Artemisinin CAS 63968-64-9 Peroxy Sesquiterpene Lactone from Artemisia annua
Product Identification
| Item | Detail |
|---|---|
| Synonyms | Artemisinin; Qing-hao-su; (3R,5aS,5bR,9aS,9bS)-3-methyl-3,5a,5b,6,7,8,9a,9b-octahydro-5a,5b-epoxy-9-methylenedihydrofuran[3′,4′:4,5]benzo[1,2-b]oxepin-2,5-dione |
| CAS RN (current) | 63968-64-9 |
| CAS RN (legacy) | 298-96-8 |
| Molecular Formula | C₁₅H₂₂O₅ |
| MW | 282.33 |
| Botanical | Artemisia annuaL., Asteraceae |
| Pharmacopoeia | ChP (青蒿素), EP (Artemisinin), USP referenced |
| HS Code (ref) | 2939 (vegetable alkaloids / bitter substances — artemisinin indexed here despite being terpene lactone) |
| Related SKUs (downstream) | Artesunate; Dihydroartemisinin (DHA); Artemether; Lumefantrine (blend API) |
Description
Artemisinin is a sesquiterpene lactone bearing an endoperoxide bridge — the pharmacophore responsible for antimalarial activity (Fe²⁺-dependent ROS generation in Plasmodium). Isolated from Artemisia annuain the 1970s (Project 523, Tu Youyou Nobel 2015), now the cornerstone of WHO ACT (Artemisinin-based Combination Therapy) — first-line for P. falciparumglobally.
Four commercial buckets drive search & procurement:
- Pharma API – ACT Procurement (B2B main): Artemisinin 63968-64-9 as parent; downstream Artesunate / DHA / Artemether as formulated APIs; ACT fixed-dose combos (AS+LF, AS+AQ, etc.) — WHO prequalified tenders, Africa/SEA/India/China pharma channel. Search cluster: “artemisinin API ACT”, “artesunate DHA manufacturer”, “WHO prequalified antimalarial”
- Anticancer & Antiviral R&D (high-value B2B): Artesunate/DHA literature signals in certain cancer cell lines (iron-activated ROS, same logic as Plasmodium) + severe viral (including severe COVID case reports, 2020–2023). Procurement searches: “artemisinin derivative anticancer R&D”, “artesunate clinical”— DTC supplement cannot claim cancer/COVID treatment (FDA/EMA warned), R&D pharma side fine
Applications
Pharma API – ACT Antimalarial – Artemisinin 63968-64-9 parent; semi-synthetic Artesunate / DHA / Artemether; ACT combos (AS+LF, AS+AQ) WHO-prequalified tenders; Africa/SEA/India/China pharma B2B
Anticancer & Antiviral R&D – Artesunate/DHA derivative pipeline; iron-activated ROS mechanism literature; severe viral (case-report level); “artemisinin derivative R&D” B2B cluster
DTC Sweet Wormwood Supplement – Artemisia annuasoft positioning: “traditional use / antioxidant / wellness”; avoid antimalarial/cancer/viral treatment claims (regulatory red line)
Traditional TCM Channel – “Qing-hao” heritage, CN TCM export brands
Reference Standard – ≥99% HPLC for Artemisinin / Artesunate / DHA QC, ACT formulation R&D
