Eupatilin CAS 22368-21-4 Polymethoxy flavone from Artemisia argyi
Product Identification
| Item | Detail |
|---|---|
| Synonyms | Eupatilin; 5,7-Dimethoxy-3′,4′,5-trihydroxyflavone; 3′,4′,5-Trihydroxy-3,5,7-trimethoxyflavone (alt numbering) |
| CAS RN | 22368-21-4 |
| Molecular Formula | C₁₈H₁₆O₇ |
| MW | 344.32 |
| Botanical (main) | Artemisia argyiH.Lév. & Vaniot (Asteraceae, “艾蒿”, Korea/China, Korean herb gastro) |
| Botanical (name-origin) | Eupatoriumspp. (Asteraceae, “异泽兰”) |
| Family | Polymethoxyflavone (PMF) — same skeleton family as Nobiletin/Tangeretin/Sinensetin (but Citrus source, diff lit) |
| Same-genus sibling | Artemisinin 63968-64-9 (A. annua, sesquiterpene lactone, malaria ACT) — diff skeleton, “Artemisia dual-SKU” |
| HS Code (ref) | 1302 / 2938 |
Description
Eupatilin is the signature PMF of Artemisia argyi— the molecule behind Korea’s Stogar® / Dacotin® (Eupatilin + Rebamipide, CKD original, approved KR for chronic gastritis / NSAID-induced gastric mucosal injury). Three commercial buckets:
- Korean Herb / GI DTC+B2B (main): Artemisia argyiP.E. Eupatilin-std 1%–10% HPLC (Korea “Ai / mugwort” gastro-herb lane)
- H.pylori / Mucosal R&D (B2B R&D + DTC soft): Eupatilin lit on H.pylori adhesion ↓, urease activity ↓, IL-8 ↓, mucosal prostaglandin ↑, VEGF ↑ — “GI botanical” cluster adjacent to Glycyrrhiza(soothing) + Zingiber(gingerols, nausea) + Silymarin(if in SKU, liver but GI crossover)
- Gastric Cancer / EGFR-HER2 R&D (R&D-only, no DTC): Eupatilin lit on EGFR / HER2 / STAT3 / MMP-2/9 in gastric cancer cell lines (SNU-16, MKN-45, AGS) — PMF family’s “lipophilic flavonoid crosses membrane → targets RTKs” angle
Applications
Korean Herb / GI DTC+B2B – Artemisia argyiP.E. Eupatilin 1%–10% HPLC (Korean “Ai / mugwort” gastro lane); Stogar-type pilot (Eupatilin + Rebamipide replication KR/SEA); DTC: “Korean traditional Artemisia gastro-supportive, mucosal repair”soft — avoid “gastritis/PPI/H.pylori Rx” claims; pure 98% for brand pilot
H.pylori / Mucosal R&D – Eupatilin H.pylori adhesion↓ / urease↓ / IL-8↓ / PGE₂↑ / VEGF↑ lit; “GI botanical” cluster adjacent Glycyrrhizinate(L)/LCA(L)/Zingiber(if SKU); DTC soft “Artemisia gastro”, not “anti-H.pylori eradicate”
Gastric Cancer / EGFR-HER2 R&D (R&D-only) – Eupatilin ≥98% SNU-16/MKN-45/AGS, EGFR/HER2/STAT3/MMP-2/9; PMF family vs Nobiletin(neuro)/Tangeretin(metab) diff angle; no DTC cancer claims; KR “botanical-adjuvant gastric” pilot niche
PMF Cluster – if Taima has Nobiletin/Tangeretin/Sinensetin (Citrus PMF) → “PMF family: Citrus-source (Nobiletin neuro / Tangeretin metab) vs Asteraceae-source (Eupatilin GI)” — same skeleton(PMF) diff plant diff lit, search “polymethoxyflavone” eats both
