Product Introduction
| Item | Specification |
| Product Name | Fisetin |
| Synonyms | 3,3′,4′,7-Tetrahydroxyflavone; Fisetten |
| CAS Number | 528-48-3 |
| Molecular Formula | C₁₅H₁₀O₆ |
| Molecular Weight | 286.24 g/mol |
| Appearance | Yellow crystalline powder, odorless, stable crystal form under sealed dark and dry conditions |
| Purity (HPLC) | ≥98.0% / ≥99.0% (Research Grade / Premium Senolytic Grade, customizable) |
| Loss on Drying | ≤ 0.2% |
| Residue on Ignition | ≤ 0.1% |
| Testing Method | HPLC / NMR / Mass Spectrometry / IR Spectrum / Biological Activity Detection |
| Production Method | Natural Plant Extraction (Cotinus coggygria) & Macroporous Resin Purification & Low-Temperature Recrystallization Technology |
| Melting Point | 330–332°C (lit.) |
| Boiling Point | 577.5°C at 760 mmHg (Predicted) |
| Density | 1.68 g/cm³ at 25°C |
| Flash Point | 218.7°C |
| Solubility | Slightly soluble in water, soluble in ethanol, methanol, DMSO and acetone; insoluble in chloroform; stable in neutral and weakly acidic environments, sensitive to strong light and high temperature |
| Core Feature | Natural flavonol senolytic compound, high-efficiency antioxidant, multi-target anti-aging and neuroprotective active monomer |
| Package | 1g/5g/10g sealed amber bottle, 100g/1kg drum; vacuum moisture-proof & light-proof packaging, custom specification available |
| Storage | Store in vacuum-sealed, low-temperature, dark and dry conditions; avoid high temperature, humid environment and strong light exposure to prevent oxidation and activity attenuation |
| Shelf Life | 24 months under standard low-temperature sealed and dark storage |
Product Description
Our Fisetin (CAS 528-48-3), chemically defined as 3,3′,4′,7-Tetrahydroxyflavone, is a high-purity natural flavonol compound extracted from Cotinus coggygria and various fruits and vegetables including strawberries, apples and grapes. Supplied in premium research grade and high-purity functional grade, Fisetin is a classic senolytic active monomer with unique tetrahydroxy flavone molecular structure. Different from common antioxidants, Fisetin not only scavenges free radicals efficiently but also selectively clears senescent cells, regulates cellular senescence pathways, and exerts comprehensive anti-inflammatory, neuroprotective and metabolic regulatory activities. It has become a core hotspot compound in anti-aging pharmacology, cognitive neuroscience, senescence biology and functional health product research. As a professional bulk Fisetin supplier, we provide low-impurity, high-activity, batch-stable Fisetin raw materials for global scientific research institutions, pharmaceutical laboratories and health care product manufacturing enterprises.
Fisetin occupies an irreplaceable core position in natural anti-aging and flavonoid pharmacology research, with outstanding multi-target pharmacological advantages. Its core senolytic mechanism lies in selectively inducing apoptosis of senescent cells without affecting normal cell activity, effectively eliminating senescence-associated secretory phenotype (SASP) and delaying tissue and organ aging progression. In terms of antioxidant activity, the four hydroxyl groups on its flavonol skeleton enable Fisetin to efficiently neutralize superoxide anions, hydroxyl radicals and hydrogen peroxide, significantly reducing intracellular oxidative stress and lipid peroxidation damage. Meanwhile, Fisetin inhibits the activation of NF-κB and other inflammatory signaling pathways, reduces the release of pro-inflammatory cytokines, and relieves chronic low-grade inflammation closely related to aging and metabolic diseases. Additionally, it exerts prominent neuroprotective effects, improving neuronal vitality, enhancing cognitive function and memory, and providing effective intervention for neurodegenerative lesion research. Our high-purity Fisetin completely eliminates plant wax impurities, mixed flavonoid residues and organic solvent traces, ensuring single-component purity and ultra-stable senolytic and antioxidant activity for high-precision biological experiments and product development.
Manufactured by Shaanxi BAISFU Bio-Engineering Co., Ltd., our premium Fisetin adopts advanced plant selective extraction combined with macroporous resin gradient separation and multi-stage low-temperature recrystallization purification technology. The entire production process strictly controls temperature, light shielding and purification gradients, effectively avoiding oxidative degradation of the flavonol active skeleton. The closed dust-free and oxygen-free production system thoroughly removes plant fiber impurities, miscellaneous flavonoids and heavy metal residues, fully retaining the complete molecular structure and comprehensive biological activity of Fisetin. The finished product presents uniform bright yellow crystalline powder with stable crystal form, no caking, no discoloration and no deterioration, fully complying with international research-grade and high-purity functional ingredient quality standards.
Every batch of Fisetin undergoes strict multi-dimensional quality inspection, including HPLC high-precision purity analysis, NMR structural verification, mass spectrometry molecular identification and cell-level senolytic activity testing. It achieves ultra-low trace residue and zero invalid impurity interference, ensuring consistent batch efficacy and excellent experimental repeatability. The product features stable solubility in common organic solvents and excellent biochemical compatibility in cell culture and in vivo animal experiment environments, fully meeting the strict raw material requirements of cellular senescence research, anti-aging mechanism exploration, cognitive protection experiments and flavonoid structure-activity relationship research.
We maintain sufficient low-temperature light-proof inventory and complete qualification documents for bulk Fisetin supply. Whether you need standard flavonol monomer tools for basic senescence pharmacology research, positive control reagents for senolytic and antioxidant efficacy verification, or high-purity raw materials for anti-aging functional product development, our premium Fisetin is a high-cost-performance and high-value choice for global buyers.
Functions & Benefits
Potent Selective Senolytic Activity (Core Benefit)
Fisetin is a classic natural senolytic compound that selectively targets and eliminates senescent cells, inhibits SASP release, blocks the spread of aging signals, and delays cellular and tissue aging. It serves as the core gold-standard tool compound for anti-aging and senescence mechanism research.
High-Efficiency Broad-Spectrum Antioxidant Effect
With four active hydroxyl groups on the flavonol skeleton, Fisetin delivers powerful free radical scavenging capacity, effectively removing intracellular reactive oxygen species, reducing oxidative stress damage, protecting cell membrane integrity, and resisting exogenous oxidative aging.
Multi-Target Anti-Inflammatory Regulation
High-purity Fisetin inhibits NF-κB inflammatory signaling pathway activation, reduces the secretion of TNF-α, IL-6 and other pro-inflammatory factors, relieves chronic low-grade inflammation, and improves inflammatory microenvironment, supporting chronic inflammation and aging-related disease research.
Excellent Neuroprotective & Cognitive Improvement Effects
Fisetin protects neuronal cells from oxidative and inflammatory damage, enhances neuronal survival and synaptic plasticity, improves learning and memory abilities, and stabilizes nervous system function, with important research value for neurodegenerative disease intervention.
High Single-Component Purity & Zero Impurity Interference
Our Fisetin adopts full-process high-precision purification technology, completely eliminating mixed flavonoid impurities and plant-derived contaminants. It ensures pure monomer senolytic and antioxidant activity, zero experimental interference and consistent batch pharmacological efficacy.
Stable Biocompatibility & Wide Application Adaptability
Fisetin has stable solubility in conventional experimental solvents and excellent cellular compatibility. It maintains stable multi-target biological activity in cell and animal models, perfectly adapting to senescence biology, antioxidant pharmacology and functional product development research.
Applications
Cellular Senescence & Anti-Aging Pharmacology Research
Used as a standard senolytic positive reagent for studying cellular senescence regulation, senescent cell clearance mechanism and aging signal pathway inhibition, widely applied in anti-aging biology and pharmacological research laboratories.
Oxidative Stress & Antioxidant Mechanism Study
Served as the core experimental compound for exploring intracellular free radical scavenging, lipid peroxidation inhibition and oxidative damage repair, supporting antioxidant ingredient efficacy verification and oxidative disease mechanism research.
Neuroprotection & Cognitive Function Research
Applied in neuronal protection, synaptic plasticity regulation and cognitive improvement experiments, providing key tool support for neurodegenerative disease prevention and brain health mechanism research.
Flavonoid Structure-Activity Relationship Research
Used as a typical tetrahydroxy flavonol model compound to compare the activity differences of different flavonoid monomers, clarifying the structure-function relationship of hydroxyl substitution sites on flavone skeletons.
Laboratory Teaching & Pharmacological Demonstration
Provided as standard high-purity Fisetin reagent for natural flavonoid pharmacology teaching, senolytic mechanism demonstration and antioxidant activity comparison tests, ensuring accurate and stable experimental data for scientific research and teaching.
FAQ
Q1: What is Fisetin mainly used for?
A: Fisetin is a natural flavonol senolytic compound. It is mainly used for cellular senescence and anti-aging mechanism research, oxidative stress regulation, neuroprotective and cognitive improvement experiments, and natural antioxidant functional product development.
Q2: What is the core advantage of Fisetin compared with common antioxidants?
A: Unlike ordinary antioxidants that only scavenge free radicals, Fisetin has dual effects of anti-oxidation and selective senescent cell clearance, fundamentally delaying cellular aging, with more comprehensive anti-aging pharmacological value and broader research prospects.
Q3: What are the core advantages of our Fisetin?
A: Our Fisetin adopts professional plant extraction and multi-stage recrystallization purification technology, featuring ultra-high single-component purity, zero mixed flavonoid and plant impurity interference, stable senolytic and antioxidant activity, and consistent batch quality for high-precision biological research.
Q4: How to store Fisetin correctly?
A: Fisetin is sensitive to high temperature, humidity and strong light, prone to oxidative deterioration and activity attenuation. It must be stored in vacuum-sealed, low-temperature, light-proof and dry dark conditions. Standard sealed low-temperature dark storage ensures 24 months of stable shelf life and biological activity.
Q5: What is the appearance of high-purity Fisetin?
A: High-purity Fisetin is uniform bright yellow fine crystalline powder at room temperature, odorless, stable crystal state, no caking, no fading and no deterioration.
Q6: Can I get free Fisetin samples for testing?
A: Yes, we provide free Fisetin samples for cellular senescence research, antioxidant efficacy verification and neuroprotective mechanism experiments. Bulk orders support customized purity and professional light-proof vacuum packaging to meet scientific research and functional ingredient production needs.
