Astragaloside A CAS 83207-58-3 Triterpene Saponin from Astragalus membranaceus
Product Identification
| Item | Detail |
|---|---|
| Synonyms | Astragaloside A; (3β,6α,16β,24R,25)-6-(β-D-Glucopyranosyloxy)-3-(β-D-xylopyranosyloxy)-9,19-cyclolanost-20-en-16,24-diol-25-O-β-D-glucopyranoside (simplified cycloartane-type) |
| CAS RN | 83207-58-3 |
| Sibling CAS (Astragaloside IV) | 84687-43-4 (isomer, different sugar pattern, more literature) |
| Upstream (aglycone) | Cycloastragenol CAS 84605-18-5 (A/IV → hydrolysis → Cycloastragenol) |
| Molecular Formula | C₄₁H₆₈O₁₄ |
| MW | 784.98 |
| Botanical | Astragalus membranaceus(Fisch.) Bge., Fabaceae |
| HS Code (ref) | 1302 / 2938 |
| Related SKUs | Astragalus P.E. (A-std); Astragaloside IV 84687-43-4; Cycloastragenol 84605-18-5 |
Description
Astragaloside A is a cycloartane-type triterpene saponin and one of the principal saponins in Astragalus membranaceusroot . Alongside Astragaloside IV, it represents the “total Astragalus saponins” fraction — most CN TCM bulk specs use Astragaloside A as the marker HPLC peak (0.1%–2% in P.E.), while IV is the R&D/pharma-preferred isomer.
Four commercial buckets:
- TCM Cardio / Nephro / Immuno (B2B main): AstragalusTCM heritage = “tonify Qi, defensive Qi, Lung/Spleen” → modern literature maps to: (a) diabetic nephropathy (DN) — albuminuria / renal I/R; (b) cardioprotection — I/R injury, heart failure adjunctive (CN pharma channel, often injectable Astragalussaponin formulations); (c) immunomodulatory — NK, cytokine, “seasonal wellness / post-infection recovery”.
- Astragalus P.E. Bulk (CN TCM export): standardized to Astragaloside A 0.1% / 0.3% / 1% / 2% HPLC — tan powder, 10:1 / 20:1 crude also quoted with “std. to Astragaloside A X%”. This is the tonnage SKU; pure 83207-58-3 ≥98% is the R&D/reference tier.
- DTC Adaptogen / Seasonal Wellness: “defensive Qi” positioning — Astragalusroot + Reishi + Elderberry + Mushroom complexes (DTC “winter wellness / immune supportive”). A/IV usually appear as part of “Astragalus P.E. std.” in these blends, not as mono pure 98% (too expensive for gram-level DTC). Pure A 98% is R&D/premium mono.
- R&D / Reference: pure ≥98% HPLC for AstragalusP.E. QC (A+IV method), telomerase/telomere-adjacent R&D (feeds into Cycloastragenol/TA-65 ecosystem), formulation pilot.
Applications
TCM Pharma – Cardio & Nephro – Astragalussaponin injectable / oral formulations (CN channel), diabetic nephropathy supportive, cardio I/R, adjunctive in heart failure; Astragaloside A as marker in HPLC panel
Astragalus P.E. Bulk (CN TCM export) – std. to Astragaloside A 0.1%–2% HPLC, 10:1/20:1 crude; “total Astragalus saponins” declaration; often blended with Astragaloside IV 84687-43-4 in R&D-grade
DTC Adaptogen / Seasonal Wellness – Astragalusroot complexes (“defensive Qi”) with Reishi/Mushroom/Elderberry; A/IV as part of std. P.E. (not mono pure, price)
Immunomodulatory R&D – NK-cell, cytokine modulation lit (A+IV both studied); TCM “Qi tonify” modern mapping
Reference Standard (≥98%) – for AstragalusP.E. QC (A+IV HPLC method), formulation R&D, stability
