Product Introduction
| Item | Specification |
| Product Name | Neohesperidin |
| Synonyms | Neohesperidoside;5-Hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy-2,3-dihydrochromen-4-one |
| CAS Number | 13241-33-3 |
| Molecular Formula | C₂₈H₃₄O₁₅ |
| Molecular Weight | 610.56 g/mol |
| Appearance | White crystalline powder / white needle crystal |
| Purity (HPLC) | ≥98.0% / ≥99.0% (customizable) |
| Loss on Drying | ≤ 1.0% |
| Residue on Ignition | ≤ 0.2% |
| Testing Method | HPLC / UV-Vis Spectroscopy / NMR |
| Production Method | Natural Citrus Peel Extraction & High-Purity Column Purification |
| Melting Point | 236–243°C |
| Boiling Point | 975.4±65.0 °C (Predicted) |
| Solubility | Soluble in hot water, ethanol, methanol and DMSO; slightly soluble in cold water; insoluble in petroleum ether |
| Natural Source | Naturally extracted from citrus peel of orange, grapefruit and pomelo, a characteristic bioactive flavonoid glycoside in Rutaceae plants |
| Package | 1 kg/aluminum foil bag, 25 kg/fiber drum; custom packaging available |
| Storage | Store at -20°C in sealed, dark and dry conditions; avoid high temperature, strong light and oxidation |
| Shelf Life | 24 months under standard low-temperature sealed storage |
Product Description
Our Neohesperidin powder is a high-purity natural citrus flavonoid glycoside active ingredient, available in 98% and 99% HPLC grades. Neohesperidin (CAS 13241-33-3), known as is a premium bioactive monomer isolated from citrus peel tissues such as pomelo, grapefruit and sweet orange. As a unique dihydroflavonoid rutinoside compound, it features a stable and complete glycoside molecular structure, excellent safety and multi-dimensional pharmacological activity. Different from common hesperidin and naringin, Neohesperidin possesses stronger metabolic regulation, anti-oxidation and tissue protection capabilities, widely applied in soothing antioxidant skincare, metabolic balance health supplements, liver protection products and biomedical scientific research. As a professional bulk Neohesperidin supplier, we provide high-purity, stable-batch and fully compliant citrus flavonoid raw materials for global industrial and research clients.
Neohesperidin belongs to the flavonoid glycoside family, with a complete rutinoside sugar chain structure attached to the flavanone parent nucleus, endowing it with moderate water solubility and excellent biological compatibility. Its core functional mechanism focuses on activating the Nrf2/HO-1 antioxidant pathway and inhibiting NF-κB and MAPK inflammatory cascades, efficiently scavenging intracellular ROS free radicals, reducing oxidative stress damage, and suppressing the release of multiple pro-inflammatory cytokines. In metabolic regulation, Neohesperidin significantly improves insulin resistance, reduces blood sugar and blood lipid levels, inhibits liver lipid accumulation, and effectively improves hyperlipidemia and hyperglycemia symptoms caused by high-fat and high-sugar diets. It also exerts prominent hepatoprotective, anti-aging, bone-protective and anti-allergic effects, with mild properties and no toxic side effects, suitable for long-term oral and topical application.
Manufactured by Shaanxi BAISFU Bio-Engineering Co., Ltd., our premium Neohesperidin powder adopts low-temperature water-alcohol selective extraction and multi-stage high-precision column chromatography purification technology. We select high-quality fresh citrus peel raw materials with stable active content, completely remove peel pectin, plant fibers, residual sugar and macromolecular impurities through gradient elution purification, and fully retain the complete molecular structure and biological activity of Neohesperidin. The entire production process avoids harmful solvent residues and chemical synthetic additives, fully complying with cosmetic-grade, food-grade and research-grade safety standards. The mature and stable production process ensures consistent batch purity, uniform powder appearance and reliable activity stability, meeting the strict formula development and experimental requirements of global customers.
Every batch of Neohesperidin powder undergoes strict multi-dimensional quality inspection, including HPLC purity testing, UV spectral characteristic verification and NMR structural identification to ensure accurate molecular structure and stable high purity. The finished white crystalline powder features low impurity content, good solubility in common organic solvents and hot water, and outstanding batch consistency. All products comply with international cosmetic additive regulations, natural functional food safety standards and research-grade compound specifications, supporting safe and standardized application in skincare products, functional foods, health supplements and biomedical research projects.
We maintain sufficient inventory and complete qualification documents for bulk Neohesperidin supply. Whether you need antioxidant and soothing raw materials for skincare formulas, blood sugar and lipid regulation ingredients for metabolic health products, or high-purity citrus flavonoid glycoside compounds for oxidative stress, inflammation and metabolic pharmacological research, our Neohesperidin powder is a cost-effective and reliable bulk raw material choice for global buyers.
Functions & Benefits
Nrf2 Antioxidant & Anti-Aging (Core Benefit)
Neohesperidin is a high-efficiency natural citrus antioxidant. It specifically activates the Nrf2/HO-1 endogenous antioxidant signaling pathway, efficiently scavenges DPPH, ABTS and intracellular reactive oxygen free radicals, inhibits cellular lipid peroxidation and oxidative DNA damage, enhances the body’s endogenous antioxidant defense system, and delays skin and systemic aging caused by long-term oxidative stress.
Broad-Spectrum Anti-Inflammatory & Anti-Allergic Soothing
This natural flavonoid glycoside effectively inhibits the activation of NF-κB and MAPK inflammatory pathways, significantly reducing the release of TNF-α, IL-6 and other pro-inflammatory factors. It relieves acute and chronic low-grade inflammation in the body, calms skin redness, swelling and sensitivity caused by external stimuli, stabilizes skin microecology, and delivers mild and durable soothing and anti-allergic repair effects.
Blood Lipid & Blood Sugar Metabolic Regulation
Modern pharmacological studies verify that Neohesperidin can effectively improve insulin resistance, enhance glucose tolerance, reduce serum triglyceride and total cholesterol levels, inhibit liver lipid accumulation and fat peroxidation, and significantly improve metabolic disorders such as hyperlipidemia and hyperglycemia, providing natural and mild metabolic conditioning effects.
Hepatoprotective & Liver Fat Regulation
Neohesperidin protects liver parenchymal cells from oxidative damage and metabolic toxic stimulation, inhibits liver inflammatory infiltration and fat deposition, optimizes liver detoxification and lipid metabolism functions, repairs mild liver damage, and effectively improves fatty liver and liver sub-health caused by abnormal metabolism.
Bone Protection & Anti-Osteoporosis Activity
In vivo experiments confirm that Neohesperidin can effectively inhibit bone loss, improve bone density, regulate bone metabolism balance, and has significant protective effects on bone tissue, with unique application value in bone health care products.
Skin Barrier Repair & Anti-Oxidation Stabilization
With excellent skin compatibility and antioxidant activity, Neohesperidin penetrates the skin to scavenge deep free radicals, relieve UV and environmental oxidative damage, repair damaged skin barriers, reduce moisture loss and skin dullness, and maintain long-term healthy and stable skin condition.
Applications
Antioxidant Soothing & Anti-Aging Skincare
Neohesperidin is widely used in antioxidant anti-aging essences, sensitive skin soothing creams, post-sun repair products and daily barrier maintenance formulas. It scavenges skin free radicals, calms inflammatory sensitivity, repairs damaged barriers, resists light aging, and is a high-value mild natural citrus active ingredient for clean beauty skincare.
Metabolic & Liver Protection Health Supplements
Applied in blood sugar and lipid regulation formulas, fatty liver conditioning supplements, cardiovascular health products and daily metabolic sub-health care products. It optimizes human glucose and lipid metabolism, protects liver and vascular health, improves insulin sensitivity, and provides comprehensive metabolic balance conditioning for sub-health groups.
Functional Food & Nutritional Fortification
As a safe natural citrus flavonoid, Neohesperidin is widely used in functional health foods, nutritional fortified products and daily dietary supplements. It enhances product antioxidant and metabolic regulation efficacy, with high safety and stable properties, suitable for long-term nutritional addition.
Biomedical & Scientific Research
Widely used in Nrf2 antioxidant mechanism research, inflammatory pathway pharmacology, glucose and lipid metabolism regulation, liver protection pharmacodynamics and bone metabolism research, serving as a standard high-purity citrus flavonoid glycoside research compound for university laboratories and medical research institutions.
Natural Functional Ingredient Innovation
Acts as a high-value citrus flavonoid intermediate for innovative functional product development, supporting the research and iteration of antioxidant, anti-inflammatory, metabolic regulation and liver-protective natural raw materials.
FAQ
Q1: What is Neohesperidin powder used for?
A: Neohesperidin powder is a high-purity natural citrus flavonoid glycoside extracted from citrus peel. It is mainly used for antioxidant anti-aging and sensitive skin soothing skincare, blood sugar & lipid regulation and liver protection conditioning, as well as biomedical anti-inflammation, metabolic pharmacology and bone protection research.
Q2: What is the difference between Neohesperidin and Hesperidin?
A: Both are citrus flavonoid glycosides. Neohesperidin has stronger metabolic regulation, hypoglycemic and lipid-lowering activity, as well as better anti-oxidation and liver protection effects; Hesperidin focuses more on vascular protection and anti-edema. Neohesperidin shows more comprehensive advantages in metabolic health and anti-aging scenarios.
Q3: Is Neohesperidin safe for long-term use?
A: Yes, Neohesperidin is a pure natural citrus-derived active ingredient with ultra-mild properties, low irritation and high biocompatibility. It complies with international cosmetic raw material standards and food-grade safety specifications, supporting long-term topical skincare and oral health product application.
Q4: What are the core advantages of Neohesperidin?
A: Neohesperidin features excellent metabolic regulation activity, with unique hypoglycemic, lipid-lowering and bone-protective effects that distinguish it from other citrus flavonoids. It integrates anti-oxidation, anti-inflammation and liver protection multi-effects, with stable molecular activity and wide application value.
Q5: How to store Neohesperidin powder correctly?
A: Neohesperidin powder is sensitive to high temperature, strong light and oxidation. It needs to be tightly sealed and stored at -20°C in a dark and dry environment. Standard low-temperature sealed storage ensures a 24-month valid shelf life.
Q6: Can I get free Neohesperidin samples?
A: Yes, we provide free Neohesperidin powder samples for skincare formula debugging, functional food development and academic pharmacological research. Bulk orders support customized purity and packaging to meet diverse production and research needs.
