Sesamin (CAS 607-80-7) — Bulk Supply | Xi’an Taima Biological Co., Ltd.
Product Introduction
Sesamin (CAS 607-80-7) is a naturally occurring lignan compound found predominantly in sesame seeds (Sesamum indicum) and sesame oil, representing one of the most biologically active plant lignans known to science.
As a fat-soluble polyphenolic lignan, sesamin exerts its biological effects through multiple mechanisms: it acts as a potent inhibitor of cytochrome P450 enzymes (CYP2A6), a selective delta-5 desaturase inhibitor that modulates arachidonic acid metabolism, and a tocopherol synergist that dramatically amplifies the antioxidant activity of vitamin E.
Xi’an Taima Biological Co., Ltd. provides pharmaceutical-grade Sesamin with purity ≥98% by HPLC, extracted from premium non-GMO sesame seeds using advanced ethanol extraction and purification technology. Our product is fully traceable from raw material sourcing to finished specification.
Product Identification
| Parameter | Information |
| Product Name | Sesamin |
| IUPAC Name | (3R,3aR,6S,6aS)-3,6-bis(1,3-benzodioxol-5-yl)hexahydrofuro[3,2-b]furan |
| CAS Number | 607-80-7 |
| Molecular Formula | C₂₀H₁₈O₆ |
| Molecular Weight | 354.35 g/mol |
| Botanical Source | Sesamum indicum L. (sesame) |
| Plant Part Used | Seeds |
| Compound Class | Lignan (furofuran-type) |
| Physical Appearance | White to off-white crystalline powder |
| Odor | Odorless to slightly characteristic |
| Solubility | Insoluble in water; soluble in ethanol, DMSO, chloroform, ethyl acetate |
| Melting Point | 121–123°C |
| Optical Rotation | [α]D20 = −68° to −72° (c=1, chloroform) |
| Storage Conditions | Cool, dry place; below 25°C; protect from light and moisture |
| Shelf Life | 24 months from manufacture date |
Applications
| Application | Product Forms | Typical Dosage | Recommended Grade |
| Dietary Supplements | Capsules, softgels, tablets, powders | 50–150 mg/day sesamin (usually combined with vitamin E) | SES-98, SES-95 |
| Sports Nutrition | Pre/post-workout formulas, protein powders, recovery blends | 50–100 mg/day for fat metabolism & endurance | SES-98 |
| Anti-aging Nutraceuticals | Anti-aging capsules, longevity formulas, NAD+/resveratrol combos | 50–100 mg/day; synergy with tocotrienols | SES-98, SES-99 |
| Functional Foods & Beverages | Fortified health drinks, nutrition bars, sesame oil enrichment | 10–30 mg per serving | SES-90 |
| Cosmetics & Skincare | Anti-aging serums, facial oils, UV-protective formulas | 0.05–0.5% in formulation | SES-95, SES-98 |
| Pharmaceutical R&D | Clinical investigation, drug interaction studies, nutraceutical APIs | Per clinical protocol | SES-99 |
FAQ
Q1: What is sesamin and how does it differ from other sesame lignans?
Sesamin (CAS 607-80-7) is the most abundant and biologically active furofuran-type lignan in sesame seeds, comprising up to 0.5% of sesame oil by weight. Unlike sesamolin (its immediate precursor), sesamin is metabolically stable and directly inhibits cytochrome P450 enzymes to enhance vitamin E activity. Compared to sesamol and sesaminol, sesamin has the best-characterized pharmacological profile with the most clinical trial data supporting cardiovascular and hepatoprotective benefits.
Q2: What is the recommended daily dosage of sesamin?
Clinical studies have used sesamin doses ranging from 50 to 150 mg per day, typically divided into 1–2 doses with meals (as a fat-soluble lignan, sesamin absorbs best with dietary fat). The most studied dose for cardiovascular benefits is 50–100 mg/day. For antioxidant enhancement and vitamin E synergism, 50 mg/day combined with mixed tocopherols (100–400 IU vitamin E) is commonly recommended.
Q3: How does sesamin enhance vitamin E activity?
Sesamin inhibits the cytochrome P450 enzymes CYP4F2 and CYP2A6, which are the primary enzymes responsible for oxidative metabolism and elimination of gamma (γ) and delta (δ) tocopherols. By blocking this metabolic pathway, sesamin increases plasma tocopherol half-life and circulating levels by 2–4 fold without increasing vitamin E intake. This is particularly valuable for gamma-tocopherol, which has superior anti-inflammatory properties compared to alpha-tocopherol.
Q4: Is sesamin safe? What are the known side effects?
Sesamin has an excellent safety profile backed by decades of human consumption via sesame seeds and oil. In clinical trials up to 150 mg/day, sesamin is generally well-tolerated with no serious adverse effects reported. Mild gastrointestinal discomfort may occur in sensitive individuals. Sesamin may enhance the effects of blood-thinning medications (anticoagulants) and blood pressure medications — patients on these drugs should consult a healthcare provider before supplementation. The NOAEL (no-observed-adverse-effect level) in animal studies is >500 mg/kg/day.
Q5: How does sesamin’s delta-5 desaturase inhibition benefit inflammation?
Delta-5 desaturase (FADS1) is the key enzyme converting dihomo-gamma-linolenic acid (DGLA) into arachidonic acid (AA). Excess AA leads to pro-inflammatory eicosanoids including PGE2 (prostaglandin E2) and LTB4 (leukotriene B4). Sesamin selectively inhibits FADS1 without affecting omega-3 (EPA/DHA) metabolism, thereby reducing AA formation and shifting the inflammatory balance toward anti-inflammatory resolution. This mechanism is especially relevant for joint health, metabolic syndrome, and chronic inflammatory conditions.
Q6: Can sesamin be combined with other ingredients in supplement formulations?
Yes — sesamin has well-documented synergistic compatibility with: (1) Vitamin E (tocopherols/tocotrienols) — classic synergistic combination for enhanced antioxidant activity; (2) CoQ10 — complementary cardiovascular antioxidant combination; (3) Omega-3 fatty acids (EPA/DHA) — complementary anti-inflammatory via different mechanisms; (4) Resveratrol — NF-κB suppression synergy; (5) Phosphatidylserine — cognitive health combination. Sesamin’s fat-soluble nature makes it well-suited for softgel and oil-based formulations.
