Product Introduction
| Item | Specification |
| Product Name | Berberine |
| Synonyms | 5,6-Dihydro-9,10-dimethoxybenzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium; Berberine free base |
| CAS Number | 2086-83-1 |
| Molecular Formula | C₂₀H₁₈NO₄ |
| Molecular Weight | 336.36 g/mol |
| Appearance | Bright yellow crystalline powder, odorless, stable crystal form under sealed dark and dry conditions |
| Purity (HPLC) | ≥98.0% / ≥99.0% (Research Grade / Pharma API Grade, customizable) |
| Loss on Drying | ≤ 0.2% |
| Residue on Ignition | ≤ 0.1% |
| Testing Method | HPLC / NMR / Mass Spectrometry / IR Spectrum / Pharmacological Activity Detection |
| Production Method | Natural Plant Extraction (Coptis Chinensis) & Multi-Stage Purification & Low-Temperature Recrystallization |
| Melting Point | 204–206°C (dec., lit.) |
| Boiling Point | 633.8°C at 760 mmHg |
| Density | 1.39 g/cm³ at 25°C |
| Flash Point | 337.1°C |
| Solubility | Slightly soluble in water, soluble in methanol, ethanol, DMSO and dilute acidic solutions; stable in dry environment, sensitive to strong light and high temperature |
| Core Feature | Natural isoquinoline alkaloid, multi-target botanical active ingredient, potent antibacterial, anti-inflammatory and metabolic regulatory activity |
| Package | 1g/5g/10g sealed amber bottle, 100g/1kg drum; vacuum moisture-proof packaging, custom specification available |
| Storage | Store in vacuum-sealed, low-temperature, dark and dry conditions; avoid strong light, high temperature and humid environment to prevent oxidation and structural degradation |
| Shelf Life | 24 months under standard low-temperature sealed storage |
Product Description
Our Berberine is a high-purity natural isoquinoline alkaloid with stable molecular structure and complete multi-target pharmacological activity, available in premium research grade and pharmaceutical API grade. Berberine (CAS 2086-83-1), commonly known as Huanglian Su, is the core bioactive ingredient extracted from traditional medicinal plants such as Coptis chinensis and Berberis vulgaris. Featuring a unique fused isoquinoline heterocyclic skeleton and quaternary ammonium cationic structure, it exhibits broad-spectrum biological activities that distinguish it from ordinary plant extracts. As a classic natural botanical drug monomer, Berberine integrates antibacterial, anti-inflammatory, hypoglycemic, lipid-lowering and antioxidant pharmacological effects, serving as a vital tool compound for natural drug mechanism research and metabolic disease pharmacology. As a professional bulk Berberine supplier, we provide low-impurity, high-activity, batch-stable Berberine raw materials for global natural product research institutions, pharmaceutical R&D laboratories and botanical API manufacturing enterprises.
Berberine occupies a foundational core position in natural medicinal chemistry, antimicrobial pharmacology and metabolic regulation research. Different from synthetic small-molecule drugs, this natural alkaloid delivers mild, efficient and multi-pathway regulatory efficacy with low drug resistance risk. In antimicrobial research, Berberine inhibits the proliferation of various gram-positive and gram-negative bacteria, fungi and parasites by disrupting microbial cell membrane integrity and interfering with nucleic acid metabolism, making it a standard positive control for antibacterial and anti-infective experiments. In metabolic pharmacology, it activates AMPK signaling pathways, improves insulin sensitivity, inhibits hepatic gluconeogenesis and regulates lipid metabolism, widely used in diabetes, hyperlipidemia and obesity mechanism research. Additionally, Berberine exerts significant anti-inflammatory, antioxidant and anti-tumor proliferation activities, supporting in-depth exploration of chronic inflammation, oxidative stress and tumor chemoprevention mechanisms. In pharmaceutical synthesis, its stable isoquinoline heterocyclic structure provides valuable modification sites for developing new natural-derived drug derivatives. Compared with ordinary low-purity Berberine products containing plant impurity residues and unstable biological activity, our high-purity purified product completely removes plant polysaccharides, flavonoid impurities and extraction solvent residues, ensuring single-component purity and stable pharmacological activity for accurate, repeatable natural drug research data.
Manufactured by Shaanxi BAISFU Bio-Engineering Co., Ltd., our premium Berberine adopts advanced low-temperature plant enzymatic extraction combined with multi-stage macroporous resin purification and gradient recrystallization process. The entire production process strictly controls extraction temperature, pH value and purification gradient, thoroughly eliminating plant tissue residues, heterozygous alkaloids and organic solvent impurities. By avoiding high-temperature-induced molecular structural damage and activity attenuation, the process fully retains the complete isoquinoline active skeleton and multi-target biological activity of Berberine. The finished product presents uniform bright yellow crystalline powder, stable crystal form, no caking, no discoloration and no deterioration, fully complying with high-standard natural product research grade and pharmaceutical botanical API grade quality requirements.
Every batch of Berberine undergoes strict multi-dimensional quality inspection, including HPLC high-precision purity analysis, NMR structural verification, mass spectrometry molecular identification and cell-level pharmacological activity testing. It ensures zero invalid impurity interference, ultra-low trace residues and consistent batch efficacy, providing reliable raw material guarantee for antibacterial mechanism research, metabolic pathway verification and natural drug derivative synthesis. The product features stable solubility in acidic aqueous solutions and organic solvents, excellent biochemical stability in cell and animal experiment environments and outstanding experimental repeatability, fully meeting the strict raw material requirements of in vitro antimicrobial tests, in vivo metabolic model experiments and new botanical drug formula development.
We maintain sufficient low-temperature inventory and complete qualification documents for bulk Berberine supply. Whether you need standard natural alkaloid monomers for pharmacological research, core reference substances for antibacterial and metabolic drug evaluation, or high-purity isoquinoline skeleton intermediates for custom derivative synthesis, our premium Berberine is a high-cost-performance and high-value natural fine chemical product choice for global buyers.
Functions & Benefits
Broad-Spectrum Antibacterial & Antiparasitic Activity (Core Benefit)
Berberine is a classic natural broad-spectrum antimicrobial alkaloid. It precisely disrupts microbial cell membrane structure, inhibits bacterial nucleic acid and protein synthesis, and effectively suppresses the growth of various pathogenic bacteria, fungi and protozoa. It serves as the gold-standard tool compound for natural antibacterial pharmacology and anti-infective research.
Unique Isoquinoline Alkaloid Structural Characteristics
As a representative fused-ring isoquinoline natural alkaloid, Berberine has a stable quaternary ammonium cation heterocyclic structure. Its unique molecular skeleton provides critical research templates for natural product structure-activity relationship, alkaloid pharmacological modification and innovative botanical drug development.
Multi-Target Metabolic Regulatory Efficacy
High-purity Berberine stably activates AMPK signal pathways, regulates blood glucose and blood lipid metabolism, improves insulin resistance, and inhibits chronic inflammatory responses. It is the primary positive control drug for metabolic disease research and natural hypoglycemic & lipid-lowering drug screening experiments.
Low-Impurity Purification & Ultra-Stable Biological Activity
Our Berberine adopts low-temperature enzymatic extraction and multi-stage impurity removal technology, eliminating plant heterozygous impurities and degradation substances generated during traditional extraction. It solves the problem of unstable activity and poor experimental repeatability of conventional crude extracts, ensuring long-term stable pharmacological efficacy.
Strict Batch Consistency & High Experimental Repeatability
Extracted and recrystallized under constant low-temperature sterile conditions, Berberine eliminates process quality fluctuations. The product has uniform crystal form, stable molecular structure and consistent batch biological activity, suitable for long-term natural drug mechanism research and high-precision pharmacological screening experiments.
Excellent Solubility & Wide Experimental Adaptability
Berberine has good solubility in acidic aqueous solutions and common organic solvents, easy to prepare into experimental stock solutions and pharmacological formula systems. It maintains stable activity in conventional cell culture and animal experiment environments, perfectly adapting to antimicrobial tests, metabolic regulation experiments and botanical drug formulation research.
Applications
Natural Antibacterial & Anti-Infective Pharmacology Research
Used as a standard high-purity natural alkaloid reagent for studying bacterial inhibition mechanisms, microbial membrane metabolism and anti-parasitic activity. Widely applied in microbiology and natural product pharmacology research institutions.
Metabolic Disease & AMPK Pathway Mechanism Study
Served as the core specific positive drug for blood glucose regulation, lipid metabolism improvement and insulin resistance model experiments, supporting the efficacy verification and mechanism exploration of new natural metabolic regulatory active substances.
Botanical API Drug R&D & Pharmacological Evaluation
Applied as a classic reference compound for new natural antibacterial, anti-inflammatory and metabolic regulatory drug development, guiding structural optimization, efficacy screening and safety evaluation of isoquinoline alkaloid pharmaceutical molecules.
Isoquinoline Alkaloid Derivative Synthesis
Used as a high-value natural isoquinoline heterocyclic skeleton intermediate for the synthesis of new high-efficiency botanical drug derivatives, supporting innovative R&D of low-toxicity multi-target natural pharmaceutical intermediates.
Laboratory Pharmacological Verification & Teaching Research
Provided as standard high-purity Berberine reagent for natural pharmacology teaching experiments, antibacterial efficacy comparative tests and alkaloid structure-activity relationship verification, ensuring accurate and stable experimental data for scientific research and teaching work.
FAQ
Q1: What is Berberine mainly used for?
A: Berberine is a classic natural isoquinoline alkaloid with multi-target pharmacological activity. It is mainly used for broad-spectrum antibacterial and anti-infective mechanism research, blood glucose and lipid metabolic regulation experiments, AMPK signal pathway verification and natural botanical drug derivative synthesis, with stable and mild biological activity.
Q2: What is the structural feature of Berberine?
A: Berberine has a unique fused isoquinoline-benzodioxole heterocyclic structure with quaternary ammonium cation modification. As a typical natural plant alkaloid, its stable conjugated skeleton endows it with broad-spectrum antibacterial and metabolic regulatory activity, which is the core structural basis for its multi-target pharmacological effects.
Q3: What are the core advantages of our Berberine?
A: Our Berberine adopts low-temperature enzymatic extraction and multi-stage recrystallization purification technology, featuring ultra-high single-component purity, zero plant heterozygous impurity interference, stable multi-target pharmacological activity and consistent batch efficacy. It effectively avoids experimental errors caused by crude extract impurities and molecular degradation, ensuring high-precision natural product research results.
Q4: How to store Berberine correctly?
A: Berberine is sensitive to strong light, high temperature and humid environments, prone to oxidation and structural degradation leading to decreased biological activity. It must be stored in vacuum-sealed, low-temperature, cool and dry dark conditions. Standard sealed low-temperature storage ensures 24 months of stable shelf life and pharmacological activity.
Q5: What is the appearance of high-purity Berberine?
A: High-purity Berberine is uniform bright yellow crystalline powder at room temperature, odorless, stable crystal state, no caking, no fading and no deterioration precipitation.
Q6: Can I get free Berberine samples for testing?
A: Yes, we provide free Berberine samples for natural antibacterial mechanism research, metabolic regulatory activity verification and isoquinoline alkaloid derivative synthesis tests. Bulk orders support customized purity and professional anti-oxidation vacuum packaging to meet high-standard scientific research and pharmaceutical API production needs.
