Product Introduction
| Item | Specification |
| Product Name | Sumatriptan |
| Synonyms | 3-[2-(Dimethylamino)ethyl]-N-methyl-1H-indole-5-methanesulfonamide; Sumatriptan base |
| CAS Number | 103628-46-2 |
| Molecular Formula | C₁₄H₂₁N₃O₂S |
| Molecular Weight | 295.40 g/mol |
| Appearance | White to off-white crystalline powder, odorless, stable crystal form under sealed dark and dry conditions |
| Purity (HPLC) | ≥98.0% / ≥99.0% (Research Grade / Pharma API Grade, customizable) |
| Loss on Drying | ≤ 0.2% |
| Residue on Ignition | ≤ 0.1% |
| Testing Method | HPLC / NMR / Mass Spectrometry / IR Spectrum / Pharmacological Activity Detection |
| Production Method | Indole Tryptamine Derivative Synthesis & Multi-Stage Purification & Low-Temperature Recrystallization |
| Melting Point | 165–167°C (lit.) |
| Boiling Point | 466.7°C at 760 mmHg |
| Density | 1.22 g/cm³ at 25°C |
| Flash Point | 236.1°C |
| Solubility | Soluble in methanol, ethanol, DMSO and aqueous acidic solutions, slightly soluble in neutral water; stable in dry environment, sensitive to strong light and high temperature |
| Core Feature | Tryptophan-derived indole tryptamine compound, selective 5-HT1B/1D serotonin receptor agonist, targeted migraine relief and neurovascular regulation activity |
| Package | 1g/5g/10g sealed amber bottle, 100g/1kg drum; vacuum moisture-proof packaging, custom specification available |
| Storage | Store in vacuum-sealed, low-temperature, dark and dry conditions; avoid strong light, high temperature and humid environment to prevent oxidation and structural degradation |
| Shelf Life | 24 months under standard low-temperature sealed storage |
Product Description
Our Sumatriptan is a high-purity indole tryptamine derivative with stable molecular structure and complete neuropharmacological activity, available in premium research grade and pharmaceutical API grade. Sumatriptan (CAS 103628-46-2) is a classic targeted neurological active compound in the indole biochemical family, structurally derived from the core Tryptophan metabolic pathway. Sharing the fundamental indole ring skeleton with Serotonin and Melatonin, Sumatriptan features unique dimethylaminoethyl and methylsulfonamide functional modifications, enabling highly selective5-HT1B/1D receptor agonist activity that differentiates it from other common indole metabolites. As a professional bulk Sumatriptan supplier, we provide low-impurity, high-activity, batch-stable Sumatriptan raw materials for global neuropharmacology research institutions, neurological drug R&D laboratories and indole derivative synthesis enterprises.
Sumatriptan holds a pivotal core position in migraine pharmacology, neurovascular regulation research and indole medicinal chemistry. As a first-generation triptan-class anti-migraine agent, it selectively activates presynaptic 5-HT1B/1D serotonin receptors, effectively inhibiting excessive neuropeptide release, relieving cranial vasodilation and blocking neurogenic inflammatory responses. This unique mechanism enables Sumatriptan to rapidly intervene in acute migraine and cluster headache attacks, serving as the gold standard tool compound for migraine mechanism research and new drug efficacy screening. Beyond headache treatment research, it is widely applied in exploring serotonin signal transduction, neurovascular coupling regulation and central nervous system sensory response mechanisms. In pharmaceutical synthesis, its specially modified indole tryptamine skeleton provides valuable structural optimization sites, supporting the development and structural upgrading of new-generation triptan derivatives and targeted neurotherapeutic molecules. Compared with ordinary low-purity Sumatriptan products with oxidative impurities and unstable receptor binding activity, our high-purity purified product eliminates synthetic intermediates, solvent residues and degradation by-products, ensuring single-component purity and stable pharmacological activity for accurate, repeatable neurological experimental data and reliable pharmaceutical R&D results.
Manufactured by Shaanxi BAISFU Bio-Engineering Co., Ltd., our premium Sumatriptan adopts advanced indole tryptamine precision synthesis combined with low-temperature oxygen-free reaction and multi-stage gradient recrystallization purification process. The entire production process strictly controls reaction temperature, pH value and purification gradient, completely removing unreacted indole raw materials, sulfonamide by-products and residual solvents. By avoiding high-temperature induced molecular structural damage and activity attenuation, the process fully retains the complete modified indole active skeleton and specific 5-HT1 receptor agonistic activity of Sumatriptan. The finished product presents uniform white to off-white crystalline powder, stable crystal form, no caking, no yellowing and no discoloration, fully complying with high-standard neurobiology research grade and pharmaceutical API raw material grade quality requirements.
Every batch of Sumatriptan undergoes strict multi-dimensional quality inspection, including HPLC high-precision purity analysis, NMR structural verification, mass spectrometry molecular identification and cell-level neuropharmacological activity testing. It ensures zero invalid impurity interference, ultra-low trace residues and consistent batch efficacy, providing reliable raw material guarantee for migraine pathological mechanism research, serotonin receptor pathway experiments and indole neurological drug synthesis. The product features stable solubility in organic solvents and acidic aqueous solutions, excellent biochemical stability in pharmacological experimental environments and outstanding experimental repeatability, fully meeting the strict raw material requirements of in vitro cell receptor experiments, in vivo neurological model tests and new neuro-drug formula development.
We maintain sufficient low-temperature inventory and complete qualification documents for bulk Sumatriptan supply. Whether you need standard 5-HT1 receptor agonist monomers for neuropharmacological research, core reference substances for migraine drug verification, or high-purity modified indole tryptamine intermediates for custom derivative synthesis, our premium Sumatriptan is a high-cost-performance and high-value biological fine chemical product choice for global buyers.
Functions & Benefits
Highly Selective 5-HT1B/1D Receptor Agonist (Core Benefit)
Sumatriptan is a classic targeted serotonin receptor agonist, specifically acting on central and peripheral 5-HT1B/1D receptors. It inhibits neurogenic inflammation, constricts dilated cranial blood vessels and blocks pain signal transmission, serving as the core standard tool compound for migraine and neurovascular pharmacological research.
Typical Modified Tryptophan-Indole Derivative
As an important functional deep-processing derivative of the Tryptophan metabolic axis, Sumatriptan complements the indole compound system together with Serotonin and Melatonin. Its unique sulfonamide and alkylamino modified structure enriches the structure-activity relationship research of indole neuroactive drugs, supporting cross-domain exploration of indole biochemistry and neuropharmacology.
Powerful Acute Migraine & Cluster Headache Intervention Activity
High-purity Sumatriptan exhibits stable and efficient targeted neurological pharmacological activity, rapidly relieving migraine with or without aura and cluster headache symptoms. It is widely used in acute headache mechanism verification, neurovascular regulation and new analgesic drug efficacy evaluation experiments.
Low-Impurity Purification & Ultra-Stable Pharmacological Activity
Our Sumatriptan adopts low-temperature oxygen-free anti-oxidation purification technology, removing oxidative degradation impurities and invalid intermediate residues generated during synthesis. It solves the problem of decreased receptor binding activity and unstable experimental data of conventional products, ensuring long-term stable pharmacological efficacy.
Strict Batch Consistency & High Experimental Repeatability
Synthesized and recrystallized under constant low-temperature sterile conditions, Sumatriptan eliminates process quality fluctuations. The product has uniform crystal form, stable molecular structure and consistent batch receptor agonistic activity, suitable for long-term neurological research and high-precision neuro-drug screening experiments.
Excellent Solubility & Wide Experimental Adaptability
Sumatriptan has good solubility in common organic solvents and acidic aqueous solutions, easy to prepare into experimental stock solutions and pharmacological formula systems. It maintains stable activity in conventional cell and animal experiment environments, perfectly adapting to neuro-receptor experiments, neurological model tests and pharmaceutical formulation research.
Applications
Migraine Pharmacology & Neurovascular Research
Used as a standard high-purity 5-HT1 receptor agonist reagent for studying migraine pathogenesis, cranial vascular regulation, neurogenic inflammation and headache pain signal pathways. Widely applied in neuropharmacology laboratories and neurological disease research institutions.
Serotonin Receptor Signal Pathway Study
Served as the core specific tool compound for 5-HT1B/1D receptor activation experiments, exploring serotonin-mediated neural signal transduction, sensory regulation and vascular autonomic regulation mechanisms, supporting in-depth research on central nervous system function.
Triptan-Class Neurological Drug R&D & Evaluation
Applied as a classic reference API for new anti-migraine drug development, guiding the structural optimization, efficacy screening and safety evaluation of indole-based neuroactive small-molecule drugs and triptan derivatives.
Modified Indole Tryptamine Derivative Synthesis
Used as a high-value functional indole tryptamine skeleton intermediate for the synthesis of new targeted neuro-analgesic derivatives, supporting innovative R&D of high-efficiency and low-side-effect neurological pharmaceutical intermediates.
Laboratory Pharmacological Verification & Teaching Research
Provided as standard high-purity Sumatriptan reagent for neuropharmacology teaching experiments, targeted receptor efficacy comparative tests and indole drug structure-activity relationship verification, ensuring accurate and stable experimental data for scientific research and teaching work.
FAQ
Q1: What is Sumatriptan mainly used for?
A: Sumatriptan is a classic indole tryptamine-based 5-HT1 receptor agonist and anti-migraine pharmacological agent. It is mainly used for acute migraine and cluster headache mechanism research, serotonin neuro-receptor pathway verification, triptan-class neurological drug development and modified indole derivative synthesis, with stable targeted neuropharmacological activity.
Q2: What is the relationship between Sumatriptan and Tryptophan metabolism?
A: Sumatriptan is a deep functional derivative of the Tryptophan indole metabolic family. Based on the core indole ring of Tryptophan, Serotonin and Melatonin, it undergoes specific sulfonamide and alkylamino modification, forming targeted neurological activity. It is an important research compound extending the indole biochemical system to neuropharmacology and precision drug research.
Q3: What are the core advantages of our Sumatriptan?
A: Our Sumatriptan adopts low-temperature oxygen-free purification and multi-stage recrystallization technology, featuring ultra-high single-component purity, zero residual intermediate interference, stable 5-HT1 receptor agonistic activity and consistent batch efficacy. It effectively avoids experimental errors caused by product oxidation and impurity interference, ensuring high-precision neuropharmacology research results.
Q4: How to store Sumatriptan correctly?
A: Sumatriptan is sensitive to strong light, high temperature and humid environments, prone to oxidation and structural degradation leading to decreased receptor activity. It must be stored in vacuum-sealed, low-temperature, cool and dry dark conditions. Standard sealed low-temperature storage ensures 24 months of stable shelf life and pharmacological activity.
Q5: What is the appearance of high-purity Sumatriptan?
A: High-purity Sumatriptan is uniform white to off-white crystalline powder at room temperature, odorless, stable crystal state, no caking, no discoloration and no deterioration precipitation.
Q6: Can I get free Sumatriptan samples for testing?
A: Yes, we provide free Sumatriptan samples for migraine mechanism research, 5-HT1 receptor activity verification and indole neuro-drug derivative synthesis tests. Bulk orders support customized purity and professional anti-oxidation vacuum packaging to meet high-standard scientific research and pharmaceutical API production needs.
