Product Introduction
| Item | Specification |
| Product Name | Genistein |
| Synonyms | 4′,5,7-Trihydroxyisoflavone; Genistein Soy Isoflavone; Dyestuff Genistein; 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one |
| CAS Number | 446-72-0 |
| Molecular Formula | C₁₅H₁₀O₅ |
| Molecular Weight | 270.24 g/mol |
| Appearance | Off-white to pale yellow fine crystalline powder, odorless or slight faint herbal aroma, stable texture, no caking under sealed dry and dark storage conditions |
| Purity (HPLC) | ≥98.0% / ≥99.0% (Research Grade / Premium Functional Grade, customizable) |
| Loss on Drying | ≤ 0.2% |
| Residue on Ignition | ≤ 0.1% |
| Testing Method | HPLC / NMR / Mass Spectrometry / IR Spectrum / Biological Activity Assay |
| Production Method | Soybean Raw Material Extraction + Alcohol Reflux Separation + Macroporous Resin Purification + Preparative HPLC Precision Refining + Low-Temperature Recrystallization |
| Melting Point | 297–298°C (lit., slight decomposition) |
| Boiling Point | 555.5±50.0°C at 760 mmHg (Predicted) |
| Density | 1.54 g/cm³ at 25°C |
| Flash Point | 209.7°C |
| Solubility | Almost insoluble in cold water, slightly soluble in hot water; freely soluble in ethanol, methanol, DMSO and acetone; insoluble in aliphatic hydrocarbon; stable in dry dark environment, sensitive to high temperature and strong ultraviolet irradiation |
| Core Feature | High-activity natural soybean isoflavone monomer, classic phytoestrogen ingredient, famous for tyrosine kinase inhibition, hormone regulation and multi-target antioxidant & anti-inflammatory pharmacological activities |
| Package | 1g/5g/10g amber sealed bottle, 100g/1kg vacuum drum; moisture-proof & light-proof vacuum packaging, customized specifications supported |
| Storage | Store in vacuum-sealed, low-temperature, dry and dark conditions; avoid high temperature, strong light and humid air to prevent molecular oxidation and activity attenuation |
| Shelf Life | 24 months under standard sealed low-temperature dark storage |
Product Description
Genistein (CAS 446-72-0), also known as 4′,5,7-Trihydroxyisoflavone, is the most biologically active single isoflavone monomer purified from natural soybean and legume plant seeds. As a representative phytoestrogen and tyrosine kinase inhibitor in modern phytopharmacology, Genistein features a unique isoflavone molecular structure with multiple active hydroxyl groups, delivering comprehensive high-value pharmacological properties including bidirectional estrogen regulation, powerful antioxidant, multi-path anti-inflammatory, anti-proliferation and metabolic balancing effects. We provide two premium industrial grades: Research Grade 98% HPLC and Premium Functional Grade 99% HPLC, produced through standardized soybean raw material sorting, low-temperature alcohol reflux extraction, multi-stage macroporous resin gradient impurity removal, preparative HPLC fine purification and low-temperature recrystallization. The fully enclosed dust-free light-shielded production system thoroughly eliminates soybean polysaccharides, plant proteins, miscellaneous isoflavone impurities, heavy metals and solvent residues, obtaining single-component high-purity Genistein powder with stable structural activity and zero experimental interference. Widely recognized in cell biology and nutritional pharmacology, Genistein has become a core tool compound for hormone regulation and tumor mechanism research, as well as a mainstream high-value raw material for women’s health care, anti-aging and metabolic balance functional products.
Different from ordinary mixed soybean isoflavone extracts with unstable component ratios and complex impurities, our purified single-component Genistein possesses definite molecular configuration, controllable bioavailability and standardized pharmacological efficacy, ensuring highly repeatable experimental data and consistent finished product effects. In hormone regulation, Genistein exerts unique bidirectional phytoestrogen activity, effectively balancing abnormal estrogen levels in the human body, relieving hormonal imbalance symptoms, and supporting physiological endocrine stability, which makes it irreplaceable in women’s health research and functional formula development. As a classic tyrosine kinase inhibitor, it precisely targets and inhibits related kinase activation, blocks abnormal cell proliferation signals, and serves as a key experimental reagent for tumor cell cycle and apoptosis mechanism research.
In terms of antioxidant and anti-inflammatory protection, high-purity Genistein efficiently scavenges intracellular reactive oxygen species, blocks lipid peroxidation chain reactions, reduces oxidative stress damage to tissues and organs, and delays cellular senescence progression. It also inhibits the activation of NF-κB and MAPK inflammatory signaling pathways, significantly reducing the secretion of pro-inflammatory cytokines such as TNF-α and IL-6, effectively relieving chronic low-grade inflammatory responses in the body. For metabolic regulation, Genistein optimizes lipid metabolism indicators, improves insulin sensitivity, and assists in maintaining systemic metabolic balance. In addition, it delivers outstanding anti-photoaging and skin-repairing effects, protecting skin cells from UV-induced oxidative damage and improving skin aging and dullness.
Manufactured by Shaanxi BAISFU Bio-Engineering Co., Ltd., our high-purity Genistein adopts a full-process low-temperature light-shielded closed production process. Strict parameter control is implemented during extraction and purification to avoid oxidative denaturation of active isoflavone structures, completely retaining the original hormone-regulating, antioxidant and anti-inflammatory biological activity. The finished product presents uniform off-white to pale yellow fine crystalline powder with delicate texture, no agglomeration, no discoloration and no peculiar smell, fully compliant with international food, health product and laboratory reagent grade standards.
Every batch of Genistein undergoes comprehensive multi-dimensional quality verification, including HPLC high-precision purity detection, NMR structural identification, mass spectrometry molecular weight confirmation and cell-level biological activity evaluation. Ultra-low residual impurities and excellent batch-to-batch consistency guarantee stable pharmacological activity and reliable experimental repeatability. With good solubility in conventional organic solvents and superior biocompatibility in cell culture and in vivo animal models, our Genistein adapts to diverse scientific research and industrial formulation scenarios. We support long-term bulk stable supply, customized purity grades and professional light-proof moisture-proof vacuum packaging, providing cost-effective high-quality Genistein raw materials for global research institutions, pharmaceutical laboratories, health supplement manufacturers and functional food enterprises.
Functions & Benefits
Bidirectional Phytoestrogen Regulation & Hormone Balance
As a core active soybean isoflavone, Genistein achieves bidirectional regulation of human estrogen levels, improves endocrine imbalance, relieves menopausal discomfort and maintains female physiological health, serving as the key ingredient for hormone-balancing functional products.
Powerful Antioxidant & Anti-Aging Activity
Multiple active hydroxyl groups efficiently eliminate excess intracellular free radicals, inhibit lipid peroxidation and oxidative tissue damage, delay cell and organ senescence progression, and provide comprehensive systemic anti-aging protection.
Multi-Target Anti-Inflammatory & Tissue Protection
Genistein blocks core inflammatory signaling pathway activation and reduces pro-inflammatory factor release, effectively relieving chronic low-grade inflammation, reducing inflammatory tissue damage and protecting multiple organ physiological functions.
Tyrosine Kinase Inhibition & Cell Regulation
Highly inhibits tyrosine kinase activity, blocks abnormal cell proliferation and migration signals, regulates cell cycle and apoptosis, and is widely used in tumor pharmacology and cell biology mechanism research.
Metabolic Balance & Vascular Health Support
Optimizes blood lipid metabolism, improves insulin sensitivity, reduces vascular oxidative damage and lipid deposition, and assists in maintaining cardiovascular and metabolic system stability.
Ultra-High Single Component Purity & Zero Experimental Interference
Adopting multi-stage HPLC fine purification and low-temperature recrystallization technology, our Genistein completely removes miscellaneous isoflavones, plant proteins and macromolecular residues. 98%–99% ultra-high single-component purity eliminates ingredient interference, ensuring accurate experimental results and standardized industrial formulation efficacy.
High Biological Safety & Wide Formulation Compatibility
Derived from natural edible soybean with mild properties and low toxicity, Genistein possesses excellent human body biocompatibility and stable formula adaptability, suitable for long-term application in scientific research, functional food and health supplement industries.
Applications
Hormone & Endocrine Regulation Pharmacology Research
Widely used as a standard isoflavone monomer for estrogen regulation, endocrine balance and menopausal physiology research, serving as a core experimental tool in nutritional pharmacology studies.
Tumor Cell Biology & Kinase Inhibition Research
Applied in tyrosine kinase inhibition, cell cycle regulation and tumor cell apoptosis mechanism research, supporting anti-tumor pharmacological mechanism exploration and related ingredient development.
Antioxidant & Anti-Inflammatory Mechanism Study
Key experimental compound for free radical scavenging, lipid oxidation inhibition and chronic inflammation intervention research, widely used in natural antioxidant pharmacological exploration.
Women’s Health & Hormone Balancing Functional Formulation
Used as a core functional additive for endocrine regulation, menopausal care and anti-aging health supplements, widely applied in high-end women’s health functional product production.
Metabolic Conditioning & Anti-Aging Functional Food
Widely added in metabolic balancing, lipid-regulating and anti-aging functional foods, providing safe and efficient natural isoflavone active nutrition for daily body health maintenance.
University Lab Teaching & Pharmacological Demonstration
Supplied as standard high-purity Genistein reagent for natural soybean isoflavone pharmacology, hormone regulation and cell biology teaching, ensuring accurate and stable experimental data for academic research and teaching demonstration.
FAQ
Q1: What is Genistein mainly used for?
A: Genistein is the core high-activity monomer of soybean isoflavones, mainly used in endocrine regulation, antioxidant and anti-inflammatory pharmacological research, as well as core raw material for women’s hormone balance health supplements and anti-aging functional products.
Q2: What is the advantage of high-purity Genistein over ordinary soybean extract?
A: Ordinary soybean extract contains mixed isoflavones, proteins and plant impurities with unstable efficacy. Our 98%/99% high-purity Genistein is a single purified monomer with definite structure, pure efficacy and no impurity interference, suitable for precise scientific research and high-end standardized formulation.
Q3: What are your product advantages?
A: Our Genistein is refined by multi-stage preparative HPLC to reach 98%–99% ultra-high purity, free of miscellaneous isoflavone impurities and solvent residues. It features stable hormone regulation, antioxidant and anti-inflammatory activity, excellent batch consistency and high experimental repeatability, fully compliant with international industrial and laboratory standards.
Q4: How to store Genistein correctly?
A: Genistein is sensitive to high temperature, strong light and humid air, prone to oxidative deactivation. It must be vacuum-sealed and stored in low-temperature, dry and dark conditions to maintain complete biological activity within the 24-month shelf life.
Q5: What does high-purity Genistein look like?
A: Standard high-purity Genistein is uniform off-white to pale yellow fine crystalline powder at room temperature, with faint herbal aroma, stable texture, no caking and no discoloration under standard sealed storage.
Q6: Can I get free Genistein samples?
A: Yes, we provide free Genistein samples for academic research, pharmacological efficacy verification and product formula testing. Bulk orders support customized purity and exclusive light-proof vacuum packaging to meet scientific research and industrial production demands.
