Forskolin (CAS 66575-29-9) – Pure Diterpene from Coleus ForskohliiRoot
Product Introduction
Forskolin is a cell-permeable diterpenoid isolated from the root of Coleus forskohlii(Lamiaceae). It is the most well-known direct activator of adenylyl cyclase (AC), raising intracellular cAMP levels in a receptor-independent manner, and is widely used as a positive control in cAMP/PKA pathway research.
Our Forskolin is offered at ≥98% / ≥99% HPLC (research grade) and also 10% / 20% / 40% HPLC (Coleus forskohlii root extract, for supplement use). White to off-white crystalline powder, strictly −20 °C sealed storage for long-term stability.
Specifications
| Item | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Purity (HPLC) | ≥98% / ≥99% (also 10%/20%/40% extract available) |
| Melting Point | 230–232 °C |
| Molecular Formula | C₂₂H₃₄O₇ |
| Molecular Weight | 410.50 |
| CAS No. | 66575-29-9 |
| EINECS | 266-410-9 |
| Solubility | Soluble in DMSO, MeOH, EtOH; slightly in EtOAc; practically insoluble in water |
| Plant Source | Coleus forskohliiroot |
| Storage | −20 °C (short term 2–8 °C), sealed, dark, dry |
| Shelf Life | 2 years as supplied |
Applications
Pharmaceutical R&D / Cell Signaling – adenylyl cyclase activator, cAMP/PKA pathway positive control, T-cell activation studies, MAPK inhibition research
Dietary Supplement Formulation – Coleus forskohliiroot extract (10%/20%) for metabolic support, traditionally used in bodyweight management formulations
Cardiovascular & Respiratory Research – studied for vasodilation, positive inotropic effect, bronchodilation (in vitro / preclinical)
Reference Standard – HPLC qualification, content determination, pharmacological screening
