Product Introduction
| Item | Specification |
| Product Name | Diindolylmethane |
| Synonyms | DIM; 3,3′-Diindolylmethane; 3-(1H-Indol-3-ylmethyl)-1H-indole; Diindolemethane |
| CAS Number | 1968-05-4 |
| Molecular Formula | C₁₇H₁₄N₂ |
| Molecular Weight | 246.31 g/mol |
| Appearance | Off-white to pale beige fine crystalline powder, odorless, stable texture, no caking under sealed dry and dark storage conditions |
| Purity (HPLC) | ≥98.0% / ≥99.0% (Research Grade / Premium Functional Grade, customizable) |
| Loss on Drying | ≤ 0.2% |
| Residue on Ignition | ≤ 0.1% |
| Testing Method | HPLC / NMR / Mass Spectrometry / IR Spectrum / Biological Activity Assay |
| Production Method | Cruciferous Vegetable Extract / Synthetic Refinement + Macroporous Resin Isolation + Preparative HPLC Purification + Low-Temperature Recrystallization |
| Melting Point | 162–164°C (lit.) |
| Boiling Point | 449.8°C at 760 mmHg (Predicted) |
| Density | 1.23 g/cm³ at 25°C |
| Flash Point | 226.1°C |
| Solubility | Insoluble in water, soluble in ethanol, methanol, DMSO, acetone and most organic solvents; slightly soluble in vegetable oil; stable in dry dark environment, sensitive to strong light and high temperature |
| Core Feature | Natural cruciferous indole derivative, classic hormone-balancing monomer, dual regulatory effect on estrogen metabolism, widely used in endocrine research and hormone balance healthcare products |
| Package | 1g/5g/10g amber sealed bottle, 100g/1kg vacuum drum; moisture-proof & light-proof vacuum packaging, customized specifications supported |
| Storage | Store in vacuum-sealed, low-temperature, dry and dark conditions; avoid high temperature, strong light and humid air to prevent molecular oxidation and activity attenuation |
| Shelf Life | 24 months under standard sealed low-temperature dark storage |
Product Description
Diindolylmethane (DIM, 3,3′-Diindolylmethane, CAS 1968-05-4) is a biologically active indole derivative naturally derived from glucobrassicin hydrolysis in cruciferous vegetables such as broccoli, cabbage and cauliflower. As a core functional metabolite of cruciferous plant nutrients, Diindolylmethane features unique aromatic heterocyclic structure, delivering targeted hormone metabolism regulation, antioxidant, anti-inflammatory and cell cycle regulatory activities. We provide high-purity Research Grade (98%) and Premium Functional Grade (99%) DIM powder, produced through standardized raw material extraction or high-precision synthetic refinement, combined with macroporous resin gradient impurity removal and preparative HPLC fine purification. The whole production process strictly eliminates heterologous indole impurities, residual raw materials and harmful byproducts, ensuring single-component purity, stable batch biological activity and zero experimental interference. With definite pharmacological targets and reliable safety, Diindolylmethane has become a key tool compound for endocrine metabolism research and a mainstream high-value raw material for hormone balance healthcare supplements and antioxidant functional products.
Different from crude cruciferous vegetable extracts with mixed active ingredients, our pure Diindolylmethane monomer possesses accurate molecular structure, controllable bioavailability and standardized efficacy, ensuring highly repeatable experimental results and stable finished product effects. The most prominent advantage of DIM is its bidirectional regulatory effect on estrogen metabolism. It effectively promotes the conversion of harmful estrogen metabolites into benign and easily excreted forms, optimizes estrogen ratio balance in the body, and improves endocrine disorders caused by estrogen imbalance. This unique metabolic regulation mechanism makes DIM irreplaceable in menopausal adjustment, body hormone balance maintenance and related pharmacological mechanism research.
In terms of antioxidant and anti-inflammatory performance, Diindolylmethane efficiently scavenges intracellular reactive oxygen species, inhibits lipid peroxidation chain reactions, protects cell membrane integrity, and reduces chronic low-grade inflammatory responses. It relieves oxidative stress damage in tissues and organs, delays cellular senescence, and improves sub-health problems caused by long-term inflammatory imbalance. Meanwhile, DIM exhibits excellent cell cycle regulation and immune balancing effects, regulating abnormal cell proliferation, enhancing immune cell activity, and maintaining systemic immune homeostasis. In addition, it delivers auxiliary metabolic regulation and liver detoxification protection, covering multiple high-value research and industrial application scenarios.
Manufactured by Shaanxi BAISFU Bio-Engineering Co., Ltd., our high-purity Diindolylmethane adopts fully closed, dust-free and light-shielded industrial production system. Strict low-temperature constant-pressure control is implemented during purification and refinement processes to avoid structural oxidation and molecular deactivation of indole active groups, completely retaining the original hormone regulation, antioxidant and immunomodulatory biological activity. The finished product presents uniform off-white to pale beige fine crystalline powder with stable texture, no agglomeration, no discoloration and no peculiar smell, free of plant residues, heavy metals and solvent residual impurities.
Every batch of Diindolylmethane undergoes comprehensive multi-dimensional quality inspection and verification, including HPLC high-precision purity detection, NMR structural identification, mass spectrometry molecular weight confirmation and cell-level biological activity evaluation. Ultra-low impurity content and excellent batch-to-batch consistency ensure stable pharmacological activity and reliable experimental data. With good solubility in conventional organic solvents and superior biocompatibility in cell culture and in vivo animal models, our DIM adapts to diverse scientific research and industrial formulation needs. We support long-term bulk stable supply, customized purity grades and professional light-proof vacuum moisture-proof packaging, providing cost-effective high-quality Diindolylmethane raw materials for global research institutions, pharmaceutical laboratories, healthcare supplement manufacturers and functional food enterprises.
Functions & Benefits
Bidirectional Estrogen Metabolism Balance Regulation
Diindolylmethane optimizes endogenous estrogen metabolic pathway, converts harmful estrogen metabolites into safe excretable components, balances estrogen proportion in the body, and improves endocrine imbalance symptoms. It is the core experimental monomer for estrogen metabolism research and hormone balance healthcare product development.
Efficient Antioxidant & Anti-Aging Activity
The unique indole heterocyclic structure of high-purity DIM enables powerful free radical scavenging capacity. It eliminates excess intracellular reactive oxygen species, blocks lipid peroxidation damage, reduces tissue oxidative stress, and delays cell and organ senescence progression, providing long-lasting systemic antioxidant protection.
Chronic Anti-Inflammatory & Immune Homeostasis
DIM inhibits the release of pro-inflammatory cytokines, relieves chronic low-grade inflammation in the body, regulates immune cell proliferation and differentiation, balances immune responses, and enhances the body’s antioxidant and immune defense system with mild and stable regulatory effects.
Cell Cycle Regulation & Physiological Protection
Diindolylmethane participates in cell cycle signal regulation, inhibits abnormal cell proliferation, maintains normal cell physiological metabolism, and provides effective physiological protection for tissue and organ health, widely used in cell pharmacology and physiological regulation research.
Liver Detoxification & Metabolic Optimization
This natural indole derivative assists in liver metabolic detoxification, optimizes internal metabolic circulation, reduces metabolic toxin accumulation, and improves body sub-health state, serving as a high-efficiency auxiliary raw material for metabolic health conditioning products.
Ultra-High Single Component Purity & Zero Interference
Adopting multi-stage HPLC fine purification and low-temperature recrystallization technology, our DIM completely removes indole analog impurities and raw material residues. 98%–99% ultra-high single-component purity avoids impurity interference, ensuring accurate experimental results and standardized industrial formulation efficacy.
High Biological Safety & Wide Compatibility
Derived from natural edible cruciferous plant metabolites with low toxicity and excellent human body biocompatibility, Diindolylmethane maintains stable biological activity in experiments and formulas, suitable for long-term application in scientific research, functional food and healthcare products.
Applications
Endocrine & Estrogen Metabolism Pharmacology Research
Widely used as a standard indole monomer for exploring estrogen metabolic regulation, endocrine balance mechanism and hormone-related physiological changes, serving as a core experimental tool in endocrinology and metabolic pharmacology research.
Anti-Inflammatory & Antioxidant Mechanism Study
Applied in intracellular free radical scavenging, lipid oxidation inhibition and chronic inflammation regulation experiments, supporting oxidative stress and inflammatory disease mechanism research and related functional product development.
Cell Physiology & Cell Cycle Regulation Research
Key experimental compound for cell cycle signal pathway exploration, abnormal cell proliferation regulation and cellular physiological homeostasis research, widely used in cell biology and molecular pharmacology studies.
High-End Hormone Balancing Healthcare Formulation
Used as a core functional additive for hormone balance, menopausal conditioning and endocrine adjustment healthcare supplements, effectively improving estrogen imbalance caused sub-health problems.
Antioxidant Functional Food & Daily Health Products
Widely added in antioxidant, anti-aging and metabolic conditioning functional foods, providing safe and efficient natural indole active nutrition for daily body health maintenance.
University Lab Teaching & Pharmacological Demonstration
Supplied as standard high-purity Diindolylmethane reagent for natural indole pharmacology, endocrine regulation and antioxidant mechanism teaching, ensuring accurate and stable experimental data for academic research and teaching.
FAQ
Q1: What is Diindolylmethane (DIM) used for?
A: Diindolylmethane is a natural indole active monomer, mainly applied in estrogen metabolism and endocrine regulation pharmacological research, antioxidant and anti-inflammatory studies, as well as core raw material for hormone balance healthcare supplements and anti-aging functional products.
Q2: What makes DIM different from common plant antioxidants?
A: Unlike conventional single-effect antioxidants, DIM has unique bidirectional hormone metabolism regulatory activity, targeting endocrine balance while providing antioxidant and anti-inflammatory effects, with higher targeted application value in hormone-related health research.
Q3: What are your product advantages?
A: Our Diindolylmethane reaches 98%–99% ultra-high purity via multi-stage HPLC purification, free of indole analog impurities and plant residues. It features stable hormone regulation and antioxidant activity, excellent batch consistency and high experimental repeatability, compliant with international research and industrial standards.
Q4: How to store Diindolylmethane correctly?
A: DIM is sensitive to strong light, high temperature and humid air, prone to oxidative deactivation. It must be vacuum-sealed and stored in low-temperature, dry and dark conditions to maintain complete biological activity within the 24-month shelf life.
Q5: What is the appearance of high-purity DIM?
A: Standard high-purity Diindolylmethane is uniform off-white to pale beige fine crystalline powder at room temperature, odorless, with stable texture, no caking and no discoloration under sealed storage.
Q6: Can I get free DIM samples?
A: Yes, we provide free Diindolylmethane samples for academic research, pharmacological efficacy verification and product formula testing. Bulk orders support customized purity and exclusive light-proof vacuum packaging to meet scientific research and industrial production demands.
