Product Introduction
| Item | Specification |
| Product Name | Quinine |
| Synonyms | (-)-Quinine; Cinchona alkaloid; 6′-Methoxycinchonan-9-ol |
| CAS Number | 130-95-0 |
| Molecular Formula | C₂₀H₂₄N₂O₂ |
| Molecular Weight | 324.42 g/mol |
| Appearance | White fine needle crystalline powder, odorless, slightly bitter taste, stable crystal form under sealed dark and dry conditions |
| Purity (HPLC) | ≥98.0% / ≥99.0% (Research Grade / Pharma API Grade, customizable) |
| Loss on Drying | ≤ 0.2% |
| Residue on Ignition | ≤ 0.1% |
| Testing Method | HPLC / NMR / Mass Spectrometry / IR Spectrum / Pharmacological Activity Detection |
| Production Method | Natural Cinchona Bark Extraction & Multi-Stage Resin Purification & Low-Temperature Recrystallization |
| Melting Point | 173–175°C (lit.) |
| Boiling Point | 495.9°C at 760 mmHg |
| Density | 1.21 g/cm³ at 25°C |
| Flash Point | 253.5°C |
| Solubility | Soluble in ethanol, chloroform, methanol and DMSO; slightly soluble in hot water; almost insoluble in cold water; stable in dry environment, sensitive to strong light and high temperature |
| Core Feature | Classic natural cinchona alkaloid, specific antimalarial activity, multi-effect anti-inflammatory and analgesic botanical monomer |
| Package | 1g/5g/10g sealed amber bottle, 100g/1kg drum; vacuum moisture-proof packaging, custom specification available |
| Storage | Store in vacuum-sealed, low-temperature, dark and dry conditions; avoid strong light, high temperature and humid environment to prevent oxidation and structural degradation |
| Shelf Life | 24 months under standard low-temperature sealed storage |
Product Description
Our Quinine is a high-purity natural cinchona alkaloid with stable stereoisomeric structure and classic multi-target pharmacological activity, available in premium research grade and pharmaceutical API grade. Quinine (CAS 130-95-0), commonly known as cinchona bark extract alkaloid, is a landmark bioactive monomer isolated and purified from the bark of Rubiaceae Cinchona trees. Featuring a unique quinoline and quinuclidine dual-ring heterocyclic skeleton, it is the world’s earliest discovered and systematically studied natural antimalarial compound, laying the foundational framework for modern antiparasitic drug research. Beyond its core antimalarial efficacy, high-purity Quinine possesses excellent anti-inflammatory, analgesic, antimicrobial and antioxidant properties, making it a versatile tool compound for natural product pharmacology, parasitic disease mechanism research and botanical drug derivative development. As a professional bulk Quinine supplier, we provide low-impurity, high-stereopurity, batch-stable Quinine raw materials for global scientific research institutions, pharmaceutical R&D laboratories and API manufacturing enterprises.
Quinine holds an irreplaceable core status in the history of natural medicinal chemistry and antiparasitic pharmacology. Its most iconic pharmacological advantage lies in its specific inhibitory effect on malaria parasites: it interferes with the heme detoxification process of plasmodium, blocks parasite metabolic pathways, and effectively kills plasmodium schizonts, thereby inhibiting malaria infection and proliferation. Different from synthetic antiparasitic drugs with severe drug resistance and side effects, natural Quinine delivers precise therapeutic activity with mild pharmacological properties, serving as a classic positive control reagent for malaria mechanism research and antiparasitic drug screening. In addition to antimalarial effects, Quinine effectively inhibits inflammatory mediator release, relieves tissue swelling and pain responses, and exerts broad-spectrum antibacterial and antifungal activity, supporting in-depth research on infectious inflammation and microbial resistance mechanisms. Its unique chiral heterocyclic structure also provides valuable modification sites for the synthesis of new high-efficiency, low-resistance antiparasitic and anti-inflammatory derivatives. Compared with ordinary low-purity cinchona crude extracts containing mixed alkaloids, plant residues and chiral impurities, our high-purity Quinine adopts precise stereochemical purification technology to eliminate invalid isomers and heterozygous impurities, ensuring single-component purity and stable repeatable pharmacological activity for high-precision experimental research and new drug development.
Manufactured by Shaanxi BAISFU Bio-Engineering Co., Ltd., our premium Quinine adopts advanced low-temperature selective extraction combined with macroporous resin gradient separation and multi-stage low-temperature recrystallization purification process. The whole production process strictly controls extraction pH, temperature and chiral separation gradient, thoroughly removing residual plant fibers, miscellaneous cinchona alkaloids, organic solvent residues and chiral impurity interference. The low-temperature oxygen-free processing technology completely avoids molecular oxidation and stereoisomerization damage, fully retaining the natural chiral configuration and complete biological activity of Quinine’s dual-ring active skeleton. The finished product presents uniform white fine needle crystalline powder, stable crystal form, no caking, no discoloration and no deterioration, fully complying with high-standard natural product research grade and pharmaceutical botanical API grade quality specifications.
Every batch of Quinine undergoes strict multi-dimensional quality inspection, including HPLC high-precision purity analysis, NMR structural verification, mass spectrometry molecular identification and cell-level pharmacological activity testing. It achieves ultra-low trace residue and zero invalid impurity interference, ensuring consistent batch efficacy and experimental stability. The product features excellent solubility in common organic solvents, stable biochemical properties in cell culture and in vivo experimental environments, and outstanding experimental repeatability, fully meeting the strict raw material requirements of plasmodium inhibition experiments, inflammatory model verification, antimicrobial pharmacology and chiral drug synthesis research.
We maintain sufficient low-temperature inventory and complete qualification documents for bulk Quinine supply. Whether you need standard cinchona alkaloid monomers for pharmacological research, core reference substances for antiparasitic drug efficacy evaluation, or high-purity chiral heterocyclic intermediates for custom derivative synthesis, our premium Quinine is a high-cost-performance and high-value natural fine chemical product choice for global buyers.
Functions & Benefits
Specific Natural Antimalarial & Antiparasitic Activity (Core Benefit)
Quinine is a classic landmark natural antiparasitic alkaloid. It specifically targets plasmodium metabolic pathways, inhibits heme crystallization and detoxification, and effectively eliminates malaria parasites. With definite pharmacological mechanism and stable activity, it is the gold-standard positive compound for malaria pharmacology and antiparasitic drug screening research.
Unique Cinchona Dual-Ring Chiral Structure
As a typical cinchona alkaloid, Quinine has a distinctive quinoline-quinuclidine fused chiral skeleton. Its special stereochemical structure provides critical research templates for studying alkaloid stereoselectivity, structure-activity relationships and chiral pharmaceutical molecule modification.
Broad-Spectrum Anti-Inflammatory, Analgesic & Antimicrobial Efficacy
High-purity Quinine stably inhibits inflammatory factor secretion, relieves acute and chronic inflammatory responses and pain reactions, and resists multiple pathogenic bacteria and fungi. It serves as a multi-functional tool reagent for infectious inflammation and antimicrobial mechanism research.
High Stereopurity & Ultra-Stable Biological Activity
Our Quinine adopts professional chiral purification and multi-stage impurity removal technology, completely eliminating invalid isomers and miscellaneous alkaloid impurities in traditional cinchona extracts. It solves the problems of unstable activity and poor experimental repeatability caused by impurity interference, ensuring long-term consistent pharmacological efficacy.
Strict Batch Consistency & High Experimental Repeatability
Extracted and recrystallized under constant low-temperature sterile conditions, Quinine eliminates process quality fluctuations. The product has uniform crystal form, stable chiral configuration and consistent batch biological activity, suitable for long-term parasitic pharmacology research and high-precision drug screening projects.
Excellent Solubility & Strong Experimental Adaptability
Quinine has good solubility in ethanol, chloroform, methanol and DMSO, easy to prepare into homogeneous experimental stock solutions and pharmacological formula systems. It maintains stable activity in conventional cell and animal experiment environments, perfectly adapting to antiparasitic tests, inflammatory model experiments and chiral drug synthesis research.
Applications
Malaria & Parasitic Disease Pharmacology Research
Used as a standard high-purity natural antimalarial reagent for studying plasmodium inhibition mechanisms, parasite metabolic pathways and antiparasitic drug resistance. Widely applied in tropical medicine and pathogenic biology laboratories.
Anti-Inflammatory & Analgesic Mechanism Study
Served as the core specific positive drug for inflammatory response and pain model experiments, supporting efficacy verification and mechanism exploration of new natural anti-inflammatory and analgesic active substances.
Botanical API R&D & Pharmacological Evaluation
Applied as a classic reference compound for new natural antiparasitic, anti-inflammatory and antimicrobial drug development, guiding structural optimization, efficacy screening and safety evaluation of cinchona alkaloid pharmaceutical molecules.
Chiral Alkaloid Derivative Synthesis
Used as a high-value natural chiral heterocyclic skeleton intermediate for the synthesis of new high-efficiency antiparasitic and anti-inflammatory derivatives, supporting innovative R&D of chiral botanical pharmaceutical intermediates.
Laboratory Teaching & Alkaloid Comparative Research
Provided as standard high-purity Quinine reagent for natural pharmacology teaching experiments, cinchona alkaloid property verification and antiparasitic efficacy comparative tests, ensuring accurate and stable experimental data for scientific research and teaching work.
FAQ
Q1: What is Quinine mainly used for?
A: Quinine is a classic natural cinchona alkaloid. It is mainly used for malaria and parasitic disease mechanism research, natural antiparasitic drug screening, inflammatory and analgesic pharmacological experiments, and chiral alkaloid derivative synthesis, with stable and specific multi-target biological activity.
Q2: What is the structural feature of Quinine?
A: Quinine has a unique quinoline-quinuclidine dual-ring chiral heterocyclic structure, which is the typical skeleton of cinchona alkaloids. Its specific chiral configuration endows it with selective plasmodium inhibition activity and differentiated pharmacological characteristics from other common alkaloids.
Q3: What are the core advantages of our Quinine?
A: Our Quinine adopts low-temperature selective extraction and chiral purification recrystallization technology, featuring ultra-high single-component purity, zero miscellaneous alkaloid and chiral isomer interference, stable specific antiparasitic activity and consistent batch efficacy. It effectively avoids experimental errors caused by crude extract impurities, ensuring high-precision natural product research results.
Q4: How to store Quinine correctly?
A: Quinine is sensitive to strong light, high temperature and humid environments, prone to oxidation and structural degradation leading to reduced biological activity. It must be stored in vacuum-sealed, low-temperature, cool and dry dark conditions. Standard sealed low-temperature storage ensures 24 months of stable shelf life and pharmacological activity.
Q5: What is the appearance of high-purity Quinine?
A: High-purity Quinine is uniform white fine needle crystalline powder at room temperature, odorless, slightly bitter taste, stable crystal state, no caking, no fading and no precipitation deterioration.
Q6: Can I get free Quinine samples for testing?
A: Yes, we provide free Quinine samples for antiparasitic mechanism research, anti-inflammatory activity verification and cinchona alkaloid derivative synthesis tests. Bulk orders support customized purity and professional anti-oxidation vacuum packaging to meet high-standard scientific research and pharmaceutical API production needs.
