Berberine Sulfate (CAS 633-66-9) – Isoquinoline Alkaloid Salt from Coptis& Phellodendron
Product Overview
Berberine Sulfate is a sulfate salt form of berberine, a quaternary isoquinoline alkaloid traditionally sourced from Coptis chinensis(goldthread) and Phellodendron amurense(Amur cork tree). It appears as yellow to yellow-brown crystalline powder, bitter taste, better water solubility than the free base, and is commonly used where Berberine HCl is not preferred in formulation (specific excipient compatibility, regional regulatory, or cost/form selection reasons).
Our Berberine Sulfate is supplied at ≥98% HPLC (alkaloid assay), yellow crystalline, suitable for pharmaceutical R&D, antimicrobial / gut-health formulation studies, veterinary & aquaculture use, and TCM monomer reference.
Specifications
| Item | Specification |
|---|---|
| Appearance | Yellow to yellow-brown crystalline powder |
| Assay (HPLC, as Berberine) | ≥98% |
| Loss on Drying | ≤5% |
| Residue on Ignition | ≤0.2% |
| Heavy Metals (Pb) | ≤10 ppm |
| Arsenic (As) | ≤2 ppm |
| Solubility | Soluble in hot water, MeOH; slightly soluble in EtOH |
| Plant Source | Coptis chinensis/ Phellodendron amurense |
| CAS No. | 633-66-9 |
| Storage | Sealed, dark, dry, RT (long term 2–8 °C) |
| Shelf Life | 2 years |
Applications
Antimicrobial / Gut Health R&D – berberine alkaloid studied for Gram+ / Gram− antibacterial, antidiarrheal, E. coli/ Salmonellainhibition (in vitro / vet)
Veterinary & Aquaculture – gut-health additive in livestock/aqua formulations (regional compliance required)
TCM Monomer / Pharma R&D – Coptis/ Huanglianmarker compound, content determination, pharmacological screening
Formulation Alternative to Berberine HCl – same bioactive cation, different salt for specific dosage-form or excipient needs
Reference Standard – HPLC qualification, TCM fingerprinting
