PO: confirm “Xn-std nutra” vs “α-acids brewing”
Cosmetic Antioxidant (minor) – Hops P.E. in KR/JP “scalp / anti-pollution” small bucket; Xn pure premium “prenylated antioxidant” angle
