Ursolic Acid CAS 77-52-1 Pentacyclic Triterpene from Rosemary, Ligustrum & Apple Peel
Product Identification
| Item | Detail |
|---|---|
| Synonyms | Ursolic Acid; 3β-Hydroxyurs-12-en-28-oic acid; Ursane-type triterpene |
| CAS RN | 77-52-1 |
| EC Number | 201-034-0 |
| Molecular Formula | C₃₀H₄₈O₃ |
| MW | 456.70 |
| Isomer Companion | Oleanolic Acid CAS 508-02-1 (Oleanane-type, co-occurs) |
| Botanical Sources | Rosmarinus officinalis(rosemary), Ligustrum lucidum, Malus domesticapeel, Eriobotrya japonica(loquat), Vacciniumspp. |
| HS Code (ref) | 2938 / 1302 (extract / triterpene) |
| Related SKUs | Oleanolic Acid CAS 508-02-1; Rosemary Extract (carnosic/rosmarinic) — separate |
Description
Ursolic acid is a pentacyclic triterpene with a C3β-OH and C17-sidechain carboxyl, widely distributed in lamiaceae/rosaceae/ericaceae. Its commercial signal splits by source:
- Rosemary leaf (Rosmarinus officinalis) → DTC cosmeceutical “retinol alternative” + antioxidant (UA + carnosic/rosmarinic often co-extracted, different SKU)
- Ligustrum lucidum / Loquat leaf → China-export bulk, TCM-heritage positioning, pharma R&D
- Apple peel → “natural apple triterpene” clean-label angle (functional beverage / cosmeceutical “apple stem” marketing adjacent)
Four commercial buckets drive search:
- Cosmeceutical – Anti-aging / Firming / “Retinol Alternative” —— UA induces collagen I/III, inhibits MMP, anti-inflammatory in keratinocyte/fibroblast assays; “rosemary ursolic acid serum” is a 2023–2026 stable EU/US DTC search cluster, often positioned as “gentler retinol alternative” (less irritation than tretinoin). Frequently co-formulated with Luteolin (CAS 491-70-3, soothing) + Centella (if you stock) + Vitamin C in KR/JP serums. SEO long-tail: “ursolic acid retinol alternative rosemary”, “natural firming triterpene”
- Sports Nutrition / Gym – Muscle Satellite Cell —— literature: UA activates Akt/mTOR in C2C12, promotes muscle satellite cell proliferation (oral (or topical in some rodent models) — DTC “natural gym” niche, small but high intent, often stacked with CoQ10 303-98-0 + D-Biotin 58-85-5 + leucine/creatine). Search: “ursolic acid muscle gym supplement”
- Metabolic & NAFLD R&D —— AMPK/PPARγ signals in literature, NAFLD/obesity rodent models; pharma R&D long-tail, often procured alongside Oleanolic Acid 508-02-1 (isomer companion, same botanical families)
- Phytopharma / Anticancer R&D —— UA literature spans PI3K/Akt, TOPO, apoptosis; mostly pre-clinical, but steady R&D procurement for 98%+ HPLC; “ursolic acid anticancer R&D” B2B cluster
Applications
Cosmeceuticals – “retinol alternative” serum, firming cream, post-procedure soothing (paired with Luteolin / Centella), INCI Ursolic Acid; rosemary-leaf source popular in EU “clean beauty”
Sports & Gym Nutrition – muscle-supportive, satellite-cell R&D signal; stacked with CoQ10 + D-Biotin + amino acids; 100–300 mg/serving typical DTC
Metabolic & NAFLD R&D – AMPK/PPARγ literature; often co-procured with Oleanolic Acid 508-02-1 as “triterpene duo” from same botanicals
Phytopharma / Anticancer R&D – 98%–99% HPLC reference, apoptosis/PI3K/Akt TOPO models; TCM-heritage “女贞子/loquat” positioning for CN-export R&D brands
Functional Beverage (apple-peel angle) – “natural apple triterpene” WONF adjacent, clean-label; low dose, usually blended with quercetin / vitamin C
