Product Introduction
| Item | Specification |
| Product Name | Hesperetin |
| Synonyms | 5,7,3′-Trihydroxy-4′-methoxyflavanone; (2S)-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one; Hesperetol; |
| CAS Number | 69097-99-0 |
| Molecular Formula | C₁₆H₁₄O₆ |
| Molecular Weight | 302.28 g/mol |
| Appearance | Pale yellow needle crystalline powder |
| Purity (HPLC) | ≥98.0% / ≥99.0% (customizable) |
| Loss on Drying | ≤ 1.0% |
| Residue on Ignition | ≤ 0.2% |
| Testing Method | HPLC / UV-Vis Spectroscopy / NMR |
| Production Method | Natural Plant Extraction & High-Purity Column Purification |
| Melting Point | 226–228°C |
| Boiling Point | 586.3±50.0 °C (Predicted) |
| Solubility | Soluble in ethanol, methanol, DMSO, acetone and dilute alkaline solution; slightly soluble in hot water; insoluble in cold water and neutral aqueous solution |
| Natural Source | Naturally extracted from citrus peels such as sweet orange, tangerine and lemon, a core bioactive flavanone compound in citrus plants |
| Package | 1 kg/aluminum foil bag, 25 kg/fiber drum; custom packaging available |
| Storage | Store at -20°C in sealed, dark and dry conditions; avoid high temperature, strong light, oxidation and alkaline environment |
| Shelf Life | 24 months under standard low-temperature sealed storage |
Product Description
Our Hesperetin powder is a high-purity natural citrus flavanone active ingredient, available in 98% and 99% HPLC grades. Hesperetin (CAS69097-99-0), commonly known as , is a premium bioactive compound isolated from citrus peels including sweet orange and tangerine. As the aglycone form of hesperidin, Hesperetin features higher bioavailability and stronger biological activity than hesperidin glycoside, possessing multi-dimensional pharmacological properties such as powerful anti-oxidation, broad-spectrum anti-inflammation, vascular protection, lipid metabolism regulation and anti-tumor activity. It is widely applied in antioxidant anti-aging skincare, cardiovascular health supplements, lipid-regulating functional products and biomedical pharmacological research. As a professional bulk Hesperetin supplier, we provide high-purity, stable-batch and fully compliant products for global industrial and scientific research clients.
Hesperetin belongs to the flavanone subclass of flavonoids, with a unique polymethoxy and polyhydroxy substituted molecular structure that endows it with excellent biochemical stability and high cell permeability. Its core functional mechanism focuses on activating the Nrf2 antioxidant pathway and inhibiting the NF-κB inflammatory cascade, efficiently scavenging intracellular reactive oxygen species, reducing oxidative stress damage, and blocking the release of multiple pro-inflammatory cytokines. In vascular health regulation, Hesperetin enhances endothelial cell vitality, improves microcirculation, maintains vascular elasticity, and effectively regulates blood lipid levels by inhibiting lipid peroxidation and abnormal fat accumulation. In addition, modern pharmacological studies confirm that Hesperetin significantly inhibits the proliferation, migration and invasion of various tumor cells, induces tumor cell apoptosis, and exerts mild anti-allergic and antiviral effects, with broad application value in health care and pharmaceutical research.
Manufactured by Shaanxi BAISFU Bio-Engineering Co., Ltd., our premium Hesperetin powder adopts low-temperature water-alcohol selective extraction and multi-stage high-precision column chromatography purification technology. We select high-quality fresh citrus peel raw materials with stable active content, completely remove plant fibers, macromolecular impurities, hesperidin glycoside residues and invalid components through gradient elution purification, and fully retain the natural flavanone active structure and high biological activity of Hesperetin. The entire production process strictly avoids harmful solvent residues and chemical synthetic additives, fully complying with cosmetic-grade, food-grade and research-grade safety standards. The mature and stable production process ensures consistent batch purity, uniform powder appearance and reliable activity stability, meeting the strict formula development and experimental requirements of global customers.
Every batch of Hesperetin powder undergoes strict multi-dimensional quality inspection, including HPLC purity testing, UV spectral characteristic verification and NMR structural identification to ensure accurate molecular structure and stable high purity. The finished pale yellow needle crystalline powder features low impurity content, good solubility in organic solvents and excellent batch consistency. All products comply with international cosmetic additive regulations, national food additive safety standards (GB 2760-2024) and research-grade compound specifications, supporting safe and standardized application in skincare products, health supplements and biomedical research projects.
We maintain sufficient inventory and complete qualification documents for bulk Hesperetin supply. Whether you need antioxidant anti-inflammatory raw materials for skincare formulas, vascular protection and lipid regulation ingredients for health products, or high-purity citrus flavanone compounds for oxidative stress, inflammation and tumor pharmacological research, our Hesperetin powder is a cost-effective and reliable bulk raw material choice for global buyers.
Functions & Benefits
High-Efficiency Nrf2 Antioxidant & Anti-Aging (Core Benefit)
Hesperetin is a high-activity natural citrus antioxidant that specifically activates the Nrf2/HO-1 signaling pathway. It efficiently scavenges DPPH, ABTS and intracellular reactive oxygen free radicals, inhibits cellular lipid peroxidation and oxidative DNA damage, enhances the body’s endogenous antioxidant defense capacity, reduces long-term oxidative stress aging, and delays skin and systemic aging processes comprehensively.
Broad-Spectrum Anti-Inflammatory & Anti-Allergic
This natural flavanone effectively inhibits the activation of NF-κB inflammatory pathway, significantly reducing the release of TNF-α, IL-6 and other pro-inflammatory factors. It relieves skin inflammatory redness, swelling and sensitivity, improves chronic low-grade inflammation in the body, and exerts mild anti-allergic effects to stabilize skin microecology without irritation or side effects.
Vascular Protection & Microcirculation Improvement
Hesperetin protects vascular endothelial cells from oxidative damage, enhances vascular wall elasticity, improves human microcirculation, reduces vascular permeability and fragility, and assists in maintaining cardiovascular system health. It is a classic natural vascular-protective active ingredient with mild and stable efficacy.
Lipid Metabolism Regulation & Metabolic Health
Modern nutritional studies verify that Hesperetin can inhibit lipid peroxidation and excessive fat accumulation, regulate blood lipid balance, improve metabolic disorders caused by high-fat diets, reduce body lipid deposition, and effectively improve sub-health problems such as slow metabolism and hyperlipidemia tendency.
Anti-Tumor Proliferation & Cell Cycle Regulation
Hesperetin inhibits the proliferation, migration and invasion of various tumor cells, blocks abnormal tumor cell cycle progression, and induces tumor cell apoptosis with extremely low toxicity to normal human cells. It is an important research compound for anti-tumor auxiliary mechanism exploration and functional formula development.
Skin Barrier Repair & Brightening Care
Hesperetin relieves skin oxidative damage and inflammatory irritation caused by external UV and environmental stimuli, reduces pigmentation precipitation and skin dullness, enhances skin barrier tolerance and self-repair ability, and brightens and evens skin tone for long-term skin maintenance.
Applications
Antioxidant Anti-Aging Skincare Products
Hesperetin is widely used in antioxidant anti-aging essences, soothing repair creams, brightening skincare products and sensitive skin care formulas. It scavenges skin free radicals, relieves inflammatory sensitivity, repairs damaged skin barriers, fades dullness, and is a high-quality natural active ingredient for clean beauty skincare.
Cardiovascular & Lipid-Regulating Health Supplements
Applied in vascular-protective nutritional formulas, blood lipid regulation supplements and daily cardiovascular health care products. It protects vascular endothelium, optimizes lipid metabolism, improves microcirculation, and provides natural and mild cardiovascular system maintenance for sub-health groups.
Functional Food & Beverage Additives
Compliant with GB 2760-2024 food additive standards, Hesperetin is used in functional beverages, nutritional fortified foods, candy and dairy products. It serves as a natural antioxidant and functional additive to enhance product nutritional value and stability.
Biomedical & Scientific Research
Widely used in Nrf2 antioxidant mechanism research, inflammatory pharmacology experiments, vascular endothelial protection research, lipid metabolism regulation and tumor cell biology studies, serving as a standard high-purity research compound for university laboratories and medical research institutions.
Natural Functional Ingredient Development
Acts as a high-value natural citrus flavanone intermediate for innovative functional product development, supporting the research and iteration of antioxidant, anti-inflammatory, vascular-protective and metabolic-regulating natural raw materials.
FAQ
Q1: What is Hesperetin powder used for?
A: Hesperetin (Hesperetin powder) is a high-activity natural citrus flavanone extracted from orange peel. It is mainly used for skincare antioxidant anti-aging and barrier repair, body anti-inflammation and anti-allergy, vascular protection and lipid metabolism regulation, as well as biomedical oxidative stress and anti-tumor pharmacological research.
Q2: Is Hesperetin safe for cosmetic and health product use?
A: Yes, Hesperetin is a pure natural plant-derived active ingredient with mild properties, low irritation and high safety. It complies with international cosmetic raw material standards and national GB 2760 food additive specifications, supporting long-term topical skincare application and oral health product addition.
Q3: What are the core advantages of Hesperetin?
A: Hesperetin is the high-bioavailability aglycone form of hesperidin, with stronger antioxidant and anti-inflammatory activity. It integrates skincare repair, vascular protection and lipid regulation multi-effects, featuring stable molecular activity, mild efficacy and comprehensive functional advantages superior to ordinary citrus flavonoids.
Q4: How to store Hesperetin powder correctly?
A: Hesperetin powder is sensitive to high temperature, strong light, oxidation and alkaline environments. It needs to be tightly sealed and stored at -20°C in a dark and dry environment. Standard low-temperature sealed storage ensures a 24-month valid shelf life.
Q5: Can I get free Hesperetin samples?
A: Yes, we provide free Hesperetin powder samples for skincare formula debugging, functional food development and academic pharmacological research. Bulk orders support customized purity and packaging to meet diverse production and research needs.
