Product Introduction
| Item | Specification |
| Product Name | Vasicine |
| Synonyms | Peganine; (R)-1,2,3,9-Tetrahydropyrrolo[2,1-b]quinazolin-3-ol; 3-Hydroxypyrrolo[2,1-b]quinazoline |
| CAS Number | 6159-55-3 |
| Molecular Formula | C₁₁H₁₂N₂O |
| Molecular Weight | 188.23 g/mol |
| Appearance | White fine crystalline powder, odorless, stable crystal form under sealed dark and dry conditions |
| Purity (HPLC) | ≥98.0% / ≥99.0% (Research Grade / Pharma API Grade, customizable) |
| Loss on Drying | ≤ 0.2% |
| Residue on Ignition | ≤ 0.1% |
| Testing Method | HPLC / NMR / Mass Spectrometry / IR Spectrum / Pharmacological Activity Detection |
| Production Method | Natural Justicia Adhatoda Leaf Extraction & Macroporous Resin Isolation & Low-Temperature Recrystallization Purification |
| Melting Point | 211°C (lit.) |
| Boiling Point | 373.8°C at 760 mmHg (Predicted) |
| Density | 1.27 g/cm³ at 25°C |
| Flash Point | 179.9°C |
| Solubility | Soluble in chloroform, ethyl acetate, methanol, ethanol and DMSO; slightly soluble in hot water; insoluble in cold water; stable under dry and dark conditions |
| Core Feature | Typical pyrroloquinazoline alkaloid, powerful bronchodilator, multi-functional anti-inflammatory and antioxidant natural monomer |
| Package | 1g/5g/10g sealed amber bottle, 100g/1kg drum; vacuum moisture-proof & light-proof packaging, custom specification available |
| Storage | Store in vacuum-sealed, low-temperature, dark and dry conditions; avoid high temperature, long-term light exposure and humid environment to prevent structural oxidation and activity attenuation |
| Shelf Life | 24 months under standard low-temperature sealed and dark storage |
Product Description
Our Vasicine (also known as Peganine) is a high-purity natural pyrroloquinazoline alkaloid with comprehensive pharmacological activity, available in premium research grade and pharmaceutical API grade. Vasicine (CAS 6159-55-3) is the signature bioactive monomer isolated and purified from the traditional medicinal plants Justicia adhatoda and Peganum harmala. Possessing a unique fused pyrrolo[2,1-b]quinazoline heterocyclic skeleton, it is renowned as a classic natural respiratory protective alkaloid, featuring prominent bronchodilatory, anti-inflammatory, antibacterial and antioxidant properties. As a core active ingredient of Adhatoda vasica, Vasicine has long been used in traditional herbal medicine for relieving cough, asthma and bronchial inflammation, and has now become a key research compound in modern respiratory pharmacology, anti-infective therapy and natural drug development. As a professional bulk Vasicine supplier, we provide low-impurity, high-activity, batch-stable Vasicine raw materials for global pharmaceutical laboratories, natural product research institutions and botanical API manufacturing enterprises.
Vasicine occupies an important position in the research of quinazoline alkaloids and respiratory pharmacology, with highly differentiated pharmacological characteristics and broad application prospects. Its core pharmacological advantage lies in its potent bronchodilatory and respiratory regulatory activity, which effectively relaxes bronchial smooth muscle, relieves bronchial spasm, improves respiratory tract patency, and alleviates cough and asthma symptoms. Different from synthetic respiratory drugs with obvious side effects, natural Vasicine exerts mild and efficient respiratory regulation with low toxicity and high safety. In addition, Vasicine can activate the PI3K/Akt signaling pathway, significantly inhibit the overexpression of pro-inflammatory factors, remove reactive oxygen species in the body, and achieve excellent anti-inflammatory and antioxidant effects. It also has broad-spectrum antibacterial activity against common respiratory pathogens, effectively assisting in improving infectious respiratory inflammation. Combined with its subsidiary pharmacological activities such as hypotensive, uterine excitatory and anti-tumor effects, Vasicine has become a multi-functional lead compound for the development of respiratory protective drugs, anti-inflammatory preparations and health care products. Compared with low-purity plant crude extracts containing mixed alkaloids and pigment impurities, our high-purity Vasicine adopts precise purification technology to remove all interfering components, ensuring single-component purity and stable pharmacological activity for high-precision experimental research and preclinical drug development.
Manufactured by Shaanxi BAISFU Bio-Engineering Co., Ltd., our premium Vasicine adopts advanced low-temperature selective solvent extraction combined with macroporous resin gradient separation and multi-stage low-temperature recrystallization purification process. The entire production process strictly controls temperature, light and humidity, effectively avoiding molecular oxidation and structural damage caused by high temperature and light exposure. The closed oxygen-free production system thoroughly eliminates plant fiber residues, miscellaneous alkaloids, pigment impurities and organic solvent traces, completely retaining the complete pyrroloquinazoline active skeleton and comprehensive biological activity of Vasicine. The finished product presents uniform white fine crystalline powder, stable crystal form, no caking, no discoloration and no deterioration, fully complying with high-standard natural product research grade and pharmaceutical botanical API grade quality specifications.
Every batch of Vasicine undergoes strict multi-dimensional quality inspection, including HPLC high-precision purity analysis, NMR structural verification, mass spectrometry molecular identification and cell-level pharmacological activity testing. It achieves ultra-low trace residue and zero invalid impurity interference, ensuring consistent batch efficacy and excellent experimental repeatability. The product features excellent solubility in common organic solvents and good biochemical compatibility in cell culture and in vivo animal experiment environments, fully meeting the strict raw material requirements of respiratory mechanism research, anti-inflammatory efficacy verification, antibacterial experiment analysis and natural alkaloid derivative synthesis.
We maintain sufficient low-temperature light-proof inventory and complete qualification documents for bulk Vasicine supply. Whether you need standard quinazoline alkaloid monomers for basic pharmacological research, positive control reagents for respiratory drug efficacy evaluation, or high-purity parent intermediates for new natural drug structural optimization, our premium Vasicine is a high-cost-performance and high-value natural fine chemical product choice for global buyers.
Functions & Benefits
Potent Bronchodilatory & Respiratory Protective Activity (Core Benefit)
Vasicine is a classic natural respiratory regulatory alkaloid. It specifically relaxes bronchial smooth muscle, relieves bronchial spasm, improves airway patency, and effectively alleviates cough, asthma and bronchitis symptoms. With mild efficacy and high safety, it is the gold-standard tool compound for respiratory pharmacology research.
Unique Pyrroloquinazoline Heterocyclic Skeleton
Featuring a rare fused pyrrolo[2,1-b]quinazoline ring structure, Vasicine has a stable and distinctive molecular skeleton. This unique structural feature endows it with specific respiratory regulation and anti-inflammatory activity, providing irreplaceable templates for structural modification and innovative development of new respiratory drugs.
Dual Anti-Inflammatory & Antioxidant Effects
High-purity Vasicine activates the PI3K/Akt signaling pathway, inhibits the release of inflammatory cytokines, relieves respiratory tract inflammatory damage, and scavenges intracellular reactive oxygen species. It effectively improves oxidative stress and inflammatory responses, supporting respiratory injury repair research.
Broad-Spectrum Antibacterial & Anti-Infective Activity
Vasicine has significant inhibitory effects on common respiratory pathogenic bacteria. It assists in eliminating pathogen-induced respiratory infections, reduces inflammatory exudation, and provides dual protection of anti-infection and anti-inflammation for respiratory system research.
High Single-Component Purity & Stable Batch Activity
Our Vasicine adopts full-process low-temperature purification and multi-stage impurity removal technology, completely eliminating miscellaneous alkaloid impurities and plant pigment interference in traditional crude extracts. It ensures pure monomer activity, zero experimental interference and consistent batch pharmacological efficacy.
Excellent Solubility & Wide Experimental Adaptability
Vasicine has good solubility in chloroform, ethyl acetate, methanol and DMSO, easy to prepare into homogeneous experimental stock solutions. It maintains stable biological activity in conventional cell and animal experiment environments, perfectly adapting to respiratory function tests, inflammatory model experiments and alkaloid structure-activity relationship research.
Applications
Respiratory Pharmacology & Airway Regulation Research
Used as a standard bronchodilatory positive reagent for studying bronchial smooth muscle regulation, airway spasm relief and respiratory disease pathological mechanisms, widely applied in respiratory pharmacology and natural medicine research laboratories.
Anti-Inflammatory & Antioxidant Mechanism Study
Served as the core experimental compound for exploring PI3K/Akt signaling pathway regulation, respiratory inflammatory injury and oxidative stress response, supporting efficacy verification of new anti-inflammatory and antioxidant natural drugs.
Respiratory Anti-Infective Drug R&D
Applied as a high-value lead compound for innovative development of natural anti-cough, anti-asthma and anti-bronchitis drugs, guiding structural optimization and efficacy upgrading of respiratory protective botanical preparations.
Natural Alkaloid Structure-Activity Relationship Research
Used as a typical pyrroloquinazoline alkaloid model compound for studying the pharmacological activity differences of fused heterocyclic skeletons, enriching the theoretical system of quinazoline alkaloid medicinal chemistry.
Laboratory Teaching & Pharmacological Demonstration
Provided as standard high-purity Vasicine reagent for natural pharmacology teaching experiments, respiratory drug mechanism demonstration and alkaloid activity comparison tests, ensuring accurate and stable experimental data for scientific research and teaching work.
FAQ
Q1: What is Vasicine mainly used for?
A: Vasicine is a natural pyrroloquinazoline alkaloid with core respiratory regulatory activity. It is mainly used for bronchial dilation and respiratory disease mechanism research, respiratory anti-inflammatory and antioxidant study, antibacterial anti-infective experiments and new natural respiratory drug development.
Q2: What are the core pharmacological effects of Vasicine?
A: Vasicine’s dominant activity is potent bronchodilation and respiratory protection. It also possesses significant anti-inflammatory, antioxidant, broad-spectrum antibacterial, hypotensive and anti-tumor pharmacological effects, with multi-dimensional natural medicinal research value.
Q3: What are the core advantages of our Vasicine?
A: Our Vasicine adopts professional low-temperature light-shielded purification technology, featuring ultra-high single-component purity, zero miscellaneous alkaloid and pigment interference, stable bronchodilatory and anti-inflammatory activity, and consistent batch quality, ensuring high-precision and repeatable pharmacological research results.
Q4: How to store Vasicine correctly?
A: Vasicine is sensitive to high temperature and long-term light exposure, prone to oxidative deterioration and activity loss. It must be stored in vacuum-sealed, low-temperature, light-proof and dry dark conditions. Standard sealed low-temperature dark storage ensures 24 months of stable shelf life and biological activity.
Q5: What is the appearance of high-purity Vasicine?
A: High-purity Vasicine is uniform white fine crystalline powder at room temperature, odorless, stable crystal state, no caking, no fading and no deterioration.
Q6: Can I get free Vasicine samples for testing?
A: Yes, we provide free Vasicine samples for respiratory regulation mechanism research, anti-inflammatory antioxidant verification and natural drug derivative synthesis experiments. Bulk orders support customized purity and professional light-proof vacuum packaging to meet high-standard scientific research and pharmaceutical API production needs.
