Product Introduction
| Item | Specification |
| Product Name | Noscapine |
| Synonyms | Narcotine; L-α-Narcotine; 6,7-Dimethoxy-3-(4-methoxy-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-yl)isobenzofuran-1(3H)-one |
| CAS Number | 128-62-1 |
| Molecular Formula | C₂₂H₂₃NO₇ |
| Molecular Weight | 413.42 g/mol |
| Appearance | White to off-white crystalline powder or glossy prismatic crystal, odorless, tasteless, stable crystal form under sealed dark and dry conditions |
| Purity (HPLC) | ≥98.0% / ≥99.0% (Research Grade / Pharma API Grade, customizable) |
| Loss on Drying | ≤ 0.2% |
| Residue on Ignition | ≤ 0.1% |
| Testing Method | HPLC / NMR / Mass Spectrometry / IR Spectrum / Cell Level Activity Detection |
| Production Method | Natural Plant Extraction & Multi-Stage Chromatographic Purification & Low-Temperature Recrystallization |
| Melting Point | 174–176°C (lit.) |
| Boiling Point | 576.2°C at 760 mmHg |
| Density | 1.42 g/cm³ at 25°C |
| Flash Point | 302.2°C |
| Solubility | Soluble in chloroform, methanol, ethanol and DMSO; slightly soluble in ether; almost insoluble in water; stable in dry environment, sensitive to strong light and high temperature |
| Core Feature | Unique phthalideisoquinoline alkaloid, natural tubulin inhibitor, low-toxic antitumor and antitussive bioactive monomer |
| Package | 1g/5g/10g sealed amber bottle, 100g/1kg drum; vacuum moisture-proof packaging, custom specification available |
| Storage | Store in vacuum-sealed, low-temperature, dark and dry conditions; avoid strong light, high temperature and humid environment to prevent oxidation and structural degradation |
| Shelf Life | 24 months under standard low-temperature sealed storage |
Product Description
Our Noscapine is a high-purity natural phthalideisoquinoline alkaloid with unique heterocyclic molecular structure and stable multi-dimensional pharmacological activity, available in premium research grade and pharmaceutical API grade. Noscapine (CAS 128-62-1), also known as Narcotine, is a rare bioactive alkaloid extracted from Papaver somniferum, featuring a distinctive fused phthalide and isoquinoline dual-ring skeleton that differentiates it from conventional protoberberine alkaloids. Unlike morphine-based opiate components, Noscapine has no addictive properties and exhibits excellent safety profiles, endowed with unique tubulin-binding, tumor cell cycle arrest, antitussive and anti-inflammatory pharmacological activities. As a high-value natural small-molecule compound, it serves as a core tool reagent for tumor cell biology research and innovative low-toxic anticancer drug development. As a professional bulk Noscapine supplier, we provide low-impurity, high-activity, batch-stable Noscapine raw materials for global natural product research institutions, tumor pharmacology laboratories and botanical API manufacturing enterprises.
Noscapine occupies a unique and irreplaceable position in natural alkaloid chemistry, tumor cell cycle regulation and non-addictive botanical drug research. Its most prominent pharmacological feature is the selective binding to tubulin, which effectively interferes with microtubule polymerization and depolymerization balance, blocks tumor cell mitosis, and induces G2/M phase cell cycle arrest, thereby inhibiting the proliferation, invasion and metastasis of various malignant tumor cells. Compared with traditional chemically synthesized tubulin inhibitors with high cytotoxicity and severe side effects, natural Noscapine delivers efficient antitumor activity with low toxicity and no significant drug resistance, making it a hot research candidate for broad-spectrum targeted tumor therapy. In addition to antitumor efficacy, Noscapine exerts significant central antitussive effects by regulating cough reflex pathways, as well as anti-inflammatory, antioxidant and neuroprotective activities, supporting multi-directional natural pharmacological exploration. In medicinal chemistry research, its unique phthalideisoquinoline fused-ring structure provides precious modification sites for the development of new high-efficiency, low-toxicity antitumor and neuroprotective derivatives. Different from low-purity crude extracts containing plant heterozygous alkaloids and pigment residues, our high-purity Noscapine adopts precision purification technology to completely remove invalid impurities, ensuring single-component purity and ultra-stable repeatable pharmacological activity for high-precision scientific research and new drug R&D.
Manufactured by Shaanxi BAISFU Bio-Engineering Co., Ltd., our premium Noscapine adopts advanced low-temperature selective extraction combined with multi-stage macroporous resin separation and gradient recrystallization purification process. The whole production process strictly controls extraction selectivity, temperature and purification gradient, thoroughly removing residual plant impurities, mixed alkaloids and organic solvent residues. The low-temperature oxygen-free processing technology effectively avoids molecular oxidation and structural isomerization, completely retaining the complete active phthalideisoquinoline skeleton and core tubulin-binding activity of Noscapine. The finished product presents uniform white to off-white glossy crystalline powder, stable crystal form, no caking, no discoloration and no deterioration, fully complying with high-standard natural product research grade and pharmaceutical botanical API grade quality specifications.
Every batch of Noscapine undergoes strict multi-dimensional quality inspection, including HPLC high-precision purity analysis, NMR structural verification, mass spectrometry molecular identification and cell-level pharmacological activity testing. It achieves ultra-low trace residue and zero invalid impurity interference, ensuring consistent batch efficacy and experimental stability. The product features stable solubility in common organic solvents, excellent biochemical stability in cell culture and animal experiment environments, and outstanding experimental repeatability, fully meeting the strict raw material requirements of in vitro tumor cell cycle experiments, in vivo antitumor efficacy verification and natural botanical drug formula optimization.
We maintain sufficient low-temperature inventory and complete qualification documents for bulk Noscapine supply. Whether you need standard phthalideisoquinoline alkaloid monomers for pharmacological research, core reference substances for natural antitumor drug evaluation, or high-purity heterocyclic skeleton intermediates for custom derivative synthesis, our premium Noscapine is a high-cost-performance and high-value natural fine chemical product choice for global buyers.
Functions & Benefits
Natural Tubulin Inhibitor & Anti-Tumor Activity (Core Benefit)
Noscapine is a classic natural microtubule regulatory alkaloid. It selectively binds to cellular tubulin, disrupts microtubule dynamic balance, blocks tumor cell mitosis, and induces cell cycle arrest. With low systemic toxicity and no addiction, it is the gold-standard tool compound for natural low-toxic antitumor pharmacology research.
Unique Phthalideisoquinoline Fused-Ring Structure
As a distinctive phthalideisoquinoline alkaloid, Noscapine has a unique dual fused-ring skeleton different from common protoberberine and isoquinoline alkaloids. Its special molecular structure provides critical templates for studying alkaloid structure-activity relationships and developing innovative natural antitumor derivatives.
Non-Addictive & Safe Pharmacological Characteristics
High-purity Noscapine retains efficient biological activity without opioid addiction, distinguishing it from other poppy-derived alkaloids. It features high safety, low cytotoxicity and low drug resistance risk, suitable for long-term pharmacological experiments and new drug preclinical safety evaluation.
Low-Impurity Purification & Ultra-Stable Biological Activity
Our Noscapine adopts low-temperature selective extraction and multi-stage impurity removal technology, completely eliminating miscellaneous alkaloids, plant pigments and degradation impurities contained in traditional crude extracts. It solves the problems of unstable activity and poor experimental repeatability of conventional products, ensuring long-term stable pharmacological efficacy.
Strict Batch Consistency & High Experimental Repeatability
Extracted and recrystallized under constant low-temperature sterile conditions, Noscapine eliminates process quality fluctuations. The product has uniform crystal form, stable molecular structure and consistent batch biological activity, suitable for long-term tumor cell mechanism research and high-precision pharmacological screening projects.
Moderate Solubility & Wide Experimental Adaptability
Noscapine has good solubility in chloroform, methanol, ethanol and DMSO, easy to prepare into homogeneous experimental stock solutions and pharmacological formula systems. It maintains stable activity in conventional cell and animal experiment environments, perfectly adapting to tumor cell cycle tests, anti-proliferation experiments and botanical drug formulation research.
Applications
Tumor Cell Cycle & Microtubule Regulation Research
Used as a standard high-purity natural tubulin inhibitor reagent for studying tumor cell mitosis, microtubule dynamic balance and G2/M phase cycle arrest mechanisms. Widely applied in tumor cell biology and pharmacological research laboratories.
Low-Toxic Antitumor Drug Screening & Mechanism Study
Served as the core specific positive drug for natural low-toxic antitumor model experiments, supporting efficacy verification and mechanism exploration of new non-addictive natural anticancer active substances.
Botanical API R&D & Pharmacological Evaluation
Applied as a classic reference compound for new natural antitumor, antitussive and anti-inflammatory drug development, guiding structural optimization, efficacy screening and safety evaluation of phthalideisoquinoline alkaloid pharmaceutical molecules.
Special Alkaloid Derivative Synthesis
Used as a high-value natural phthalideisoquinoline skeleton intermediate for the synthesis of new high-efficiency, low-toxicity antitumor and neuroprotective alkaloid derivatives, supporting innovative R&D of special botanical pharmaceutical intermediates.
Laboratory Teaching & Alkaloid Comparative Research
Provided as standard high-purity Noscapine reagent for natural pharmacology teaching experiments, special isoquinoline alkaloid comparative tests and structure-activity relationship verification, ensuring accurate and stable experimental data for scientific research and teaching work.
FAQ
Q1: What is Noscapine mainly used for?
A: Noscapine is a unique natural phthalideisoquinoline alkaloid. It is mainly used for tumor microtubule regulation and cell cycle arrest mechanism research, low-toxic natural antitumor drug screening, non-addictive antitussive pharmacology experiments and special alkaloid derivative synthesis, with stable and safe multi-target biological activity.
Q2: What is the structural feature of Noscapine?
A: Noscapine has a rare fused phthalideisoquinoline dual-ring heterocyclic structure, consisting of phthalide and isoquinoline functional skeletons. Different from conventional protoberberine alkaloids, this unique structure endows it with specific tubulin-binding selectivity and low-toxic antitumor specificity.
Q3: What are the core advantages of our Noscapine?
A: Our Noscapine adopts low-temperature selective extraction and multi-stage recrystallization purification technology, featuring ultra-high single-component purity, zero miscellaneous alkaloid and pigment interference, stable tubulin inhibitory activity and consistent batch efficacy. It effectively avoids experimental errors caused by crude extract impurities, ensuring high-precision natural product research results.
Q4: How to store Noscapine correctly?
A: Noscapine is sensitive to strong light, high temperature and humid environments, prone to oxidation and structural degradation leading to reduced biological activity. It must be stored in vacuum-sealed, low-temperature, cool and dry dark conditions. Standard sealed low-temperature storage ensures 24 months of stable shelf life and pharmacological activity.
Q5: What is the appearance of high-purity Noscapine?
A: High-purity Noscapine is uniform white to off-white glossy crystalline powder or prismatic crystal at room temperature, odorless, tasteless, stable crystal state, no caking, no fading and no precipitation deterioration.
Q6: Can I get free Noscapine samples for testing?
A: Yes, we provide free Noscapine samples for tumor microtubule regulation research, low-toxic antitumor activity verification and phthalideisoquinoline alkaloid derivative synthesis tests. Bulk orders support customized purity and professional anti-oxidation vacuum packaging to meet high-standard scientific research and pharmaceutical API production needs.
