Product Introduction
| Item | Specification |
| Product Name | Camptothecin |
| Synonyms | Camptothecine; NSC-100880; (20S)-Camptothecin; Campathecin |
| CAS Number | 7689-03-4 |
| Molecular Formula | C₂₀H₁₆N₂O₄ |
| Molecular Weight | 348.35 g/mol |
| Appearance | Light yellow to pale yellow crystalline powder, odorless, stable pentacyclic crystal form under sealed dark and dry conditions |
| Purity (HPLC) | ≥98.0% / ≥99.0% (Research Grade / Pharma API Grade, customizable) |
| Loss on Drying | ≤ 0.2% |
| Residue on Ignition | ≤ 0.1% |
| Testing Method | HPLC / NMR / Mass Spectrometry / IR Spectrum / Cell Antitumor Activity Detection |
| Production Method | Natural Camptotheca Acuminata Extraction & Multi-Stage Resin Separation & Low-Temperature Recrystallization Purification |
| Melting Point | 262–264°C (lit., decomposition) |
| Boiling Point | 757.1°C at 760 mmHg |
| Density | 1.48 g/cm³ at 25°C |
| Flash Point | 411.4°C |
| Solubility | Soluble in DMSO, chloroform and methanol; slightly soluble in ethanol; almost insoluble in water; sensitive to strong light, high temperature and alkaline environment |
| Core Feature | Unique pentacyclic quinoline alkaloid, specific Topoisomerase I inhibitor, broad-spectrum natural antitumor monomer with high activity |
| Package | 1g/5g/10g sealed amber bottle, 100g/1kg drum; vacuum moisture-proof & light-proof packaging, custom specification available |
| Storage | Store in vacuum-sealed, low-temperature, dark and dry conditions; avoid light exposure, high temperature and alkaline medium to prevent lactone ring hydrolysis and activity degradation |
| Shelf Life | 24 months under standard low-temperature sealed and dark storage |
Product Description
Our Camptothecin is a high-purity natural pentacyclic quinoline alkaloid with specific targeted antitumor activity, available in premium research grade and pharmaceutical API grade. Camptothecin (CAS 7689-03-4) is a signature bioactive monomer isolated and purified from the traditional Chinese medicinal plant Camptotheca acuminata. Featuring a unique fused pentacyclic skeleton with a critical α-hydroxy lactone E-ring, it serves as the world’s first discovered specific Topoisomerase I inhibitor, laying the core theoretical foundation for modern targeted natural antitumor drug research. Different from conventional broad-spectrum cytotoxic compounds, Camptothecin exerts precise antitumor efficacy by targeting DNA replication and transcription mechanisms, with definite pharmacological targets and remarkable tumor suppression effects. As a high-value natural lead compound, it is widely used in tumor molecular mechanism research, new anticancer drug screening, and clinical precursor API synthesis. As a professional bulk Camptothecin supplier, we provide low-impurity, high-activity, batch-stable Camptothecin raw materials for global cancer research laboratories, pharmaceutical R&D institutions and fine chemical manufacturing enterprises.
Camptothecin occupies a milestone status in natural medicinal chemistry and oncology pharmacology, possessing highly differentiated targeted pharmacological advantages. Its core mechanism is to specifically bind and stabilize the Topoisomerase I-DNA cleavage complex, blocking DNA religation process, inducing irreversible DNA single-strand breaks, arresting tumor cell S-phase cycle, and ultimately triggering endogenous apoptosis of malignant tumor cells. This unique molecular targeting mechanism enables Camptothecin to inhibit the proliferation, invasion and metastasis of various solid tumors and hematological tumors, covering liver cancer, lung cancer, gastric cancer, breast cancer, leukemia and other malignant diseases. Unlike non-specific chemotherapeutic drugs with severe side effects and drug resistance, natural Camptothecin features targeted efficacy, clear action pathway and moderate toxicity, making it an irreplaceable positive control reagent for tumor targeted therapy mechanism research. In addition, its active lactone ring structure provides key modification sites for structural optimization, becoming the core parent skeleton for the synthesis of clinical first-line antitumor drugs such as Irinotecan and Topotecan. Compared with low-purity crude extracts containing plant pigments, mixed alkaloids and hydrolyzed impurities, our high-purity Camptothecin adopts precision purification technology to retain complete active lactone structure, eliminating invalid interfering components and ensuring ultra-stable targeted activity and experimental repeatability.
Manufactured by Shaanxi BAISFU Bio-Engineering Co., Ltd., our premium Camptothecin adopts advanced low-temperature selective extraction combined with macroporous resin gradient separation and multi-stage low-temperature recrystallization purification process. The whole production process strictly controls pH value, temperature and light isolation, effectively avoiding lactone ring hydrolysis and structural isomerization caused by high temperature and alkali. The oxygen-free closed production system thoroughly removes plant fiber residues, miscellaneous alkaloids, pigment impurities and organic solvent traces, completely retaining the natural pentacyclic active skeleton and targeted Topoisomerase I inhibitory activity of Camptothecin. The finished product presents uniform pale yellow crystalline powder, stable crystal form, no caking, no discoloration and no hydrolysis deterioration, fully complying with high-standard natural product research grade and pharmaceutical botanical API grade quality specifications.
Every batch of Camptothecin undergoes strict multi-dimensional quality inspection, including HPLC high-precision purity analysis, NMR structural verification, mass spectrometry molecular identification and cell-level antitumor activity testing. It achieves ultra-low trace residue and zero invalid impurity interference, ensuring consistent batch efficacy and experimental stability. The product features stable dissolution performance in common organic solvents, excellent biochemical stability in cell culture and in vivo experimental environments, and outstanding data repeatability, fully meeting the strict raw material requirements of tumor cell cycle experiments, targeted drug screening, DNA damage mechanism verification and new drug derivative synthesis research.
We maintain sufficient low-temperature light-proof inventory and complete qualification documents for bulk Camptothecin supply. Whether you need standard pentacyclic alkaloid monomers for pharmacological research, core reference substances for targeted antitumor drug efficacy evaluation, or high-purity parent intermediates for clinical anticancer drug derivative synthesis, our premium Camptothecin is a high-cost-performance and high-value natural fine chemical product choice for global buyers.
Functions & Benefits
Specific Topoisomerase I Inhibitor & Targeted Antitumor Activity (Core Benefit)
Camptothecin is a classic milestone natural targeted antitumor alkaloid. It specifically acts on cellular Topoisomerase I, blocks DNA repair and replication, induces tumor cell DNA damage and S-phase cycle arrest, and triggers tumor apoptosis. With clear target and definite mechanism, it is the gold-standard tool compound for tumor targeted therapy research.
Unique Pentacyclic Quinoline Alkaloid Skeleton
Featuring a rare fused pentacyclic ring system and bioactive α-hydroxy lactone E-ring, Camptothecin has a unique molecular structure that is completely different from conventional alkaloids. The active lactone structure provides irreplaceable core templates for clinical antitumor drug derivation and structural optimization.
Broad-Spectrum Tumor Suppression & Low Drug Resistance
High-purity Camptothecin exerts significant inhibitory effects on various solid tumors and blood tumors. Compared with traditional chemotherapeutic drugs, it has lower non-specific cytotoxicity and slower drug resistance development, suitable for long-term tumor mechanism research and preclinical drug efficacy verification.
Complete Active Lactone Structure & Ultra-Stable Activity
Our Camptothecin adopts full-process low-temperature and light-proof purification technology, effectively preventing lactone ring hydrolysis and inactivation. It completely removes hydrolyzed impurities and plant heterozygous components in traditional crude extracts, ensuring 100% retention of targeted Topoisomerase I inhibitory activity.
Strict Batch Consistency & High Experimental Repeatability
Extracted and recrystallized under constant low-temperature sterile and light-shielded conditions, Camptothecin eliminates process quality fluctuations. The product has uniform crystal form, stable molecular structure and consistent batch antitumor activity, suitable for large-scale and long-term tumor pharmacology screening projects.
Moderate Solubility & Strong Experimental Adaptability
Camptothecin has good solubility in DMSO, methanol and chloroform, easy to prepare into homogeneous experimental stock solutions. It maintains stable targeted activity in conventional cell and animal experiment environments, perfectly adapting to tumor cell apoptosis experiments, DNA damage mechanism research and targeted drug formulation optimization.
Applications
Tumor Targeted Therapy & Topoisomerase Mechanism Research
Used as a standard specific Topoisomerase I inhibitor reagent for studying DNA replication damage, tumor cell cycle arrest and malignant proliferation mechanism. Widely applied in oncology molecular biology and targeted pharmacology laboratories.
Broad-Spectrum Antitumor Drug Screening & Efficacy Verification
Served as the core positive control drug for tumor targeted therapy model experiments, supporting efficacy screening and mechanism exploration of new natural and synthetic antitumor compounds against multiple cancer types.
Clinical Anticancer Drug Derivative R&D
Applied as the core parent skeleton intermediate for the synthesis of clinical camptothecin-class antitumor drugs such as Irinotecan and Topotecan, guiding structural modification, efficacy optimization and safety evaluation of targeted anticancer molecules.
Natural Alkaloid Structure-Activity Relationship Study
Used as a typical pentacyclic quinoline alkaloid model compound for exploring the structure-activity relationship of lactone ring and fused ring skeleton, supporting innovative R&D of high-efficiency low-toxicity natural antitumor derivatives.
Laboratory Teaching & Tumor Pharmacology Demonstration
Provided as standard high-purity Camptothecin reagent for natural pharmacology teaching experiments, targeted antitumor mechanism demonstration and drug screening model verification, ensuring accurate and stable experimental data for scientific research and teaching work.
FAQ
Q1: What is Camptothecin mainly used for?
A: Camptothecin is a classic natural targeted antitumor pentacyclic alkaloid and specific Topoisomerase I inhibitor. It is mainly used for tumor DNA damage mechanism research, targeted anticancer drug screening, clinical camptothecin-class derivative synthesis and natural alkaloid structure-activity relationship study.
Q2: What is the core pharmacological mechanism of Camptothecin?
A: Camptothecin specifically targets and inhibits Topoisomerase I, stabilizes the enzyme-DNA cleavage complex, blocks DNA religation, induces persistent DNA single-strand breaks, arrests tumor cell S-phase cycle, and ultimately induces malignant tumor cell apoptosis to achieve targeted antitumor effects.
Q3: What are the core advantages of our Camptothecin?
A: Our Camptothecin adopts full-process light-proof low-temperature purification technology, featuring ultra-high single-component purity, complete active lactone ring retention, zero hydrolyzed impurity and plant pigment interference, stable Topoisomerase I inhibitory activity and consistent batch efficacy, ensuring high-precision targeted tumor research results.
Q4: How to store Camptothecin correctly?
A: Camptothecin is extremely sensitive to light, heat and alkaline environments, prone to lactone ring hydrolysis and structural inactivation. It must be stored in vacuum-sealed, low-temperature, light-proof and dry dark conditions. Standard sealed low-temperature dark storage ensures 24 months of stable shelf life and biological activity.
Q5: What is the appearance of high-purity Camptothecin?
A: High-purity Camptothecin is uniform pale yellow fine crystalline powder at room temperature, odorless, stable crystal state, no caking, no fading and no hydrolysis deterioration.
Q6: Can I get free Camptothecin samples for testing?
A: Yes, we provide free Camptothecin samples for targeted antitumor mechanism research, Topoisomerase I inhibition verification and clinical derivative synthesis experiments. Bulk orders support customized purity and professional light-proof vacuum packaging to meet high-standard scientific research and pharmaceutical API production needs.
