Product Introduction
| Item | Specification |
| Product Name | Hamamelitannin |
| Synonyms | Hamamelis tannin; 2′,5-Digalloyl-hamamelofuranose |
| CAS Number | 469-32-9 |
| Molecular Formula | C₂₀H₂₀O₁₄ |
| Molecular Weight | 484.36 g/mol |
| Appearance | White to off-white crystalline powder |
| Purity (HPLC) | ≥98.0% / ≥99.0% (customizable) |
| Loss on Drying | ≤ 1.0% |
| Residue on Ignition | ≤ 0.2% |
| Testing Method | HPLC / UV-Vis Spectroscopy / NMR |
| Production Method | Natural Plant Extraction & High-Purity Column Purification |
| Melting Point | 145–147°C |
| Density | 1.77±0.1 g/cm³ |
| Solubility | Soluble in water, methanol, ethanol and polar solvents, excellent water solubility for aqueous cosmetic formulas |
| Natural Source | Naturally extracted from Hamamelis virginiana (Witch Hazel) bark and leaves, the core active gallotannin monomer of witch hazel extract |
| Package | 1 kg/aluminum foil bag, 25 kg/fiber drum; custom packaging available |
| Storage | Store at 2-8°C in sealed, dark and dry conditions; avoid high temperature and oxidation |
| Shelf Life | 24 months under standard low-temperature sealed storage |
Product Description
Our Hamamelitannin powder is a high-purity natural gallotannin active ingredient, available in 98% and 99% HPLC grades. Hamamelitannin (CAS 469-32-9), known as is the signature core active monomer of natural Witch Hazel, delivering far higher efficacy and stability than conventional witch hazel crude extracts. As a unique galloyl-type tannin compound, it features excellent water solubility, mild skin-friendly activity and multi-dimensional cosmetic efficacy, integrating targeted anti-biofilm antibacterial, rapid anti-inflammatory, high-efficiency antioxidant and sebum-regulating properties. It serves as the key functional substance behind classic witch hazel soothing, purifying and oil-controlling skincare effects, widely applied in calming toners, acne repair products, oily skin conditioning formulas and anti-infection biomedical research. As a professional bulk Hamamelitannin supplier, we provide high-purity, low-impurity, high-activity witch hazel tannin raw materials for global cosmetic manufacturers and scientific research institutions.
Hamamelitannin belongs to the high-value gallotannin subclass of natural polyphenols, with distinct functional positioning different from ellagitannins such as Geraniin and Corilagin. It possesses unique quorum sensing inhibitory and anti-bacterial biofilm advantages, forming a differentiated efficacy system with other tannin ingredients. Unlike Geraniin’s anti-glycation whitening and hypoglycemic effects and Corilagin’s anti-fibrosis and lipid-lowering properties, Hamamelitannin specializes in targeting skin surface microbial imbalance and oily skin problems. It effectively inhibits Staphylococcus aureus biofilm formation, blocks bacterial adhesion and reproduction, and fundamentally improves recurrent inflammatory acne and pore inflammation caused by microbial imbalance. Its abundant phenolic hydroxyl groups rapidly scavenge DPPH, ABTS and superoxide anion free radicals, relieve UV-induced redness and daily inflammatory irritation, and stabilize skin microecology. Benefiting from superior water solubility, it is perfectly compatible with various water-based skincare systems, easier to formulate and more stable than other tannin monomers.
Manufactured by Shaanxi BAISFU Bio-Engineering Co., Ltd., our premium Hamamelitannin powder adopts low-temperature water-alcohol directional extraction and multi-stage high-precision column chromatography purification technology. We select high-quality natural Hamamelis virginiana bark raw materials with stable active content, completely remove plant fibers, invalid tannin polymers, pigments and macromolecular impurities through gradient elution purification, and fully retain the high-activity monomer structure and biological potency of Hamamelitannin. The entire production process eliminates harmful solvent residues and chemical synthetic additives, fully complying with cosmetic-grade and research-grade safety standards. The refined purification technology solves the defects of low active content, mixed impurities and unstable efficacy of traditional witch hazel extracts, ensuring uniform powder appearance, stable batch activity and excellent water solubility for standardized formula development.
Every batch of Hamamelitannin powder undergoes strict multi-dimensional quality inspection, including HPLC high-precision purity testing, UV spectral characteristic verification and NMR structural identification to ensure accurate molecular structure and stable high purity. The finished powder features low impurity content, strong water solubility, mild activity and outstanding batch consistency. All products comply with international cosmetic additive regulations and natural plant ingredient safety standards, supporting safe and standardized application in daily calming skincare, oily acne skin conditioning and biomedical pharmacological research.
We maintain sufficient inventory and complete qualification documents for bulk Hamamelitannin supply. Whether you need high-efficiency soothing and antibacterial active raw materials for calming skincare formulas, oil-control purifying ingredients for oily and acne-prone skin products, or high-purity natural tannin monomers for anti-biofilm pharmacological research, our Hamamelitannin powder is a cost-effective and high-value bulk raw material choice for global buyers.
Functions & Benefits
Anti-Biofilm Antibacterial & Microecology Stabilization (Core Benefit)
Hamamelitannin acts as a natural quorum sensing inhibitor, featuring excellent inhibitory activity against skin harmful bacteria such as Staphylococcus aureus. It effectively dissolves and blocks bacterial biofilm formation, inhibits bacterial adhesion and proliferation on the skin surface, reduces bacterial-induced pore blockage, inflammatory swelling and recurrent acne problems. Different from ordinary bacteriostatic ingredients, it does not damage beneficial skin flora, gently regulates skin microbial balance, and avoids barrier damage caused by excessive sterilization.
Rapid Anti-Inflammatory & Skin Calming
It suppresses NF-κB inflammatory signaling pathway and reduces the release of pro-inflammatory factors, rapidly relieves skin redness, stinging and swelling caused by UV stimulation, bacterial infection and external irritation. With ultra-mild skin-friendly properties, it calms sensitive discomfort, stabilizes fragile skin barriers, and provides instant soothing maintenance for stressed skin.
High-Efficiency Antioxidant & Anti-Aging Protection
Hamamelitannin exhibits potent superoxide anion free radical scavenging capacity, with superior cell protection activity compared with gallic acid. It efficiently eliminates intracellular oxidative stress, inhibits lipid peroxidation and fibroblast oxidative damage, reduces skin dullness and rough texture caused by oxidation, and builds a gentle and long-term endogenous antioxidant defense barrier for daily skin anti-aging maintenance.
Sebum Regulation & Pore Purification
As the core active ingredient of witch hazel, it mildly regulates skin sebum secretion, improves excessive oiliness and shiny skin, unclogs accumulated pore metabolites, refines rough enlarged pores, and maintains long-lasting oil-water balance for oily and combination skin.
Broad-Spectrum Antiviral & Cytoprotective Effect
Modern pharmacological studies confirm that Hamamelitannin has broad-spectrum antiviral activity and can protect endothelial cells from inflammatory damage. It reduces oxidative and inflammatory stress damage to skin cells, enhances skin self-resistance to external environmental stimulation, and improves sub-health skin condition.
Selective Anti-Tumor & Research Value
Hamamelitannin presents specific cytotoxic activity against colon cancer cells and inhibits tumor cell proliferation and migration, showing good tumor chemoprevention potential. It is widely used in biomedical research on quorum sensing inhibition, anti-biofilm mechanism and tumor cell apoptosis.
Applications
Calming & Sensitive Soothing Skincare
Hamamelitannin is widely used in witch hazel calming toners, post-sun repair lotions, sensitive soothing essences and daily mild skincare formulas. It integrates anti-inflammatory soothing, antioxidant maintenance and microecology stabilization multi-effects, effectively improving skin redness, sensitivity and dullness, serving as the core high-activity substitute for traditional low-purity witch hazel extracts.
Oily & Acne-Prone Skin Care
Applied in oil-control purifying essences, inflammatory acne repair creams and pore-refining skincare products. It targets bacterial biofilm-induced recurrent acne, pore inflammation and excessive sebum secretion, purifies clogged pores, improves oily skin dullness and roughness, and maintains long-term skin cleanliness and freshness.
Antioxidant & Protective Functional Formulas
Used in daily antioxidant skincare and mild protective functional products. It relieves skin oxidative damage caused by environmental stress, delays mild skin aging, stabilizes skin oil-water balance, and improves overall skin health status for long-term daily maintenance.
Biomedical & Pharmacological Research
Widely used in natural quorum sensing inhibition research, bacterial biofilm resistance mechanism exploration, antiviral pharmacology and tumor cell apoptosis studies. It acts as a standard high-purity gallotannin monomer for laboratory pharmacological experiments and ingredient activity verification.
High-End Cosmetic Ingredient Innovation
As the high-purity core active monomer of witch hazel, it replaces inefficient and unstable crude witch hazel extracts. It upgrades the efficacy and safety of calming and oil-control skincare products, supports the innovative iteration of mild antibacterial, soothing and pore-purifying cosmetic formulas, and enriches the application system of natural tannin skincare ingredients.
FAQ
Q1: What is Hamamelitannin powder used for?
A: Hamamelitannin powder is a high-purity natural witch hazel gallotannin monomer. It is mainly used for skincare soothing, antibacterial purification, oily skin oil control and acne repair, as well as biomedical anti-biofilm, antioxidant and anti-tumor pharmacological research.
Q2: What are the unique advantages of Hamamelitannin?
A: Different from ellagitannin ingredients like Corilagin and Geraniin, Hamamelitannin features excellent water solubility and exclusive anti-bacterial biofilm & quorum sensing inhibitory activity. It targets skin microbial imbalance and oily acne problems with ultra-mild properties, perfectly fitting aqueous skincare formulas and daily sensitive skin maintenance scenarios.
Q3: Is Hamamelitannin safe for cosmetic use?
A: Yes, Hamamelitannin is a pure natural plant-derived active ingredient extracted from traditional cosmetic-grade witch hazel. It features ultra-mild properties, low irritation and high skin affinity, fully complying with international cosmetic additive safety standards, suitable for long-term daily skincare application.
Q4: What is the difference between Hamamelitannin and other tannins?
A: Ellagitannins focus on anti-glycation, anti-fibrosis and metabolic regulation, while Hamamelitannin specializes in mild antibacterial biofilm inhibition, oil control and skin calming. It has irreplaceable advantages in daily oily acne skincare and mild skin purification, forming a complementary functional system with other high-value tannin monomers.
Q5: How to store Hamamelitannin powder correctly?
A: Hamamelitannin powder is sensitive to high temperature and oxidation. It needs to be tightly sealed, protected from light, and stored at 2-8°C in a dry environment. Standard low-temperature sealed storage ensures a 24-month valid shelf life.
Q6: Can I get free Hamamelitannin samples?
A: Yes, we provide free Hamamelitannin powder samples for calming skincare formula debugging, oily skin product development and academic pharmacological research. Bulk orders support customized purity and packaging to meet diverse production and research needs.
