Product Introduction
| Item | Specification |
| Product Name | Ondansetron |
| Synonyms | 1,2,3,9-Tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-4H-carbazol-4-one; Ondansetron base |
| CAS Number | 99614-02-3 |
| Molecular Formula | C₁₈H₁₉N₃O |
| Molecular Weight | 293.36 g/mol |
| Appearance | White to off-white crystalline powder, odorless, stable crystal form under sealed dark and dry conditions |
| Purity (HPLC) | ≥98.0% / ≥99.0% (Research Grade / Pharma API Grade, customizable) |
| Loss on Drying | ≤ 0.2% |
| Residue on Ignition | ≤ 0.1% |
| Testing Method | HPLC / NMR / Mass Spectrometry / IR Spectrum / Pharmacological Activity Detection |
| Production Method | Carbazole-Indole Heterocyclic Synthesis & Multi-Stage Purification & Low-Temperature Recrystallization |
| Melting Point | 178–180°C (lit.) |
| Boiling Point | 491.1°C at 760 mmHg |
| Density | 1.26 g/cm³ at 25°C |
| Flash Point | 250.6°C |
| Solubility | Soluble in methanol, ethanol, DMSO and dilute acidic solutions, slightly soluble in neutral water; stable in dry environment, sensitive to strong light and high temperature |
| Core Feature | Indole-based carbazole heterocyclic compound, highly selective 5-HT3 receptor antagonist, potent peripheral and central antiemetic activity |
| Package | 1g/5g/10g sealed amber bottle, 100g/1kg drum; vacuum moisture-proof packaging, custom specification available |
| Storage | Store in vacuum-sealed, low-temperature, dark and dry conditions; avoid strong light, high temperature and humid environment to prevent oxidation and structural degradation |
| Shelf Life | 24 months under standard low-temperature sealed storage |
Product Description
Our Ondansetron is a high-purity carbazole-indole heterocyclic derivative with stable molecular structure and complete neuropharmacological activity, available in premium research grade and pharmaceutical API grade. Ondansetron (CAS 99614-02-3) is a landmark selective serotonin receptor antagonist in the indole biochemical family, structurally based on a fused carbazole-indole ring system, differentiating it from conventional tryptamine indoles. As a highly specific 5-HT3 receptor antagonist, it exhibits no obvious affinity for other serotonin, dopamine or adrenergic receptors, delivering targeted and high-safety antiemetic efficacy. As a professional bulk Ondansetron supplier, we provide low-impurity, high-activity, batch-stable Ondansetron raw materials for global neuropharmacology research institutions, oncological pharmaceutical R&D laboratories and indole heterocyclic derivative synthesis enterprises.
Ondansetron occupies a core foundational position in antiemetic pharmacology, neuro-gastrointestinal regulation research and indole medicinal chemistry. As the first-generation gold-standard 5-HT3 antagonist, it exerts dual peripheral and central antiemetic effects: peripherally, it blocks 5-HT3 receptors on vagal afferent nerves in the gastrointestinal tract, inhibiting the emetic reflex triggered by chemotherapy and radiotherapy-induced serotonin release; centrally, it acts on the chemoreceptor trigger zone in the medulla oblongata, further suppressing nausea and vomiting signals. This unique dual-target mechanism enables Ondansetron to effectively prevent and treat chemotherapy-induced nausea and vomiting (CINV), radiation-induced emesis and postoperative nausea and vomiting (PONV). In pharmacological research, it serves as an essential tool compound for exploring 5-HT3 receptor signal transduction, neuro-gastrointestinal coupling and emetic reflex regulation. In pharmaceutical synthesis, its fused indole-carbazole skeleton provides valuable structural modification sites, supporting the development of new-generation high-efficiency antiemetic derivatives. Compared with ordinary low-purity Ondansetron products with oxidative impurities and unstable receptor antagonistic activity, our high-purity purified product eliminates synthetic intermediates, solvent residues and degradation by-products, ensuring single-component purity and stable pharmacological activity for accurate, repeatable neurological and gastrointestinal experimental data.
Manufactured by Shaanxi BAISFU Bio-Engineering Co., Ltd., our premium Ondansetron adopts advanced carbazole-indole heterocyclic precision synthesis combined with low-temperature oxygen-free reaction and multi-stage gradient recrystallization purification process. The entire production process strictly controls reaction temperature, pH value and purification gradient, completely removing unreacted indole raw materials, imidazole by-products and residual solvents. By avoiding high-temperature induced molecular structural damage and activity attenuation, the process fully retains the complete fused heterocyclic active skeleton and specific 5-HT3 receptor antagonistic activity of Ondansetron. The finished product presents uniform white to off-white crystalline powder, stable crystal form, no caking, no yellowing and no discoloration, fully complying with high-standard neuropharmacology research grade and pharmaceutical API raw material grade quality requirements.
Every batch of Ondansetron undergoes strict multi-dimensional quality inspection, including HPLC high-precision purity analysis, NMR structural verification, mass spectrometry molecular identification and cell-level neuropharmacological activity testing. It ensures zero invalid impurity interference, ultra-low trace residues and consistent batch efficacy, providing reliable raw material guarantee for antiemetic mechanism research, 5-HT3 receptor pathway experiments and indole heterocyclic drug synthesis. The product features stable solubility in organic solvents and acidic aqueous solutions, excellent biochemical stability in pharmacological experimental environments and outstanding experimental repeatability, fully meeting the strict raw material requirements of in vitro receptor blocking experiments, in vivo antiemetic model tests and new anti-nausea drug formula development.
We maintain sufficient low-temperature inventory and complete qualification documents for bulk Ondansetron supply. Whether you need standard 5-HT3 receptor antagonist monomers for neuropharmacological research, core reference substances for antiemetic drug efficacy verification, or high-purity fused indole heterocyclic intermediates for custom derivative synthesis, our premium Ondansetron is a high-cost-performance and high-value biological fine chemical product choice for global buyers.
Functions & Benefits
Highly Selective 5-HT3 Receptor Antagonist (Core Benefit)
Ondansetron is a classic high-specificity 5-HT3 serotonin receptor blocker with no significant binding activity to other neurotransmitter receptors. It precisely inhibits peripheral vagal afferent activation and central emetic signal transmission, serving as the core standard tool compound for antiemetic pharmacology and 5-HT3 pathway research.
Fused Indole-Carbazole Heterocyclic Structure
As a unique fused-ring indole derivative, Ondansetron expands the structural diversity of indole medicinal compounds. Its integrated carbazole-indole skeleton and imidazole methyl modification provide critical research templates for indole heterocyclic structure-activity relationship and new drug development.
Dual Central & Peripheral Antiemetic Efficacy
High-purity Ondansetron stably exerts dual antiemetic effects on gastrointestinal peripheral nerves and medullary chemoreceptor trigger zone, effectively improving chemotherapy, radiotherapy and postoperative nausea and vomiting symptoms. It is the primary positive control drug for antiemetic pharmacological evaluation experiments.
Low-Impurity Purification & Ultra-Stable Pharmacological Activity
Our Ondansetron adopts low-temperature oxygen-free anti-oxidation purification technology, removing oxidative degradation impurities and invalid intermediate residues generated during heterocyclic synthesis. It solves the problem of decreased receptor blocking activity and unstable experimental data of conventional products, ensuring long-term stable pharmacological efficacy.
Strict Batch Consistency & High Experimental Repeatability
Synthesized and recrystallized under constant low-temperature sterile conditions, Ondansetron eliminates process quality fluctuations. The product has uniform crystal form, stable molecular structure and consistent batch receptor antagonistic activity, suitable for long-term neurogastroenterology research and high-precision antiemetic drug screening experiments.
Excellent Solubility & Wide Experimental Adaptability
Ondansetron has good solubility in common organic solvents and acidic aqueous solutions, easy to prepare into experimental stock solutions and pharmacological formula systems. It maintains stable activity in conventional cell and animal experiment environments, perfectly adapting to receptor blocking tests, in vivo antiemetic model experiments and pharmaceutical formulation research.
Applications
5-HT3 Receptor Pharmacology & Neuro-GI Research
Used as a standard high-purity 5-HT3 receptor antagonist reagent for studying serotonin-mediated neuro-gastrointestinal signal transduction, vagal nerve reflex regulation and central emetic mechanism. Widely applied in neuropharmacology and gastroenterology research institutions.
Chemotherapy/Radiation/Postoperative Emesis Mechanism Study
Served as the core specific positive drug for CINV, RINV and PONV model experiments, supporting the efficacy verification and mechanism exploration of new antiemetic and gastrointestinal regulatory active substances.
Antiemetic API Drug R&D & Pharmacological Evaluation
Applied as a classic reference compound for new anti-nausea and antiemetic drug development, guiding structural optimization, efficacy screening and safety evaluation of indole heterocyclic neuro-gastrointestinal drugs.
Fused Indole Heterocyclic Derivative Synthesis
Used as a high-value fused indole-carbazole skeleton intermediate for the synthesis of new targeted neuro-gastrointestinal regulatory derivatives, supporting innovative R&D of high-efficiency and low-side-effect antiemetic pharmaceutical intermediates.
Laboratory Pharmacological Verification & Teaching Research
Provided as standard high-purity Ondansetron reagent for neuropharmacology teaching experiments, 5-HT3 receptor efficacy comparative tests and indole heterocyclic structure-activity relationship verification, ensuring accurate and stable experimental data for scientific research and teaching work.
FAQ
Q1: What is Ondansetron mainly used for?
A: Ondansetron is a classic indole-carbazole based selective 5-HT3 receptor antagonist. It is mainly used for antiemetic pharmacological mechanism research, chemotherapy/radiation/postoperative vomiting intervention experiments, neuro-gastrointestinal signal pathway verification and fused indole heterocyclic drug synthesis, with high-target and high-stability pharmacological activity.
Q2: What is the structural feature of Ondansetron?
A: Different from ordinary tryptamine indoles, Ondansetron has a unique fused indole-carbazole bicyclic structure with imidazole methyl functional modification. It is a high-value heterocyclic indole derivative specifically targeting 5-HT3 receptors, representing an important branch of indole medicinal chemistry in neuro-gastrointestinal regulation.
Q3: What are the core advantages of our Ondansetron?
A: Our Ondansetron adopts low-temperature oxygen-free purification and multi-stage recrystallization technology, featuring ultra-high single-component purity, zero residual heterocyclic intermediate interference, stable 5-HT3 receptor antagonistic activity and consistent batch efficacy. It effectively avoids experimental errors caused by product oxidation and impurity interference, ensuring high-precision pharmacological research results.
Q4: How to store Ondansetron correctly?
A: Ondansetron is sensitive to strong light, high temperature and humid environments, prone to oxidation and structural degradation leading to decreased receptor blocking activity. It must be stored in vacuum-sealed, low-temperature, cool and dry dark conditions. Standard sealed low-temperature storage ensures 24 months of stable shelf life and pharmacological activity.
Q5: What is the appearance of high-purity Ondansetron?
A: High-purity Ondansetron is uniform white to off-white crystalline powder at room temperature, odorless, stable crystal state, no caking, no discoloration and no deterioration precipitation.
Q6: Can I get free Ondansetron samples for testing?
A: Yes, we provide free Ondansetron samples for antiemetic mechanism research, 5-HT3 receptor activity verification and fused indole heterocyclic derivative synthesis tests. Bulk orders support customized purity and professional anti-oxidation vacuum packaging to meet high-standard scientific research and pharmaceutical API production needs.
