Product Introduction
| Item | Specification |
| Product Name | Loperamide |
| Synonyms | 4-(4-Chlorophenyl)-4-hydroxypiperidine-1-carboxylic acid 4-(4-chlorophenyl)-4-piperidinyl ester |
| CAS Number | 53179-11-8 |
| Molecular Formula | C₂₉H₃₃ClN₂O₂ |
| Molecular Weight | 477.04 g/mol |
| Appearance | White crystalline powder, odorless, stable crystal state at room temperature |
| Purity (HPLC/GC) | ≥98.0% / ≥99.0% (Pharma Grade / Research Grade, customizable) |
| Loss on Drying | ≤ 0.2% |
| Residue on Ignition | ≤ 0.1% |
| Testing Method | HPLC / GC / NMR / Mass Spectrometry / IR Spectrum |
| Production Method | Precision Organic Synthesis & Multi-Stage Recrystallization & High-Purity Purification |
| Melting Point | 223–225°C (lit.) |
| Boiling Point | 545.2°C at 760 mmHg |
| Density | 1.21 g/cm³ at 25°C |
| Flash Point | 283.5°C |
| Solubility | Slightly soluble in water, freely soluble in methanol, ethanol, DMSO and organic solvent systems, stable in acidic and neutral reaction environments |
| Core Feature | Complete pyridine-piperidine bicyclic skeleton, high directional cleavage activity, exclusive core precursor for industrial Anabasine synthesis |
| Package | 10g/100g sealed bottle, 1kg/5kg drum; custom packaging available |
| Storage | Store in sealed, cool, dark and dry conditions; avoid high temperature and strong light to prevent molecular structural deterioration |
| Shelf Life | 24 months under standard sealed storage |
Product Description
Our Loperamide is a high-purity pharmaceutical-grade piperidine alkaloid intermediate with complete and stable bicyclic molecular skeleton, available in 98% and 99% premium grades. Loperamide (CAS 53179-11-8) is a classic nitrogen-containing heterocyclic compound in the fine chemical and biomedical industry, most famous as the core industrial precursor for high-purity Anabasine synthesis. Different from terpenoid products such as Borneol and Terpinen-4-ol focused on fragrance modulation and cosmetic antisepsis, and differentiated from common phenolic and quinone active ingredients focused on skincare and antioxidant efficacy, Loperamide is professionally positioned inhigh-precision alkaloid derivatization synthesis and biomedical pharmacological research, featuring unique directional molecular cleavage and cyclization rearrangement activity. As a professional bulk Loperamide supplier, we provide low-impurity, high-reactivity, stable-batch pharmaceutical intermediates for global fine chemical factories, biomedical research institutions and natural alkaloid synthesis enterprises.
Loperamide has irreplaceable core industrial value in Anabasine mass production. Its inherent pyridine-piperidine fused bicyclic structure is highly consistent with the molecular skeleton of Anabasine, which determines its absolute advantages in targeted synthesis. Under precise catalytic and temperature-controlled conditions, Loperamide can undergo directional deprotection, molecular chain cleavage and internal cyclization rearrangement reaction, efficiently removing redundant functional groups and retaining the pure active skeleton of Anabasine. Compared with traditional plant extraction routes that rely on raw material growth cycles and contain miscellaneous alkaloid impurities, the Loperamide synthetic route completely solves the problems of low yield, unstable purity, complex impurities and high batch fluctuation of natural Anabasine, becoming the only mature and efficient industrial process for high-end research-grade and industrial-grade Anabasine production.
Manufactured by Shaanxi BAISFU Bio-Engineering Co., Ltd., our premium Loperamide adopts advanced precision organic synthesis technology combined with multi-stage low-temperature recrystallization and ultra-purification process. We strictly control reaction temperature, pressure and catalytic ratio in the whole production process, completely remove unreacted raw materials, intermediate by-products, solvent residues and structural isomer impurities, and maximize the retention of stable bicyclic active skeleton. The whole production process complies with pharmaceutical-grade intermediate production standards, avoiding the defects of low-purity industrial Loperamide such as many interfering impurities and poor reaction selectivity. The finished product presents uniform white crystalline powder, stable chemical properties, no hygroscopic deterioration, and excellent structural reaction activity.
Every batch of Loperamide undergoes strict multi-dimensional quality inspection, including HPLC high-precision purity analysis, NMR structural verification, mass spectrometry molecular identification and impurity residue detection. It ensures ultra-high single-component purity, zero heterologous skeleton interference and stable batch consistency, which is the key guarantee for high-yield and high-purity Anabasine downstream synthesis. The product features stable crystal structure, moderate solubility, excellent low-temperature reaction stability and formula compatibility, fully meeting the high-standard raw material requirements of fine chemical derivatization, biomedical experiments and large-scale industrial synthesis.
We maintain sufficient inventory and complete qualification documents for bulk Loperamide supply. Whether you need high-activity skeleton raw materials for Anabasine industrial synthesis, standard monomers for biomedical pharmacological research, or key intermediates for custom alkaloid derivative development, our high-purity pharmaceutical-grade Loperamide is a high-cost-performance and high-value fine chemical raw material choice for global buyers.
Functions & Benefits
Exclusive Core Precursor for Industrial Anabasine Synthesis (Core Benefit)
Loperamide is the most mature and efficient industrial raw material for high-purity Anabasine production. It retains the complete pyridine-piperidine bicyclic skeleton required for Anabasine molecules. Through precise cleavage and rearrangement reaction, it can be efficiently converted into high-purity Anabasine with zero miscellaneous alkaloid interference, supporting stable mass production of high-standard Anabasine products.
High-Precision Alkaloid Derivatization Intermediate
With stable heterocyclic skeleton structure and high directional reaction activity, Loperamide has excellent selectivity in deprotection, cleavage, cyclization and modification reactions. It is widely used in the custom synthesis and structural optimization of various piperidine alkaloid derivatives, with controllable reaction process and stable product quality.
Professional Biomedical Research Tool Compound
Loperamide has specific pharmacological activity and stable molecular properties, serving as an important tool compound for neuropharmacological research, opioid receptor mechanism exploration and alkaloid toxicology research. It provides accurate experimental support for biomedical and pharmaceutical research institutions.
Ultra-Low Impurity & High Structural Stability
Pharmaceutical-grade purified Loperamide eliminates industrial impurities, structural isomers and residual solvents. It features ultra-high single-component purity, stable physical and chemical properties, no adverse interference on downstream synthesis reactions, and ensures zero batch difference of end alkaloid products.
Strict Batch Consistency & Industrial Adaptability
Synthetic and recrystallized Loperamide avoids raw material source fluctuations and seasonal quality differences. The product has stable crystal form and reaction activity, suitable for long-term continuous industrial production and high-precision laboratory customized experiments.
Excellent Solubility & Reaction Compatibility
Loperamide has good solubility in various polar organic solvents and stable activity in acidic and neutral reaction systems. It is easy to dissolve and compound, with high reaction conversion rate, perfectly adapting to diverse organic synthesis and formula debugging scenarios.
Applications
High-Purity Anabasine Industrial Synthesis
As the exclusive core starting raw material, Loperamide undergoes directional cleavage, deprotection and cyclization rearrangement, then obtains high-purity Anabasine through high-vacuum rectification and purification. This synthetic route completely replaces traditional plant extraction and becomes the mainstream process for high-end Anabasine mass production.
Biomedical & Pharmacological Research
High-purity Loperamide is widely used in neuropharmacology, receptor mechanism research and alkaloid drug efficacy testing. It serves as a standard experimental monomer for university laboratories, pharmaceutical research institutes and toxicology detection institutions.
Fine Chemical Alkaloid Derivative Custom Synthesis
Used as a key heterocyclic intermediate for structural modification and derivatization of piperidine alkaloids. It supports the research and development of new biological pesticides, pharmacological active molecules and fine chemical additives.
Organic Synthesis & Industrial Raw Material Manufacturing
Applied in the production of high-purity nitrogen heterocyclic compounds and custom fine chemical synthesis projects. It provides stable and high-quality raw material support for downstream fine chemical product upgrading and technological innovation.
Laboratory Scientific Research & Formula Debugging
Provided as standard high-purity Loperamide monomer for alkaloid synthesis mechanism verification, pharmacological activity testing and custom experimental development, supporting scientific research innovation and new product iteration.
FAQ
Q1: What is Loperamide mainly used for?
A: Loperamide is a high-value pharmaceutical-grade piperidine alkaloid intermediate. Its core industrial application is serving as the exclusive synthetic precursor for high-purity Anabasine. It is also widely used in biomedical pharmacological research, alkaloid derivative synthesis and fine chemical custom synthesis.
Q2: Why use Loperamide to synthesize Anabasine?
A: Loperamide has a complete pyridine-piperidine bicyclic skeleton consistent with Anabasine. The synthetic route features high reaction selectivity, few by-products, ultra-low miscellaneous alkaloid impurities and stable batch quality. It completely solves the defects of low purity and unstable efficacy of plant-extracted Anabasine, being the preferred industrial process.
Q3: What are the core advantages of our Loperamide?
A: Our Loperamide adopts pharmaceutical-grade purification technology, with ultra-high single-component purity, stable molecular structure, low impurity content and high reaction activity. It has absolute advantages in Anabasine synthesis yield and product purity, with stable batch consistency and strong industrial applicability.
Q4: How to store Loperamide correctly?
A: Loperamide is sensitive to high temperature and strong light. It needs to be stored in sealed, cool, dry and dark conditions to prevent molecular structural deterioration and impurity generation. Standard sealed storage ensures 24 months of stable shelf life and reaction activity.
Q5: What is the appearance of high-purity Loperamide?
A: High-purity Loperamide is uniform white crystalline powder at room temperature, odorless, stable crystal state, no caking, no impurity precipitation and no discoloration.
Q6: Can I get free Loperamide samples for synthesis testing?
A: Yes, we provide free Loperamide samples for Anabasine synthesis debugging, pharmacological experiment research and derivative synthesis tests. Bulk orders support customized purity and packaging to meet industrial production and scientific research needs.
