Escin Monosodium Salt – CAS 20977-05-3 Water-Soluble Escin for Injectable Pharma API
Product Identification
| Item | Detail |
|---|---|
| Synonyms | Escin Monosodium Salt; Sodium Aescinate; Escin Na; (ChP: “Qi Ye Zao Gan Na”) |
| CAS RN | 20977-05-3 |
| Upstream CAS (free escin) | 6805-41-0 (Aescine/Escin, β-escin mixture) |
| Molecular Nature | Escin monosodium (C₅₅H₈₅O₂₄Na family, MW ~1154; mixture same aglycone as escin, one carboxyl salified) |
| Botanical Source | Aesculus hippocastanumL. seed; also A. chinensis(Suo Luo Zi) |
| HS Code (ref) | 2938 / 3003 (extract → API) |
| Pharmacopoeia | ChP (七叶皂苷钠 monograph); reference to EP escin monograph for upstream |
| Related SKUs | Aescine CAS 6805-41-0 (free); Horse Chestnut Extract 20% escin; Rutin NF11 → Troxerutin (same “natural→salt for BA” logic) |
Description
Escin monosodium salt is the water-soluble sodium salt of escin, developed to unlock the veno-active & anti-edema signal of horse chestnut saponins in injectable and oral-solution formats where free escin (poorly aq.-soluble saponin) cannot go.
The commercial logic mirrors two other Taima SKU gradients:
- Sophorarutin (90131-19-4) → hydroxyethylation → Troxerutin (7085-55-4, water-soluble, IV ChP)
- Epimediumicariin (489-32-7) → hydrolysis → Icaritin (118525-40-9, lipophilic BA↑, R&D/pharma)
…here: Aesculusescin (6805-41-0) → salification → Escin monosodium salt (20977-05-3, water-soluble, injectable API).
Three commercial buckets:
- Pharma API – China/India Hospital Channel (main): ChP “七叶皂苷钠” injectable powder/lyophilized — legacy indication cerebral edema, traumatic/sprain edema, postoperative venous edema, hemorrhoid flare adjunctive. This is the single largest tonnage channel for CAS 20977-05-3 globally; procurement searches: “escin monosodium salt API”, “sodium aescinate injection China”, “七叶皂苷钠 manufacturer”.
- Venotonic Oral Solution / Pharma-adjacent: sodium salt’s water solubility enables oral solution sachets (vs. free escin which is capsule/gel only) — niche but growing in Asia EU-export pharma SKUs; also vet pharma (equine limb edema, niche).
- R&D / Reference / Formulation Pilot: ≥98% HPLC for API QC, stability, injectable formulation R&D, biosimilar-type pilots in emerging markets.
Applications
Pharma Injectable API (ChP) – lyophilized powder for injection; cerebral edema, traumatic edema, postoperative venous stasis, hemorrhoid adjunctive (legacy but steady China/India hospital channel)
Venotonic Oral Solution (pharma-grade) – water-soluble escin sodium enables sachet/oral liquid (free escin cannot); Asia-export EU-pharma niche
Vet Pharma (niche) – equine limb edema, performance-animal recovery (off-label, formulation-dependent)
R&D / Reference Standard – ≥98% HPLC for ChP escin-Na QC, injectable formulation pilot, stability study
Upstream link – bulk buyers often also procure AesculusHorse Chestnut Extract 20% escin (CAS 6805-41-0) for DTC venotonic; Taima cross-links both tiers
