Product Introduction
| Item | Specification |
| Product Name | Quinidine |
| Synonyms | Quinidine; Cinchonan-9-ol, 6′-methoxy-, (9S)-; Quinidine base |
| CAS Number | 56-54-2 |
| Molecular Formula | C₂₀H₂₄N₂O₂ |
| Molecular Weight | 324.42 g/mol |
| Appearance | White fine crystalline powder or needle crystals, odorless, intensely bitter taste, stable crystal form under sealed dark and dry conditions |
| Purity (HPLC) | ≥98.0% / ≥99.0% (Research Grade / Pharma API Grade, customizable) |
| Loss on Drying | ≤ 0.2% |
| Residue on Ignition | ≤ 0.1% |
| Testing Method | HPLC / NMR / Mass Spectrometry / IR Spectrum / Cardiac Electrophysiology Activity Detection |
| Production Method | Natural Cinchona Bark Extraction & Stereoselective Isolation & Multi-Stage Recrystallization Purification |
| Melting Point | 178–180°C (lit.) |
| Boiling Point | 495.9°C at 760 mmHg |
| Density | 1.21 g/cm³ at 25°C |
| Flash Point | 253.5°C |
| Solubility | Soluble in ethanol, chloroform, methanol and DMSO; slightly soluble in hot water; almost insoluble in cold water; sensitive to light and heat, avoids humid environment |
| Core Feature | Stereoisomer of Quinine, classic Class IA antiarrhythmic cinchona alkaloid, specific sodium/potassium ion channel blocking activity |
| Package | 1g/5g/10g sealed amber bottle, 100g/1kg drum; vacuum moisture-proof packaging, custom specification available |
| Storage | Store in vacuum-sealed, low-temperature, dark and dry conditions; avoid strong light, high temperature and humid environment to prevent optical rotation change and structural degradation |
| Shelf Life | 24 months under standard low-temperature sealed storage |
Product Description
Our Quinidine is a high-purity natural chiral cinchona alkaloid with stable stereochemical configuration and specific cardiovascular pharmacological activity, available in premium research grade and pharmaceutical API grade. Quinidine (CAS 56-54-2) is a vital bioactive monomer isolated and purified from Cinchona tree bark, serving as the diastereomer of Quinine with identical molecular formula but distinct spatial stereostructure. As a classic prototype Class IA antiarrhythmic agent, Quinidine uniquely targets cardiac ion channels, featuring precise sodium and potassium channel blocking effects that regulate myocardial electrical activity, prolong action potential duration and stabilize cardiac rhythm. Beyond its core cardiovascular regulatory function, it retains mild antimalarial, anti-inflammatory and antimicrobial properties, making it a core tool compound for cardiac electrophysiology research, antiarrhythmic drug screening and cinchona alkaloid stereochemistry comparative studies. As a professional bulk Quinidine supplier, we provide high-stereopurity, low-impurity, batch-stable Quinidine raw materials for global cardiovascular pharmacology laboratories, natural product research institutions and pharmaceutical API manufacturing enterprises.
Quinidine holds a pivotal position in cinchona alkaloid research and cardiovascular pharmacology, possessing completely differentiated pharmacological characteristics from its stereoisomer Quinine. While Quinine is famous for antimalarial efficacy, Quinidine exhibits superior cardiac electrophysiological regulation activity, regarded as one of the earliest and most representative natural antiarrhythmic drugs in clinical history. Its core pharmacological mechanism lies in blocking voltage-gated sodium channels (Nav1.5) and potassium channels (hERG, Kv1.4, Kv4.2), which reduces myocardial automaticity, slows conduction velocity, prolongs effective refractory period, and effectively inhibits various atrial and ventricular arrhythmias. This unique ion-channel regulatory property makes Quinidine an indispensable positive control reagent for arrhythmia model experiments and antiarrhythmic mechanism verification. In addition, Quinidine retains moderate plasmodium inhibition and broad-spectrum antimicrobial activity, supporting multi-directional natural pharmacological exploration. Its typical chiral dual-ring skeleton provides irreplaceable research templates for studying alkaloid stereostructure-activity relationships, guiding the structural optimization and innovative derivation of high-efficiency low-toxicity antiarrhythmic drugs. Different from mixed cinchona crude extracts containing quinine stereoisomer impurities and plant residues, our high-purity Quinidine adopts professional stereoselective separation technology to eliminate invalid isomer interference, ensuring single-component purity and ultra-stable repeatable pharmacological activity for high-precision scientific research and pharmaceutical R&D.
Manufactured by Shaanxi BAISFU Bio-Engineering Co., Ltd., our premium Quinidine adopts advanced low-temperature selective extraction combined with stereoselective resin isolation and multi-stage gradient recrystallization purification process. The whole production process strictly controls extraction pH, temperature and chiral separation precision, thoroughly removing plant fiber residues, quinine stereoisomer impurities, miscellaneous alkaloids and organic solvent traces. The low-temperature oxygen-free closed processing technology effectively prevents stereoisomerization and molecular oxidation damage, completely retaining the natural stable chiral configuration and complete ion-channel blocking activity of Quinidine. The finished product presents uniform white fine needle crystalline powder, stable crystal form, no caking, no discoloration and no deterioration, fully complying with high-standard natural product research grade and pharmaceutical botanical API grade quality specifications.
Every batch of Quinidine undergoes strict multi-dimensional quality inspection, including HPLC high-precision purity analysis, NMR stereostructure verification, mass spectrometry molecular identification and cell-level cardiac electrophysiology activity testing. It achieves ultra-low trace residue and zero stereoisomer impurity interference, ensuring consistent batch efficacy and experimental stability. The product features excellent solubility in common organic solvents, stable biochemical properties in cell culture and in vivo animal experiment environments, and outstanding experimental repeatability, fully meeting the strict raw material requirements of cardiac electrophysiology tests, arrhythmia model verification, stereochemical comparison experiments and chiral drug synthesis research.
We maintain sufficient low-temperature inventory and complete qualification documents for bulk Quinidine supply. Whether you need standard chiral cinchona alkaloid monomers for pharmacological research, core reference substances for antiarrhythmic drug efficacy evaluation, or high-purity stereoisomer intermediates for natural alkaloid derivative synthesis, our premium Quinidine is a high-cost-performance and high-value natural fine chemical product choice for global buyers.
Functions & Benefits
Classic Class IA Antiarrhythmic & Cardiac Ion Channel Regulation (Core Benefit)
Quinidine is a landmark natural antiarrhythmic alkaloid. It specifically blocks cardiac sodium and potassium ion channels, stabilizes myocardial electrical activity, prolongs action potential and refractory period, and inhibits ectopic pacemaker activity. With definite pharmacological mechanism and stable efficacy, it is the gold-standard tool compound for cardiovascular electrophysiology and antiarrhythmic drug research.
Typical Quinine Stereoisomer & Chiral Comparative Research Value
As the diastereomer of Quinine, Quinidine has identical molecular formula but different spatial configuration. The significant pharmacological differences between the two make Quinidine a core research object for studying alkaloid stereostructure-activity relationships, providing critical templates for chiral drug modification and screening.
Mild Antimalarial, Anti-Inflammatory & Antimicrobial Activity
High-purity Quinidine retains the inherent biological activity of cinchona alkaloids, with moderate plasmodium inhibition, inflammatory factor regulation and broad-spectrum antibacterial effects. It supports multi-dimensional pharmacological research on parasitic diseases and infectious inflammation.
High Stereopurity & Zero Isomer Interference
Our Quinidine adopts professional stereoselective separation and multi-stage impurity removal technology, completely eliminating quinine stereoisomer impurities and plant heterozygous components in traditional cinchona extracts. It solves the problem of confused experimental data caused by isomer mixing, ensuring ultra-pure single-component activity.
Strict Batch Consistency & High Experimental Repeatability
Extracted and purified under constant low-temperature sterile chiral separation conditions, Quinidine eliminates batch-to-batch stereochemical and efficacy fluctuations. The product has stable chiral configuration, uniform crystal form and consistent biological activity, suitable for long-term cardiovascular pharmacology and high-precision stereochemistry research projects.
Excellent Solubility & Wide Experimental Adaptability
Quinidine has good solubility in ethanol, chloroform, methanol and DMSO, easy to prepare into homogeneous experimental stock solutions and pharmacological formula systems. It maintains stable activity in conventional cell and animal experiment environments, perfectly adapting to cardiac electrophysiology tests, drug efficacy verification and chiral alkaloid comparison experiments.
Applications
Cardiac Electrophysiology & Antiarrhythmic Drug Research
Used as a standard Class IA antiarrhythmic positive reagent for studying myocardial ion channel mechanism, cardiac rhythm regulation and arrhythmia pathological models. Widely applied in cardiovascular pharmacology and drug screening laboratories.
Cinchona Alkaloid Stereochemistry Comparative Study
Served as the core stereoisomer control of Quinine, used for verifying the structure-activity relationship of chiral cinchona alkaloids, analyzing the pharmacological differences caused by spatial configuration changes, and guiding chiral drug molecular design.
Botanical API R&D & Pharmacological Evaluation
Applied as a classic reference compound for new natural antiarrhythmic, antiparasitic and anti-inflammatory drug development, guiding structural optimization, efficacy screening and safety evaluation of cinchona alkaloid pharmaceutical molecules.
Chiral Alkaloid Derivative Synthesis
Used as a high-value natural chiral heterocyclic skeleton intermediate for the synthesis of new high-efficiency antiarrhythmic and antiparasitic derivatives, supporting innovative R&D of chiral botanical pharmaceutical intermediates.
Laboratory Teaching & Pharmacological Mechanism Teaching
Provided as standard high-purity Quinidine reagent for natural pharmacology teaching experiments, cardiovascular drug mechanism demonstration and stereoisomer pharmacological comparison tests, ensuring accurate and stable experimental data for scientific research and teaching work.
FAQ
Q1: What is Quinidine mainly used for?
A: Quinidine is a classic natural cinchona chiral alkaloid and representative Class IA antiarrhythmic compound. It is mainly used for cardiac electrophysiology and antiarrhythmic mechanism research, quinine stereoisomer comparative pharmacology, mild antiparasitic experiments and chiral alkaloid derivative synthesis.
Q2: What is the structural difference between Quinidine and Quinine?
A: Quinidine is the diastereomer of Quinine, sharing the same molecular formula and dual-ring skeleton but differing in spatial chiral configuration. This subtle stereostructure difference endows Quinidine with dominant antiarrhythmic activity, while Quinine mainly presents antimalarial efficacy, forming completely differentiated pharmacological characteristics.
Q3: What are the core advantages of our Quinidine?
A: Our Quinidine adopts professional stereoselective purification technology, featuring ultra-high single-component stereopurity, zero quinine isomer interference, stable ion-channel blocking activity and consistent batch efficacy. It effectively avoids experimental errors caused by isomer mixing and crude extract impurities, ensuring high-precision stereopharmacology research results.
Q4: How to store Quinidine correctly?
A: Quinidine is sensitive to strong light, high temperature and humid environments, prone to optical rotation changes and structural degradation. It must be stored in vacuum-sealed, low-temperature, cool and dry dark conditions. Standard sealed low-temperature storage ensures 24 months of stable shelf life and stereochemical activity.
Q5: What is the appearance of high-purity Quinidine?
A: High-purity Quinidine is uniform white fine needle crystalline powder at room temperature, odorless, extremely bitter taste, stable crystal state, no caking, no fading and no deterioration.
Q6: Can I get free Quinidine samples for testing?
A: Yes, we provide free Quinidine samples for cardiac antiarrhythmic mechanism research, cinchona alkaloid stereoisomer comparison tests and chiral derivative synthesis experiments. Bulk orders support customized purity and professional anti-oxidation vacuum packaging to meet high-standard scientific research and pharmaceutical API production needs.
