Product Introduction
| Item | Specification |
| Product Name | Arctigenin |
| Synonyms | (-)-Arctigenin;; Arctiin aglycone |
| CAS Number | 7770-78-7 |
| Molecular Formula | C₂₁H₂₄O₆ |
| Molecular Weight | 372.41 g/mol |
| Appearance | White to off-white crystalline powder |
| Purity (HPLC) | ≥98.0% / ≥99.0% (customizable) |
| Loss on Drying | ≤ 1.0% |
| Residue on Ignition | ≤ 0.2% |
| Testing Method | HPLC / UV-Vis Spectroscopy / NMR |
| Production Method | Natural Plant Extraction & High-Purity Column Purification |
| Melting Point | 102–104°C |
| Boiling Point | 591.1±50.0 °C (Predicted) |
| Solubility | Slightly soluble in water, soluble in ethanol, methanol, DMSO, acetone and common organic solvents |
| Natural Source | Naturally extracted from Arctium lappa (burdock) seeds, a high-activity natural dibenzylbutyrolactone-type lignan monomer |
| Package | 1 kg/aluminum foil bag, 25 kg/fiber drum; custom packaging available |
| Storage | Store at 2-8°C in sealed, dark and dry conditions; avoid high temperature, strong light and air oxidation |
| Shelf Life | 24 months under standard low-temperature sealed storage |
Product Description
Our Arctigenin powder is a high-purity natural lignan active ingredient, available in 98% and 99% HPLC grades. Arctigenin (CAS 7770-78-7), commonly known as , is a premium dibenzylbutyrolactone-type lignan monomer refined from traditional medicinal burdock seeds. As the deglycosylated active metabolite of arctiin, it possesses far higher bioavailability and cell permeability than crude burdock extract. Featuring a unique fused lactone ring and dimethoxy phenolic structure, it integrates ultra-efficient anti-inflammation, broad-spectrum antiviral, AMPK-activated metabolic regulation, powerful antioxidant, neuroprotective and multi-target anti-tumor activities. Widely applied in sensitive soothing skincare, immune & metabolic health supplements, antiviral functional products and high-end biomedical pharmacological research. As a professional bulk Arctigenin supplier, we provide high-purity, low-impurity, stable-batch natural burdock lignan raw materials for global industrial and scientific research clients.
Arctigenin belongs to the high-value natural lignan family, with structural and functional advantages distinguishing it from flavonoids, phenolic acids and stilbene antioxidants. Different from SECO lignan and resveratrol, Arctigenin has exclusive PDE4 inhibitory anti-inflammatory and AMPK pathway metabolic regulation capabilities, plus excellent blood-brain barrier penetration and antiviral specificity. Its core functional mechanism targets the NF-κB/MAPK/JAK inflammatory axis, efficiently blocking the release of TNF-α, IL-6 and multiple pro-inflammatory factors, showing outstanding effects on stubborn skin inflammation and immune inflammation. It activates the AMPK energy-sensing pathway, inhibits hepatic lipogenesis and gluconeogenesis, and optimizes blood sugar and lipid metabolism balance. In skincare, it repairs inflammatory skin damage, improves psoriasis-like inflammation and sensitive redness, and scavenges oxidative free radicals to delay skin aging. In pharmacology, it exerts significant inhibitory effects on various tumor cells and influenza viruses, with mild properties and high biocompatibility for long-term topical and oral application.
Manufactured by Shaanxi BAISFU Bio-Engineering Co., Ltd., our premium Arctigenin powder adopts low-temperature enzymatic hydrolysis and multi-stage high-precision preparative column chromatography purification technology. We select high-quality mature burdock seeds as raw materials, efficiently convert arctiin into high-activity arctigenin through directional enzymatic hydrolysis, and completely remove plant fibers, macromolecular impurities, residual sugars and invalid pigments via gradient elution. The entire production process strictly eliminates harmful solvent residues and chemical synthetic additives, fully complying with cosmetic-grade, food-grade and research-grade safety standards. The refined purification process solves the problems of low active conversion rate and unstable activity of traditional burdock extracts, ensures uniform white crystalline powder appearance and consistent batch efficacy, meeting the strict formula development and high-precision experimental requirements of global customers.
Every batch of Arctigenin powder undergoes strict multi-dimensional quality inspection, including HPLC high-precision purity testing, UV spectral characteristic verification and NMR structural identification to ensure accurate molecular structure and stable high purity. The finished powder features low impurity content, excellent solubility in conventional organic solvents, strong structural stability and outstanding batch consistency. All products comply with international cosmetic additive regulations, natural functional food safety standards and high-end research-grade compound specifications, supporting safe and standardized application in sensitive repair skincare, immune metabolic health products, antiviral functional foods and cutting-edge biomedical research projects.
We maintain sufficient inventory and complete qualification documents for bulk Arctigenin supply. Whether you need anti-inflammatory and soothing active raw materials for sensitive skincare formulas, AMPK metabolic conditioning and immune regulation ingredients for health products, or high-purity lignan compounds for antiviral, neuroprotective and anti-tumor pharmacological research, our Arctigenin powder is a cost-effective and high-value bulk raw material choice for global buyers.
Functions & Benefits
PDE4 Inhibitory Anti-Inflammation & Sensitive Skin Repair (Core Benefit)
Arctigenin is a natural PDE4 inhibitor, efficiently suppressing keratinocyte hyperactivation and inflammatory cell chemotaxis. It blocks multiple inflammatory signaling cascades including NF-κB and MAPK, significantly relieves stubborn skin redness, swelling and chronic sensitive inflammation, improves psoriasis and inflammatory skin lesions, and repairs damaged skin barrier with mild and efficient soothing effects.
AMPK Activation & Sugar-Lipid Metabolic Balance
It activates the intracellular AMPK energy metabolic pathway, promotes muscle glucose uptake, inhibits hepatic gluconeogenesis and fat synthesis, and effectively regulates blood lipid and blood sugar balance. It improves insulin resistance, reduces body lipid deposition, and assists in metabolic syndrome conditioning and cardiovascular health maintenance.
Broad-Spectrum Antioxidant & Anti-Aging
Arctigenin efficiently scavenges intracellular ROS free radicals, inhibits lipid peroxidation and mitochondrial oxidative damage, reduces systemic oxidative stress, and delays cell senescence and skin photoaging. It stabilizes skin microecology, improves dull and tired skin texture, and builds a long-term endogenous antioxidant defense barrier.
Broad-Spectrum Antiviral & Immune Regulation
Modern pharmacological studies confirm that Arctigenin has significant inhibitory activity against influenza A virus and HIV-related viral proteins. It regulates body immune balance, reduces inflammatory damage caused by viral infection, enhances systemic immune defense capability, and serves as a natural antiviral and immune protective active ingredient.
Multi-Target Anti-Tumor Activity
Arctigenin inhibits the proliferation, migration and invasion of various malignant tumor cells including pancreatic cancer, glioma and lung cancer. It blocks tumor cell growth signaling pathways, induces tumor cell apoptosis, and exerts excellent auxiliary anti-tumor and chemoprevention effects with high safety.
Blood-Brain Barrier Penetrable Neuroprotection
With excellent lipophilicity and blood-brain barrier permeability, Arctigenin relieves neuroinflammation and oxidative nerve damage, protects nerve cell activity, improves cerebral microcirculation, and alleviates cognitive decline and neurasthenia caused by aging, providing comprehensive nervous system protection.
Applications
Sensitive Soothing & Inflammatory Repair Skincare
Arctigenin is widely used in sensitive skin soothing essences, barrier repair creams, inflammatory skin conditioning and post-procedure repair skincare products. It integrates targeted anti-inflammation, antioxidant anti-aging and barrier repair multi-effects, effectively improving chronic sensitivity, redness, inflammatory dullness and skin immune disorders, being a premium natural active ingredient for problem skin care.
Metabolic & Immune Health Supplements
Applied in sugar-lipid balance conditioning products, immune regulation supplements, antiviral daily health products and sub-health metabolic conditioning formulas. It activates AMPK metabolism, optimizes blood sugar and lipid levels, enhances immune defense, and provides safe and natural body conditioning for sub-health and hypermetabolic groups.
Functional Food & Nutritional Fortification
Used in antioxidant functional foods, immune-nourishing dietary supplements and daily health functional products. It enhances product antioxidant and immune-regulating activity, upgrades nutritional health value, and supports daily antiviral and metabolic health maintenance.
Biomedical & Pharmacological Research
Widely used in PDE4 inflammatory mechanism research, AMPK metabolic pathway exploration, antiviral pharmacology, neuroprotection and multi-target anti-tumor mechanism research, serving as a core standard lignan research compound for university laboratories and medical research institutions.
High-End Lignan Ingredient Innovation
As a high-activity burdock-derived lignan monomer, it supports the research and development of targeted anti-inflammatory, metabolic regulating and antiviral functional products, filling the market gap of natural PDE4 inhibitory active raw materials and promoting innovative iteration of sensitive skincare and metabolic health products.
FAQ
Q1: What is Arctigenin powder used for?
A: Arctigenin powder is a high-purity natural burdock seed lignan compound. It is mainly used for sensitive skin anti-inflammatory repair skincare, sugar-lipid metabolic balance conditioning, immune regulation and antiviral health care, as well as biomedical neuroprotection and multi-target anti-tumor pharmacological research.
Q2: What are the unique advantages of Arctigenin?
A: Different from ordinary lignans and polyphenol ingredients, Arctigenin features exclusive natural PDE4 inhibitory anti-inflammation and AMPK metabolic activation effects, with excellent blood-brain barrier penetration and targeted antiviral activity. It shows unique advantages in repairing stubborn sensitive inflammation and regulating sugar-lipid metabolism that other antioxidants cannot match.
Q3: Is Arctigenin safe for cosmetic and food use?
A: Yes, Arctigenin is a pure natural plant-derived active ingredient extracted from edible burdock seeds, a traditional medicinal and edible plant. It features mild properties, low irritation and high human compatibility, complying with international cosmetic and food-grade additive safety standards, supporting long-term topical skincare and oral health product application.
Q4: What is the difference between Arctigenin and other lignans?
A: SECO lignan focuses on hormone balance regulation, while Arctigenin is specialized in targeted anti-inflammation, antiviral defense and sugar-lipid metabolism improvement. It has stronger targeted anti-inflammatory and metabolic regulating activity, with broader pharmacological application value in immune and metabolic health fields.
Q5: How to store Arctigenin powder correctly?
A: Arctigenin powder is sensitive to high temperature, strong light and oxidation. It needs to be tightly sealed, protected from light, and stored at 2-8°C in a dry environment. Standard low-temperature and light-proof sealed storage ensures a 24-month valid shelf life.
Q6: Can I get free Arctigenin samples?
A: Yes, we provide free Arctigenin powder samples for sensitive skincare formula debugging, metabolic health product development and academic pharmacological research. Bulk orders support customized purity and packaging to meet diverse production and research needs.
