Product Introduction
| Item | Specification |
| Product Name | Clopidogrel |
| Synonyms | Methyl (S)-(2-chlorophenyl)(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)acetate |
| CAS Number | 113665-84-2 |
| Molecular Formula | C₁₆H₁₆ClNO₂S |
| Molecular Weight | 321.82 g/mol |
| Appearance | White to off-white crystalline powder, odorless, stable crystal morphology at room temperature |
| Purity (HPLC/GC) | ≥98.0% / ≥99.0% (Pharma Grade / Research Grade, customizable) |
| Loss on Drying | ≤ 0.2% |
| Residue on Ignition | ≤ 0.1% |
| Testing Method | HPLC / GC / NMR / Mass Spectrometry / IR Spectrum |
| Production Method | Precision Asymmetric Synthesis & Multi-Stage Recrystallization Purification & Chiral Resolution |
| Melting Point | 184–186°C (lit.) |
| Boiling Point | 423.4°C at 760 mmHg |
| Density | 1.32 g/cm³ at 25°C |
| Flash Point | 209.8°C |
| Solubility | Slightly soluble in water, freely soluble in methanol, ethanol, DMSO and polar organic solvents, stable in neutral and weakly acidic reaction systems |
| Core Feature | Complete chlorophenyl-piperidine skeleton, high molecular reconfiguration activity, exclusive core precursor for industrial Loperamide synthesis |
| Package | 10g/100g sealed amber bottle, 1kg/5kg drum; custom packaging available |
| Storage | Store in sealed, cool, dark and dry conditions; avoid high temperature, strong light and humid environment to prevent chiral isomerization and molecular degradation |
| Shelf Life | 24 months under standard sealed storage |
Product Description
Our Clopidogrel is a high-purity pharmaceutical-grade thienopyridine heterocyclic intermediate with stable chiral molecular structure, available in 98% and 99% premium grades. Clopidogrel (CAS 113665-84-2) is a core nitrogen-sulfur heterocyclic compound in the fine chemical and pharmaceutical intermediate industry, most famous as the exclusive industrial precursor for high-purity Loperamide synthesis. Different from terpenoid products such as Borneol and Terpinen-4-ol focused on fragrance modulation and cosmetic antisepsis, and differentiated from alkaloid end products such as Anabasine and Loperamide used for biopesticide and biomedical research, Clopidogrel is professionally positioned in high-end heterocyclic skeleton reconfiguration synthesis and chiral pharmaceutical intermediate manufacturing, featuring unique directional molecular cleavage, group substitution and cyclization rearrangement activity. As a professional bulk Clopidogrel supplier, we provide low-impurity, high-activity, batch-stable chiral intermediates for global fine chemical factories, biomedical research institutions and alkaloid industrial synthesis enterprises.
Clopidogrel has irreplaceable core industrial value in standardized Loperamide mass production. It retains the complete and stable chlorophenyl-piperidine core skeleton required for Loperamide molecular structure, with high structural homology and matching reaction activity. Under precise inert environment and composite catalytic conditions, Clopidogrel can undergo directional deprotection, side-chain cleavage and intramolecular rearrangement cyclization, efficiently converting its inherent thienopyridine heterocyclic structure into the standard piperidine alkaloid skeleton of Loperamide. Compared with traditional full organic synthesis routes of Loperamide that feature complex reaction steps, low conversion rate and numerous isomer impurities, the Clopidogrel reconfiguration synthesis route greatly simplifies the production process, reduces by-product generation, and fundamentally guarantees the high purity and batch consistency of downstream Loperamide products, becoming the mainstream high-standard industrial production process.
Manufactured by Shaanxi BAISFU Bio-Engineering Co., Ltd., our premium Clopidogrel adopts advanced precision asymmetric synthesis combined with multi-stage low-temperature recrystallization and high-precision chiral resolution technology. The whole production process is carried out under strict inert gas protection and constant temperature control, effectively avoiding chiral racemization, molecular oxidation and structural distortion. We completely remove unreacted raw materials, chiral isomer impurities, solvent residues and macromolecular by-products, eliminating the defects of ordinary industrial Clopidogrel such as low chiral purity, high miscellaneous impurity content and unstable reaction activity. The finished product presents uniform white crystalline powder, stable physical and chemical properties, no hygroscopic deterioration, and excellent skeleton reconfiguration activity for downstream synthesis.
Every batch of Clopidogrel undergoes strict multi-dimensional quality inspection, including HPLC high-precision chiral purity analysis, NMR structural verification, mass spectrometry molecular identification and trace impurity residue detection. It ensures ultra-high single-component purity, zero invalid chiral isomer interference and stable batch consistency, which is the core guarantee for high-yield and high-purity Loperamide industrial synthesis. The product features stable crystal structure, moderate solubility in polar solvents, excellent low-temperature reaction stability and formula compatibility, fully meeting the strict raw material standards of pharmaceutical intermediate derivation, chiral biomedical experiments and large-scale alkaloid synthesis.
We maintain sufficient inventory and complete qualification documents for bulk Clopidogrel supply. Whether you need high-activity skeleton raw materials for industrial Loperamide mass production, standard chiral monomers for biomedical pharmacological research, or key intermediates for custom heterocyclic derivative development, our high-purity pharmaceutical-grade Clopidogrel is a high-cost-performance and high-value fine chemical raw material choice for global buyers.
Functions & Benefits
Exclusive Core Precursor for Industrial Loperamide Synthesis (Core Benefit)
Clopidogrel is the most mature and efficient industrial raw material for high-purity Loperamide production. Its inherent chlorophenyl-piperidine skeleton highly matches the molecular structure of Loperamide. Through precise directional cleavage and molecular reconfiguration reaction, it can be efficiently converted into high-purity Loperamide with ultra-low isomer impurities, supporting stable mass production of high-standard pharmaceutical-grade Loperamide products.
High-Precision Chiral Heterocyclic Intermediate
With stable chiral molecular structure and high directional reaction selectivity, Clopidogrel has excellent performance in deprotection, side-chain cleavage, skeleton rearrangement and group substitution reactions. It is widely used in the custom synthesis and structural optimization of various piperidine heterocyclic derivatives, with controllable reaction process and stable finished product quality.
Professional Chiral Biomedical Research Tool Compound
Clopidogrel has specific chiral pharmacological activity and stable molecular properties, serving as an important tool compound for cardiovascular pharmacology, chiral drug mechanism research and heterocyclic alkaloid toxicology research. It provides accurate and repeatable experimental support for global biomedical and pharmaceutical research institutions.
Ultra-Low Impurity & Chiral Structural Stability
Pharmaceutical-grade purified Clopidogrel eliminates industrial impurities, invalid chiral isomers and residual solvents. It features ultra-high single-component purity, stable stereochemical structure, no adverse interference on downstream reconfiguration synthesis reactions, and ensures zero batch difference of end Loperamide products.
Strict Batch Consistency & Industrial Adaptability
Synthesized and chiral-resolved Clopidogrel avoids raw material source fluctuations and structural quality differences. The product has stable crystal form and skeleton reaction activity, suitable for long-term continuous industrial production and high-precision laboratory customized chiral experiments.
Excellent Solubility & Reaction Compatibility
Clopidogrel has good solubility in various polar organic solvents and stable activity in neutral and weakly acidic reaction systems. It is easy to dissolve and compound, with high molecular reconfiguration conversion rate, perfectly adapting to diverse heterocyclic synthesis and formula debugging scenarios.
Applications
High-Purity Loperamide Industrial Synthesis
As the exclusive core starting raw material, Clopidogrel undergoes directional deprotection, side-chain cleavage and chiral molecular rearrangement, then obtains high-purity Loperamide through multi-stage recrystallization and high-vacuum purification. This reconfiguration synthetic route is the mainstream high-end process to replace traditional full synthesis, ensuring high yield and ultra-low impurity of finished Loperamide.
Chiral Biomedical & Pharmacological Research
High-purity Clopidogrel is widely used in chiral drug mechanism research, cardiovascular pharmacology experiments and heterocyclic compound efficacy testing. It serves as a standard experimental monomer for university laboratories, pharmaceutical research institutes and drug safety detection institutions.
Heterocyclic Derivative Custom Synthesis
Used as a key chiral heterocyclic intermediate for structural modification and derivatization of piperidine and thiophene compounds. It supports the research and development of new pharmaceutical intermediates, biological active molecules and fine chemical additives.
Fine Chemical Industrial Raw Material Manufacturing
Applied in the production of high-purity chiral nitrogen-sulfur heterocyclic compounds and custom fine chemical synthesis projects. It provides stable and high-quality raw material support for downstream pharmaceutical intermediate upgrading and technological innovation.
Laboratory Scientific Research & Formula Debugging
Provided as standard high-purity Clopidogrel monomer for heterocyclic skeleton synthesis mechanism verification, chiral activity testing and custom experimental development, supporting scientific research innovation and new product iteration.
FAQ
Q1: What is Clopidogrel mainly used for?
A: Clopidogrel is a high-value pharmaceutical-grade chiral heterocyclic intermediate. Its core industrial application is serving as the exclusive synthetic precursor for high-purity Loperamide. It is also widely used in chiral biomedical pharmacological research, heterocyclic derivative synthesis and fine chemical custom synthesis.
Q2: Why use Clopidogrel to synthesize Loperamide?
A: Clopidogrel has a highly matched chlorophenyl-piperidine skeleton with Loperamide. The reconfiguration synthetic route features high molecular utilization rate, high reaction selectivity, few by-products and ultra-low chiral isomer impurities. It completely solves the defects of complex process and unstable purity of traditional fully synthetic Loperamide, being the preferred industrial process for high-end Loperamide mass production.
Q3: What are the core advantages of our Clopidogrel?
A: Our Clopidogrel adopts pharmaceutical-grade chiral resolution and multi-stage purification technology. It features ultra-high single-component purity, stable chiral stereostructure, ultra-low residual impurities and high skeleton reconfiguration activity. It has absolute advantages in improving Loperamide synthesis yield and finished product purity, with excellent batch consistency and strong industrial applicability.
Q4: How to store Clopidogrel correctly?
A: Clopidogrel is sensitive to high temperature, strong light and humidity, and prone to chiral isomerization and molecular degradation. It needs to be stored in sealed, cool, dry and dark conditions. Standard sealed storage ensures 24 months of stable shelf life and reaction activity.
Q5: What is the appearance of high-purity Clopidogrel?
A: High-purity Clopidogrel is uniform white to off-white crystalline powder at room temperature, odorless, stable crystal state, no caking, no impurity precipitation and no discoloration.
Q6: Can I get free Clopidogrel samples for synthesis testing?
A: Yes, we provide free Clopidogrel samples for Loperamide synthesis debugging, chiral pharmacological experiment research and heterocyclic derivative synthesis tests. Bulk orders support customized purity and packaging to meet industrial production and scientific research needs.
