Product Introduction
| Product Name | Apigenin |
| Synonyms | 4′,5,7-Trihydroxyflavone; Apigenol; C.I. Natural Yellow 1 |
| CAS Number | 520-36-5 |
| Molecular Formula | C₁₅H₁₀O₅ |
| Molecular Weight | 270.24 g/mol |
| Appearance | Light yellow to yellow crystalline powder, odorless, stable crystal form under sealed dark and dry conditions |
| Purity (HPLC) | ≥98.0% / ≥99.0% (Research Grade / Premium Functional Grade, customizable) |
| Loss on Drying | ≤ 0.2% |
| Residue on Ignition | ≤ 0.1% |
| Testing Method | HPLC / NMR / Mass Spectrometry / IR Spectrum / Biological Activity Detection |
| Production Method | Natural Plant Extraction (Celery, Chamomile) & Acid Hydrolysis & Macroporous Resin Purification & Low-Temperature Recrystallization Technology |
| Melting Point | 345–350°C (lit.) |
| Boiling Point | 556.1°C at 760 mmHg (Predicted) |
| Density | 1.548 g/cm³ at 25°C |
| Flash Point | 212.4°C |
| Solubility | Insoluble in water, soluble in DMSO, ethanol, methanol and alkaline solutions; slightly soluble in hot organic solvents; stable in neutral and weakly acidic environments, sensitive to strong light and high temperature |
| Core Feature | Typical 4′,5,7-trihydroxy flavonoid, multi-target natural active monomer, with anti-tumor, anti-inflammatory and neuroprotective dual activities |
| Package | 1g/5g/10g sealed amber bottle, 100g/1kg drum; vacuum moisture-proof & light-proof packaging, custom specification available |
| Storage | Store in vacuum-sealed, low-temperature, dark and dry conditions; avoid high temperature, humid environment and strong light exposure to prevent oxidative degradation and activity loss |
| Shelf Life | 24 months under standard low-temperature sealed and dark storage |
Product Description
Our Apigenin (CAS 520-36-5), chemically known as 4′,5,7-Trihydroxyflavone, is a high-purity natural flavonoid monomer widely extracted from celery, chamomile, parsley and citrus fruits. Supplied in premium research grade and functional ingredient grade, Apigenin features a classic triple-hydroxylated flavone skeleton, endowing it with stable chemical properties and comprehensive multi-target pharmacological activities. As one of the most extensively studied natural flavonoids, Apigenin stands out for its high safety, low toxicity and broad biological functions, including potent antioxidant, anti-inflammatory, anti-proliferative, neuroprotective and hepatoprotective effects. It serves as a core tool compound in tumor pharmacology, immune regulation research, nervous system protection and chronic disease intervention, and is also a popular raw material for high-end antioxidant and health-care product development. As a professional bulk Apigenin supplier, we provide low-impurity, high-activity, batch-stable Apigenin raw materials for global scientific research institutions, pharmaceutical laboratories and functional food manufacturing enterprises.
Apigenin occupies a pivotal position in natural flavonoid pharmacology research, with unique structural and functional advantages distinguishing it from other flavone compounds. Its three active hydroxyl groups on the flavone skeleton enable efficient free radical scavenging, effectively reducing intracellular reactive oxygen species levels and inhibiting lipid peroxidation, thus relieving oxidative stress damage. In terms of anti-inflammatory activity, Apigenin specifically blocks the NF-κB inflammatory signaling pathway, significantly reducing the secretion of pro-inflammatory cytokines such as TNF-α and IL-6, and alleviating chronic low-grade inflammation closely associated with tumors, aging and metabolic disorders. Moreover, Apigenin exerts selective anti-tumor proliferation activity, inhibiting the growth and migration of various cancer cells without significant toxicity to normal cells, making it a key lead compound for anti-tumor auxiliary drug research. It also delivers prominent neuroprotective, liver-protective and immune-regulatory functions, improving neuronal survival, protecting hepatocytes, and balancing immune cell activity. Our high-purity Apigenin completely eliminates plant-derived impurities, mixed flavonoid residues and solvent traces, ensuring single-component purity and ultra-stable multi-target biological activity for high-precision pharmacological experiments and product development.
Manufactured by Shaanxi BAISFU Bio-Engineering Co., Ltd., our premium Apigenin adopts advanced natural plant selective extraction, acid hydrolysis deglycosylation combined with macroporous resin gradient purification and multi-stage low-temperature recrystallization technology. The entire production process strictly controls extraction temperature, pH value and purification gradients, effectively avoiding oxidative degradation of the flavone active skeleton. The closed dust-free and oxygen-free production system thoroughly removes plant fiber impurities, pigment residues and heavy metal contaminants, fully retaining the complete molecular structure and comprehensive biological activity of Apigenin. The finished product presents uniform light yellow crystalline powder with stable crystal form, no caking, no discoloration and no deterioration, fully complying with international research-grade and high-purity functional ingredient quality standards.
Functions & Benefits
Broad-Spectrum Antioxidant Activity (Core Benefit)
Apigenin features three active hydroxyl groups on the flavone skeleton, enabling efficient scavenging of intracellular free radicals and reactive oxygen species. It inhibits lipid peroxidation, reduces oxidative stress damage, protects cell membrane integrity, and effectively delays oxidative aging of tissues and cells, serving as a classic natural antioxidant tool compound.
Potent Anti-Inflammatory & Chronic Inflammation Relief
High-purity Apigenin specifically inhibits NF-κB signaling pathway activation, downregulates the expression of multiple pro-inflammatory factors, and relieves chronic low-grade inflammation. It improves the systemic inflammatory microenvironment and provides effective intervention for inflammation-related disease research.
Selective Anti-Tumor Proliferation Effect
Apigenin selectively inhibits the proliferation, migration and invasion of various tumor cells, induces tumor cell apoptosis, and blocks tumor angiogenesis. With no obvious toxic side effects on normal cells, it is an ideal safe anti-tumor auxiliary research monomer and lead compound for new anti-cancer drug development.
Excellent Neuroprotective & Hepatoprotective Properties
Apigenin protects neuronal cells from oxidative and inflammatory damage, enhances synaptic plasticity, and improves cognitive function. It also stabilizes hepatocyte activity, reduces liver oxidative damage and inflammatory injury, providing dual protection for nerve and liver tissue.
High Single-Component Purity & Zero Impurity Interference
Our Apigenin adopts full-process high-precision purification technology, completely eliminating mixed flavonoid impurities, plant pigments and organic solvent residues. It ensures pure monomer multi-target activity, zero experimental interference and consistent batch pharmacological efficacy.
High Safety & Wide Application Adaptability
As a natural dietary flavonoid with high biocompatibility and low toxicity, Apigenin maintains stable biological activity in cell and animal models. It perfectly adapts to multi-scenario research such as pharmacology, oncology, immunology and functional product development.
Applications
Tumor Pharmacology & Anti-Cancer Mechanism Research
Used as a standard natural anti-tumor monomer for studying tumor cell proliferation inhibition, apoptosis induction and metastasis mechanism, widely applied in oncology pharmacology and anti-cancer drug screening laboratories.
Inflammatory Pathway & Oxidative Stress Research
Served as the core experimental compound for exploring NF-κB inflammatory regulation, free radical scavenging and oxidative damage repair mechanisms, supporting chronic inflammation and oxidative disease intervention research.
Neuroprotection & Cognitive Function Study
Applied in neuronal protection, synaptic plasticity regulation and cognitive improvement experiments, providing key tool support for neurodegenerative disease prevention and brain health mechanism research.
Flavonoid Structure-Activity Relationship Research
Used as a typical 4′,5,7-trihydroxy flavone model compound to compare the activity differences of different flavonoid monomers, clarifying the structure-function relationship of hydroxyl substitution sites on flavone skeletons.
Laboratory Teaching & Pharmacological Demonstration
Provided as standard high-purity Apigenin reagent for natural flavonoid pharmacology teaching, anti-inflammatory and anti-tumor mechanism demonstration and antioxidant activity comparison tests, ensuring accurate and stable experimental data for scientific research and teaching.
FAQ
Q1: What is Apigenin mainly used for?
A: Apigenin is a natural flavonoid active monomer. It is mainly used for anti-tumor proliferation mechanism research, oxidative stress and antioxidant experiments, chronic inflammation regulation, neuroprotective research and natural functional health product development.
Q2: What are the core advantages of Apigenin?
A: Apigenin features high safety, low toxicity and multi-target activity. It integrates anti-oxidation, anti-inflammation, anti-tumor and neuroprotection functions, with wider pharmacological application value and higher biological safety than most single-function plant monomers.
Q3: What are the core advantages of our Apigenin?
A: Our Apigenin adopts professional plant extraction and multi-stage recrystallization purification technology, featuring ultra-high single-component purity, zero mixed flavonoid and plant impurity interference, stable multi-target biological activity, and consistent batch quality for high-precision scientific research.
Q4: How to store Apigenin correctly?
A: Apigenin is sensitive to high temperature, humidity and strong light, prone to oxidative deterioration and activity attenuation. It must be stored in vacuum-sealed, low-temperature, light-proof and dry dark conditions. Standard sealed low-temperature dark storage ensures 24 months of stable shelf life and biological activity.
Q5: What is the appearance of high-purity Apigenin?
A: High-purity Apigenin is uniform light yellow to yellow fine crystalline powder at room temperature, odorless, stable crystal state, no caking, no fading and no deterioration.
Q6: Can I get free Apigenin samples for testing?
A: Yes, we provide free Apigenin samples for anti-tumor mechanism research, antioxidant and anti-inflammatory efficacy verification and neuroprotective experiments. Bulk orders support customized purity and professional light-proof vacuum packaging to meet scientific research and functional ingredient production needs.
