High Purity Eurycomanone Powder Pasakbumin A Pharmaceutical Research Raw Material
Product Introduction
Eurycomanone (CAS 84633-29-4), also known as Pasakbumin A, is the primary bioactive quassinoid compound isolated from Eurycoma longifolia Jack (commonly known as Tongkat Ali or Malaysian Ginseng), a flowering plant in the Simaroubaceae family native to Southeast Asia (Malaysia, Indonesia, Thailand, Vietnam). Among 60+ identified quassinoids in the E. longifolia root, eurycomanone is the most abundant, pharmacologically significant, and analytically validated marker compound, accounting for approximately 40-50% of the total quassinoid fraction.
Product Grades & Specifications
| Grade | Eurycomanone Content | Total Quassinoids | Form | Primary Application |
| Standard Extract 100:1 | 0.8-1.5% (HPLC) | ~22% | Brown powder | Dietary supplements (capsules/tablets) |
| High-Potency Extract | 2.0-5.0% (HPLC) | ~35-45% | Light brown powder | Sports nutrition, premium supplements |
| Enriched Fraction | 10-30% (HPLC) | Not less than 50% | Yellow-brown powder | Functional foods, clinical research |
| Purified Eurycomanone | ≥90% (HPLC/LC-MS) | Not applicable | Off-white to light yellow powder | Pharmaceutical R&D, reference standards |
| Ultra-Pure Eurycomanone | ≥98% (HPLC) | Not applicable | White to off-white powder | Analytical standard, drug development |
Applications
| Industry Sector | Application | Dosage Form | Eurycomanone Grade |
| Dietary Supplements | Testosterone booster capsules/tablets; male vitality formulas | Capsules (200-400 mg), tablets | Standard Extract 0.8-5% |
| Sports Nutrition | Pre-workout formulas; post-workout recovery; muscle-building stacks | Capsules, powder blends, RTD | High-Potency 2-5% |
| Men’s Sexual Health | Libido enhancement; erectile support; fertility formulas | Capsules, softgels | Standard Extract 0.8-5% |
| Stress/Adaptogen Formulas | Cortisol management; adrenal support; mood balance | Capsules, powder sticks | Standard Extract 0.8-2% |
| Functional Foods & Beverages | Fortified coffees, teas, energy drinks, protein bars | Water-dispersible microencapsulated powder | Standard Extract 0.8-2% |
| Traditional Medicine | TCM/ayurvedic/jamu formulations; herbal decoctions | Raw powder, extracts | Standard Extract 0.8-5% |
| Women’s Health (Emerging) | PCOS hormonal balance; menopausal support; libido | Capsules, tinctures | Standard Extract 0.8-2% |
| Pharmaceutical R&D | Drug discovery; reference standards; mechanism studies | Purified compound | ≥90% to ≥98% HPLC |
FAQ
Q1: What is the difference between eurycomanone and Tongkat Ali extract?
Eurycomanone is the primary bioactive quassinoid compound within Tongkat Ali (Eurycoma longifolia) root extract. Tongkat Ali extract contains 60+ quassinoids, of which eurycomanone is the most abundant and pharmacologically validated. When you purchase “Tongkat Ali extract,” the clinically meaningful variable is the HPLC-verified eurycomanone percentage — not the labeled extract ratio (e.g., “100:1”). Our standardized extracts guarantee eurycomanone content; our purified grades provide the isolated compound for research and pharmaceutical applications.
Q2: How does eurycomanone increase testosterone differently from other supplements?
Eurycomanone is the only botanical ingredient that combines dual enzymatic inhibition: (a) aromatase (CYP19) inhibition preserves existing testosterone by preventing its conversion to estrogen; and (b) phosphodiesterase (PDE) inhibition amplifies cAMP-driven testosterone biosynthesis in Leydig cells. Most other “testosterone boosters” either provide precursor nutrients (D-aspartic acid, zinc) or lack confirmed direct enzymatic targets (Tribulus terrestris). This dual mechanism is supported by molecular docking, in vitro enzyme assays, and clinical meta-analysis data.
Q3: What clinical dose is supported by evidence?
The most consistently replicated effective dose in RCTs is 200 mg/day of standardized extract containing 0.8-1.5% eurycomanone (~22% total quassinoids), equivalent to the Physta® specification. Doses of 100 mg/day have also shown significant effects in older men (Chinnappan 2021). Higher doses (400-600 mg/day) have been used in some trials but without clear evidence of dose-dependent superiority. The optimal dose for purified eurycomanone (>90%) has not been established in clinical trials; dosing should be calculated based on eurycomanone equivalency to the standardized extract data.
Q4: How long does it take to see results?
Hormonal changes can begin within 2 weeks (Chan 2021 reported significant T increase at 14 days), but clinically meaningful symptomatic improvements (libido, energy, mood, body composition) typically require 4-12 weeks of consistent use. The Leitao 2021 6-month trial demonstrated sustained and progressive benefits, suggesting that longer-duration supplementation produces greater cumulative effects.
Q5: Is eurycomanone / Tongkat Ali safe for long-term use?
Clinical trial data supports safety for durations up to 6 months, with no serious adverse events reported. The EFSA 2021 assessment noted in vitro genotoxicity signals at high concentrations (not confirmed in vivo), which is being addressed by ongoing long-term safety studies. As with any testosterone-modulating supplement, periodic monitoring of PSA (prostate), liver enzymes (AST/ALT), and testosterone/estradiol levels is recommended for long-term users, particularly men over 40.
Q6: Can eurycomanone be used by athletes subject to drug testing?
Yes. Eurycomanone / Tongkat Ali extract does not appear on the WADA Prohibited List. Importantly, clinical studies have confirmed that Tongkat Ali does NOT elevate the urinary testosterone/epitestosterone (T/E) ratio, the primary WADA biomarker for exogenous testosterone doping. Athletes should still verify product purity and choose supplements manufactured in facilities with sports-certification (e.g., Informed-Sport or NSF Certified for Sport) to avoid cross-contamination risks.
