Cycloastragenol CAS 84605-18-5 Triterpene Aglycone from Astragalus membranaceus
Product Identification
| Item | Detail |
|---|---|
| Synonyms | Cycloastragenol; 3β,6α,16β,24(R),25-Pentahydroxy-9,19-cyclolanost-20-ene-6-O-β-D-glucoside aglycone (simplified: cycloartane triterpene aglycone) |
| CAS RN | 84605-18-5 |
| Upstream CAS (Astragaloside IV) | 84687-43-4 / 83207-58-3 (index varies by vendor) |
| Molecular Formula | C₃₀H₅₀O₅ |
| MW | 490.72 |
| Botanical | Astragalus membranaceus(Fisch.) Bge., Fabaceae (“Huang-Qi”) |
| HS Code (ref) | 1302 / 2938 (extract / triterpene) |
| Related SKUs | Astragalus Root P.E. (Astragaloside IV 0.5%–98%); Astragaloside IV CAS 84687-43-4; Icariin→Icaritin (same aglycone logic); Quercetin 117-39-5 (senolytic D+Q, telomere R&D邻聚) |
Description
Cycloastragenol is a cycloartane-type triterpene aglycone from Astragalus membranaceusroot, produced by hydrolyzing the more abundant Astragaloside IV (the major saponin of Huang-Qi). Literature signals cluster around:
- Telomere / aging biology – cycloastragenol is the active constituent cited in telomerase-activation / telomere-length maintenance papers (TA-65 commercial formula is based on this molecule); DTC positions as “telomere support / healthy-aging”
- Immunomodulatory – Astragalusroot TCM heritage (“qi tonify, defensive Qi”) maps to modern NK-cell / cytokine literature; Cycloastragenol is one of several triterpene actors
- BA advantage vs. Astragaloside IV – smaller, more lipophilic, better membrane permeability in literature assays (same “glycoside → aglycone” logic as icariin→icaritin)
Applications
DTC Healthy-Aging / Telomere Support – 5–50 mg Cycloastragenol + Astragalus root blend; “TA-65 alternative” positioning (trademark-disclaimed); telomere biology R&D interest; dose µg→low mg (potent vs. root powder gram-level)
Immunomodulatory / Adaptogen – Astragalus membranaceusTCM heritage (“defensive Qi / seasonal wellness”); Cycloastragenol as premium triterpene fraction; stacked with Icariin / Quercetin / CoQ10 in “TCM aging stack”
Pharma / TCM R&D – telomerase/telomere assay reagent (pure ≥98%), AstragalusP.E. QC (hydrolyzed Astragaloside IV method), formulation pilot
Cosmeceutical (emerging) – “Astragalus + Ginseng” anti-aging serum archetype (KR/JP), Cycloastragenol as triterpene actives
Reference Standard – 98%–99% HPLC for Astragalusextract quantification (Astragaloside IV vs. Cycloastragenol hydrolyzed method)
