Product Introduction
| Item | Specification |
| Product Name | Hesperidin |
| Synonyms | Hesperidoside; Cirantin; Hesperetin 7-rutinoside; |
| CAS Number | 520-26-3 |
| Molecular Formula | C₂₈H₃₄O₁₅ |
| Molecular Weight | 610.56 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity (HPLC) | ≥98.0% / ≥99.0% (customizable) |
| Loss on Drying | ≤ 1.0% |
| Residue on Ignition | ≤ 0.2% |
| Testing Method | HPLC / UV-Vis Spectroscopy / NMR |
| Production Method | Natural Plant Extraction & High-Purity Column Purification |
| Melting Point | 250–255°C (Decomposition) |
| Boiling Point | 930.1±65.0 °C (Predicted) |
| Solubility | Slightly soluble in methanol and hot water; practically insoluble in cold water, ethanol, acetone and most organic solvents; soluble in dilute alkaline solution |
| Natural Source | Naturally extracted from citrus peels and immature fruits of sweet orange, tangerine and lemon, a major flavanone glycoside in citrus plants |
| Package | 1 kg/aluminum foil bag, 25 kg/fiber drum; custom packaging available |
| Storage | Store at 2–8°C in sealed, dark and dry conditions; avoid high temperature, strong light, oxidation and alkaline environment |
| Shelf Life | 24 months under standard low-temperature sealed storage |
Product Description
Our Hesperidin powder is a high-purity natural citrus flavanone glycoside active ingredient, available in 98% and 99% HPLC grades. Hesperidin (CAS 520-26-3), commonly known as, is the most abundant and representative bioactive flavonoid isolated from citrus peels and immature citrus fruits. As the glycoside precursor of Hesperetin, Hesperidin features excellent water solubility characteristics, stable molecular structure and mild biocompatibility, with core pharmacological activities including high-efficiency anti-oxidation, broad-spectrum anti-inflammation, vascular wall strengthening, lipid metabolism regulation and antibacterial protection. It is widely applied in daily antioxidant skincare, vascular health supplements, functional food additives and biomedical pharmacological research. As a professional bulk Hesperidin supplier, we provide high-purity, stable-batch and fully compliant products for global industrial and scientific research clients.
Hesperidin belongs to the flavanone glycoside subclass of flavonoids, with a unique rutinoside group structure that differentiates it from aglycone Hesperetin. This structural feature endows Hesperidin with superior water solubility and better compatibility for oral formulations and water-based skincare products. Its core functional mechanism relies on activating the Nrf2 endogenous antioxidant pathway and inhibiting the NF-κB inflammatory cascade, effectively scavenging excess free radicals in the body, reducing oxidative stress damage, and blocking the release of multiple pro-inflammatory cytokines. In vascular health maintenance, Hesperidin significantly enhances capillary toughness, reduces vascular fragility and permeability, improves human microcirculation, and assists in preventing subcutaneous bruising and vascular aging. Meanwhile, it can effectively regulate blood lipid metabolism, inhibit lipid peroxidation and fat deposition, and assist in improving hyperlipidemia and metabolic sub-health. In addition, Hesperidin has broad-spectrum antibacterial and mild immunomodulatory effects, with stable efficacy and no toxic side effects for long-term use.
Manufactured by Shaanxi BAISFU Bio-Engineering Co., Ltd., our premium Hesperidin powder adopts low-temperature water-phase selective extraction and multi-stage high-precision column chromatography purification technology. We select high-quality fresh citrus peel and young fruit raw materials with stable active content, completely remove plant fibers, macromolecular impurities, residual sugars and invalid components through gradient elution purification, and fully retain the natural glycoside active structure and biological activity of Hesperidin. The entire production process strictly avoids harmful solvent residues and chemical synthetic additives, fully complying with cosmetic-grade, food-grade and research-grade safety standards. The mature and stable production process ensures consistent batch purity, uniform powder appearance and reliable activity stability, meeting the strict formula development and experimental requirements of global customers.
Every batch of Hesperidin powder undergoes strict multi-dimensional quality inspection, including HPLC purity testing, UV spectral characteristic verification and NMR structural identification to ensure accurate molecular structure and stable high purity. The finished off-white crystalline powder features low impurity content, good water-based formula compatibility and excellent batch consistency. All products comply with international cosmetic additive regulations, national GB 2760 food additive safety standards and research-grade compound specifications, supporting safe and standardized application in skincare products, functional foods, health supplements and biomedical research projects.
We maintain sufficient inventory and complete qualification documents for bulk Hesperidin supply. Whether you need water-soluble antioxidant anti-inflammatory raw materials for skincare formulas, vascular protection and lipid regulation ingredients for health products, natural antibacterial additives for functional foods, or high-purity citrus flavanone glycoside compounds for pharmacological research, our Hesperidin powder is a cost-effective and reliable bulk raw material choice for global buyers.
Functions & Benefits
Natural Nrf2 Antioxidant & Anti-Aging (Core Benefit)
Hesperidin is a classic natural citrus antioxidant that activates the Nrf2/HO-1 antioxidant signaling pathway. It efficiently scavenges DPPH, ABTS and intracellular reactive oxygen free radicals, inhibits cellular lipid peroxidation and oxidative DNA damage, enhances the body’s endogenous antioxidant defense capacity, reduces long-term oxidative stress aging, and delays skin and systemic aging processes comprehensively.
Broad-Spectrum Anti-Inflammatory & Soothing Relief
This natural flavanone glycoside effectively inhibits the activation of NF-κB inflammatory pathway, significantly reducing the release of TNF-α, IL-6 and other pro-inflammatory factors. It relieves skin inflammatory redness, swelling and sensitivity, improves chronic low-grade inflammation in the body, stabilizes skin microecology, and delivers mild and non-irritating soothing effects suitable for long-term use.
Vascular Strengthening & Microcirculation Optimization
Hesperidin is famous for its vascular-protective properties. It enhances capillary wall toughness and elasticity, reduces vascular fragility and exudation, improves human peripheral microcirculation, relieves vascular stasis and subcutaneous bruising, and effectively prevents vascular aging and microcirculation disorders, being a core raw material for vascular health care.
Lipid Metabolism Regulation & Metabolic Balance
Modern nutritional studies verify that Hesperidin can inhibit liver lipid peroxidation and excessive fat accumulation, regulate blood lipid balance, improve metabolic disorders caused by high-fat diets, reduce body lipid deposition, and effectively improve sub-health problems such as slow metabolism and dyslipidemia tendency.
Broad-Spectrum Antibacterial & Immunomodulatory
Hesperidin exerts significant inhibitory effects on multiple common pathogenic bacteria including Bacillus subtilis and Salmonella. It reduces bacterial-induced inflammatory damage, regulates body immune balance, enhances low immunity caused by chronic inflammation, and provides mild and safe immune protection.
Skin Barrier Repair & Sensitive Skin Care
Hesperidin relieves skin oxidative damage and inflammatory irritation caused by UV radiation and environmental pollution, reduces skin redness, dullness and pigmentation tendency, enhances skin barrier tolerance and self-repair ability, and maintains stable and healthy skin condition for sensitive skin.
Applications
Antioxidant Soothing Skincare Products
Hesperidin is widely used in water-based antioxidant essences, soothing repair lotions, sensitive skin care products and daily anti-aging skincare formulas. It features good water solubility, effectively scavenges skin free radicals, relieves inflammatory sensitivity, repairs damaged barriers, and is a high-quality mild active ingredient for clean beauty.
Vascular & Metabolic Health Supplements
Applied in capillary protection nutritional formulas, blood lipid regulation supplements and daily cardiovascular sub-health conditioning products. It strengthens vascular toughness, optimizes microcirculation and lipid metabolism, and provides long-term mild vascular protection for sub-health groups.
Functional Food & Beverage Additives
Compliant with GB 2760 food additive standards, Hesperidin is widely used in functional beverages, nutritional fortified foods, dairy products and health candies. It serves as a natural antioxidant and antibacterial preservative to extend product shelf life and enhance nutritional value.
Biomedical & Scientific Research
Widely used in Nrf2 antioxidant mechanism research, vascular microcirculation pharmacology, lipid metabolism regulation, antibacterial activity experiments and flavonoid structure-activity relationship studies, serving as a standard high-purity research compound for university laboratories and medical research institutions.
Natural Functional Ingredient Development
Acts as a high-value water-soluble citrus flavonoid intermediate for innovative functional product development, supporting the research and iteration of antioxidant, anti-inflammatory, vascular-protective and antibacterial natural raw materials.
FAQ
Q1: What is Hesperidin powder used for?
A: Hesperidin (Hesperidin powder) is a high-activity water-soluble natural citrus flavanone glycoside extracted from orange peel. It is mainly used for skincare antioxidant soothing and barrier repair, vascular strengthening and microcirculation improvement, body lipid metabolism regulation, natural antibacterial preservation, and biomedical inflammation and oxidative stress research.
Q2: Is Hesperidin safe for cosmetic and food use?
A: Yes, Hesperidin is a pure natural plant-derived active ingredient with mild properties, zero irritation and high safety. It complies with international cosmetic raw material standards and national GB 2760 food additive specifications, supporting long-term topical skincare application and oral food and health product addition.
Q3: What is the difference between Hesperidin and Hesperetin?
A: Hesperidin is the water-soluble glycoside form, while Hesperetin is the fat-soluble aglycone form after hydrolysis. Hesperidin has better water solubility and is more suitable for water-based formulas and oral products; Hesperetin has higher cell permeability and is more suitable for high-efficiency anti-aging and pharmacological research.
Q4: How to store Hesperidin powder correctly?
A: Hesperidin powder is sensitive to high temperature, strong light, oxidation and alkaline environments. It needs to be tightly sealed and stored at 2–8°C in a dark and dry environment. Standard low-temperature sealed storage ensures a 24-month valid shelf life.
Q5: Can I get free Hesperidin samples?
A: Yes, we provide free Hesperidin powder samples for skincare formula debugging, functional food development and academic pharmacological research. Bulk orders support customized purity and packaging to meet diverse production and research needs.
