Product Introduction
| Item | Specification |
| Product Name | Protocatechuic Acid |
| Synonyms | 3,4-Dihydroxybenzoic acid; PCA |
| CAS Number | 99-50-3 |
| Molecular Formula | C₇H₆O₄ |
| Molecular Weight | 154.12 g/mol |
| Appearance | White to off-white crystalline powder |
| Purity (HPLC) | ≥98.0% / ≥99.0% (customizable) |
| Loss on Drying | ≤ 1.0% |
| Residue on Ignition | ≤ 0.2% |
| Testing Method | HPLC / UV-Vis Spectroscopy / NMR |
| Production Method | Natural Plant Extraction & High-Purity Column Purification |
| Melting Point | 197–200°C |
| Boiling Point | 417.5±35.0 °C (Predicted) |
| Solubility | Soluble in hot water, ethanol, methanol and DMSO; slightly soluble in cold water; excellent water solubility compared with ordinary phenolic acids |
| Natural Source | Naturally extracted from green tea, rosemary, hibiscus and various fruits and vegetables, a key active natural phenolic acid and anthocyanin metabolite |
| Package | 1 kg/aluminum foil bag, 25 kg/fiber drum; custom packaging available |
| Storage | Store at -20°C in sealed, dark and dry conditions; avoid high temperature, strong light and oxidation |
| Shelf Life | 24 months under standard low-temperature sealed storage |
Product Description
Our Protocatechuic Acid powder is a high-purity natural bioactive phenolic acid ingredient, available in 98% and 99% HPLC grades. Protocatechuic Acid (CAS 99-50-3), commonly known as is a high-value dihydroxybenzoic acid monomer widely extracted from natural plants such as green tea, rosemary and hibiscus sabdariffa. As a core metabolite of anthocyanins and polyphenols, it features a stable 3,4-dihydroxy phenolic structure, endowing it with stronger antioxidant activity than most conventional phenolic acids. It integrates powerful free radical scavenging, broad-spectrum anti-inflammation, liver and nerve protection, antibacterial and metabolic regulation effects, widely applied in antioxidant soothing skincare, liver protection health supplements, neuroprotective functional products and advanced biomedical pharmacological research. As a professional bulk Protocatechuic Acid supplier, we provide high-purity, low-impurity, stable-batch natural phenolic acid raw materials for global industrial and scientific research clients.
Protocatechuic Acid belongs to the dihydroxy phenolic acid subclass, with two active hydroxyl groups on the benzene ring, forming its unique high-activity biochemical properties. Different from Vanillic Acid and other single-hydroxy phenolic acids, PCA possesses stronger oxidative stress resistance and inflammatory inhibition capabilities. Its core functional mechanism activates the Nrf2/ARE endogenous antioxidant pathway, efficiently scavenges intracellular ROS, DPPH and ABTS free radicals, inhibits lipid peroxidation and cellular oxidative damage. Meanwhile, it significantly blocks NF-κB and MAPK inflammatory signaling cascades, reduces the release of TNF-α, IL-6 and multiple pro-inflammatory factors, and relieves acute and chronic low-grade inflammation. In pharmacological applications, PCA shows prominent hepatoprotective effects against chemical-induced liver toxicity, improves non-alcoholic fatty liver lesions, exerts significant neuroprotective and cardiovascular protective activity, and also inhibits the proliferation of malignant cells, with ultra-high safety and no toxic side effects for long-term topical and oral use.
Manufactured by Shaanxi BAISFU Bio-Engineering Co., Ltd., our premium Protocatechuic Acid powder adopts low-temperature water-alcohol synergistic extraction and multi-stage high-precision column chromatography purification technology. We select high-quality natural plant raw materials rich in protocatechuic acid, completely remove plant fibers, macromolecular impurities, residual sugar and invalid pigment components through gradient elution purification, and fully retain the complete molecular structure and biological activity of PCA. The entire production process strictly avoids harmful solvent residues and chemical synthetic additives, fully complying with cosmetic-grade, food-grade and research-grade safety standards. The mature and stable production process ensures consistent batch purity, uniform powder appearance and reliable activity stability, meeting the strict formula development and experimental requirements of global customers.
Every batch of Protocatechuic Acid powder undergoes strict multi-dimensional quality inspection, including HPLC purity testing, UV spectral characteristic verification and NMR structural identification to ensure accurate molecular structure and stable high purity. The finished white crystalline powder features low impurity content, good water and organic solvent solubility, stable activity and excellent batch consistency. All products comply with international cosmetic additive regulations, natural functional food safety standards and research-grade compound specifications, supporting safe and standardized application in skincare products, health supplements, functional foods and biomedical research projects.
We maintain sufficient inventory and complete qualification documents for bulk Protocatechuic Acid supply. Whether you need high-efficiency antioxidant soothing raw materials for skincare formulas, liver protection and neuroprotective functional ingredients for health products, or high-purity phenolic acid compounds for oxidative stress, inflammation and metabolic pharmacological research, our Protocatechuic Acid powder is a cost-effective and reliable bulk raw material choice for global buyers.
Functions & Benefits
High-Efficiency Nrf2 Antioxidant & Anti-Aging (Core Benefit)
Protocatechuic Acid is a high-activity natural phenolic antioxidant, with stronger free radical scavenging capacity than ordinary plant phenolic acids. It specifically activates the Nrf2 endogenous antioxidant defense system, efficiently eliminates DPPH, ABTS and intracellular reactive oxygen species, inhibits cellular lipid peroxidation and oxidative DNA damage, reduces long-term oxidative stress damage to skin and organs, and effectively delays natural aging and photoaging processes.
Broad-Spectrum Anti-Inflammatory & Sensitive Skin Soothing
PCA powerfully inhibits NF-κB and MAPK inflammatory pathway activation, significantly reducing the release of various pro-inflammatory cytokines. It relieves acute inflammatory irritation and chronic low-grade inflammation in the body, calms skin redness, swelling and sensitivity caused by UV radiation, external stimulation and microbial infection, stabilizes skin microecology, and provides mild and efficient soothing and repair effects for fragile and sensitive skin.
Outstanding Hepatoprotective & Lipid-Regulating Effects
Modern pharmacological studies verify that Protocatechuic Acid has significant liver protective activity. It resists chemical-induced liver toxicity, inhibits liver inflammatory infiltration and fat accumulation, improves non-alcoholic fatty liver symptoms, optimizes liver lipid metabolism and detoxification functions, repairs damaged liver cells, and effectively improves liver sub-health caused by oxidative stress and metabolic disorders.
Unique Neuroprotective & Cardiovascular Protection
As a rare neuroprotective phenolic acid, PCA protects nerve cells from oxidative damage and apoptosis, improves cerebral microcirculation, and helps maintain nervous system health. It also regulates vascular lipid metabolism, inhibits vascular oxidative damage, enhances cardiovascular stability, and delivers dual protection for nerves and cardiovascular system.
Broad-Spectrum Antibacterial & Antimicrobial Activity
Protocatechuic Acid exerts significant inhibitory effects on common harmful bacteria and microorganisms. It can reduce microbial-induced inflammatory reactions, inhibit bacterial reproduction, assist in maintaining skin and mucosal microbial balance, and achieve safe and green antibacterial effects without chemical preservatives.
Oxidative Metabolism Improvement & Body Conditioning
PCA optimizes systemic oxidative metabolism, reduces inflammatory oxidative damage in tissues, assists in balancing lipid levels, improves metabolic disorders caused by long-term sub-health status, and enhances overall body antioxidant capacity and immune stability.
Applications
Antioxidant Soothing & Anti-Aging Skincare
Protocatechuic Acid is widely used in high-efficiency antioxidant anti-aging products, sensitive skin soothing essences, post-sun repair formulas and barrier maintenance skincare. It scavenges deep skin free radicals, calms inflammatory sensitivity, resists light aging, repairs damaged skin barriers, and is a premium natural active ingredient for clean and effective skincare formulation.
Liver Protection & Metabolic Health Supplements
Applied in fatty liver conditioning products, liver detoxification supplements, cardiovascular health formulas and sub-health metabolic regulation products. It improves liver lipid metabolism, protects liver function, regulates blood lipid balance, and provides comprehensive natural conditioning for people with long-term oxidative stress and metabolic disorders.
Neuroprotective Functional Food & Nutrition
Used in brain health nutritional products, nervous system care formulas and daily antioxidant functional foods. Relying on its unique neuroprotective activity, it supports nerve cell health, relieves brain oxidative fatigue, and enriches the nutritional value of functional food products.
Biomedical & Scientific Research
Widely used in Nrf2 antioxidant mechanism research, inflammatory pathway pharmacology, liver protection and lipid metabolism research, neuroprotective pharmacology and tumor cell inhibition research, serving as a standard high-purity phenolic acid research compound for university laboratories and medical research institutions.
Natural Functional Ingredient Innovation
Acts as a core high-activity phenolic acid intermediate for innovative functional product development, supporting the research and iteration of high-efficiency antioxidant, anti-inflammatory, liver-protective and neuroprotective natural raw materials.
FAQ
Q1: What is Protocatechuic Acid powder used for?
A: Protocatechuic Acid (PCA) powder is a high-purity natural phenolic acid extracted from green tea and multiple plants. It is mainly used for high-efficiency antioxidant soothing skincare, liver protection and lipid metabolism regulation, nerve and cardiovascular health care, as well as biomedical anti-inflammation and anti-oxidation pharmacological research.
Q2: What is the advantage of Protocatechuic Acid over other phenolic acids?
A: Compared with Vanillic Acid and other common phenolic acids, Protocatechuic Acid has stronger antioxidant and anti-inflammatory activity, with unique neuroprotective and fatty liver improvement effects. It has comprehensive efficacy and higher biological activity, suitable for high-end functional formula development.
Q3: Is Protocatechuic Acid safe for cosmetic and food use?
A: Yes, Protocatechuic Acid is a pure natural plant-derived phenolic acid with mild properties, low irritation and high biocompatibility. It complies with international cosmetic raw material standards and food-grade additive specifications, supporting long-term topical skincare and oral health product application.
Q4: What are the core advantages of Protocatechuic Acid?
A: Protocatechuic Acid features high-activity antioxidant and comprehensive protective efficacy, integrating anti-inflammation, liver protection, neuroprotection, cardiovascular protection and antibacterial effects. It has stable molecular structure, mild safety and irreplaceable advantages in high-efficiency functional raw materials.
Q5: How to store Protocatechuic Acid powder correctly?
A: Protocatechuic Acid powder is sensitive to high temperature, strong light and oxidation. It needs to be tightly sealed and stored at -20°C in a dark and dry environment. Standard low-temperature sealed storage ensures a 24-month valid shelf life.
Q6: Can I get free Protocatechuic Acid samples?
A: Yes, we provide free Protocatechuic Acid powder samples for skincare formula debugging, functional food development and academic pharmacological research. Bulk orders support customized purity and packaging to meet diverse production and research needs.
