Product Introduction
| Item | Specification |
| Product Name | 4-Dimethylaminopyridine |
| Synonyms | DMAP; N,N-Dimethylpyridin-4-amine; 4-(Dimethylamino)pyridine |
| CAS Number | 1122-58-3 |
| Molecular Formula | C₇H₁₀N₂ |
| Molecular Weight | 122.17 g/mol |
| Appearance | White to off-white crystalline powder, slight amine odor, stable crystal form at room temperature |
| Purity (HPLC/GC) | ≥98.0% / ≥99.0% (Industrial Grade / Research Grade, customizable) |
| Loss on Drying | ≤ 0.2% |
| Residue on Ignition | ≤ 0.1% |
| Testing Method | HPLC / GC / NMR / Mass Spectrometry / IR Spectrum |
| Production Method | Precision Amination Synthesis & Multi-Stage Recrystallization & Low-Temperature Purification |
| Melting Point | 108–113°C (lit.) |
| Boiling Point | 162°C at 50 mmHg |
| Density | 1.012 g/cm³ at 25°C |
| Flash Point | 110°C |
| Solubility | Freely soluble in water, methanol, ethanol, chloroform and polar organic solvents, slightly soluble in aliphatic hydrocarbons, stable in neutral and weakly alkaline systems |
| Core Feature | High nucleophilic catalytic activity, superior to conventional pyridine catalysts, mild reaction conditions, high conversion rate and wide reaction adaptability |
| Package | 10g/100g sealed amber bottle, 1kg/5kg drum; custom packaging available |
| Storage | Store in sealed, cool, dark and dry conditions; avoid strong light, high temperature and humid environment to prevent moisture absorption and activity attenuation |
| Shelf Life | 24 months under standard sealed storage |
Product Description
Our 4-Dimethylaminopyridine (DMAP) is a high-purity pyridine derivative catalytic reagent with excellent nucleophilic reactivity, available in 98% industrial grade and 99% research premium grade. 4-Dimethylaminopyridine (CAS 1122-58-3) is a high-efficiency organic catalyst widely recognized in fine chemical synthesis, pharmaceutical manufacturing and polymer material research. Different from common pyridine compounds such as Pyridoxine for biochemical nutrition and Sulfapyridine for antibacterial pharmacology, DMAP is professionally positioned inhigh-efficiency catalytic synthesis and organic reaction optimization. Benefiting from the electron-donating effect of the 4-dimethylamino group on the pyridine ring, it exhibits significantly stronger alkalinity and nucleophilic catalytic activity than ordinary pyridine, making it an irreplaceable core catalyst for acylation, esterification, condensation and rearrangement reactions.
4-Dimethylaminopyridine occupies a pivotal core position in modern organic synthesis and pharmaceutical intermediate industry. As a super nucleophilic catalyst, DMAP can effectively reduce reaction activation energy, accelerate reaction rate, and improve product yield and purity under mild temperature and pressure conditions. It is widely applicable to esterification of carboxylic acids, alcohol acylation, amine acylation, anhydride condensation and heterocyclic compound rearrangement reactions. In the synthesis of high-purity pharmaceutical intermediates such as Milrinone, Clopidogrel and other heterocyclic drugs, DMAP can effectively optimize the reaction pathway, reduce side reactions and avoid impurity generation, greatly improving the batch stability of finished pharmaceutical products. Compared with traditional pyridine and triethylamine catalysts, DMAP features lower dosage, higher efficiency, milder reaction conditions and wider substrate adaptability.
Manufactured by Shaanxi BAISFU Bio-Engineering Co., Ltd., our premium 4-Dimethylaminopyridine adopts advanced precision amination synthesis technology combined with multi-stage low-temperature recrystallization and gradient impurity removal purification process. The whole production process strictly controls reaction temperature, pH value and purification gradient, completely removing unreacted pyridine raw materials, amine by-products, solvent residues and macromolecular impurities. We effectively avoid catalyst activity attenuation caused by residual impurities, fully retaining the high nucleophilic catalytic activity and stable pyridine ring structure of DMAP. The finished product presents uniform white crystalline powder, no caking, no discoloration, low moisture absorption and stable physical and chemical properties, fully complying with industrial catalytic grade and high-precision scientific research grade quality standards.
Every batch of 4-Dimethylaminopyridine undergoes strict multi-dimensional quality inspection, including HPLC high-precision purity analysis, NMR structural verification, mass spectrometry molecular identification and trace impurity residue detection. It ensures ultra-high single-component purity, zero invalid impurity interference and stable batch catalytic activity, providing reliable catalyst guarantee for high-end fine chemical synthesis and pharmaceutical intermediate production. The product features excellent solubility in common organic solvents, stable catalytic performance in mild acid-base environments and high reaction compatibility, fully meeting the strict raw material requirements of laboratory formula debugging, pilot-scale amplification and large-scale industrial continuous production.
We maintain sufficient inventory and complete qualification documents for bulk 4-Dimethylaminopyridine supply. Whether you need high-efficiency catalytic reagents for pharmaceutical intermediate synthesis, standard catalysts for organic reaction mechanism research, or high-purity raw materials for custom fine chemical derivation, our premium DMAP is a high-cost-performance and high-value catalytic product choice for global buyers.
Functions & Benefits
Superior Nucleophilic Catalytic Activity (Core Benefit)
4-Dimethylaminopyridine has far higher nucleophilic catalytic efficiency than conventional pyridine catalysts. It can significantly accelerate acylation, esterification and condensation reactions under mild conditions, reduce reaction temperature and time, effectively improve synthetic yield and reduce energy consumption, serving as the preferred high-efficiency catalyst for fine organic synthesis.
Wide Organic Reaction Adaptability
DMAP shows excellent catalytic performance for carboxylic acid esterification, alcohol and amine acylation, anhydride ring-opening condensation and heterocyclic molecular rearrangement reactions. It is compatible with most polar organic solvent systems, with stable catalytic activity and strong substrate universality, suitable for diversified synthetic process development.
Professional Pharmaceutical Synthesis Catalyst
High-purity 4-Dimethylaminopyridine features ultra-low impurity content and no catalytic side interference. It can effectively inhibit by-product generation in pharmaceutical intermediate synthesis, improve finished product purity and batch consistency, and is widely used in the synthesis optimization of heterocyclic drugs, cardiovascular drugs and antibiotic intermediates.
Ultra-Low Impurity & Stable Catalytic Performance
Purified pharmaceutical-grade DMAP removes residual raw materials, organic impurities and heavy metal contamination. It maintains stable high-efficiency catalytic activity for a long time, no failure or attenuation during reaction, ensuring stable and controllable synthetic process and consistent product quality.
Strict Batch Consistency & Industrial Stability
Synthetic and recrystallized 4-Dimethylaminopyridine eliminates raw material quality fluctuations. The product has uniform crystal form, stable solubility and consistent catalytic efficiency, suitable for long-term continuous industrial production and repeated scientific research experiments.
Excellent Solubility & Formula Compatibility
DMAP has excellent solubility in water and various polar organic solvents, easy to dissolve and disperse evenly in reaction systems. It features fast catalytic response and high reaction conversion rate, perfectly adapting to laboratory debugging and large-scale industrial production scenarios.
Applications
Pharmaceutical Intermediate Catalytic Synthesis
Used as a core high-efficiency catalyst for the synthesis of heterocyclic drugs, cardiovascular drugs, antibacterial drugs and vitamin derivatives such as Milrinone, Clopidogrel and Pyridoxine. It optimizes acylation and condensation processes, improves product yield and reduces impurity residues.
Fine Chemical Organic Synthesis
Widely applied in esterification, acylation, alkylation and rearrangement reactions of fine chemicals. It serves as a key catalytic reagent for the custom synthesis of high-purity fine chemical monomers and functional heterocyclic derivatives, simplifying synthetic routes and improving production efficiency.
Polymer Material Preparation
Used as a curing catalyst and reaction accelerator for polyurethane, epoxy resin and polyester polymer materials. It improves material cross-linking efficiency, optimizes product mechanical properties and enhances material production stability.
Chemical Analysis & Laboratory Research
Applied in organic reaction mechanism verification, catalytic performance testing and experimental formula debugging. High-purity DMAP provides accurate and stable catalytic conditions for university laboratories and chemical research institutions, ensuring repeatable experimental data.
New Process Development & Industrial Upgrading
Used for the optimization and upgrading of traditional low-efficiency synthetic processes, replacing traditional low-activity catalysts. It helps enterprises reduce production costs, improve product purity and realize high-efficiency and green chemical production.
FAQ
Q1: What is 4-Dimethylaminopyridine (DMAP) mainly used for?
A: 4-Dimethylaminopyridine (DMAP) is a high-efficiency nucleophilic organic catalyst. It is mainly used for catalytic synthesis of pharmaceutical intermediates, fine chemical acylation/esterification reactions, polymer material curing and laboratory organic research, with outstanding high-efficiency catalytic advantages.
Q2: What is the advantage of DMAP over ordinary pyridine catalysts?
A: DMAP has a unique dimethylamino-substituted pyridine structure, which endows it with stronger alkalinity and nucleophilic catalytic activity. It features lower dosage, faster reaction speed, milder reaction conditions and fewer side reactions than ordinary pyridine, significantly improving synthetic yield and product purity.
Q3: What are the core advantages of our DMAP?
A: Our 4-Dimethylaminopyridine adopts multi-stage recrystallization purification technology, featuring ultra-high single-component purity, ultra-low trace impurities, stable catalytic activity and zero batch difference. It can effectively optimize organic synthetic processes, reduce by-products and improve finished product quality, with significant industrial and scientific research value.
Q4: How to store 4-Dimethylaminopyridine correctly?
A: DMAP is slightly hygroscopic and sensitive to high temperature and strong light. It needs to be stored in sealed, cool, dry and dark conditions to prevent moisture absorption agglomeration and catalytic activity attenuation. Standard sealed storage ensures 24 months of stable shelf life.
Q5: What is the appearance of high-purity DMAP?
A: High-purity 4-Dimethylaminopyridine is uniform white to off-white crystalline powder at room temperature, with slight amine odor, stable crystal state, no caking and no discoloration.
Q6: Can I get free DMAP samples for catalytic testing?
A: Yes, we provide free 4-Dimethylaminopyridine samples for organic catalytic reaction verification, synthetic process debugging and pharmaceutical intermediate synthesis tests. Bulk orders support customized purity and packaging to meet industrial and scientific research demands.
