Monobenzone CAS 103-16-2 | High Purity Monobenzone Powder (≥99% HPLC)
Product Introduction
Monobenzone (CAS 103-16-2), also known as 4-Benzyloxyphenol, Hydroquinone Monobenzyl Ether, PBP or Benoquin, is an off-white to beige crystalline powder belonging to the monobenzyl ether of hydroquinone family. It is practically insoluble in water, freely soluble in ethanol, chloroform, DMSO and methanol. Monobenzone is principally used as a potent topical depigmenting agent in dermatological therapy for universal vitiligo and as a pharmaceutical intermediate / API precursor in organic synthesis.
Physical & Chemical Properties
Appearance: Off-white to beige / amber crystalline powder
Assay (HPLC): ≥ 99.0%
Melting Point: 119 – 122 °C (lit.)
Boiling Point: ~359 °C @ 760 mmHg
Density: 1.26 g/cm³
Flash Point: 213 °C
Solubility: Slightly soluble in water; soluble in ethanol, methanol, chloroform, DMSO, ether
pKa: 10.29 ± 0.15 (predicted)
Loss on Drying: ≤ 0.5%
Residue on Ignition: ≤ 0.3%
Storage: Store below +30 °C, cool, dry, protected from light; keep tightly closed.
Applications
Dermatological Depigmentation (Vitiligo)
Monobenzone is applied topically in the management of extensive / universal vitiligo to achieve uniform skin tone. It acts by inhibiting tyrosinase and exerting cytotoxic effects on melanocytes, resulting in irreversible depigmentation of treated areas. Typically formulated as ointment or liniment; listed in USP.
Pharmaceutical Intermediate
Used in API synthesis, pigmentary disorder research, and melanin-metabolism studies. Common in vitiligo animal models (e.g. monobenzone-induced mouse model, Exp Dermatol 2013).
Industrial Uses
Rubber antioxidant / anti-degradant (registered trade names: Agerite Alba, etc.)
Acrylic resin polymerization inhibitor
Azo-dye intermediate & polyester fibre dyeing auxiliary
FAQ
Q: What is Monobenzone used for?
A: Primarily for universal vitiligo depigmentation therapy and as a pharma intermediate.
Q: Is Monobenzone reversible?
A: No — melanocyte loss is generally irreversible; uniform tone is the therapeutic goal.
Q: Can I buy Monobenzone CAS 103-16-2 in bulk?
A: Yes, we supply ≥99% HPLC grade Monobenzone powder in 1 / 5 / 25 kg packs for qualified B2B buyers (pharma mfg, lab, industrial).
