Product Introduction
| Item | Specification |
| Product Name | Isorhapontigenin |
| Synonyms | 32507-66-7; (E)-5-[2-(4-hydroxy-3-methoxyphenyl)vinyl]benzene-1,3-diol |
| CAS Number | 32507-66-7 |
| Molecular Formula | C₁₅H₁₄O₄ |
| Molecular Weight | 258.27 g/mol |
| Appearance | White to off-white crystalline powder |
| Purity (HPLC) | ≥98.0% / ≥99.0% (customizable) |
| Loss on Drying | ≤ 1.0% |
| Residue on Ignition | ≤ 0.2% |
| Testing Method | HPLC / UV-Vis Spectroscopy / NMR |
| Production Method | Natural Plant Extraction & High-Purity Column Purification |
| Melting Point | 180–184°C |
| Boiling Point | 471.8±35.0 °C (Predicted) |
| Solubility | Slightly soluble in water, soluble in ethanol, methanol, DMSO, acetone and common organic solvents |
| Natural Source | Naturally extracted from Gnetum parvifolium, Gnetum cleistostachyum and Rheum officinale, a rare high-activity natural trans-stilbene polyphenol and resveratrol analog |
| Package | 1 kg/aluminum foil bag, 25 kg/fiber drum; custom packaging available |
| Storage | Store at 2-8°C in sealed, dark and dry conditions; avoid high temperature, strong light and air oxidation |
| Shelf Life | 24 months under standard low-temperature sealed storage |
Product Description
Our Isorhapontigenin powder is a high-purity natural trans-stilbene active ingredient, available in 98% and 99% HPLC grades. Isorhapontigenin (CAS 32507-66-7), commonly known as , is a rare natural polyphenol compound and structural analog of resveratrol, widely enriched in traditional medicinal plants such as Gnetum and Rheum officinale. Featuring a unique trihydroxy monomethoxy stilbene structure, it integrates the advantages of resveratrol and methylated stilbenes, delivering stronger pharmacological activity, better bioavailability and higher metabolic stability than conventional stilbene compounds. It possesses multi-dimensional core efficacy including ultra-high antioxidant capacity, broad-spectrum drug-resistant anti-inflammation, cellular autophagy activation, neuroprotection and broad-spectrum anti-tumor activity, standing out among natural stilbene ingredients. Widely applied in high-end anti-aging skincare, chronic inflammation conditioning health supplements, neuroprotective functional products and advanced biomedical pharmacological research. As a professional bulk Isorhapontigenin supplier, we provide high-purity, low-impurity, stable-batch natural stilbene raw materials for global industrial and scientific research clients.
Isorhapontigenin belongs to the high-value trans-stilbene subclass of natural polyphenols, with a stable conjugated double bond and specific methoxy-hydroxyl substituted benzene ring structure. Different from resveratrol and pterostilbene, Isorhapontigenin has unique AP-1/JUN pathway activation and corticosteroid-resistant anti-inflammatory advantages, with exclusive autophagy regulation and lung-protective anti-tumor targeting properties. Its core functional mechanism activates the SESN2/JUN antioxidant signaling axis to effectively inhibit intracellular ROS generation, block lipid peroxidation and oxidative cell senescence. In skincare applications, it scavenges photooxidative free radicals, repairs UV-damaged skin barriers, relieves stubborn inflammatory sensitivity, and improves skin dullness and aging problems. In physiological regulation, it induces cellular autophagy, cleanses senescent cells and metabolic waste, and regulates immune inflammatory balance. In pharmacology, it exerts significant inhibitory effects on malignant cell proliferation, migration and invasion, especially showing excellent targeted activity against lung cancer cells, while protecting nerve cells and improving neuro-inflammatory damage, with high safety and long-term oral & topical application compatibility.
Manufactured by Shaanxi BAISFU Bio-Engineering Co., Ltd., our premium Isorhapontigenin powder adopts low-temperature directional extraction and multi-stage high-precision preparative column chromatography purification technology. We select high-quality wild Gnetum and Rheum plant raw materials with stable active content, completely remove plant fibers, macromolecular impurities, residual polysaccharides and invalid pigments through gradient elution purification, and fully retain the complete trans-stilbene molecular structure and biological activity of Isorhapontigenin. The entire production process strictly excludes harmful solvent residues and chemical synthetic additives, fully complying with cosmetic-grade, food-grade and research-grade safety standards. The refined purification process solves the problems of low natural content and unstable activity of Isorhapontigenin, ensures uniform white crystalline powder appearance and consistent batch efficacy, meeting the strict formula development and high-precision experimental requirements of global customers.
Every batch of Isorhapontigenin powder undergoes strict multi-dimensional quality inspection, including HPLC high-precision purity testing, UV spectral characteristic verification and NMR structural identification to ensure accurate molecular structure and stable high purity. The finished powder features low impurity content, excellent solubility in conventional organic solvents, strong structural stability and outstanding batch consistency. All products comply with international cosmetic additive regulations, natural functional food safety standards and high-end research-grade compound specifications, supporting safe and standardized application in high-end skincare products, anti-aging health supplements, neuroprotective functional foods and cutting-edge biomedical research projects.
We maintain sufficient inventory and complete qualification documents for bulk Isorhapontigenin supply. Whether you need high-efficiency anti-oxidation and anti-sensitive repair raw materials for high-end skincare formulas, autophagy-activated anti-aging and anti-inflammatory conditioning ingredients for health products, or high-purity stilbene compounds for neuroprotection, anti-tumor and drug-resistant inflammation pharmacological research, our Isorhapontigenin powder is a cost-effective and high-value bulk raw material choice for global buyers.
Functions & Benefits
Ultra-Strong Antioxidant & Anti-Photoaging (Core Benefit)
Isorhapontigenin efficiently activates the SESN2/JUN endogenous antioxidant pathway, significantly inhibits intracellular ROS production, and delivers stronger free radical scavenging capacity than resveratrol. It blocks UV-induced skin oxidative damage and lipid peroxidation, delays photoaging and fine line generation, repairs dull and aging skin, and builds a long-term stable skin antioxidant defense barrier.
Drug-Resistant Anti-Inflammatory & Sensitive Skin Repair
Different from conventional anti-inflammatory ingredients, Isorhapontigenin targets unique inflammatory signaling pathways, effectively improving corticosteroid-resistant chronic inflammation. It inhibits the release of multiple pro-inflammatory factors, relieves skin redness, swelling and sensitive irritation caused by external stimulation and chronic inflammation, stabilizes skin microecology, and provides mild and efficient barrier repair effects.
Cellular Autophagy Activation & Deep Anti-Aging
As a natural autophagy inducer, Isorhapontigenin effectively activates cellular autophagy, clears senescent cells and metabolic waste in the body, promotes cell renewal and repair, improves skin and organ sub-aging state, and achieves deep anti-aging effects at the cellular level, superior to ordinary antioxidant ingredients.
Broad-Spectrum Anti-Tumor & Targeted Lung Protection
Modern pharmacological studies confirm that Isorhapontigenin exerts significant broad-spectrum anti-tumor activity, especially with prominent targeted inhibitory effects on non-small cell lung cancer cells. It inhibits malignant cell proliferation, migration and invasion, induces tumor cell apoptosis, and assists in improving lung inflammatory damage, showing great clinical auxiliary application potential.
Neuroprotective & Neural Anti-Inflammatory Effects
Isorhapontigenin protects nerve cells from oxidative stress and inflammatory damage, improves cerebral microcirculation, relieves neuroinflammation, and effectively improves sub-health problems such as neurasthenia and oxidative nerve aging, providing comprehensive neural system protection.
Metabolic Balance & Immune Regulation
It regulates systemic oxidative metabolism and immune balance, reduces chronic low-grade inflammation in the body, improves metabolic disorders caused by long-term oxidative stress, and enhances body immune stability and antioxidant capacity, assisting in overall sub-health conditioning.
Applications
High-End Anti-Aging & Sensitive Repair Skincare
Isorhapontigenin is widely used in luxury anti-aging essences, post-sun repair products, sensitive skin soothing creams and barrier repair formulas. It integrates ultra-strong anti-oxidation, photoaging resistance, stubborn anti-inflammation and autophagy renewal multi-effects, effectively improving sensitive redness, dullness, fine lines and light aging, being a top-tier rare active ingredient for high-end problem skin and anti-aging skincare iteration.
Cellular Anti-Aging & Anti-Inflammatory Health Supplements
Applied in cellular autophagy anti-aging products, chronic inflammation conditioning formulas, lung health care and neuroprotective health supplements. It activates cell self-repair, improves stubborn inflammatory sub-health, protects lung and nerve tissues, and provides deep anti-aging and organ protection conditioning for sub-health and middle-aged groups.
High-End Functional Food & Nutritional Fortification
Used in high-end antioxidant functional foods, nutritional fortified beverages and natural health dietary products. It enhances product biological activity, delays oxidative deterioration, and upgrades the nutritional and health value of functional foods with natural anti-aging and anti-inflammatory properties.
Biomedical & Pharmacological Research
Widely used in autophagy mechanism research, drug-resistant inflammation pharmacology, lung cancer targeted therapy, neuroprotection and stilbene compound structure-activity relationship research, serving as a high-value standard research compound for university laboratories and medical research institutions.
Rare Functional Ingredient Innovation
As an upgraded rare stilbene ingredient superior to resveratrol, it supports the research and development of high-efficiency anti-aging, anti-sensitive and targeted protective functional products, promoting the innovative iteration of high-end natural active raw materials.
FAQ
Q1: What is Isorhapontigenin powder used for?
A: Isorhapontigenin powder is a high-purity rare natural trans-stilbene compound extracted from Gnetum and Rheum plants. It is mainly used for high-end anti-aging and sensitive repair skincare, cellular autophagy anti-aging health care, stubborn chronic inflammation conditioning, lung and nerve protection, as well as biomedical anti-tumor and pharmacological mechanism research.
Q2: What are the unique advantages of Isorhapontigenin?
A: Compared with resveratrol and pterostilbene, Isorhapontigenin has exclusive drug-resistant anti-inflammatory and autophagy activation capabilities, with stronger antioxidant activity and targeted lung anti-tumor efficacy. It solves the limitations of ordinary stilbene ingredients in improving stubborn inflammation and deep cellular aging, with more comprehensive and targeted functional advantages.
Q3: Is Isorhapontigenin safe for cosmetic and food use?
A: Yes, Isorhapontigenin is a pure natural plant-derived active ingredient extracted from traditional edible and medicinal plants. It features mild properties, low irritation and high biocompatibility, complying with international cosmetic and food-grade additive safety standards, supporting long-term topical skincare and oral health product application.
Q4: What is the difference between Isorhapontigenin and other stilbenes?
A: Resveratrol focuses on basic anti-oxidation, pterostilbene excels in SIRT1 longevity and metabolic regulation, whileIsorhapontigenin is specialized in autophagy activation and drug-resistant stubborn anti-inflammation, with unique neuroprotective and targeted lung anti-tumor effects, filling the gap of high-efficiency sensitive repair and deep anti-aging ingredients.
Q5: How to store Isorhapontigenin powder correctly?
A: Isorhapontigenin powder is sensitive to high temperature, strong light and oxidation. It needs to be tightly sealed, protected from light, and stored at 2-8°C in a dry environment. Standard low-temperature and light-proof sealed storage ensures a 24-month valid shelf life.
Q6: Can I get free Isorhapontigenin samples?
A: Yes, we provide free Isorhapontigenin powder samples for high-end skincare formula debugging, anti-aging health product development and academic pharmacological research. Bulk orders support customized purity and packaging to meet diverse production and research needs.
