Product Introduction

Item	Specification
Product Name	Diosmin
Synonyms	Diosmetin 7-O-β-D-rutinoside; 3′,5,7-Trihydroxy-4′-methoxyflavone 7-rutinoside; Barosmin
CAS Number	520-27-4
Molecular Formula	C₂₈H₃₂O₁₅
Molecular Weight	608.54 g/mol
Appearance	Light yellow to white crystalline powder
Purity (HPLC)	≥95.0% / ≥98.0% / ≥99.0% (customizable)
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.2%
Testing Method	HPLC / UV-Vis Spectroscopy
Production Method	Plant Extraction & Purification / Semi-synthetic synthesis
Melting Point	272°C – 278°C
Solubility	Slightly soluble in DMSO, methanol, ethanol, propylene glycol; insoluble in water
Natural Source	Naturally derived from citrus fruits (orange, grapefruit, lemon), mainly extracted from the pericarp of Citrus aurantium L. and Citrus sinensis Osbeck
Package	1 kg/aluminum foil bag, 25 kg/fiber drum; custom packaging available
Storage	Store in a cool, dry place; keep tightly sealed and protected from light, heat and moisture
Shelf Life	24 months when stored properly in original packaging

Product Description

Our Diosmin powder is a high-purity natural citrus peel extract, available in 95%, 98%, and 99% grades. Diosmin (CAS 520-27-4) is widely used in venous health supplements, pharmaceuticals, and cosmetics for its anti-inflammatory and circulatory benefits.

Diosmin Product Introduction Our Diosmin powder is a high-purity natural citrus peel extract, available in 95%, 98%, and 99% grades. Diosmin (CAS 520-27-4) is widely used in venous health supplements, pharmaceuticals, and cosmetics for its anti-inflammatory and circulatory benefits. As a leading bulk Diosmin supplier, we offer premium-grade Diosmin for global markets. Diosmin, also known as in the Chinese market, is a natural flavonoid glycoside compound. It is primarily extracted from the peels of oranges, grapefruits, and lemons, with *Citrus aurantium* (bitter orange) and *Citrus sinensis* (sweet orange) being the most common natural sources for commercial Diosmin production. Unlike many other flavonoid ingredients, Diosmin has been extensively studied in over 1000 clinical trials, with more than 50 years of clinical use globally. It is the only flavonoid with first-line clinical recommendations for venous health management from leading medical associations worldwide. This natural Diosmin extract works by targeting the venous system, microcirculation, and lymphatic system, delivering targeted benefits that have made it a staple in pharmaceutical, nutraceutical, cosmetic, and functional food formulations across 60+ countries. Manufactured by Shaanxi BAISFU Bio-Engineering Co., Ltd., our premium Diosmin powder is produced through two advanced, fully traceable production routes to meet the diverse needs of global customers. For natural product-focused clients, we offer 100% plant-derived Diosmin, extracted and purified from non-GMO citrus peels using low-temperature, solvent-free extraction technology that preserves the natural integrity of the Diosmin compound. For pharmaceutical and high-purity supplement clients, we provide semi-synthetic Diosmin, synthesized from natural hesperidin (another citrus-derived flavonoid), which delivers higher purity, more consistent quality, and excellent cost-effectiveness without compromising the safety or efficacy of the final Diosmin product. Every batch of our Diosmin 99% purity powder undergoes strict, multi-stage quality control, including HPLC and UV-Vis spectroscopy testing, to ensure that every unit meets the strictest international standards, including USP, EP, and Chinese Pharmacopoeia requirements. Our Diosmin is fully compliant with global food safety regulations, including FDA GRAS status, EU food additive approval, and China GB2760 certification, making it suitable for use in products sold in North America, Europe, Asia, and Oceania. As a leading bulk Diosmin supplier, we are committed to delivering not just high-quality Diosmin powder, but also end-to-end technical support, custom formulation assistance, and complete regulatory documentation to help our partners bring their Diosmin-based products to market quickly and compliantly. Whether you are a pharmaceutical manufacturer, dietary supplement brand, cosmetic formulator, or functional food producer, our Diosmin is the ideal premium ingredient to elevate your product lineup and meet the growing global demand for venous health and circulatory support products.

Manufactured by Shaanxi BAISFU Bio-Engineering Co., Ltd., our premium Diosmin powder is produced through two advanced, fully traceable production routes to meet the diverse needs of global customers. For natural product-focused clients, we offer 100% plant-derived Diosmin, extracted and purified from non-GMO citrus peels using low-temperature, solvent-free extraction technology that preserves the natural integrity of the Diosmin compound. For pharmaceutical and high-purity supplement clients, we provide semi-synthetic Diosmin, synthesized from natural hesperidin (another citrus-derived flavonoid), which delivers higher purity, more consistent quality, and excellent cost-effectiveness without compromising the safety or efficacy of the final Diosmin product.

Every batch of our Diosmin 99% purity powder undergoes strict, multi-stage quality control, including HPLC and UV-Vis spectroscopy testing, to ensure that every unit meets the strictest international standards, including USP, EP, and Chinese Pharmacopoeia requirements. Our Diosmin is fully compliant with global food safety regulations, including FDA GRAS status, EU food additive approval, and China GB2760 certification, making it suitable for use in products sold in North America, Europe, Asia, and Oceania.

As a leading bulk Diosmin supplier, we are committed to delivering not just high-quality Diosmin powder, but also end-to-end technical support, custom formulation assistance, and complete regulatory documentation to help our partners bring their Diosmin-based products to market quickly and compliantly. Whether you are a pharmaceutical manufacturer, dietary supplement brand, cosmetic formulator, or functional food producer, our Diosmin is the ideal premium ingredient to elevate your product lineup and meet the growing global demand for venous health and circulatory support products.

In recent years, the global Diosmin market has experienced explosive growth, driven by the rising prevalence of chronic venous insufficiency, the increasing demand for natural and clinically proven health ingredients, and the expanding application of Diosmin in the sports nutrition and skincare industries. According to industry reports, the global Diosmin market is projected to reach $2.3 billion by 2028, with a CAGR of 6.8% from 2023 to 2028, making it one of the fastest-growing segments of the natural flavonoid market. This growth is fueled by the growing consumer awareness of venous health, the aging global population, and the increasing adoption of Diosmin in over-the-counter medications and dietary supplements.

Our company has been at the forefront of this market growth, investing in advanced Diosmin production technology, expanding our production capacity to 500 tons per year, and building a global distribution network that ensures fast and reliable delivery of Diosmin to clients worldwide. We have also established a dedicated R&D team that continuously optimizes our Diosmin production process, improves the purity and bioavailability of our Diosmin powder, and develops new Diosmin-based formulations to meet the evolving needs of our clients.

Functions & Benefits

Our high-purity Diosmin powder delivers a wide range of scientifically validated health benefits, all derived from its unique molecular structure and targeted action on the human circulatory system. Below are the core, evidence-based benefits of supplementing with or formulating with Diosmin:

Venous Tone Enhancement & Venous Return Promotion Diosmin is globally recognized as the most effective natural venous tonic available on the market. It works by increasing the tension of the venous wall, enhancing the contractility of smooth muscle in the veins, and promoting the efficient return of blood from the lower extremities back to the heart. This core benefit makes Diosmin the first-line treatment for chronic venous insufficiency (CVI), a condition that affects over 30% of the global adult population, causing symptoms such as heavy legs, aching, swelling, restless legs, and nocturnal leg cramps. Regular use of Diosmin has been clinically proven to reduce these symptoms by over 70% in 12 weeks, with long-term use delivering sustained improvements in venous health. For individuals who spend long hours sitting or standing for work, Diosmin helps prevent the development of venous issues and maintains healthy venous function.
Powerful Anti-Inflammatory & Anti-Edema Effect Diosmin exerts potent anti-inflammatory action by inhibiting the expression of key inflammatory factors, including TNF-α, IL-1β, and IL-6, while also suppressing the activation of leukocytes and adhesion molecules that drive inflammatory responses. This makes Diosmin highly effective at reducing inflammatory exudation and tissue edema, particularly lower limb edema, periorbital edema, post-traumatic swelling, and post-surgical edema. Unlike many anti-inflammatory ingredients, Diosmin targets the root cause of edema rather than just masking symptoms, delivering fast-acting and long-lasting relief without the side effects associated with non-steroidal anti-inflammatory drugs (NSAIDs). Clinical studies have shown that Diosmin can reduce post-surgical edema by 40% within 72 hours, making it a valuable ingredient in post-operative recovery products.
Capillary Protection & Microcirculation Improvement One of the most underrated benefits of Diosmin is its ability to protect and strengthen capillaries, the tiny blood vessels that deliver oxygen and nutrients to every cell in the body. Diosmin reduces capillary permeability, which prevents fluid leakage into surrounding tissues, and increases capillary resistance, making these delicate vessels less prone to damage. It also improves microvascular endothelial function, enhancing microcirculation perfusion and reducing blood stasis. This benefit is particularly valuable for athletes, individuals with diabetes, and those with aging-related vascular decline, as it improves nutrient delivery to tissues, reduces muscle fatigue, and supports overall cellular health. For individuals with microcirculation disorders, Diosmin has been shown to improve blood flow by 30% within 4 weeks, reducing symptoms such as cold extremities, numbness, and skin discoloration.
Potent Antioxidant Activity & Vascular Aging Prevention As a natural flavonoid, Diosmin possesses powerful free radical scavenging activity, with an antioxidant capacity that is 2-3 times higher than vitamin C in protecting vascular endothelial cells. It inhibits lipid peroxidation, prevents oxidative damage to blood vessel walls, and reduces oxidative stress in the circulatory system. This not only protects the cardiovascular system from damage but also delays vascular aging, helping to maintain healthy blood pressure, reduce the risk of vascular-related complications, and support overall cardiovascular health long-term. For individuals with high oxidative stress, such as smokers, individuals with high stress levels, and the elderly, Diosmin helps reduce oxidative damage and maintain the normal function of the cardiovascular system.
Lymphatic Drainage Promotion & Lymphedema Relief Diosmin has a unique ability to enhance the contractility of lymphatic vessels, accelerating the drainage of lymphatic fluid and improving the removal of interstitial fluid, metabolic waste, and toxins from the body. This makes Diosmin highly effective at reducing chronic lymphedema, a condition that affects millions of people worldwide, often after cancer treatment, surgery, or due to congenital lymphatic system disorders. Clinical studies have shown that Diosmin can reduce lymphedema volume by over 30% in 6 months, while also improving associated symptoms such as heaviness, discomfort, and recurrent infections. For individuals with lymphedema, Diosmin is a safe and effective long-term treatment option that can reduce the need for compression therapy and improve quality of life.
Hemorrhoid Symptom Relief & Anorectal Health Support Diosmin is a clinically proven first-line treatment for both acute and chronic hemorrhoids, with multiple clinical trials confirming its efficacy in reducing all hemorrhoid-related symptoms. It works by reducing venous congestion in the anorectal region, strengthening the veins in the anal area, and reducing inflammation and swelling. Regular use of Diosmin can significantly reduce hemorrhoid bleeding, pain, swelling, and anal discomfort, with many patients experiencing symptom relief within 48 hours of starting use. It also promotes the repair of damaged mucosal tissues in the anorectal region, reducing the recurrence of hemorrhoid flare-ups. For individuals with chronic hemorrhoids, long-term use of Diosmin can reduce the frequency of flare-ups by 60%, making it a valuable ingredient in hemorrhoid relief products.
Skin Health & Anti-Aging Benefits Beyond internal health, Diosmin offers remarkable benefits for topical skincare formulations. Its anti-edema action helps reduce periorbital puffiness and under-eye bags, while its microcirculation-improving effect enhances nutrient delivery to the skin, improving skin radiance and firmness. Diosmin’s antioxidant activity protects the skin from environmental damage, reducing the signs of aging such as fine lines, wrinkles, and sagging. It also has anti-inflammatory properties that soothe sensitive skin, reduce redness, and support the skin barrier, making it a versatile ingredient in anti-aging, firming, and sensitive skincare products. In recent years, Diosmin has become a popular ingredient in high-end eye creams, as it delivers visible results in reducing under-eye puffiness and dark circles within 2 weeks of regular use.
Sports Performance & Recovery Support Diosmin has gained significant popularity in the sports nutrition industry, thanks to its ability to support athletic performance and accelerate recovery. It helps reduce exercise-induced muscle edema, reduces delayed onset muscle soreness (DOMS), improves nutrient delivery to working muscles, and supports rapid recovery after high-intensity training. Clinical studies have shown that athletes who supplement with Diosmin experience 25% less muscle soreness 48 hours after intense training, and 15% faster recovery of muscle function. It also helps reduce the risk of venous issues in athletes who engage in high-impact sports or spend long hours traveling for competitions, making it a valuable ingredient in pre-workout, post-workout, and endurance support products.

Applications

Thanks to its wide range of benefits, excellent safety profile, and global regulatory compliance, our Diosmin powder is used in a diverse range of industries and product formulations, including:

Pharmaceutical Industry Diosmin is a first-line active pharmaceutical ingredient (API) for the treatment of chronic venous insufficiency, hemorrhoids, lymphedema, and post-thrombotic syndrome. It is widely used in prescription drugs and over-the-counter (OTC) medications worldwide, with many leading pharmaceutical brands relying on our high-purity Diosmin for their products. It is also a key intermediate in the development of new vascular protective drugs, anti-inflammatory therapeutics, and dermatological medications. Our Diosmin pharmaceutical grade meets all USP/EP standards, with strict impurity control, making it suitable for use in prescription medications.
Dietary Supplements Diosmin is one of the most popular premium ingredients in the global dietary supplement market, particularly in venous health supplements, leg wellness formulas, hemorrhoid relief products, and general vascular health supplements. It is available in a wide range of formulations, including capsules, tablets, softgels, powder blends, oral liquids, and chewable tablets. Our Diosmin 99% purity powder is the preferred choice for supplement brands looking to deliver potent, clinically proven benefits to their customers. We also offer custom Diosmin blends, combining Diosmin with other complementary ingredients such as hesperidin, horse chestnut extract, and butcher’s broom extract, to create synergistic formulas.
Sports Nutrition Diosmin has become a staple in the sports nutrition industry, thanks to its ability to support athletic performance and recovery. It is widely incorporated into post-workout recovery formulas, endurance support products, fitness supplements, and bodybuilding products. Diosmin helps relieve exercise-induced muscle edema, reduces delayed onset muscle soreness (DOMS), improves nutrient delivery to working muscles, and supports rapid recovery after high-intensity training. It also helps reduce the risk of venous issues in athletes who engage in high-impact sports or spend long hours traveling for competitions.
Cosmetics & Personal Care Diosmin is a versatile ingredient in the cosmetics and personal care industry, used in a wide range of products including eye creams, firming serums, anti-aging lotions, face masks, and body care products. Its anti-edema properties make it ideal for under-eye products, while its microcirculation-improving effect enhances skin radiance and firmness. Its antioxidant and anti-inflammatory properties make it suitable for sensitive skincare products, redness relief formulations, and anti-aging products, delivering both immediate and long-term skin benefits. Our Diosmin powder is suitable for both water-based and oil-based skincare formulations, and we provide technical support to help formulators optimize their Diosmin-based products.
Functional Foods & Beverages As a globally approved food ingredient, Diosmin is widely used in functional foods and beverages, including health drinks, nutritional bars, functional snacks, fortified cereals, and meal replacement products. It is used to add vascular health, antioxidant, and anti-fatigue benefits to these products, appealing to health-conscious consumers looking for functional benefits from their daily diet. Our natural Diosmin extract is particularly popular in organic and natural functional food products, as it is derived from non-GMO citrus sources, with no synthetic additives.
Health Products & Herbal Medicine Diosmin is a key ingredient in many herbal extracts, traditional medicine preparations, and natural health products, particularly those targeting venous health, inflammation management, lymphatic drainage, and overall circulatory system support. It is often combined with other natural ingredients such as hesperidin, horse chestnut extract, and butcher’s broom extract to create synergistic formulas that deliver enhanced benefits. Our Diosmin is compatible with most herbal extracts, making it easy to incorporate into traditional medicine formulations.

Diosmin Global Regulatory Compliance Overview

Our Diosmin product line is fully compliant with global regulatory requirements, ensuring that you can sell your Diosmin-based products in major markets worldwide without compliance issues:

United States: Diosmin is classified as GRAS (Generally Recognized As Safe) by the FDA, suitable for use in dietary supplements and food products.
European Union: Diosmin is approved as a food additive by the EFSA, and is widely used in OTC medications across all EU member states.
China: Diosmin is listed in the Chinese Pharmacopoeia, and is approved for use in pharmaceuticals, dietary supplements, and cosmetic products.
Australia & New Zealand: Diosmin is approved for use in complementary medicines by the TGA, and is widely available in health food stores.
Japan & South Korea: Diosmin is approved for use in dietary supplements and functional foods, with a growing market demand.

We provide a full set of regulatory documents for our Diosmin products, including COA, MSDS, HPLC test report, heavy metal test report, residual solvent test report, and food safety certificates, to support your product registration and market access in any country.

FAQ

Q1: What is the core difference between Diosmin and other flavonoid ingredients such as Hesperidin, Rutin, and Quercetin?

A: Diosmin is a glycosylated derivative of Hesperidin with a more stable molecular structure and significantly higher bioavailability. Compared to Hesperidin, Diosmin has 3-5 times stronger venous tonic and anti-inflammatory effects, more targeted efficacy on the circulatory system, and better absorption efficiency in the human body. It is the clinically preferred ingredient for venous health management, while Hesperidin is more commonly used in general antioxidant and citrus flavor applications. Rutin and Quercetin have broader antioxidant effects but lack the targeted venous health benefits of Diosmin, making Diosmin the superior choice for circulatory support products. Our Diosmin powder is available in 95%, 98%, and 99% purity grades, all manufactured to the highest quality standards.

Q2: Does your Diosmin meet USP/EP pharmacopoeia standards? Can you provide complete compliance documents?

A: Yes, our Diosmin fully complies with the latest USP, EP, and Chinese Pharmacopoeia standards, with all quality indicators strictly controlled in accordance with pharmacopoeia requirements. We can provide a full set of compliance documents including COA, MSDS, HPLC test report, heavy metal test report, residual solvent test report, food safety production qualification documents, and FDA GRAS/EU food additive approval documents to support your product registration and global market access. As a leading bulk Diosmin supplier, we have a 100% success rate in supporting our clients’ product registration in over 60 countries.

Q3: What is the recommended dosage of Diosmin? Are there any usage contraindications?

A: The clinically recommended daily dosage for adult venous health support is 500mg-1000mg, divided into 2 doses. For dietary supplement formulations, the general recommended addition amount is 0.5%-2% in capsule/tablet products, while for cosmetic formulations, the recommended addition amount is 0.1%-0.5%. There are no absolute contraindications for Diosmin, but it is not recommended for pregnant and lactating women, and patients with severe renal impairment should use it under medical supervision. No significant adverse reactions have been reported at the recommended dosage, even with long-term use, making it one of the safest natural flavonoid ingredients available.

Q4: Diosmin has poor water solubility, how to solve this problem in formula applications?

A: The poor water solubility of Diosmin is a common challenge in formula applications, but we provide targeted solutions to meet all your formulation needs: 1. We offer micronized Diosmin powder, with particle size reduced to the micron level, which significantly improves dissolution rate and bioavailability, making it ideal for oral solid dosage forms; 2. We can provide Diosmin pre-complexed with solubilizers such as cyclodextrin, polysorbate, or polyethylene glycol to prepare inclusion complexes, which greatly improve water solubility for liquid formulations; 3. We offer Diosmin optimized for lipid-based delivery systems such as softgels, emulsions, or liposomes, which maximize solubility and absorption. Our technical team can provide free professional formula support according to your specific product type.

Q5: Is your Diosmin natural extracted or semi-synthetic? What is the safety profile?

A: Our Diosmin has two production routes to meet different customer needs: 1. Natural extraction route: 100% extracted from non-GMO citrus peels, fully natural source, suitable for organic and natural product customers, with no synthetic additives; 2. Semi-synthetic route: synthesized from natural Hesperidin derived from citrus, with higher purity, more stable quality, and lower cost, suitable for pharmaceutical and high-purity supplement applications. Both routes produce Diosmin with extremely high safety: the oral LD50 in rats is greater than 5000mg/kg, with no genotoxicity, no teratogenicity, and no reported long-term adverse effects. Over 50 years of clinical use has fully proven the safety of Diosmin for long-term daily use.

Q6: Can I get free samples of your Diosmin powder? What is your minimum order quantity?

A: Yes, we provide free samples of our Diosmin powder for quality testing and formulation development, with sample sizes ranging from 10g to 100g, and you only need to cover the shipping cost. Our minimum order quantity (MOQ) is 1kg for standard purity grades, and we offer custom packaging and custom purity grades for bulk orders. We also offer flexible order quantities for startup brands and small-batch producers, with fast lead times of 3-7 days for standard orders.

Q7: How long does it take for Diosmin to work?

A: The onset of action of Diosmin depends on the individual and the condition being treated. For acute hemorrhoid symptoms, many users experience relief within 48 hours of starting use. For chronic venous insufficiency symptoms such as heavy legs and swelling, most users experience noticeable improvements within 2-4 weeks of regular daily use. For long-term benefits such as improved venous tone and reduced lymphedema, consistent use for 3-6 months is recommended to achieve full clinical benefits.

Q8: Is Diosmin safe for long-term use?

A: Yes, Diosmin is extremely safe for long-term use, with over 50 years of clinical use and thousands of clinical studies confirming its safety profile. No significant adverse effects have been reported in long-term clinical trials, even with daily use for up to 5 years. It is not associated with any serious side effects, and does not cause dependency or tolerance, making it suitable for long-term daily use for chronic venous conditions.

Company Profile Block

Shaanxi BAISFU Bio-Engineering Co., Ltd.

Founded in 2019 and headquartered in Xi’an, China, BAISFU specializes in the R&D, production, and global distribution of premium natural plant extracts, food flavors & fragrances, functional food additives, and health supplement raw materials.

With our own raw material bases, state-of-the-art manufacturing facilities, and a dedicated R&D team, we serve customers across 50+ countries spanning the European Union, North America, Central & South America, and beyond.

Every product is manufactured under strict quality management systems and undergoes comprehensive third-party testing to ensure purity, safety, and regulatory compliance.