Parthenolide CAS 20554-84-1 Sesquiterpene Lactone from Tanacetum parthenium

Product Identification

Description

Parthenolide is a germacranolide-type sesquiterpene lactone​ carrying an α-methylene-γ-lactone​ warhead (Michael acceptor) plus a furan epoxide — the structural basis for covalent modification of NF-κB pathway proteins (IκB kinase complex inhibition in literature). First isolated from Tanacetum parthenium(Feverfew), historically used in European traditional medicine for "occasional head tension / women's seasonal wellness".

Four commercial buckets:

• DTC Feverfew / "Migraine-Support" Soft Positioning (DTC biggest):​ Feverfew 300–400 mg capsules, often blended with Butterbur, Magnesium, Riboflavin B2, CoQ10​ (migraine-adjacent stack — "women's wellness / occasional head tension" DTC archetype). ⚠️ Compliance:​ "Migraine" is Rx (triptans/ergots) in US/EU — DTC copy must land "traditional use / occasional headache wellness / women's seasonal", NOT "treat/prevent migraine" (FDA warning letters exist on feverfew brands). Search cluster: "feverfew supplement", "Tanacetum parthenium capsules".
• NF-κB & Anticancer R&D (B2B high-value):​ Parthenolide is the canonical NF-κB probe molecule​ — dozens of papers on IKK/NF-κB, cytokine storm, AML (parthenolide induces apoptosis in AML blasts in literature), pancreatic/colon lines. B2B R&D procurement: "parthenolide NF-kappa-B inhibitor", "sesquiterpene lactone probe", "parthenolide anticancer R&D". Links to Taima's Quercetin 117-39-5 (senolytic D+Q)​ and Artemisinin 63968-64-9 (anticancer R&D)​ — "sesquiterpene + flavonoid R&D" inner-link cluster.
• Cosmeceutical Soothing (emerging):​ Feverfew P.E. (Parthenolide-std) is a recurring actives in KR/JP clean beauty — "soothing / sensitive skin / scalp care", often "Centella + Feverfew + Luteolin"​ triple (links to Luteolin CAS 491-70-3 page, "Centella + Luteolin" combo). INCI Tanacetum Parthenium (Feverfew) Extract.
• Reference Standard / Feverfew P.E. QC:​ pure ≥98% HPLC for quantifying Parthenolide in Feverfew extracts (HPLC method: Parthenolide as single peak marker, 0.2%–0.8% in crude P.E.).

Applications

DTC Feverfew Capsules​ – Tanacetum parthenium300–400 mg, traditional use positioning ("occasional head tension / women's seasonal wellness"); often stacked Butterbur + Magnesium + Riboflavin B2 + CoQ10; "migraine" is Rx — keep DTC to structure-function / traditional use language

NF-κB & Anticancer R&D​ – Parthenolide as canonical NF-κB probe (IKK complex inhibition literature); AML/apoptotic pathways; cytokine-storm screening; "sesquiterpene lactone R&D" cluster (inner-link to Quercetin senolytic / Artemisinin anticancer)

Cosmeceutical Soothing​ – Feverfew P.E. (Parthenolide-std) in sensitive-skin / scalp serums; "Centella + Feverfew + Luteolin" KR/JP clean-beauty triple; INCI Tanacetum Parthenium Extract

Feverfew P.E. Bulk (TCM-export / DTC brand)​ – std. to Parthenolide 0.2% / 0.5% / 0.8% HPLC; 10:1 crude also available

Reference Standard (≥98%)​ – for Feverfew P.E. QC, NF-κB assay reagent, formulation R&D