| Item | Specification |
| Product Name | Phloretin |
| Synonyms | 3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one; Trihydroxyphenylacetone |
| CAS Number | 60-82-2 |
| Molecular Formula | C₁₅H₁₄O₅ |
| Molecular Weight | 274.27 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity (HPLC) | ≥98.0% / ≥99.0% (customizable) |
| Loss on Drying | ≤ 1.0% |
| Residue on Ignition | ≤ 0.2% |
| Testing Method | HPLC / UV-Vis Spectroscopy / NMR |
| Production Method | Natural Plant Extraction & High-Purity Column Purification |
| Melting Point | 260°C (decomposition) |
| Solubility | Soluble in hot water, ethanol, methanol, acetone and DMSO; slightly soluble in cold water; insoluble in ether and benzene |
| Natural Source | Naturally extracted from apple peel, pear peel and rose plants, a premium natural dihydrochalcone flavonoid compound |
| Package | 1 kg/aluminum foil bag, 25 kg/fiber drum; custom packaging available |
| Storage | Store in a cool, dry place; keep tightly sealed and protected from light, heat and moisture |
| Shelf Life | 24 months when stored properly in original packaging |
Product Description
Our Phloretin powder is a high-purity natural dihydrochalcone flavonoid, available in 98% and 99% HPLC grades. Phloretin (CAS 60-82-2) is a rare bioactive compound predominantly isolated from apple peel and pomace, featuring a unique molecular structure that endows it with superior biological activity compared to conventional plant flavonoids. It is globally renowned for its powerful antioxidant, tyrosinase inhibition, anti-inflammatory, anti-tumor and metabolic regulation properties, widely applied in high-end skincare, dietary supplements, functional food and biomedical research fields. As a professional bulk Phloretin supplier, we provide high-purity, stable-batch compliant products for global industrial and research clients.
Phloretin belongs to the dihydrochalcone family, with distinct structural advantages that deliver multi-target efficacy. Its antioxidant capacity is 8–10 times higher than vitamin C and 2–3 times stronger than quercetin, enabling it to efficiently scavenge multiple free radicals and inhibit lipid peroxidation. In skincare applications, it acts as a classic brightening ingredient by blocking tyrosinase activity and melanin synthesis, while repairing skin barrier and relieving inflammation. In pharmacological research, Phloretin exhibits broad-spectrum anti-proliferative effects on tumor cells, regulates cell cycle and induces cancer cell apoptosis, making it a hot research compound in anti-tumor drug development. Additionally, it can improve metabolic homeostasis and inhibit fat accumulation, supporting weight management and lipid regulation.
Manufactured by Shaanxi BAISFU Bio-Engineering Co., Ltd., our premium Phloretin powder adopts low-temperature selective extraction and high-precision column chromatography purification technology. We strictly select fresh apple pomace and fruit peel raw materials to retain complete natural biological activity, removing macromolecular impurities and residual pigments through multi-stage purification. The entire production process avoids harmful solvent residues and chemical additives, complying with cosmetic-grade, food-grade and research-grade safety standards. This mature production process ensures consistent batch purity, stable solubility and reliable activity, meeting the rigorous requirements of high-end formula development and scientific experiments.
Every batch of Phloretin powder undergoes strict multi-stage quality inspection, including HPLC purity detection, UV spectral verification and NMR structural identification. The finished products feature uniform color, high solubility, low impurity content and stable biological activity. All products comply with international cosmetic safety regulations, food additive standards and research-grade raw material specifications, supporting safe and standardized application in skincare products, health supplements, functional foods and biomedical research projects.
We maintain sufficient inventory and complete qualification documents for bulk Phloretin supply. Whether you need brightening antioxidant raw materials for skincare formulas, metabolic regulation ingredients for health products, or high-purity compounds for anti-tumor pharmacological research, our Phloretin powder is a cost-effective and reliable bulk raw material choice for global buyers.
Functions & Benefits
Ultra-Strong Antioxidant & Anti-Aging (Core Benefit)
Phloretin delivers exceptional free radical scavenging capacity, effectively eliminating DPPH, ABTS and superoxide anion free radicals in the body and skin. It activates the Nrf2/ARE antioxidant pathway, upregulates endogenous antioxidant enzymes, inhibits cellular lipid peroxidation, reduces oxidative DNA damage, and delays skin and body aging. Its superior antioxidant performance far exceeds common natural antioxidants, providing long-term oxidative stress protection for cells.
Tyrosinase Inhibition & Skin Brightening
As a classic brightening active ingredient, Phloretin precisely inhibits tyrosinase activity, the core enzyme of melanin synthesis. It blocks melanin production and transfer, fades pigmentation, dullness and freckles, and evens skin tone. With mild and non-irritating properties, it penetrates the skin efficiently, brightens from the source, and is suitable for various high-end whitening and brightening skincare formulas.
Significant Anti-Inflammatory & Skin Repair
Phloretin effectively suppresses the release of pro-inflammatory cytokines and blocks chronic inflammatory signaling pathways. It relieves skin redness, sensitivity and inflammatory damage caused by external irritation, repairs damaged skin barriers, enhances skin tolerance, and improves fragile and sensitive skin conditions, achieving dual effects of soothing and repairing.
Broad-Spectrum Anti-Tumor & Cell Regulation
Modern pharmacological studies verify that Phloretin has excellent anti-tumor activity. It arrests tumor cell cycle progression, inhibits abnormal cell proliferation and angiogenesis, induces mitochondrial-mediated cancer cell apoptosis, and suppresses tumor metastasis. With low toxicity to normal cells, it is a key research compound for anti-tumor drug development and cancer auxiliary treatment research.
Metabolic Regulation & Weight Management
Phloretin optimizes human lipid and glucose metabolism, inhibits fat accumulation and liver lipid deposition, and improves metabolic homeostasis. It effectively reduces weight gain caused by high-fat diet, regulates blood lipid levels, and assists in improving sub-health metabolic disorders, with high application value in weight management health products.
UV Protection & Skin Barrier Stabilization
Phloretin resists UV-induced oxidative damage, reduces photodamage and photoaging of the skin, and alleviates sunburn and redness. It enhances skin water-locking capacity, stabilizes skin microenvironment, and maintains long-term skin health and elasticity.
Applications
High-End Cosmetics & Skincare
Phloretin is a core raw material for whitening essences, antioxidant anti-aging serums, soothing repair creams and sensitive skincare products. It is widely used in brightening, anti-oxidation, anti-photoaging and skin barrier repair formulas in clean beauty products.
Dietary Supplements & Functional Foods
Applied in antioxidant health supplements, metabolic regulation formulas, anti-aging nutritional products and weight management functional foods. It provides natural antioxidant and metabolic conditioning effects for daily health care.
Biomedical & Scientific Research
Widely used in tumor pharmacological research, cell cycle regulation experiments, anti-inflammatory mechanism studies and metabolic disease research, serving as a standard high-purity research compound for university laboratories and medical research institutions.
Pharmaceutical Intermediate Development
Acts as a key flavonoid intermediate for innovative drug development targeting anti-tumor, anti-inflammation and metabolic regulation, supporting the research and iteration of targeted therapeutic drugs.
Health Care Product Formulations
Used in daily anti-aging, antioxidant and metabolic conditioning health products, providing safe and efficient natural active ingredients for long-term body sub-health improvement.
FAQ
Q1: What is Phloretin powder used for?
A: Phloretin powder is a high-activity natural dihydrochalcone compound. It is mainly used for skincare brightening and anti-oxidation, skin soothing and repair, body anti-inflammatory conditioning, metabolic regulation, and biomedical anti-tumor pharmacological research.
Q2: Is Phloretin safe for skincare and oral use?
A: Yes, it is a natural apple-derived active ingredient with mild properties, high safety and no irritation. It complies with global cosmetic and food safety standards, supporting long-term topical skincare application and oral health product addition.
Q3: What are the core advantages of Phloretin?
A: Phloretin integrates ultra-strong anti-oxidation, whitening, anti-inflammation and anti-tumor efficacy. Its antioxidant activity is far higher than ordinary vitamins and flavonoids, with efficient skin penetration and multi-target regulation functions, featuring higher comprehensive value than conventional plant extracts.
Q4: How should Phloretin be stored?
A: Phloretin powder is sensitive to strong light, high temperature and moisture. It needs tight sealing and storage in a cool, dry and dark environment. The standard shelf life is 24 months under proper storage conditions.
Q5: Can I get free Phloretin samples?
A: Yes, we provide free Phloretin powder samples for skincare formula testing, health product debugging and academic research. Bulk orders support customized purity and packaging to meet diverse production and research needs.
