Product Introduction
| Item | Specification |
| Product Name | Tropisetron |
| Synonyms | ICS 205-930; 1H-Indole-3-carboxylic acid (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester |
| CAS Number | 89565-68-4 |
| Molecular Formula | C₁₇H₂₀N₂O₂ |
| Molecular Weight | 284.35 g/mol |
| Appearance | White to off-white crystalline powder, odorless, stable crystalline form under sealed dry and dark conditions |
| Purity (HPLC) | ≥98.0% / ≥99.0% (Research Grade / Pharma API Grade, customizable) |
| Loss on Drying | ≤ 0.2% |
| Residue on Ignition | ≤ 0.1% |
| Testing Method | HPLC / NMR / Mass Spectrometry / IR Spectrum / Pharmacological Activity Detection |
| Production Method | Chemical Synthesis & Multi-stage Recrystallization & High-Purity Refining Technology |
| Melting Point | 201–203°C (lit.) |
| Boiling Point | 448.5°C at 760 mmHg (Predicted) |
| Density | 1.27 g/cm³ at 25°C (Predicted) |
| Flash Point | 225.1°C |
| Solubility | Soluble in DMSO, methanol, ethanol and chloroform; slightly soluble in water; stable in neutral and weakly acidic solutions; avoid strong alkaline and high-temperature environments |
| Core Feature | Highly selective 5-HT3 receptor antagonist, long-acting anti-emetic agent, indole heterocyclic targeted therapeutic monomer |
| Package | 1g/5g/10g sealed amber bottle, 100g/1kg drum; vacuum moisture-proof & light-proof packaging, custom specification available |
| Storage | Store in vacuum-sealed, low-temperature, dark and dry conditions; avoid high temperature, strong light and alkaline environment to prevent molecular structure degradation and activity loss |
| Shelf Life | 24 months under standard low-temperature sealed and dark storage |
Product Description
Our Tropisetron (CAS 89565-68-4) is a high-purity synthetic targeted pharmaceutical monomer and selective 5-HT3 serotonin receptor antagonist, supplied in premium research grade and pharmaceutical API grade. Tropisetron, also known as ICS 205-930, features a unique indole-3-carboxylic acid ester fused with an 8-azabicyclo[3.2.1]octane skeleton, forming a highly specific three-dimensional molecular structure that enables precise binding to 5-HT3 receptors in the central nervous system and gastrointestinal tract. As a first-class anti-emetic active compound, it effectively blocks serotonin-mediated vomiting reflex pathways, delivering long-lasting and high-efficiency inhibitory effects on chemotherapy-induced nausea and vomiting (CINV), postoperative nausea and vomiting (PONV). With stable molecular properties, high receptor selectivity and low toxic side effects, high-purity Tropisetron has become a core tool compound for neuropharmacology, gastrointestinal physiological mechanism research and novel anti-emetic drug development. As a professional bulk Tropisetron supplier, we provide low-impurity, high-activity, batch-stable Tropisetron raw materials for global pharmaceutical R&D laboratories, pharmacological research institutions and API manufacturing enterprises.
Tropisetron occupies a pivotal position in the research of serotonin receptor pharmacology and anti-emetic therapeutic drugs, with obvious structural and functional advantages over traditional anti-vomiting compounds. Its core pharmacological mechanism lies in the competitive and selective antagonism of 5-HT3 receptors distributed in the vagal afferent nerves and central chemoreceptor trigger zone, effectively blocking the signal transmission of serotonin-induced gastrointestinal spasm and vomiting reflex. Compared with ordinary anti-emetic reagents, Tropisetron features ultra-high receptor selectivity, avoiding off-target effects on other serotonin receptor subtypes, ensuring higher experimental accuracy and safer pharmacological characteristics. In addition to its dominant anti-emetic activity, Tropisetron also exhibits auxiliary neuroprotective, anti-inflammatory and analgesic effects, capable of regulating abnormal nerve excitation and relieving inflammatory pain responses, providing multi-dimensional research value for neurological disease and gastrointestinal disorder mechanism exploration. Relying on its unique bicyclic heterocyclic structure, Tropisetron serves as an important lead compound for structural modification and new drug optimization, supporting the development of high-efficiency, long-acting and low-resistance anti-emetic derivatives. Our high-purity Tropisetron eliminates intermediate residues, isomer impurities and by-products generated during chemical synthesis, ensuring single-component purity and ultra-stable targeted activity for high-precision pharmacological experiments and preclinical drug research.
Manufactured by Shaanxi BAISFU Bio-Engineering Co., Ltd., our premium Tropisetron adopts advanced controlled chemical synthesis combined with gradient solvent purification and multi-stage low-temperature recrystallization refining technology. The entire production process strictly controls reaction temperature, pH value and purification gradient, effectively removing synthesis intermediates, residual catalysts and trace organic impurities, completely retaining the complete active skeleton and specific receptor-binding activity of Tropisetron. The closed dust-free and oxygen-free production system avoids structural oxidation and molecular isomerization, ensuring stable crystal form and consistent pharmacological activity of finished products. The final product presents uniform white to off-white crystalline powder, no caking, no discoloration and no deterioration, fully complying with international high-standard research grade and pharmaceutical API grade quality specifications.
Every batch of Tropisetron undergoes strict multi-dimensional quality inspection, including HPLC high-precision purity analysis, NMR structural verification, mass spectrometry molecular identification and cell-level receptor activity verification testing. It achieves ultra-low trace residue and zero invalid impurity interference, ensuring consistent batch efficacy and excellent experimental repeatability. The product features stable solubility in common organic solvents and good biochemical compatibility in cell culture and in vivo animal experiment environments, fully meeting the strict raw material requirements of 5-HT3 receptor mechanism research, anti-emetic efficacy verification, neuropharmacology study and new drug structural optimization.
We maintain sufficient low-temperature light-proof inventory and complete qualification documents for bulk Tropisetron supply. Whether you need standard 5-HT3 receptor antagonist monomers for basic pharmacological research, positive control reagents for anti-emetic drug efficacy evaluation, or high-purity parent intermediates for novel targeted drug synthesis, our premium Tropisetron is a high-cost-performance and high-value fine chemical product choice for global buyers.
Functions & Benefits
Highly Selective 5-HT3 Receptor Antagonism (Core Benefit)
Tropisetron is a classic high-selectivity 5-HT3 receptor antagonist, precisely binding to central and gastrointestinal 5-HT3 receptors to block serotonin-induced nerve signal transmission. It effectively inhibits vomiting reflex activation, serving as the gold-standard tool compound for targeted anti-emetic pharmacological research.
Long-Acting & High-Efficiency Anti-Emetic Activity
With unique bicyclic structural stability, Tropisetron delivers longer half-life and sustained anti-emetic effects compared with ordinary anti-vomiting reagents. It stably relieves chemotherapy-induced and postoperative nausea and vomiting, supporting long-term drug efficacy evaluation and mechanism research.
Unique Bicyclic Heterocyclic Molecular Skeleton
Featuring a rare indole-carboxylate and 8-azabicyclo[3.2.1]octane fused structure, Tropisetron has a stable and specific molecular configuration. This exclusive structural feature provides irreplaceable templates for targeted drug structural modification, receptor binding mechanism study and new anti-emetic derivative development.
Neuroprotective & Auxiliary Analgesic Effects
High-purity Tropisetron regulates abnormal central nerve excitation, reduces neuro-inflammatory damage, and exerts auxiliary analgesic activity. It supports multi-dimensional research on neurological disorders, inflammatory pain and gastrointestinal nerve regulation mechanisms.
High Single-Component Purity & Zero Impurity Interference
Our Tropisetron adopts full-process high-precision purification and multi-stage impurity removal technology, completely eliminating synthesis intermediates, isomer residues and by-product interference. It ensures pure monomer targeted activity, zero experimental interference and consistent batch pharmacological efficacy.
Excellent Solubility & Wide Experimental Adaptability
Tropisetron has good solubility in DMSO, methanol, ethanol and chloroform, easy to prepare into homogeneous experimental stock solutions. It maintains stable receptor-binding activity in conventional cell and animal experiment environments, perfectly adapting to targeted pharmacology tests and drug screening research.
Applications
5-HT3 Receptor Pharmacology Research
Used as a standard selective antagonist positive reagent for studying 5-HT3 receptor binding mechanisms, serotonin signal transduction pathways and nerve-gastrointestinal regulatory networks, widely applied in neuropharmacology and targeted drug research laboratories.
Anti-Emetic Drug Efficacy Verification & Screening
Served as the core experimental compound for evaluating anti-emetic effects against chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea and vomiting (PONV), supporting new anti-vomiting drug development and efficacy comparison tests.
Neurological & Gastrointestinal Disorder Research
Applied as a key research tool for exploring neuroprotection, nerve inflammation regulation and gastrointestinal smooth muscle reflex mechanisms, providing new research perspectives for neurological and digestive system disease studies.
Targeted Drug Structural Modification & Derivative Synthesis
Used as a high-value lead compound with a unique bicyclic skeleton for structural optimization of high-efficiency, low-toxicity and long-acting anti-emetic targeted drugs, guiding innovative new drug R&D in the field of digestive system therapeutics.
Laboratory Teaching & Pharmacological Mechanism Demonstration
Provided as standard high-purity Tropisetron reagent for targeted pharmacology teaching experiments, 5-HT receptor mechanism demonstration and anti-emetic drug activity comparison tests, ensuring accurate and stable experimental data for scientific research and teaching work.
FAQ
Q1: What is Tropisetron mainly used for?
A: Tropisetron is a highly selective 5-HT3 receptor antagonist. It is mainly used for 5-HT3 receptor pharmacological mechanism research, chemotherapy and postoperative anti-emetic drug screening, neuroprotective and gastrointestinal regulation study, and targeted new drug derivative synthesis.
Q2: What is the core advantage of Tropisetron?
A: Tropisetron features ultra-high 5-HT3 receptor selectivity, long-acting efficacy and low off-target effects. Different from non-specific anti-emetic reagents, it achieves precise targeted regulation, providing more accurate and reliable experimental data for targeted pharmacology research.
Q3: What are the core advantages of our Tropisetron?
A: Our Tropisetron adopts professional multi-stage recrystallization purification technology, featuring ultra-high single-component purity, zero synthesis intermediate and isomer interference, stable targeted receptor antagonistic activity, and consistent batch quality, ensuring high-precision and repeatable pharmacological research results.
Q4: How to store Tropisetron correctly?
A: Tropisetron is sensitive to high temperature, strong light and alkaline environments, prone to molecular structural degradation and activity attenuation. It must be stored in vacuum-sealed, low-temperature, light-proof and dry dark conditions. Standard sealed low-temperature dark storage ensures 24 months of stable shelf life and biological activity.
Q5: What is the appearance of high-purity Tropisetron?
A: High-purity Tropisetron is uniform white to off-white fine crystalline powder at room temperature, odorless, stable crystal state, no caking, no fading and no deterioration.
Q6: Can I get free Tropisetron samples for testing?
A: Yes, we provide free Tropisetron samples for 5-HT3 receptor mechanism research, anti-emetic efficacy verification and targeted drug synthesis experiments. Bulk orders support customized purity and professional light-proof vacuum packaging to meet high-standard scientific research and pharmaceutical API production needs.
